Phyre 2 Results for P19174

Email	l.a.kelley@imperial.ac.uk
Description	P19174
Date	Wed May 9 17:43:44 BST 2012
Unique Job ID	1975ec919504b475

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3ohmB_

Top template information

PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Confidence and coverage

Confidence:

100.0%

Coverage:

56%

717 residues ( 56% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A G A A S P C A N G C G P G A P S D A E V L H L C R S L E V G T V M T L F Y S K K S Q R P E R K T F Q V K L E T R Q I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence T W S R G A D K I E G A I D I R E I K E I R P G K T S R D F D R Y Q E D P A F R P D Q S H C F V I L Y G M E F R L K T L

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence S L Q A T S E D E V N M W I K G L T W L M E D T L Q A P T P L Q I E R W L R K Q F Y S V D R N R E D R I S A K D L K N M

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence L S Q V N Y R V P N M R F L R E R L T D L E Q R S G D I T Y G Q F A Q L Y R S L M Y S A Q K T M D L P F L E A S T L R A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence G E R P E L C R V S L P E F Q Q F L L D Y Q G E L W A V D R L Q V Q E F M L S F L R D P L R E I E E P Y F F L D E F V T

Secondary structure

SS confidence

Disorder ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence F L F S K E N S V W N S Q L D A V C P D T M N N P L S H Y W I S S S H N T Y L T G D Q F S S E S S L E A Y A R C L R M G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence C R C I E L D C W D G P D G M P V I Y H G H T L T T K I K F S D V L H T I K E H A F V A S E Y P V I L S I E D H C S I A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence Q Q R N M A Q Y F K K V L G D T L L T K P V E I S A D G L P S P N Q L K R K I L I K H K K L A E G S A Y E E V P T S M M

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence Y S E N D I S N S I K N G I L Y L E D P V N H E W Y P H Y F V L T S S K I Y Y S E E T S S D Q G N E D E E E P K E V S S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ?
?
? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S T E L H S N E K W F H G K L G A G R D G R H I A E R L L T E Y C I E T G A P D G S F L V R E S E T F V G D Y T L S F W

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence R N G K V Q H C R I H S R Q D A G T P K F F L T D N L V F D S L Y D L I T H Y Q Q V P L R C N E F E M R L S E P V P Q T

Secondary structure

SS confidence

Disorder
?
? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence N A H E S K E W Y H A S L T R A Q A E H M L M R V P R D G A F L V R K R N E P N S Y A I S F R A E G K I K H C R V Q Q E

Secondary structure

SS confidence

Disorder ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence G Q T V M L G N S E F D S L V D L I S Y Y E K H P L Y R K M K L R Y P I N E E A L E K I G T A E P D Y G A L Y E G R N P

Secondary structure

SS confidence

Disorder
? ? ? ?
?
? ?
? ? ? ? ? ? ?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence G F Y V E A N P M P T F K C A V K A L F D Y K A Q R E D E L T F I K S A I I Q N V E K Q E G G W W R G D Y G G K K Q L W

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ?
?
? ?
? ?
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence F P S N Y V E E M V N P V A L E P E R E H L D E N S P L G D L L R G V L D V P A C Q I A I R P E G K N N R L F V F S I S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
?
? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence M A S V A H W S L D V A A D S Q E E L Q D W V K K I R E V A Q T A D A R L T E G K I M E R R K K I A L E L S E L V V Y C

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence R P V P F D E E K I G T E R A C Y R D M S S F P E T K A E K Y V N K A K G K K F L Q Y N R L Q L S R I Y P K G Q R L D S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence S N Y D P L P M W I C G S Q L V A L N F Q T P D K P M Q M N Q A L F M T G R H C G Y V L Q P S T M R D E A F D P F D K S

Secondary structure

SS confidence

Disorder
? ? ?
?
?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S L R G L E P C A I S I E V L G A R H L P K N G R G I V C P F V E I E V A G A E Y D S T K Q K T E F V V D N G L N P V W

Secondary structure

SS confidence

Disorder ? ? ?
?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence P A K P F H F Q I S N P E F A F L R F V V Y E E D M F S D Q N F L A Q A T F P V K G L K T G Y R A V P L K N N Y S E D L

Secondary structure

SS confidence

Disorder
?
? ? ?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence E L A S L L I K I D I F P A K E N G D L S P F S G T S L R E R G S D A S G Q L F H G R A R E G S F E S R Y Q Q P F E D F

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290

Sequence R I S Q E H L A D H F D S R E R R A P R R T R V N G D N R L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3ohm chain B

Region: 25 - 1238
Aligned: 717
Modelled: 742
Confidence: 100.0%
Identity: 34%
PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Phyre2

PDB 3qr0 chain A

Region: 25 - 1237
Aligned: 732
Modelled: 757
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: A: PDB Molecule:phospholipase c-beta (plc-beta);
PDBTitle: crystal structure of s. officinalis plc21

Phyre2

PDB 2fju chain B

Region: 25 - 1213
Aligned: 673
Modelled: 702
Confidence: 100.0%
Identity: 36%
PDB header:signaling protein,apoptosis/hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: activated rac1 bound to its effector phospholipase c beta 2

Phyre2

PDB 1djy chain B

Region: 170 - 1213
Aligned: 555
Modelled: 569
Confidence: 100.0%
Identity: 44%
PDB header:lipid degradation
Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c,
PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate

Phyre2

PDB 2zkm chain X domain 4

Region: 319 - 1072
Aligned: 292
Modelled: 294
Confidence: 100.0%
Identity: 54%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 1qas chain A domain 3

Region: 323 - 1076
Aligned: 274
Modelled: 275
Confidence: 100.0%
Identity: 62%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 3gqi chain B

Region: 545 - 770
Aligned: 226
Modelled: 226
Confidence: 100.0%
Identity: 100%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2b3o chain A

Region: 549 - 762
Aligned: 199
Modelled: 210
Confidence: 100.0%
Identity: 30%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

Region: 549 - 762
Aligned: 199
Modelled: 214
Confidence: 100.0%
Identity: 31%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2shp chain A

Region: 547 - 762
Aligned: 201
Modelled: 216
Confidence: 100.0%
Identity: 32%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2zkm chain X domain 2

Region: 1089 - 1213
Aligned: 118
Modelled: 125
Confidence: 100.0%
Identity: 31%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 1qas chain A domain 2

Region: 1087 - 1213
Aligned: 124
Modelled: 127
Confidence: 100.0%
Identity: 34%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2oq1 chain A

Region: 549 - 758
Aligned: 195
Modelled: 205
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2lqn chain A

Region: 538 - 858
Aligned: 302
Modelled: 310
Confidence: 99.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2ozo chain A

Region: 549 - 778
Aligned: 215
Modelled: 225
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 1a81 chain E

Region: 547 - 758
Aligned: 200
Modelled: 208
Confidence: 99.9%
Identity: 27%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2eyz chain A

Region: 538 - 856
Aligned: 288
Modelled: 300
Confidence: 99.9%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2zkm chain X domain 3

Region: 25 - 148
Aligned: 122
Modelled: 124
Confidence: 99.9%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Pleckstrin-homology domain (PH domain)

Phyre2

PDB 2fjl chain A

Region: 489 - 933
Aligned: 150
Modelled: 150
Confidence: 99.9%
Identity: 100%
PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the split ph domain in phospholipase2 c-gamma1

Phyre2

PDB 2zkm chain X domain 1

Region: 153 - 318
Aligned: 128
Modelled: 150
Confidence: 99.9%
Identity: 20%
Fold: EF Hand-like
Superfamily: EF-hand
Family: EF-hand modules in multidomain proteins

Phyre2

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	G	A	A	S	P	C	A	N	G	C	G	P	G	A	P	S	D	A	E	V	L	H	L	C	R	S	L	E	V	G	T	V	M	T	L	F	Y	S	K	K	S	Q	R	P	E	R	K	T	F	Q	V	K	L	E	T	R	Q	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																			?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	T	W	S	R	G	A	D	K	I	E	G	A	I	D	I	R	E	I	K	E	I	R	P	G	K	T	S	R	D	F	D	R	Y	Q	E	D	P	A	F	R	P	D	Q	S	H	C	F	V	I	L	Y	G	M	E	F	R	L	K	T	L
Secondary structure
SS confidence
Disorder					?	?	?	?																											?	?	?	?	?	?	?														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	S	L	Q	A	T	S	E	D	E	V	N	M	W	I	K	G	L	T	W	L	M	E	D	T	L	Q	A	P	T	P	L	Q	I	E	R	W	L	R	K	Q	F	Y	S	V	D	R	N	R	E	D	R	I	S	A	K	D	L	K	N	M
Secondary structure
SS confidence
Disorder																										?	?	?	?	?																?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	L	S	Q	V	N	Y	R	V	P	N	M	R	F	L	R	E	R	L	T	D	L	E	Q	R	S	G	D	I	T	Y	G	Q	F	A	Q	L	Y	R	S	L	M	Y	S	A	Q	K	T	M	D	L	P	F	L	E	A	S	T	L	R	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?																		?	?											?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	G	E	R	P	E	L	C	R	V	S	L	P	E	F	Q	Q	F	L	L	D	Y	Q	G	E	L	W	A	V	D	R	L	Q	V	Q	E	F	M	L	S	F	L	R	D	P	L	R	E	I	E	E	P	Y	F	F	L	D	E	F	V	T
Secondary structure
SS confidence
Disorder	?	?	?																																												?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	F	L	F	S	K	E	N	S	V	W	N	S	Q	L	D	A	V	C	P	D	T	M	N	N	P	L	S	H	Y	W	I	S	S	S	H	N	T	Y	L	T	G	D	Q	F	S	S	E	S	S	L	E	A	Y	A	R	C	L	R	M	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	C	R	C	I	E	L	D	C	W	D	G	P	D	G	M	P	V	I	Y	H	G	H	T	L	T	T	K	I	K	F	S	D	V	L	H	T	I	K	E	H	A	F	V	A	S	E	Y	P	V	I	L	S	I	E	D	H	C	S	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	Q	Q	R	N	M	A	Q	Y	F	K	K	V	L	G	D	T	L	L	T	K	P	V	E	I	S	A	D	G	L	P	S	P	N	Q	L	K	R	K	I	L	I	K	H	K	K	L	A	E	G	S	A	Y	E	E	V	P	T	S	M	M
Secondary structure
SS confidence
Disorder																									?	?	?																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	Y	S	E	N	D	I	S	N	S	I	K	N	G	I	L	Y	L	E	D	P	V	N	H	E	W	Y	P	H	Y	F	V	L	T	S	S	K	I	Y	Y	S	E	E	T	S	S	D	Q	G	N	E	D	E	E	E	P	K	E	V	S	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?		?	?	?	?						?					?	?	?	?	?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	T	E	L	H	S	N	E	K	W	F	H	G	K	L	G	A	G	R	D	G	R	H	I	A	E	R	L	L	T	E	Y	C	I	E	T	G	A	P	D	G	S	F	L	V	R	E	S	E	T	F	V	G	D	Y	T	L	S	F	W
Secondary structure
SS confidence
Disorder	?	?	?	?												?	?	?	?	?	?												?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	R	N	G	K	V	Q	H	C	R	I	H	S	R	Q	D	A	G	T	P	K	F	F	L	T	D	N	L	V	F	D	S	L	Y	D	L	I	T	H	Y	Q	Q	V	P	L	R	C	N	E	F	E	M	R	L	S	E	P	V	P	Q	T
Secondary structure
SS confidence
