Phyre 2 Results for Q95XA9

Email	l.a.kelley@imperial.ac.uk
Description	Q95XA9
Date	Sun Jun 30 11:04:27 BST 2013
Unique Job ID	e743689df95aa392
Sequence	MHSSENTTPN ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:63.556 Y:57.930 Z:56.501

Model (left) based on template c3bxjB_

Top template information

PDB header:signaling protein
Chain: B: PDB Molecule:ras gtpase-activating protein syngap;
PDBTitle: crystal structure of the c2-gap fragment of syngap

Confidence and coverage

Confidence:

100.0%

Coverage:

32%

293 residues ( 32% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

819 residues ( 88%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M H S S E N T T P N S S T E G P L F L K T H T N P T P P D I S P N D V W Y H G E L N E H D A N H L L Q G T S P G A F L V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence R Q T G Q T R F Y L S I L D Q D G Y P K H L P I R Q L T P P H Y F F E G K R F E T L R D I V D A Y Q L A V I P V R K G G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence I M P I N G E I Q E T K Y L C V R R F E Q R E I D E M N S E I G D I L S V C E T D E T G W M L G R N E T S G S V G I I L

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence R S H L E P L I T E V A D L S D L P Y F Y D T V S T D M V Q Y S P I G T F L L R R S S K G T D T Y A L L V K T Q F D L V

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E K F L I V G C P S R G F S L A G R P F P T I G H V L T R Y C D R A I S G G V R L T H A V C V K H Q R K S S S R R S T A

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E V R W P P F I G N E T A S M S S S Q Y D D G L R E Q K P R R M F R G T S I D T A L A S S S S F L T S S T A M P S P S T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence T V S T G I P E H L I D R F H D E D V N N H P E T S S S T T T V A A T V A L R K S R E E K Q W K E C W L T L S D I P G G

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ? ? ? ? ? ? ?
? ?
? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence S S Q L S V F D S M G S K L R Q Q V D L S T C T L F W L D E S V F C A D G C L F L S P S F P Q Q Q P P T L Y L C F R P Y

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence T A F L K W I R I L R S R T I Y Q D V P P P M L Q G T I S V G E P N S Q V S I L S I E I D K F R S E L L K S D M F Y S A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence Q V S L N G V K I G V S N A F A P A G N K G P N E M P V V V I D S K F V I P C I P T C S T N I Q L S M N S H S S I G K R

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence G R P C G V T V T I C L N E N N E S I C Q S Q A D S T G F V F R A Q R N R C P V L P L D R Y K P L L D M I R E C P S S I

Secondary structure

SS confidence

Disorder ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence L S W P S Q V L P S H L K Q F M Y T C I S H L Y A L N P Q F M S Q V I R R I I N D I L V T S T A E D V F R K D S L A T G

Secondary structure

SS confidence

Disorder
?
? ? ?
? ?
?
? ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence I I T Q C L R H L F K T P F D E F L L E N A Q F S Q S L K Q Q N L D S G G G A V E L L V N F V D Q R L L T I P L A T R L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L T I A A E C A G C R F G D E Q H E Q H L I K R T L S A L L I L R V L N P I I F S T L N T G I G S Q I A K L V Q I S A N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence S A A S Q T P T D S L T P A A S T I R R M F D R I I F L V N Q Q Q P A E S P E D S E I G E V H T E W I S C L T Y M I G H

Secondary structure

SS confidence

Disorder
? ? ? ?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . .

Sequence S L T I R S A T S S E D V H L P L P V L E L I R L H H L

Secondary structure

SS confidence

Disorder
?
? ? ? ?
? ?
? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 29%)

Alpha helix ( 34%)

Beta strand ( 19%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3bxj chain B

Region: 623 - 920
Aligned: 293
Modelled: 298
Confidence: 100.0%
Identity: 17%
PDB header:signaling protein
Chain: B: PDB Molecule:ras gtpase-activating protein syngap;
PDBTitle: crystal structure of the c2-gap fragment of syngap

Phyre2

PDB 1wer chain A

Region: 641 - 923
Aligned: 278
Modelled: 283
Confidence: 100.0%
Identity: 17%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: p120GAP domain-like

Phyre2

PDB 1nf1 chain A

Region: 644 - 871
Aligned: 213
Modelled: 216
Confidence: 100.0%
Identity: 18%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: p120GAP domain-like

Phyre2

PDB 2b3o chain A

Region: 36 - 301
Aligned: 204
Modelled: 207
Confidence: 100.0%
Identity: 24%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

Region: 33 - 327
Aligned: 216
Modelled: 218
Confidence: 100.0%
Identity: 21%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 3fay chain A

Region: 643 - 876
Aligned: 234
Modelled: 234
Confidence: 100.0%
Identity: 17%
PDB header:membrane protein
Chain: A: PDB Molecule:ras gtpase-activating-like protein iqgap1;
PDBTitle: crystal structure of the gap-related domain of iqgap1

Phyre2

PDB 3gqi chain B

Region: 34 - 288
Aligned: 190
Modelled: 195
Confidence: 100.0%
Identity: 23%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 3ps5 chain A

Region: 36 - 284
Aligned: 186
Modelled: 190
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2oq1 chain A

Region: 27 - 286
Aligned: 240
Modelled: 249
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 1a81 chain E

Region: 36 - 286
Aligned: 200
Modelled: 203
Confidence: 100.0%
Identity: 20%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 4fl2 chain A

Region: 36 - 336
Aligned: 282
Modelled: 286
Confidence: 100.0%
Identity: 19%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2ozo chain A

Region: 31 - 289
Aligned: 242
Modelled: 259
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 2lqn chain A

Region: 25 - 193
Aligned: 167
Modelled: 169
Confidence: 99.9%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2abl chain A

Region: 121 - 286
Aligned: 158
Modelled: 162
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 2fo0 chain A

Region: 133 - 295
Aligned: 157
Modelled: 163
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2eyy chain A

Region: 26 - 198
Aligned: 170
Modelled: 173
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i

Phyre2

PDB 1x27 chain F

Region: 133 - 287
Aligned: 149
Modelled: 155
Confidence: 99.9%
Identity: 21%
PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas

Phyre2

PDB 1k9a chain B

Region: 132 - 288
Aligned: 156
Modelled: 157
Confidence: 99.9%
Identity: 19%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 3nhn chain A

Region: 130 - 287
Aligned: 151
Modelled: 158
Confidence: 99.9%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region

Phyre2

PDB 3qwy chain A

Region: 28 - 185
Aligned: 155
Modelled: 158
Confidence: 99.9%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2

Phyre2

PDB 2d9z chain A

Region: 385 - 492
Aligned: 103
Modelled: 103
Confidence: 99.3%
Identity: 17%
PDB header:signaling protein
Chain: A: PDB Molecule:protein kinase c, nu type;
PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human

Phyre2

PDB 3feh chain A

Region: 298 - 492
Aligned: 144
Modelled: 144
Confidence: 99.3%
Identity: 12%
PDB header:hydrolase activator
Chain: A: PDB Molecule:centaurin-alpha-1;
PDBTitle: crystal structure of full length centaurin alpha-1

Phyre2

PDB 2coa chain A domain 1

Region: 391 - 492
Aligned: 97
Modelled: 97
Confidence: 99.3%
Identity: 12%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2r09 chain A

Region: 383 - 492
Aligned: 103
Modelled: 102
Confidence: 99.3%
Identity: 16%
PDB header:signaling protein
Chain: A: PDB Molecule:cytohesin-3;
PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor

Phyre2

PDB 2fjl chain A domain 1

Region: 391 - 492
Aligned: 95
Modelled: 95
Confidence: 99.3%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2lul chain A

Region: 382 - 494
Aligned: 103
Modelled: 103
Confidence: 99.2%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase tec;
PDBTitle: solution nmr structure of ph domain of tyrosine-protein kinase tec2 from homo sapiens, northeast structural genomics consortium (nesg)3 target hr3504c

Phyre2

PDB 2cjt chain A domain 1

Region: 517 - 636
Aligned: 108
Modelled: 108
Confidence: 98.8%
Identity: 14%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2cjs chain A domain 1

Region: 518 - 653
Aligned: 124
Modelled: 124
Confidence: 98.7%
Identity: 11%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 1qas chain A domain 2

Region: 518 - 637
Aligned: 117
Modelled: 117
Confidence: 98.6%
Identity: 11%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 1wfm chain A

Region: 514 - 622
Aligned: 100
Modelled: 100
Confidence: 98.5%
Identity: 9%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 3m7f chain B

Region: 512 - 635
Aligned: 111
Modelled: 111
Confidence: 98.5%
Identity: 8%
PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex

Phyre2

PDB 1gmi chain A

Region: 520 - 636
Aligned: 107
Modelled: 107
Confidence: 98.4%
Identity: 13%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

100

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c2lulA_

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d2cjta1

182

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d2cjsa1

189

d1qasa2

190

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d1wfma_

195

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c3m7fB_

197

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d1gmia_

199

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	H	S	S	E	N	T	T	P	N	S	S	T	E	G	P	L	F	L	K	T	H	T	N	P	T	P	P	D	I	S	P	N	D	V	W	Y	H	G	E	L	N	E	H	D	A	N	H	L	L	Q	G	T	S	P	G	A	F	L	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?																						?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	R	Q	T	G	Q	T	R	F	Y	L	S	I	L	D	Q	D	G	Y	P	K	H	L	P	I	R	Q	L	T	P	P	H	Y	F	F	E	G	K	R	F	E	T	L	R	D	I	V	D	A	Y	Q	L	A	V	I	P	V	R	K	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	I	M	P	I	N	G	E	I	Q	E	T	K	Y	L	C	V	R	R	F	E	Q	R	E	I	D	E	M	N	S	E	I	G	D	I	L	S	V	C	E	T	D	E	T	G	W	M	L	G	R	N	E	T	S	G	S	V	G	I	I	L
Secondary structure
SS confidence
Disorder																																																					?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	R	S	H	L	E	P	L	I	T	E	V	A	D	L	S	D	L	P	Y	F	Y	D	T	V	S	T	D	M	V	Q	Y	S	P	I	G	T	F	L	L	R	R	S	S	K	G	T	D	T	Y	A	L	L	V	K	T	Q	F	D	L	V
Secondary structure
SS confidence
Disorder										?	?																?			?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	K	F	L	I	V	G	C	P	S	R	G	F	S	L	A	G	R	P	F	P	T	I	G	H	V	L	T	R	Y	C	D	R	A	I	S	G	G	V	R	L	T	H	A	V	C	V	K	H	Q	R	K	S	S	S	R	R	S	T	A
Secondary structure
SS confidence
Disorder											?																										?													?	?	?	?	?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	V	R	W	P	P	F	I	G	N	E	T	A	S	M	S	S	S	Q	Y	D	D	G	L	R	E	Q	K	P	R	R	M	F	R	G	T	S	I	D	T	A	L	A	S	S	S	S	F	L	T	S	S	T	A	M	P	S	P	S	T
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?					?																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	T	V	S	T	G	I	P	E	H	L	I	D	R	F	H	D	E	D	V	N	N	H	P	E	T	S	S	S	T	T	T	V	A	A	T	V	A	L	R	K	S	R	E	E	K	Q	W	K	E	C	W	L	T	L	S	D	I	P	G	G
Secondary structure
SS confidence
Disorder	?	?	?																?	?	?	?	?	?	?	?	?	?	?		?	?						?	?	?	?	?	?	?	?	?	?									?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	S	S	Q	L	S	V	F	D	S	M	G	S	K	L	R	Q	Q	V	D	L	S	T	C	T	L	F	W	L	D	E	S	V	F	C	A	D	G	C	L	F	L	S	P	S	F	P	Q	Q	Q	P	P	T	L	Y	L	C	F	R	P	Y
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?																															?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	T	A	F	L	K	W	I	R	I	L	R	S	R	T	I	Y	Q	D	V	P	P	P	M	L	Q	G	T	I	S	V	G	E	P	N	S	Q	V	S	I	L	S	I	E	I	D	K	F	R	S	E	L	L	K	S	D	M	F	Y	S	A
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	Q	V	S	L	N	G	V	K	I	G	V	S	N	A	F	A	P	A	G	N	K	G	P	N	E	M	P	V	V	V	I	D	S	K	F	V	I	P	C	I	P	T	C	S	T	N	I	Q	L	S	M	N	S	H	S	S	I	G	K	R
Secondary structure
SS confidence
Disorder										?	?	?		?	?	?	?	?	?	?	?	?	?																					?							?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	G	R	P	C	G	V	T	V	T	I	C	L	N	E	N	N	E	S	I	C	Q	S	Q	A	D	S	T	G	F	V	F	R	A	Q	R	N	R	C	P	V	L	P	L	D	R	Y	K	P	L	L	D	M	I	R	E	C	P	S	S	I
Secondary structure
SS confidence
Disorder	?				?						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																												?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	L	S	W	P	S	Q	V	L	P	S	H	L	K	Q	F	M	Y	T	C	I	S	H	L	Y	A	L	N	P	Q	F	M	S	Q	V	I	R	R	I	I	N	D	I	L	V	T	S	T	A	E	D	V	F	R	K	D	S	L	A	T	G
Secondary structure
SS confidence
Disorder																										?																?	?	?			?	?		?			?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	I	I	T	Q	C	L	R	H	L	F	K	T	P	F	D	E	F	L	L	E	N	A	Q	F	S	Q	S	L	K	Q	Q	N	L	D	S	G	G	G	A	V	E	L	L	V	N	F	V	D	Q	R	L	L	T	I	P	L	A	T	R	L
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?	?	?	?	?	?	?																			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	L	T	I	A	A	E	C	A	G	C	R	F	G	D	E	Q	H	E	Q	H	L	I	K	R	T	L	S	A	L	L	I	L	R	V	L	N	P	I	I	F	S	T	L	N	T	G	I	G	S	Q	I	A	K	L	V	Q	I	S	A	N
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?																								?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	S	A	A	S	Q	T	P	T	D	S	L	T	P	A	A	S	T	I	R	R	M	F	D	R	I	I	F	L	V	N	Q	Q	Q	P	A	E	S	P	E	D	S	E	I	G	E	V	H	T	E	W	I	S	C	L	T	Y	M	I	G	H
Secondary structure
SS confidence
Disorder				?	?	?	?		?	?					?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.
Sequence	S	L	T	I	R	S	A	T	S	S	E	D	V	H	L	P	L	P	V	L	E	L	I	R	L	H	H	L
Secondary structure
SS confidence
Disorder				?		?	?	?	?		?	?												?	?	?	?	?
Disorder confidence