Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP46109
DateSat Jun 16 10:40:36 BST 2012
Unique Job IDc2d4291e76481a57

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2lqnA_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
Confidence and coverage
Confidence:100.0% Coverage:100%
303 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
Secondary structure 






























SS confidence 



























































Disorder  ??????????




















?



























Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
Secondary structure 







































SS confidence 



























































Disorder 





























??




















?????

Disorder confidence 



























































 
   .........130.........140.........150.........160.........170.........180
Sequence  AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
Secondary structure 



































SS confidence 



























































Disorder 







?





?????







































Disorder confidence 



























































 
   .........190.........200.........210.........220.........230.........240
Sequence  LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
Secondary structure 
























































SS confidence 



























































Disorder 

???????????????????????????????????????????????????????
?
Disorder confidence 



























































 
   .........250.........260.........270.........280.........290.........300
Sequence  KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD
Secondary structure 


























SS confidence 



























































Disorder 










???

















?




















??????
Disorder confidence 



























































 
   ...
Sequence  ENE
Secondary structure 


SS confidence 


Disorder  ???
Disorder confidence 


 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2lqn chain A

3D model

Region: 1 - 303
Aligned: 303
Modelled: 303
Confidence: 100.0%
Identity: 100%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2eyz chain A

3D model

Region: 1 - 302
Aligned: 285
Modelled: 293
Confidence: 100.0%
Identity: 61%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2dvj chain A

3D model

Region: 3 - 218
Aligned: 209
Modelled: 216
Confidence: 100.0%
Identity: 59%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii

Phyre2

PDB 2eyy chain A

3D model

Region: 1 - 190
Aligned: 182
Modelled: 190
Confidence: 100.0%
Identity: 68%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i

Phyre2

PDB 3qwx chain X

3D model

Region: 4 - 180
Aligned: 158
Modelled: 159
Confidence: 100.0%
Identity: 37%
PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174

Phyre2

PDB 3qwy chain A

3D model

Region: 5 - 180
Aligned: 157
Modelled: 158
Confidence: 100.0%
Identity: 38%
PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2

Phyre2

PDB 2l3s chain A

3D model

Region: 125 - 295
Aligned: 162
Modelled: 171
Confidence: 100.0%
Identity: 57%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 1gri chain A

3D model

Region: 126 - 297
Aligned: 166
Modelled: 172
Confidence: 100.0%
Identity: 22%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 1ng2 chain A

3D model

Region: 125 - 297
Aligned: 129
Modelled: 130
Confidence: 100.0%
Identity: 19%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 1ov3 chain A

3D model

Region: 119 - 293
Aligned: 131
Modelled: 132
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 2eo3 chain A

3D model

Region: 1 - 104
Aligned: 104
Modelled: 104
Confidence: 100.0%
Identity: 100%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 7 - 113
Aligned: 107
Modelled: 107
Confidence: 99.9%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2oq1 chain A

3D model

Region: 7 - 107
Aligned: 101
Modelled: 101
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2gsb chain A

3D model

Region: 7 - 108
Aligned: 102
Modelled: 102
Confidence: 99.9%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2

PDB 2dly chain A

3D model

Region: 1 - 110
Aligned: 110
Modelled: 110
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 2eyv chain A domain 1

3D model

Region: 13 - 104
Aligned: 92
Modelled: 92
Confidence: 99.9%
Identity: 82%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1fhs chain A

3D model

Region: 8 - 115
Aligned: 108
Modelled: 108
Confidence: 99.9%
Identity: 21%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 3hiz chain B

3D model

Region: 8 - 105
Aligned: 98
Modelled: 98
Confidence: 99.9%
Identity: 29%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2y3a chain B

3D model

Region: 1 - 112
Aligned: 111
Modelled: 112
Confidence: 99.9%
Identity: 22%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2fo0 chain A

3D model

Region: 4 - 131
Aligned: 128
Modelled: 128
Confidence: 99.9%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2
1