Disorder																																											?		?	?	?	?								?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	N	A	H	E	S	K	E	W	Y	H	A	S	L	T	R	A	Q	A	E	H	M	L	M	R	V	P	R	D	G	A	F	L	V	R	K	R	N	E	P	N	S	Y	A	I	S	F	R	A	E	G	K	I	K	H	C	R	V	Q	Q	E
Secondary structure
SS confidence
Disorder	?	?	?																					?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	G	Q	T	V	M	L	G	N	S	E	F	D	S	L	V	D	L	I	S	Y	Y	E	K	H	P	L	Y	R	K	M	K	L	R	Y	P	I	N	E	E	A	L	E	K	I	G	T	A	E	P	D	Y	G	A	L	Y	E	G	R	N	P
Secondary structure
SS confidence
Disorder																								?	?	?	?												?		?	?				?	?	?	?	?	?	?		?		?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	G	F	Y	V	E	A	N	P	M	P	T	F	K	C	A	V	K	A	L	F	D	Y	K	A	Q	R	E	D	E	L	T	F	I	K	S	A	I	I	Q	N	V	E	K	Q	E	G	G	W	W	R	G	D	Y	G	G	K	K	Q	L	W
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?		?															?	?																										?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	F	P	S	N	Y	V	E	E	M	V	N	P	V	A	L	E	P	E	R	E	H	L	D	E	N	S	P	L	G	D	L	L	R	G	V	L	D	V	P	A	C	Q	I	A	I	R	P	E	G	K	N	N	R	L	F	V	F	S	I	S
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?		?			?	?	?	?		?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	M	A	S	V	A	H	W	S	L	D	V	A	A	D	S	Q	E	E	L	Q	D	W	V	K	K	I	R	E	V	A	Q	T	A	D	A	R	L	T	E	G	K	I	M	E	R	R	K	K	I	A	L	E	L	S	E	L	V	V	Y	C
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?			?		?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	R	P	V	P	F	D	E	E	K	I	G	T	E	R	A	C	Y	R	D	M	S	S	F	P	E	T	K	A	E	K	Y	V	N	K	A	K	G	K	K	F	L	Q	Y	N	R	L	Q	L	S	R	I	Y	P	K	G	Q	R	L	D	S
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?																																									?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	S	N	Y	D	P	L	P	M	W	I	C	G	S	Q	L	V	A	L	N	F	Q	T	P	D	K	P	M	Q	M	N	Q	A	L	F	M	T	G	R	H	C	G	Y	V	L	Q	P	S	T	M	R	D	E	A	F	D	P	F	D	K	S
Secondary structure
SS confidence
Disorder																																						?	?	?										?		?			?	?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	L	R	G	L	E	P	C	A	I	S	I	E	V	L	G	A	R	H	L	P	K	N	G	R	G	I	V	C	P	F	V	E	I	E	V	A	G	A	E	Y	D	S	T	K	Q	K	T	E	F	V	V	D	N	G	L	N	P	V	W
Secondary structure
SS confidence
Disorder	?	?	?																				?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	P	A	K	P	F	H	F	Q	I	S	N	P	E	F	A	F	L	R	F	V	V	Y	E	E	D	M	F	S	D	Q	N	F	L	A	Q	A	T	F	P	V	K	G	L	K	T	G	Y	R	A	V	P	L	K	N	N	Y	S	E	D	L
Secondary structure
SS confidence
Disorder																								?		?	?	?																													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	E	L	A	S	L	L	I	K	I	D	I	F	P	A	K	E	N	G	D	L	S	P	F	S	G	T	S	L	R	E	R	G	S	D	A	S	G	Q	L	F	H	G	R	A	R	E	G	S	F	E	S	R	Y	Q	Q	P	F	E	D	F
Secondary structure
SS confidence
Disorder														?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290
Sequence	R	I	S	Q	E	H	L	A	D	H	F	D	S	R	E	R	R	A	P	R	R	T	R	V	N	G	D	N	R	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence