Phyre 2 Results for P09831

Email	l.a.kelley@imperial.ac.uk
Description	P09831
Date	Wed Jan 25 15:20:14 GMT 2012
Unique Job ID	722e2134c401d045

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2vdcF_

Top template information

PDB header:oxidoreductase
Chain: F: PDB Molecule:glutamate synthase [nadph] large chain;
PDBTitle: the 9.5 a resolution structure of glutamate synthase from2 cryo-electron microscopy and its oligomerization behavior3 in solution: functional implications.

Confidence and coverage

Confidence:

100.0%

Coverage:

98%

1453 residues ( 98% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M L Y D K S L E R D N C G F G L I A H I E G E P S H K V V R T A I H A L A R M Q H R G A I L A D G K T G D G C G L L L Q

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ?
? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence K P D R F F R I V A Q E R G W R L A K N Y A V G M L F L N K D P E L A A A A R R I V E E E L Q R E T L S I V G W R D V P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence T N E G V L G E I A L S S L P R I E Q I F V N A P A G W R P R D M E R R L F I A R R R I E K R L E A D K D F Y V C S L S

Secondary structure

SS confidence

Disorder
? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence N L V N I Y K G L C M P T D L P R F Y L D L A D L R L E S A I C L F H Q R F S T N T V P R W P L A Q P F R Y L A H N G E

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence I N T I T G N R Q W A R A R T Y K F Q T P L I P D L H D A A P F V N E T G S D S S S M D N M L E L L L A G G M D I I R A

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence M R L L V P P A W Q N N P D M D P E L R A F F D F N S M H M E P W D G P A G I V M S D G R F A A C N L D R N G L R P A R

Secondary structure

SS confidence

Disorder
?
? ? ?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y V I T K D K L I T C A S E V G I W D Y Q P D E V V E K G R V G P G E L M V I D T R S G R I L H S A E T D D D L K S R H

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence P Y K E W M E K N V R R L V P F E D L P D E E V G S R E L D D D T L A S Y Q K Q F N Y S A E E L D S V I R V L G E N G Q

Secondary structure

SS confidence

Disorder ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence E A V G S M G D D T P F A V L S S Q P R I I Y D Y F R Q Q F A Q V T N P P I D P L R E A H V M S L A T S I G R E M N V F

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence C E A E G Q A H R L S F K S P I L L Y S D F K Q L T T M K E E H Y R A D T L D I T F D V T K T T L E A T V K E L C D K A

Secondary structure

SS confidence

Disorder
? ?
?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence E K M V R S G T V L L V L S D R N I A K D R L P V P A P M A V G A I Q T R L V D Q S L R C D A N I I V E T A S A R D P H

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence H F A V L L G F G A T A I Y P Y L A Y E T L G R L V D T H A I A K D Y R T V M L N Y R N G I N K G L Y K I M S K M G I S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence T I A S Y R C S K L F E A V G L H D D V V G L C F Q G A V S R I G G A S F E D F Q Q D L L N L S K R A W L A R K P I S Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence G G L L K Y V H G G E Y H A Y N P D V V R T L Q Q A V Q S G E Y S D Y Q E Y A K L V N E R P A T T L R D L L A I T P G E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
?
? ?
?
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence N A V N I A D V E P A S E L F K R F D T A A M S I G A L S P E A H E A L A E A M N S I G G N S N S G E G G E D P A R Y G

Secondary structure

SS confidence

Disorder ?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence T N K V S R I K Q V A S G R F G V T P A Y L V N A D V I Q I K V A Q G A K P G E G G Q L P G D K V T P Y I A K L R Y S V

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence P G V T L I S P P P H H D I Y S I E D L A Q L I F D L K Q V N P K A M I S V K L V S E P G V G T I A T G V A K A Y A D L

Secondary structure

SS confidence

Disorder ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence I T I A G Y D G G T G A S P L S S V K Y A G C P W E L G L V E T Q Q A L V A N G L R H K I R L Q V D G G L K T G V D I I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence K A A I L G A E S F G F G T G P M V A L G C K Y L R I C H L N N C A T G V A T Q D D K L R K N H Y H G L P F K V T N Y F

Secondary structure

SS confidence

Disorder
?
? ?
?
? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence E F I A R E T R E L M A Q L G V T R L V D L I G R T D L L K E L D G F T A K Q Q K L A L S K L L E T A E P H P G K A L Y

Secondary structure

SS confidence

Disorder
? ? ?
? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence C T E N N P P F D N G L L N A Q L L Q Q A K P F V D E R Q S K T F W F D I R N T D R S V G A S L S G Y I A Q T H G D Q G

Secondary structure

SS confidence

Disorder
?
?
? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence L A A D P I K A Y F N G T A G Q S F G V W N A G G V E L Y L T G D A N D Y V G K G M A G G L I A I R P P V G S A F R S H

Secondary structure

SS confidence

Disorder ? ?
?
?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence E A S I I G N T C L Y G A T G G R L Y A A G R A G E R F G V R N S G A I T V V E G I G D N G C E Y M T G G I V C I L G K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence T G V N F G A G M T G G F A Y V L D E S G D F R K R V N P E L V E V L S V D A L A I H E E H L R G L I T E H V Q H T G S

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . .

Sequence Q R G E E I L A N W S T F A T K F A L V K P K S S D V K A L L G H R S R S A A E L R V Q A Q

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2vdc chain F

Region: 12 - 1472
Aligned: 1453
Modelled: 1453
Confidence: 100.0%
Identity: 45%
PDB header:oxidoreductase
Chain: F: PDB Molecule:glutamate synthase [nadph] large chain;
PDBTitle: the 9.5 a resolution structure of glutamate synthase from2 cryo-electron microscopy and its oligomerization behavior3 in solution: functional implications.

Phyre2

PDB 1lm1 chain A

Region: 12 - 1469
Aligned: 1421
Modelled: 1421
Confidence: 100.0%
Identity: 47%
PDB header:oxidoreductase
Chain: A: PDB Molecule:ferredoxin-dependent glutamate synthase;
PDBTitle: structural studies on the synchronization of catalytic centers in2 glutamate synthase: native enzyme

Phyre2

PDB 1ofd chain A domain 2

Region: 443 - 1204
Aligned: 753
Modelled: 762
Confidence: 100.0%
Identity: 48%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 1ea0 chain A domain 2

Region: 430 - 1184
Aligned: 752
Modelled: 755
Confidence: 100.0%
Identity: 47%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 1ea0 chain A domain 3

Region: 12 - 428
Aligned: 414
Modelled: 414
Confidence: 100.0%
Identity: 43%
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family: Class II glutamine amidotransferases

Phyre2

PDB 1ofd chain A domain 3

Region: 12 - 433
Aligned: 420
Modelled: 422
Confidence: 100.0%
Identity: 43%
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family: Class II glutamine amidotransferases

Phyre2

PDB 1ea0 chain A domain 1

Region: 1205 - 1472
Aligned: 265
Modelled: 268
Confidence: 100.0%
Identity: 45%
Fold: Single-stranded right-handed beta-helix
Superfamily: Alpha subunit of glutamate synthase, C-terminal domain
Family: Alpha subunit of glutamate synthase, C-terminal domain

Phyre2

PDB 1ofd chain A domain 1

Region: 1207 - 1472
Aligned: 262
Modelled: 266
Confidence: 100.0%
Identity: 49%
Fold: Single-stranded right-handed beta-helix
Superfamily: Alpha subunit of glutamate synthase, C-terminal domain
Family: Alpha subunit of glutamate synthase, C-terminal domain

Phyre2

PDB 1p0k chain A

Region: 832 - 1187
Aligned: 286
Modelled: 314
Confidence: 99.9%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 1ecj chain B

Region: 155 - 409
Aligned: 216
Modelled: 222
Confidence: 99.9%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:glutamine phosphoribosylpyrophosphate
PDBTitle: escherichia coli glutamine phosphoribosylpyrophosphate2 (prpp) amidotransferase complexed with 2 amp per tetramer

Phyre2

PDB 1tb3 chain A domain 1

Region: 799 - 1170
Aligned: 313
Modelled: 341
Confidence: 99.9%
Identity: 16%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 1gph chain 1

Region: 12 - 400
Aligned: 209
Modelled: 227
Confidence: 99.9%
Identity: 29%
PDB header:transferase(glutamine amidotransferase)
Chain: 1: PDB Molecule:glutamine phosphoribosyl-pyrophosphate amidotransferase;
PDBTitle: structure of the allosteric regulatory enzyme of purine biosynthesis

Phyre2

PDB 2e77 chain B

Region: 785 - 1175
Aligned: 342
Modelled: 363
Confidence: 99.8%
Identity: 15%
PDB header:oxidoreductase
Chain: B: PDB Molecule:lactate oxidase;
PDBTitle: crystal structure of l-lactate oxidase with pyruvate complex

Phyre2

PDB 1ecf chain A domain 2

Region: 155 - 407
Aligned: 214
Modelled: 220
Confidence: 99.8%
Identity: 23%
Fold: Ntn hydrolase-like
Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases)
Family: Class II glutamine amidotransferases

Phyre2

PDB 1vrd chain A domain 1

Region: 830 - 1172
Aligned: 282
Modelled: 303
Confidence: 99.8%
Identity: 21%
Fold: TIM beta/alpha-barrel
Superfamily: Inosine monophosphate dehydrogenase (IMPDH)
Family: Inosine monophosphate dehydrogenase (IMPDH)

Phyre2

PDB 2rdu chain A

Region: 834 - 1162
Aligned: 283
Modelled: 301
Confidence: 99.8%
Identity: 21%
PDB header:oxidoreductase
Chain: A: PDB Molecule:hydroxyacid oxidase 1;
PDBTitle: crystal structure of human glycolate oxidase in complex with2 glyoxylate

Phyre2

PDB 1gox chain A

Region: 834 - 1168
Aligned: 284
Modelled: 307
Confidence: 99.8%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 2cu0 chain A domain 1

Region: 818 - 1172
Aligned: 311
Modelled: 336
Confidence: 99.8%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Inosine monophosphate dehydrogenase (IMPDH)
Family: Inosine monophosphate dehydrogenase (IMPDH)

Phyre2

PDB 1p4c chain A

Region: 796 - 1170
Aligned: 322
Modelled: 334
Confidence: 99.8%
Identity: 16%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

PDB 1kbi chain A domain 1

Region: 793 - 1173
Aligned: 336
Modelled: 346
Confidence: 99.8%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: FMN-linked oxidoreductases
Family: FMN-linked oxidoreductases

Phyre2

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Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	L	Y	D	K	S	L	E	R	D	N	C	G	F	G	L	I	A	H	I	E	G	E	P	S	H	K	V	V	R	T	A	I	H	A	L	A	R	M	Q	H	R	G	A	I	L	A	D	G	K	T	G	D	G	C	G	L	L	L	Q
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?													?	?	?		?	?	?																		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	K	P	D	R	F	F	R	I	V	A	Q	E	R	G	W	R	L	A	K	N	Y	A	V	G	M	L	F	L	N	K	D	P	E	L	A	A	A	A	R	R	I	V	E	E	E	L	Q	R	E	T	L	S	I	V	G	W	R	D	V	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	T	N	E	G	V	L	G	E	I	A	L	S	S	L	P	R	I	E	Q	I	F	V	N	A	P	A	G	W	R	P	R	D	M	E	R	R	L	F	I	A	R	R	R	I	E	K	R	L	E	A	D	K	D	F	Y	V	C	S	L	S
Secondary structure
SS confidence
Disorder			?	?			?	?			?																																					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	N	L	V	N	I	Y	K	G	L	C	M	P	T	D	L	P	R	F	Y	L	D	L	A	D	L	R	L	E	S	A	I	C	L	F	H	Q	R	F	S	T	N	T	V	P	R	W	P	L	A	Q	P	F	R	Y	L	A	H	N	G	E
Secondary structure
SS confidence
Disorder																																											?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	I	N	T	I	T	G	N	R	Q	W	A	R	A	R	T	Y	K	F	Q	T	P	L	I	P	D	L	H	D	A	A	P	F	V	N	E	T	G	S	D	S	S	S	M	D	N	M	L	E	L	L	L	A	G	G	M	D	I	I	R	A
Secondary structure
SS confidence
Disorder														?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	M	R	L	L	V	P	P	A	W	Q	N	N	P	D	M	D	P	E	L	R	A	F	F	D	F	N	S	M	H	M	E	P	W	D	G	P	A	G	I	V	M	S	D	G	R	F	A	A	C	N	L	D	R	N	G	L	R	P	A	R
Secondary structure
SS confidence
Disorder										?		?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	V	I	T	K	D	K	L	I	T	C	A	S	E	V	G	I	W	D	Y	Q	P	D	E	V	V	E	K	G	R	V	G	P	G	E	L	M	V	I	D	T	R	S	G	R	I	L	H	S	A	E	T	D	D	D	L	K	S	R	H
Secondary structure
SS confidence
Disorder																											?																																?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	P	Y	K	E	W	M	E	K	N	V	R	R	L	V	P	F	E	D	L	P	D	E	E	V	G	S	R	E	L	D	D	D	T	L	A	S	Y	Q	K	Q	F	N	Y	S	A	E	E	L	D	S	V	I	R	V	L	G	E	N	G	Q
Secondary structure
SS confidence
Disorder	?									?					?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	E	A	V	G	S	M	G	D	D	T	P	F	A	V	L	S	S	Q	P	R	I	I	Y	D	Y	F	R	Q	Q	F	A	Q	V	T	N	P	P	I	D	P	L	R	E	A	H	V	M	S	L	A	T	S	I	G	R	E	M	N	V	F
Secondary structure
SS confidence
Disorder																	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	C	E	A	E	G	Q	A	H	R	L	S	F	K	S	P	I	L	L	Y	S	D	F	K	Q	L	T	T	M	K	E	E	H	Y	R	A	D	T	L	D	I	T	F	D	V	T	K	T	T	L	E	A	T	V	K	E	L	C	D	K	A
Secondary structure
SS confidence
Disorder							?	?																																						?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	E	K	M	V	R	S	G	T	V	L	L	V	L	S	D	R	N	I	A	K	D	R	L	P	V	P	A	P	M	A	V	G	A	I	Q	T	R	L	V	D	Q	S	L	R	C	D	A	N	I	I	V	E	T	A	S	A	R	D	P	H
Secondary structure
SS confidence
Disorder																				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	H	F	A	V	L	L	G	F	G	A	T	A	I	Y	P	Y	L	A	Y	E	T	L	G	R	L	V	D	T	H	A	I	A	K	D	Y	R	T	V	M	L	N	Y	R	N	G	I	N	K	G	L	Y	K	I	M	S	K	M	G	I	S
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	T	I	A	S	Y	R	C	S	K	L	F	E	A	V	G	L	H	D	D	V	V	G	L	C	F	Q	G	A	V	S	R	I	G	G	A	S	F	E	D	F	Q	Q	D	L	L	N	L	S	K	R	A	W	L	A	R	K	P	I	S	Q
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	G	G	L	L	K	Y	V	H	G	G	E	Y	H	A	Y	N	P	D	V	V	R	T	L	Q	Q	A	V	Q	S	G	E	Y	S	D	Y	Q	E	Y	A	K	L	V	N	E	R	P	A	T	T	L	R	D	L	L	A	I	T	P	G	E
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?																	?										?	?		?																?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	N	A	V	N	I	A	D	V	E	P	A	S	E	L	F	K	R	F	D	T	A	A	M	S	I	G	A	L	S	P	E	A	H	E	A	L	A	E	A	M	N	S	I	G	G	N	S	N	S	G	E	G	G	E	D	P	A	R	Y	G
Secondary structure
SS confidence
Disorder	?									?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	T	N	K	V	S	R	I	K	Q	V	A	S	G	R	F	G	V	T	P	A	Y	L	V	N	A	D	V	I	Q	I	K	V	A	Q	G	A	K	P	G	E	G	G	Q	L	P	G	D	K	V	T	P	Y	I	A	K	L	R	Y	S	V
Secondary structure
SS confidence
Disorder																																								?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	P	G	V	T	L	I	S	P	P	P	H	H	D	I	Y	S	I	E	D	L	A	Q	L	I	F	D	L	K	Q	V	N	P	K	A	M	I	S	V	K	L	V	S	E	P	G	V	G	T	I	A	T	G	V	A	K	A	Y	A	D	L
Secondary structure
SS confidence
Disorder	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	I	T	I	A	G	Y	D	G	G	T	G	A	S	P	L	S	S	V	K	Y	A	G	C	P	W	E	L	G	L	V	E	T	Q	Q	A	L	V	A	N	G	L	R	H	K	I	R	L	Q	V	D	G	G	L	K	T	G	V	D	I	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	K	A	A	I	L	G	A	E	S	F	G	F	G	T	G	P	M	V	A	L	G	C	K	Y	L	R	I	C	H	L	N	N	C	A	T	G	V	A	T	Q	D	D	K	L	R	K	N	H	Y	H	G	L	P	F	K	V	T	N	Y	F
Secondary structure
SS confidence
Disorder														?					?	?		?																	?	?	?			?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	E	F	I	A	R	E	T	R	E	L	M	A	Q	L	G	V	T	R	L	V	D	L	I	G	R	T	D	L	L	K	E	L	D	G	F	T	A	K	Q	Q	K	L	A	L	S	K	L	L	E	T	A	E	P	H	P	G	K	A	L	Y
Secondary structure
SS confidence
Disorder																																		?	?	?																	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	C	T	E	N	N	P	P	F	D	N	G	L	L	N	A	Q	L	L	Q	Q	A	K	P	F	V	D	E	R	Q	S	K	T	F	W	F	D	I	R	N	T	D	R	S	V	G	A	S	L	S	G	Y	I	A	Q	T	H	G	D	Q	G
Secondary structure
SS confidence
Disorder		?		?		?	?	?																																																?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	L	A	A	D	P	I	K	A	Y	F	N	G	T	A	G	Q	S	F	G	V	W	N	A	G	G	V	E	L	Y	L	T	G	D	A	N	D	Y	V	G	K	G	M	A	G	G	L	I	A	I	R	P	P	V	G	S	A	F	R	S	H
Secondary structure
SS confidence
Disorder	?	?																																																					?					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	E	A	S	I	I	G	N	T	C	L	Y	G	A	T	G	G	R	L	Y	A	A	G	R	A	G	E	R	F	G	V	R	N	S	G	A	I	T	V	V	E	G	I	G	D	N	G	C	E	Y	M	T	G	G	I	V	C	I	L	G	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	T	G	V	N	F	G	A	G	M	T	G	G	F	A	Y	V	L	D	E	S	G	D	F	R	K	R	V	N	P	E	L	V	E	V	L	S	V	D	A	L	A	I	H	E	E	H	L	R	G	L	I	T	E	H	V	Q	H	T	G	S
Secondary structure
SS confidence
Disorder																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.
Sequence	Q	R	G	E	E	I	L	A	N	W	S	T	F	A	T	K	F	A	L	V	K	P	K	S	S	D	V	K	A	L	L	G	H	R	S	R	S	A	A	E	L	R	V	Q	A	Q
Secondary structure
SS confidence
Disorder																																				?		?	?	?	?	?	?	?	?	?
Disorder confidence