c2lqnA_
2

c2eyzA_
3

c2dvjA_
4

c2eyyA_
5

c3qwxX_
6

c3qwyA_
7

c2l3sA_
8

c1griA_
9

c1ng2A_
10

c1ov3A_
11

c2eo3A_
12

d2oq1a1
13

c2oq1A_
14

c2gsbA_
15

c2dlyA_
16

d2eyva1
17

d1fhsa_
18

c3hizB_
19

c2y3aB_
20

c2fo0A_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58



59



60



61



62



63



64



65



66



67



68



69



70



71



72



73



74



75



76



77



78



79



80



81



82



83



84



85



86



87



88



89



90



91



92



93



94



95



96



97



98



99



100



101



102



103



104



105



106



107



108



109



110



111



112



113



114



115



116



117



118



119



120



121



122



123



124



125



126



127



128



129



130



131



132



133



134



135



136



137



138



139



140



141



142



143



144



145



146



147



148



149



150



151



152



153



154



155



156



157



158



159



160



161



162



163



164



165



166



167



168



169



170



171



172



173



174



175



176



177



178



179



180



181



182



183



184



185



186



187



188



189



190



191



192



193



194



195



196



197



198



199



200



201



202



203



204



205



206



207



208



209



210



211



212



213



214



215



216



217



218



219



220



221



222



223



224



225



226



227



228



229



230



231



232



233



234



235



236



237



238



239



240



241



242



243



244



245



246



247



248



249



250



251



252



253



254



255



256



257



258



259



260



261



262



263



264



265



266



267



268



269



270



271



272



273



274



275



276



277



278



279



280



281



282



283



284



285



286



287



288



289



290



291



292



293



294



295



296



297



298



299



300



301



302



303



304



305



306



307



308



309



310



311



312



313



314



315



316



317



318



319



320



321



322



323



324



325



326



327



328



329



330



331



332



333



334



335



336



337



338



339



340



341



342



343



344



345



346



347



348



349



350



351



352



353



354



355



356



357



358



359



360



361



362



363



364



365



366



367



368



369



370



371



372



373



374






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2lqnA_



100.0 100 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
2c2eyzA_



100.0 61 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
3c2dvjA_



100.0 59 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
4c2eyyA_



100.0 68 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
5c3qwxX_



100.0 37 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
6c3qwyA_



100.0 38 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
7c2l3sA_



100.0 57 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
8c1griA_



100.0 22 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
9c1ng2A_



100.0 19 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
10c1ov3A_



100.0 18 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
11c2eo3A_



100.0 100 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
12d2oq1a1



99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
13c2oq1A_



99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
14c2gsbA_



99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
15c2dlyA_



99.9 27 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
16d2eyva1



99.9 82 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
17d1fhsa_



99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
18c3hizB_



99.9 29 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
19c2y3aB_



99.9 22 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
20c2fo0A_



99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
21c3gqiB_



not modelled 99.9 29 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
22d2oq1a2



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23d1a81e1



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
24c2dlzA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
25d3c7ia1



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26c2ablA_



not modelled 99.9 34 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
27c2shpA_



not modelled 99.9 22 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
28d1blja_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29d1a81a1



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30c2eo6A_



not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
31c2crhA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
32d2shpa2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
33d1r1qa_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34d1a81e2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35c2vifA_



not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
36d2izva2



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1rjaa_



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1csya_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39d1k9aa2



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40d1a81a2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41c2ozoA_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
42c1k9aB_



not modelled 99.9 30 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
43c1oplA_



not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
44d1jwoa_



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c1ka6A_



not modelled 99.9 23 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
46d1pica_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1opka2



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d1jyra_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d1nrva_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50c2eobA_



not modelled 99.9 26 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
51c1y57A_



not modelled 99.9 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
52d1lkka_



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
53c2ci8A_



not modelled 99.9 29 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
54c2ysxA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
55c2b3oA_



not modelled 99.9 26 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
56c2lctA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
57c1x6cA_



not modelled 99.9 35 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
58d1d4ta_



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59c1x27F_



not modelled 99.9 33 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
60c2c9wA_



not modelled 99.9 23 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
61d1ayaa_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62c3ps5A_



not modelled 99.9 26 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
63d1g83a2



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64c3nhnA_



not modelled 99.9 37 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
65d1o48a_



not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c2ge9A_



not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
67c2dcrA_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
68c2c0iA_



not modelled 99.9 32 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
69c2kk6A_



not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
70d1i3za_



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71d1f2fa_



not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72d2cs0a1



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
73d1bkla_



not modelled 99.9 35 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c1a81E_



not modelled 99.9 23 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
75d1qcfa2



not modelled 99.9 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1qada_



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77c2h8hA_



not modelled 99.9 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
78d1fu6a_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79c2izvA_



not modelled 99.9 20 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
80d2qmsa1



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2knoA_



not modelled 99.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
82d2shpa3



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83d1mila_



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d2c9wa2



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1luia_



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86c2hmhA_



not modelled 99.9 23 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
87c2ekxA_



not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
88c2el8A_



not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
89d1rpya_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90c3mazA_



not modelled 99.9 16 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
91c1rqqC_



not modelled 99.8 26 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
92d2fcia1



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
93d1xa6a2



not modelled 99.8 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94c1g83A_



not modelled 99.8 35 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
95c2dm0A_



not modelled 99.8 26 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
96d1cwea_



not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97c3gxxB_



not modelled 99.8 17 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
98c2dbkA_



not modelled 99.8 93 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structures of the sh3 domain of human crk-like2 protein
99c2cr4A_



not modelled 99.8 20 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
100c1mv3A_



not modelled 99.8 15 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
101c2eyxA_



not modelled 99.8 70 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: c-terminal sh3 domain of ct10-regulated kinase
102d1udla_



not modelled 99.8 24 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
103c2bzxA_



not modelled 99.7 100 PDB header:sh3 domain
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: atomic model of crkl-sh3c monomer
104c2ebpA_



not modelled 99.7 27 PDB header:cell adhesion
Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1;
PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1
105c3or8A_



not modelled 99.7 20 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
106c2dx0B_



not modelled 99.7 31 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
107c2dx1A_



not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef
108c2xp1A_



not modelled 99.7 11 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
109d1ng2a2



not modelled 99.7 14 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
110c2ed0A_



not modelled 99.7 22 PDB header:signaling protein
Chain: A: PDB Molecule:abl interactor 2;
PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2)
111c3nmzD_



not modelled 99.7 18 PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef
112c2cubA_



not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1
113c2dybA_



not modelled 99.7 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)
114c2nwmA_



not modelled 99.7 31 PDB header:cell adhesion
Chain: A: PDB Molecule:vinexin;
PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin
115c2yuoA_



not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:run and tbc1 domain containing 3;
PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3
116c2ysqA_



not modelled 99.7 24 PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9;
PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9
117c2ekhA_



not modelled 99.6 15 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a;
PDBTitle: solution structures of the sh3 domain of human kiaa0418
118c2kymA_



not modelled 99.6 19 PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide
119c2bz8B_



not modelled 99.6 36 PDB header:sh3 domain
Chain: B: PDB Molecule:sh3-domain kinase binding protein 1;
PDBTitle: n-terminal sh3 domain of cin85 bound to cbl-b peptide
120c1x2qA_



not modelled 99.6 20 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite