Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	T	K	L	T	R	R	E	Q	R	A	R	A	Q	H	F	I	D	T	L	E	G	T	A	F	P	N	S	K	R	I	Y	I	T	G	T	H	P	G	V	R	V	P	M	R	E	I	Q	L	S	P	T	L	I	G	G	S	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?		?	?	?	?																								?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	Q	P	Q	Y	E	E	N	E	A	I	P	V	Y	D	T	S	G	P	Y	G	D	P	Q	I	A	I	N	V	Q	Q	G	L	A	K	L	R	Q	P	W	I	D	A	R	G	D	T	E	E	L	T	V	R	S	S	D	Y	T	K	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																		?	?	?	?	?	?	?	?	?		?			?																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	L	A	D	D	G	L	D	E	L	R	F	S	G	V	L	T	P	K	R	A	K	A	G	R	R	V	T	Q	L	H	Y	A	R	Q	G	I	I	T	P	E	M	E	F	I	A	I	R	E	N	M	G	R	E	R	I	R	S	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																							?		?	?	?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	R	H	Q	H	P	G	M	S	F	G	A	H	L	P	E	N	I	T	A	E	F	V	R	D	E	V	A	A	G	R	A	I	I	P	A	N	I	N	H	P	E	S	E	P	M	I	I	G	R	N	F	L	V	K	V	N	A	N	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	N	S	A	V	T	S	S	I	E	E	E	V	E	K	L	V	W	S	T	R	W	G	A	D	T	V	M	D	L	S	T	G	R	Y	I	H	E	T	R	E	W	I	L	R	N	S	P	V	P	I	G	T	V	P	I	Y	Q	A	L
Secondary structure
SS confidence
Disorder					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	K	V	N	G	I	A	E	D	L	T	W	E	A	F	R	D	T	L	L	E	Q	A	E	Q	G	V	D	Y	F	T	I	H	A	G	V	L	L	R	Y	V	P	M	T	A	K	R	L	T	G	I	V	S	R	G	G	S	I	M	A
Secondary structure
SS confidence
Disorder				?				?																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		K	W	C	L	S	H	H	Q	E	N	F	L	Y	Q	H	F	R	E	I	C	E	I	C	A	A	Y	D	V	S	L	S	L	G	D	G	L	R	P	G	S	I	Q	D	A	N	D	E	A	Q	F	A	E	L	H	T	L	G	E	L	T
Secondary structure
SS confidence
Disorder									?																																		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		K	I	A	W	E	Y	D	V	Q	V	M	I	E	G	P	G	H	V	P	M	Q	M	I	R	R	N	M	T	E	E	L	E	H	C	H	E	A	P	F	Y	T	L	G	P	L	T	T	D	I	A	P	G	Y	D	H	F	T	S	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		G	A	A	M	I	G	W	F	G	C	A	M	L	C	Y	V	T	P	K	E	H	L	G	L	P	N	K	E	D	V	K	Q	G	L	I	T	Y	K	I	A	A	H	A	A	D	L	A	K	G	H	P	G	A	Q	I	R	D	N	A	M
Secondary structure
SS confidence
Disorder																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		S	K	A	R	F	E	F	R	W	E	D	Q	F	N	L	A	L	D	P	F	T	A	R	A	Y	H	D	E	T	L	P	Q	E	S	G	K	V	A	H	F	C	S	M	C	G	P	K	F	C	S	M	K	I	S	Q	E	V	R	D	Y
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.
Sequence		A	A	T	Q	T	I	E	M	G	M	A	D	M	S	E	N	F	R	A	R	G	G	E	I	Y	L	R	K	E	E	A
Secondary structure
SS confidence
Disorder			?									?									?	?	?					?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3epm chain B Region: 23 - 566 Aligned: 510 Modelled: 544 Confidence: 100.0% Identity: 67% PDB header:biosynthetic protein Chain: B: PDB Molecule:thiamine biosynthesis protein thic; PDBTitle: crystal structure of caulobacter crescentus thic Phyre2 PDB 3pnz chain D Region: 248 - 550 Aligned: 257 Modelled: 264 Confidence: 95.3% Identity: 13% PDB header:hydrolase Chain: D: PDB Molecule:phosphotriesterase family protein; PDBTitle: crystal structure of the lactonase lmo2620 from listeria monocytogenes Phyre2 PDB 1ad1 chain A Region: 244 - 521 Aligned: 211 Modelled: 240 Confidence: 93.9% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Dihydropteroate synthetase Phyre2 PDB 1ub3 chain A Region: 193 - 356 Aligned: 150 Modelled: 164 Confidence: 91.1% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 2hjp chain A Region: 236 - 386 Aligned: 136 Modelled: 151 Confidence: 90.7% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:phosphonopyruvate hydrolase; PDBTitle: crystal structure of phosphonopyruvate hydrolase complex with2 phosphonopyruvate and mg++ Phyre2 PDB 1h1y chain A Region: 238 - 457 Aligned: 186 Modelled: 186 Confidence: 90.3% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: D-ribulose-5-phosphate 3-epimerase Phyre2 PDB 3qc3 chain B Region: 229 - 351 Aligned: 106 Modelled: 109 Confidence: 90.3% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:d-ribulose-5-phosphate-3-epimerase; PDBTitle: crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699)2 from homo sapiens at 2.20 a resolution Phyre2 PDB 1mzh chain A Region: 192 - 356 Aligned: 148 Modelled: 165 Confidence: 90.1% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1tx2 chain A Region: 222 - 520 Aligned: 232 Modelled: 262 Confidence: 89.8% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:dhps, dihydropteroate synthase; PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis Phyre2 PDB 1tx2 chain A Region: 222 - 520 Aligned: 232 Modelled: 262 Confidence: 89.8% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Dihydropteroate synthetase Phyre2 PDB 2zvr chain A Region: 235 - 387 Aligned: 148 Modelled: 153 Confidence: 89.5% Identity: 11% PDB header:isomerase Chain: A: PDB Molecule:uncharacterized protein tm_0416; PDBTitle: crystal structure of a d-tagatose 3-epimerase-related2 protein from thermotoga maritima Phyre2 PDB 3bof chain A domain 1 Region: 307 - 453 Aligned: 140 Modelled: 142 Confidence: 89.0% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Methyltetrahydrofolate-utiluzing methyltransferases Phyre2 PDB 3db2 chain C Region: 332 - 461 Aligned: 106 Modelled: 109 Confidence: 87.4% Identity: 18% PDB header:oxidoreductase Chain: C: PDB Molecule:putative nadph-dependent oxidoreductase; PDBTitle: crystal structure of a putative nadph-dependent oxidoreductase2 (dhaf_2064) from desulfitobacterium hafniense dcb-2 at 1.70 a3 resolution Phyre2 PDB 2vef chain B Region: 307 - 521 Aligned: 203 Modelled: 214 Confidence: 87.2% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:dihydropteroate synthase; PDBTitle: dihydropteroate synthase from streptococcus pneumoniae Phyre2 PDB 1ajz chain A Region: 244 - 520 Aligned: 212 Modelled: 237 Confidence: 86.0% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Dihydropteroate synthetase Phyre2 PDB 2fli chain A domain 1 Region: 235 - 351 Aligned: 98 Modelled: 102 Confidence: 85.5% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: D-ribulose-5-phosphate 3-epimerase Phyre2 PDB 3bol chain B Region: 307 - 453 Aligned: 140 Modelled: 141 Confidence: 85.2% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+ Phyre2 PDB 2o7q chain A Region: 240 - 387 Aligned: 134 Modelled: 148 Confidence: 84.4% Identity: 24% PDB header:oxidoreductase,transferase Chain: A: PDB Molecule:bifunctional 3-dehydroquinate dehydratase/shikimate PDBTitle: crystal structure of the a. thaliana dhq-dehydroshikimate-sdh-2 shikimate-nadp(h) Phyre2 PDB 2zdr chain A domain 2 Region: 216 - 392 Aligned: 161 Modelled: 163 Confidence: 83.8% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: NeuB-like Phyre2 PDB 2q02 chain A domain 1 Region: 254 - 408 Aligned: 124 Modelled: 129 Confidence: 83.6% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: IolI-like Phyre2 1 c3epmB_ 2 c3pnzD_ 3 d1ad1a_ 4 d1ub3a_ 5 c2hjpA_ 6 d1h1ya_ 7 c3qc3B_ 8 d1mzha_ 9 c1tx2A_ 10 d1tx2a_ 11 c2zvrA_ 12 d3bofa1 13 c3db2C_ 14 c2vefB_ 15 d1ajza_ 16 d2flia1 17 c3bolB_ 18 c2o7qA_ 19 d2zdra2 20 d2q02a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235