Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9W4A9
DateWed Feb 13 11:40:50 GMT 2013
Unique Job ID6a634b058052ce20

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1xa6A_
Top template information
PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
Confidence and coverage
Confidence:100.0% Coverage: 80%
393 residues ( 80% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPRNTEAGAGNANTGGSGGVGGAPEPSSPVQKVWKPELYKLQLEAPAPCPLRCQRTLPLP
Secondary structure 












































SS confidence 



























































Disorder  ????????????????????
?
??




?











?
???????????????
Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  PAKSTAEAVEANNLAGRLYGSEYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSL
Secondary structure 





































SS confidence 



























































Disorder  ??????????????


?



???
??




???
?
???



?????????




Disorder confidence 



























































 
   .........130.........140.........150.........160.........170.........180
Sequence  RFNKRPKHYKLLYKPGVGHYLRGQDKRFDTVHDMVADGLINFHMQLHASPIIQQINQQTK
Secondary structure 












SS confidence 



























































Disorder 















??


?
????












?















???
Disorder confidence 



























































 
   .........190.........200.........210.........220.........230.........240
Sequence  NCYQQSPYMTLNGRKLRALSNELGKAAAKESKESPAEEKEQKQEEPPPPAVDPMPLVYEK
Secondary structure 

















































SS confidence 



























































Disorder  ???????????
????????????????????????????????????????????????
Disorder confidence 



























































 
   .........250.........260.........270.........280.........290.........300
Sequence  PHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACGFVAHSKCSELVPPKCVPDLKRIRG
Secondary structure 
























SS confidence 



























































Disorder  ?
??
????
???












??


?








?

????????????????
Disorder confidence 



























































 
   .........310.........320.........330.........340.........350.........360
Sequence  VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREG
Secondary structure 
























SS confidence 



























































Disorder 


























































?
Disorder confidence 



























































 
   .........370.........380.........390.........400.........410.........420
Sequence  EKTDMSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAV
Secondary structure 





















SS confidence 



























































Disorder 














































?











Disorder confidence 



























































 
   .........430.........440.........450.........460.........470.........480
Sequence  RRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLIATPQHMTNLTEEIFML
Secondary structure 














SS confidence 



























































Disorder 

























???















????
??







Disorder confidence 



























































 
   .........490....
Sequence  SSLITHCKTIFATS
Secondary structure 



SS confidence 













Disorder 










???
Disorder confidence 













 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1xa6 chain A

3D model

Region: 32 - 491
Aligned: 393
Modelled: 401
Confidence: 100.0%
Identity: 44%
PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin

Phyre2

PDB 3byi chain A

3D model

Region: 293 - 492
Aligned: 198
Modelled: 200
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)

Phyre2

PDB 1xa6 chain A domain 1

3D model

Region: 300 - 491
Aligned: 191
Modelled: 192
Confidence: 100.0%
Identity: 41%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 3iug chain A

3D model

Region: 299 - 492
Aligned: 183
Modelled: 194
Confidence: 100.0%
Identity: 30%
PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics

Phyre2

PDB 3fk2 chain B

3D model

Region: 299 - 491
Aligned: 189
Modelled: 193
Confidence: 100.0%
Identity: 30%
PDB header:signaling protein, hydrolase activator
Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1;
PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1

Phyre2

PDB 2ngr chain B

3D model

Region: 298 - 492
Aligned: 191
Modelled: 195
Confidence: 100.0%
Identity: 24%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.

Phyre2

PDB 2ee5 chain A

3D model

Region: 292 - 492
Aligned: 197
Modelled: 201
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant

Phyre2

PDB 1tx4 chain A

3D model

Region: 298 - 491
Aligned: 190
Modelled: 194
Confidence: 100.0%
Identity: 24%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 3msx chain B

3D model

Region: 299 - 491
Aligned: 186
Modelled: 190
Confidence: 100.0%
Identity: 25%
PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20

Phyre2

PDB 3kuq chain A

3D model

Region: 297 - 485
Aligned: 185
Modelled: 189
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain

Phyre2

PDB 2ovj chain A

3D model

Region: 305 - 492
Aligned: 184
Modelled: 188
Confidence: 100.0%
Identity: 30%
PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap.

Phyre2

PDB 1f7c chain A

3D model

Region: 318 - 493
Aligned: 171
Modelled: 176
Confidence: 100.0%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:rhogap protein;
PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase

Phyre2

PDB 1f7c chain A

3D model

Region: 318 - 493
Aligned: 171
Modelled: 176
Confidence: 100.0%
Identity: 29%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 3qis chain A

3D model

Region: 294 - 484
Aligned: 179
Modelled: 190
Confidence: 100.0%
Identity: 21%
PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl

Phyre2

PDB 3eap chain D

3D model

Region: 295 - 493
Aligned: 177
Modelled: 199
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase activator
Chain: D: PDB Molecule:rho gtpase-activating protein 11a;
PDBTitle: crystal structure of the rhogap domain of arhgap11a

Phyre2

PDB 2qv2 chain A

3D model

Region: 299 - 486
Aligned: 177
Modelled: 188
Confidence: 100.0%
Identity: 23%
PDB header:hydrolase
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway

Phyre2

PDB 1pbw chain A

3D model

Region: 306 - 486
Aligned: 177
Modelled: 181
Confidence: 100.0%
Identity: 24%
Fold: GTPase activation domain, GAP
Superfamily: GTPase activation domain, GAP
Family: BCR-homology GTPase activation domain (BH-domain)

Phyre2

PDB 1pbw chain B

3D model

Region: 305 - 494
Aligned: 184
Modelled: 190
Confidence: 100.0%
Identity: 24%
PDB header:phosphotransferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase;
PDBTitle: structure of bcr-homology (bh) domain

Phyre2

PDB 2xs6 chain A

3D model

Region: 304 - 487
Aligned: 162
Modelled: 179
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2

Phyre2

PDB 1xa6 chain A domain 2

3D model

Region: 32 - 193
Aligned: 140
Modelled: 147
Confidence: 99.8%
Identity: 38%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2
1

c1xa6A_
2

c3byiA_
3

d1xa6a1
4

c3iugA_
5

c3fk2B_
6

c2ngrB_
7

c2ee5A_
8

d1tx4a_
9

c3msxB_
10

c3kuqA_
11

c2ovjA_
12

c1f7cA_
13

d1f7ca_
14

c3qisA_
15

c3eapD_
16

c2qv2A_
17

d1pbwa_
18

c1pbwB_
19

c2xs6A_
20

d1xa6a2
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58



59



60



61



62



63



64



65



66



67



68



69



70



71



72



73



74



75



76



77



78



79



80



81



82



83



84



85



86



87



88



89



90



91



92



93



94



95



96



97



98



99



100



101



102



103



104



105



106



107



108



109



110



111



112



113



114



115



116



117



118



119



120



121



122



123



124



125



126



127



128



129



130



131



132



133



134



135



136



137



138



139



140



141



142



143



144



145



146



147



148



149



150



151



152



153



154



155



156



157



158



159



160



161



162



163



164



165



166



167



168



169



170



171



172



173






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1xa6A_



100.0 44 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
2c3byiA_



100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 15;
PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15)
3d1xa6a1



100.0 41 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
4c3iugA_



100.0 30 PDB header:splicing
Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics;
PDBTitle: crystal structure of the rhogap domain of rics
5c3fk2B_



100.0 30 PDB header:signaling protein, hydrolase activator
Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1;
PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1
6c2ngrB_



100.0 24 PDB header:hydrolase
Chain: B: PDB Molecule:protein (gtpase activating protein (rhg));
PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap.
7c2ee5A_



100.0 28 PDB header:hydrolase
Chain: A: PDB Molecule:rho gtpase activating protein 5 variant;
PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant
8d1tx4a_



100.0 24 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
9c3msxB_



100.0 25 PDB header:protein binding
Chain: B: PDB Molecule:rho gtpase-activating protein 20;
PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20
10c3kuqA_



100.0 25 PDB header:hydrolase activator
Chain: A: PDB Molecule:rho gtpase-activating protein 7;
PDBTitle: crystal structure of the dlc1 rhogap domain
11c2ovjA_



100.0 30 PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap.
12c1f7cA_



100.0 29 PDB header:signaling protein
Chain: A: PDB Molecule:rhogap protein;
PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase
13d1f7ca_



100.0 29 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
14c3qisA_



100.0 21 PDB header:hydrolase/protein binding
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl
15c3eapD_



100.0 25 PDB header:hydrolase activator
Chain: D: PDB Molecule:rho gtpase-activating protein 11a;
PDBTitle: crystal structure of the rhogap domain of arhgap11a
16c2qv2A_



100.0 23 PDB header:hydrolase
Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1;
PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway
17d1pbwa_



100.0 24 Fold:GTPase activation domain, GAP
Superfamily:GTPase activation domain, GAP
Family:BCR-homology GTPase activation domain (BH-domain)
18c1pbwB_



100.0 24 PDB header:phosphotransferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase;
PDBTitle: structure of bcr-homology (bh) domain
19c2xs6A_



100.0 24 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of the rhogap domain of human pik3r2
20d1xa6a2



