PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c1gthD_

Fold library id	PDB Header	Molecule	Title
c1gthD_	PDB header: oxidoreductase	Chain: D: PDB Molecule: dihydropyrimidine dehydrogenase;	PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil

Links to external resources
Added to library: Tue Mar 16 14:27:30 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence A P V L S K D V A D I E S I L A L N P R T Q S H A A L H S T L A K K L D K K H W K R N P D K N C F H C E K L E N N F D D I K H T T L G E R G

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
T T T S
S S
S
T T
T T
T T

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence A L R E A M R C L K C A D A P C Q K S C P T H L D I K S F I T S I S N K N Y Y G A A K M I F S D N P L G L T C G M V C P T S D L C V G G C N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
T S T T
T T
T T
G G G S G G G G
G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence L Y A T E E G S I N I G G L Q Q F A S E V F K A M N I P Q I R N P C L P S Q E K M P E A Y S A K I A L L G A G P A S I S C A S F L A R L G Y

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) G G G S T T
T
B
T T S
G G G S
G G G G
S T

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence S D I T I F E K Q E Y V G G L S T S E I P Q F R L P Y D V V N F E I E L M K D L G V K I I C G K S L S E N E I T L N T L K E E G Y K A A F I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S S S
S T T S
T T T S
T T T
S
B S T T S B
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence G I G L P E P K T D D I F Q G L T Q D Q G F Y T S K D F L P L V A K S S K A G M C A C H S P L P S I R G A V I V L G A G D T A F D C A T S A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
G G G T T
T T T T
T T T
S S
S
S

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence L R C G A R R V F L V F R K G F V N I R A V P E E V E L A K E E K C E F L P F L S P R K V I V K G G R I V A V Q F V R T E Q D E T G K W N E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S S
G G G
S
T T
S
S S S
S S S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence D E D Q I V H L K A D V V I S A F G S V L R D P K V K E A L S P I K F N R W D L P E V D P E T M Q T S E P W V F A G G D I V G M A N T T V E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T T T S
B
T T S S B
T T T
B
S S T T
G G G G T
S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence S V N D G K Q A S W Y I H K Y I Q A Q Y G A S V S A K P E L P L F Y T P V D L V D I S V E M A G L K F I N P F G L A S A A P T T S S S M I R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S S
B
G G G G
T T S S S
S S G G G S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence R A F E A G W G F A L T K T F S L D K D I V T N V S P R I V R G T T S G P M Y G P G Q S S F L N I E L I S E K T A A Y W C Q S V T E L K A D

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
S
B
G G G
S S
T T
S
S S
S
S
S S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence F P D N I V I A S I M C S Y N K N D W M E L S R K A E A S G A D A L E L N L S C P H G M G E R G M G L A C G Q D P E L V R N I C R W V R Q A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T S
S
T T
S
S S G G G G T
T

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence V Q I P F F A K L T P N V T D I V S I A R A A K E G G A D G V T A T N T V S G L M G L K A D G T P W P A V G A G K R T T Y G G V S G T A I R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S
S S
T
S
B
T T S
B S S
B T T T T B
S G G G

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence P I A L R A V T T I A R A L P G F P I L A T G G I D S A E S G L Q F L H S G A S V L Q V C S A V Q N Q D F T V I Q D Y C T G L K A L L Y L K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T T
S S
S T T
S S T S
T T T

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence S I E E L Q G W D G Q S P G T E S H Q K G K P V P R I A E L M G K K L P N F G P Y L E Q R K K I I A E E K M R L K E Q N A A F P P L E R K P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T
G G G T T S B T T B
T T
T T T T T S
S S

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence F I P K K P I P A I K D V I G K A L Q Y L G T F G E L S N I E Q V V A V I D E E M C I N C G K C Y M T C N D S G Y Q A I Q F D P E T H L P T

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T T T G G G
G G G S
S S S
T T T
S
S
T T T

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . .

Sequence V T D T C T G C T L C L S V C P I I D C I R M V S R T T P Y E P K R G L P L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S S T T S
S
S S

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	A	P	V	L	S	K	D	V	A	D	I	E	S	I	L	A	L	N	P	R	T	Q	S	H	A	A	L	H	S	T	L	A	K	K	L	D	K	K	H	W	K	R	N	P	D	K	N	C	F	H	C	E	K	L	E	N	N	F	D	D	I	K	H	T	T	L	G	E	R	G
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				T	T	S									T	T	T	S					S	S																			S			T	T								T	T							T	T
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	A	L	R	E	A	M	R	C	L	K	C	A	D	A	P	C	Q	K	S	C	P	T	H	L	D	I	K	S	F	I	T	S	I	S	N	K	N	Y	Y	G	A	A	K	M	I	F	S	D	N	P	L	G	L	T	C	G	M	V	C	P	T	S	D	L	C	V	G	G	C	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T						T	S	T	T													T	T														T	T										G	G	G	S	G	G	G	G		G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	L	Y	A	T	E	E	G	S	I	N	I	G	G	L	Q	Q	F	A	S	E	V	F	K	A	M	N	I	P	Q	I	R	N	P	C	L	P	S	Q	E	K	M	P	E	A	Y	S	A	K	I	A	L	L	G	A	G	P	A	S	I	S	C	A	S	F	L	A	R	L	G	Y
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	G	G	G	S	T	T																				T				B			T	T	S			G	G	G	S		G	G	G	G									S														T
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	S	D	I	T	I	F	E	K	Q	E	Y	V	G	G	L	S	T	S	E	I	P	Q	F	R	L	P	Y	D	V	V	N	F	E	I	E	L	M	K	D	L	G	V	K	I	I	C	G	K	S	L	S	E	N	E	I	T	L	N	T	L	K	E	E	G	Y	K	A	A	F	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								S	S	S	S		S	T					T	S		T	T	T	S														T	T	T						S			B	S	T	T	S	B								T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	G	I	G	L	P	E	P	K	T	D	D	I	F	Q	G	L	T	Q	D	Q	G	F	Y	T	S	K	D	F	L	P	L	V	A	K	S	S	K	A	G	M	C	A	C	H	S	P	L	P	S	I	R	G	A	V	I	V	L	G	A	G	D	T	A	F	D	C	A	T	S	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											G	G	G	T	T			T	T	T	T																	T	T	T		S	S									S								S
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	L	R	C	G	A	R	R	V	F	L	V	F	R	K	G	F	V	N	I	R	A	V	P	E	E	V	E	L	A	K	E	E	K	C	E	F	L	P	F	L	S	P	R	K	V	I	V	K	G	G	R	I	V	A	V	Q	F	V	R	T	E	Q	D	E	T	G	K	W	N	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T		S							S	S		G	G	G			S											T	T						S										S	S	S													S	S	S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	D	E	D	Q	I	V	H	L	K	A	D	V	V	I	S	A	F	G	S	V	L	R	D	P	K	V	K	E	A	L	S	P	I	K	F	N	R	W	D	L	P	E	V	D	P	E	T	M	Q	T	S	E	P	W	V	F	A	G	G	D	I	V	G	M	A	N	T	T	V	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											S																		T	T	T	T	S		B		T	T	S	S	B				T	T	T		B		S	S	T	T					G	G	G	G	T				S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	S	V	N	D	G	K	Q	A	S	W	Y	I	H	K	Y	I	Q	A	Q	Y	G	A	S	V	S	A	K	P	E	L	P	L	F	Y	T	P	V	D	L	V	D	I	S	V	E	M	A	G	L	K	F	I	N	P	F	G	L	A	S	A	A	P	T	T	S	S	S	M	I	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																				T	T					S	S							B		G	G	G	G								T	T				S	S	S					S	S	G	G	G	S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	R	A	F	E	A	G	W	G	F	A	L	T	K	T	F	S	L	D	K	D	I	V	T	N	V	S	P	R	I	V	R	G	T	T	S	G	P	M	Y	G	P	G	Q	S	S	F	L	N	I	E	L	I	S	E	K	T	A	A	Y	W	C	Q	S	V	T	E	L	K	A	D
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)						T		S							B			G	G	G						S	S							T	T		S			S	S			S								S		S	S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	F	P	D	N	I	V	I	A	S	I	M	C	S	Y	N	K	N	D	W	M	E	L	S	R	K	A	E	A	S	G	A	D	A	L	E	L	N	L	S	C	P	H	G	M	G	E	R	G	M	G	L	A	C	G	Q	D	P	E	L	V	R	N	I	C	R	W	V	R	Q	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T	S										S															T	T		S										S	S	G	G	G	G	T		T
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	V	Q	I	P	F	F	A	K	L	T	P	N	V	T	D	I	V	S	I	A	R	A	A	K	E	G	G	A	D	G	V	T	A	T	N	T	V	S	G	L	M	G	L	K	A	D	G	T	P	W	P	A	V	G	A	G	K	R	T	T	Y	G	G	V	S	G	T	A	I	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		S	S								S		S	S													T		S														B		T	T	S		B	S	S		B	T	T	T	T	B								S	G	G	G
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	P	I	A	L	R	A	V	T	T	I	A	R	A	L	P	G	F	P	I	L	A	T	G	G	I	D	S	A	E	S	G	L	Q	F	L	H	S	G	A	S	V	L	Q	V	C	S	A	V	Q	N	Q	D	F	T	V	I	Q	D	Y	C	T	G	L	K	A	L	L	Y	L	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														S	T	T							S	S			S										T	T		S					S					T	S		T	T																T
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	S	I	E	E	L	Q	G	W	D	G	Q	S	P	G	T	E	S	H	Q	K	G	K	P	V	P	R	I	A	E	L	M	G	K	K	L	P	N	F	G	P	Y	L	E	Q	R	K	K	I	I	A	E	E	K	M	R	L	K	E	Q	N	A	A	F	P	P	L	E	R	K	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T		G	G	G	T	T	S	B	T	T	B								T	T							T	T	T	T	T	S				S	S
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	F	I	P	K	K	P	I	P	A	I	K	D	V	I	G	K	A	L	Q	Y	L	G	T	F	G	E	L	S	N	I	E	Q	V	V	A	V	I	D	E	E	M	C	I	N	C	G	K	C	Y	M	T	C	N	D	S	G	Y	Q	A	I	Q	F	D	P	E	T	H	L	P	T
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S	S									T	T	T	T	G	G	G				G	G	G	S		S	S	S								T	T	T															S		S						T	T	T
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.
Sequence	V	T	D	T	C	T	G	C	T	L	C	L	S	V	C	P	I	I	D	C	I	R	M	V	S	R	T	T	P	Y	E	P	K	R	G	L	P	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			T	T												S	S	T	T	S								S							S	S