99.8 38 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
21c3hizB_



not modelled 99.3 25 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
22c2oq1A_



not modelled 99.2 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
23c2lqnA_



not modelled 99.2 26 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
24c2eo6A_



not modelled 99.2 25 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
25c2ozoA_



not modelled 99.2 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
26c2y3aB_



not modelled 99.2 22 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
27c2shpA_



not modelled 99.1 30 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
28d2oq1a1



not modelled 99.1 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29c2c9wA_



not modelled 99.1 25 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
30c4fl2A_



not modelled 99.1 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
31c2fo0A_



not modelled 99.1 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
32c2vifA_



not modelled 99.1 26 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
33c3ps5A_



not modelled 99.1 27 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
34c2crhA_



not modelled 99.1 21 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
35d1fhsa_



not modelled 99.1 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36c2b3oA_



not modelled 99.1 27 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
37c3gqiB_



not modelled 99.1 29 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
38d1a81a1



not modelled 99.1 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39c2el8A_



not modelled 99.1 17 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
40d2izva2



not modelled 99.1 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1rpya_



not modelled 99.1 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d2oq1a2



not modelled 99.1 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43d1k9aa2



not modelled 99.1 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44d2eyva1



not modelled 99.1 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2gsbA_



not modelled 99.0 18 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
46c1k9aB_



not modelled 99.0 21 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
47c2dlyA_



not modelled 99.0 20 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
48d1rjaa_



not modelled 99.0 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49c2izvA_



not modelled 99.0 20 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
50d2c9wa2



not modelled 99.0 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51c2ysxA_



not modelled 99.0 20 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
52c1oplA_



not modelled 99.0 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
53d1a81e1



not modelled 99.0 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54d2cs0a1



not modelled 99.0 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1r1qa_



not modelled 99.0 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c2dlzA_



not modelled 99.0 19 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
57c2hdxB_



not modelled 99.0 25 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
58c1x6cA_



not modelled 99.0 24 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
59c2hmhA_



not modelled 99.0 19 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
60d1a81a2



not modelled 99.0 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d1nrva_



not modelled 99.0 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d1jwoa_



not modelled 99.0 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63d1a81e2



not modelled 99.0 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64d1csya_



not modelled 99.0 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65c2eo3A_



not modelled 99.0 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
66c1ka6A_



not modelled 99.0 21 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
67d1opka2



not modelled 99.0 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68d1jyra_



not modelled 99.0 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2ablA_



not modelled 99.0 33 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
70c2lctA_



not modelled 99.0 27 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
71c1rqqC_



not modelled 99.0 26 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
72c2ci8A_



not modelled 99.0 23 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
73c1a81E_



not modelled 99.0 23 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
74d2shpa2



not modelled 99.0 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d3c7ia1



not modelled 98.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76c2dvjA_



not modelled 98.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
77d1ayaa_



not modelled 98.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78d1blja_



not modelled 98.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79d2shpa3



not modelled 98.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80d1i3za_



not modelled 98.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2eobA_



not modelled 98.9 20 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
82c2augB_



not modelled 98.9 25 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
83c2eyzA_



not modelled 98.9 31 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
84d1lkka_



not modelled 98.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1pica_



not modelled 98.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86d1d4ta_



not modelled 98.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87d2qmsa1



not modelled 98.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d1qcfa2



not modelled 98.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c3pfqA_



not modelled 98.9 37 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
90d1f2fa_



not modelled 98.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91c1y57A_



not modelled 98.9 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
92c2knoA_



not modelled 98.8 22 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
93d1fu6a_



not modelled 98.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1cwea_



not modelled 98.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c3mazA_



not modelled 98.8 15 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
96d1qada_



not modelled 98.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97d1g83a2



not modelled 98.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98c1x27F_



not modelled 98.8 20 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
99d1bkla_



not modelled 98.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
100d1mila_



not modelled 98.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101c2kk6A_



not modelled 98.8 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
102d1o48a_



not modelled 98.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103c2dcrA_



not modelled 98.8 21 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
104c2h8hA_



not modelled 98.8 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
105d1luia_



not modelled 98.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d1xa6a3



not modelled 98.7 63 Fold:Cysteine-rich domain
Superfamily:Cysteine-rich domain
Family:Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)
107c3nhnA_



not modelled 98.7 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
108c2ekxA_



not modelled 98.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
109c2cr4A_



not modelled 98.7 17 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
110c3gxxB_



not modelled 98.7 18 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
111c2eliA_



not modelled 98.7 29 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c alpha type;
PDBTitle: solution structure of the second phorbol2 esters/diacylglycerol binding domain of human protein3 kinase c alpha type
112c2c0iA_



not modelled 98.7 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
113c2eyyA_



not modelled 98.7 31 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
114c2ge9A_



not modelled 98.7 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
115c2dm0A_



not modelled 98.7 18 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
116c4b6dA_



not modelled 98.6 29 PDB header:signaling protein
Chain: A: PDB Molecule:rac gtpase-activating protein 1;
PDBTitle: structure of the atypical c1 domain of mgcracgap
117d2fcia1



not modelled 98.6 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
118c2e73A_



not modelled 98.6 32 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c gamma type;
PDBTitle: solution structure of the phorbol esters/diacylglycerol2 binding domain of protein kinase c gamma
119d1tbna_



not modelled 98.6 29 Fold:Cysteine-rich domain
Superfamily:Cysteine-rich domain
Family:Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)
120c1g83A_



not modelled 98.6 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite