Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP27240
DateThu Jan 5 11:43:19 GMT 2012
Unique Job IDfcf7bb3e919ef4db

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3qa8A_
Top template information
PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta
Confidence and coverage
Confidence:100.0% Coverage: 75%
175 residues ( 75% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MIQKSKIKDLVVFTDENNSKYLNVLNDFLSYNINIIKVFRSIDDTKVMLIDTDYGKLILK
Secondary structure 




















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Disorder  ???????




















































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   .........70.........80.........90.........100.........110.........120
Sequence  VFSPKVKRNERFFKSLLKGDYYERLFEQTQKVRNEGLNTLNDFYLLAERKTLRFVHTYIM
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Disorder 


??
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   .........130.........140.........150.........160.........170.........180
Sequence  IIEYIDGIELCDMPDIDDALKNKIQQSINALHQHGMVSGDPHRGNFIIKNGEVRIIDLSG
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Disorder 








????

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   .........190.........200.........210.........220.........230..
Sequence  KRASAQRKAKDRIDLERHYGIKNEIRDLGYYLLVYRKKMRNFMRRLKGKPAR
Secondary structure 













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Disorder 
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??????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3qa8 chain A

3D model

Region: 34 - 222
Aligned: 175
Modelled: 175
Confidence: 100.0%
Identity: 15%
PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta

Phyre2

PDB 1ym7 chain C

3D model

Region: 31 - 222
Aligned: 183
Modelled: 183
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)

Phyre2

PDB 2acx chain B

3D model

Region: 28 - 222
Aligned: 183
Modelled: 183
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp

Phyre2

PDB 3pfq chain A

3D model

Region: 31 - 222
Aligned: 181
Modelled: 192
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii

Phyre2

PDB 3c4y chain A

3D model

Region: 28 - 222
Aligned: 183
Modelled: 195
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a

Phyre2

PDB 2pzi chain A

3D model

Region: 26 - 222
Aligned: 183
Modelled: 183
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng;
PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017

Phyre2

PDB 3e7e chain A

3D model

Region: 30 - 222
Aligned: 176
Modelled: 176
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:mitotic checkpoint serine/threonine-protein kinase bub1;
PDBTitle: structure and substrate recruitment of the human spindle checkpoint2 kinase bub

Phyre2

PDB 2j0k chain B

3D model

Region: 27 - 222
Aligned: 180
Modelled: 182
Confidence: 100.0%
Identity: 12%
PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.

Phyre2

PDB 1koa chain A

3D model

Region: 23 - 222
Aligned: 185
Modelled: 185
Confidence: 100.0%
Identity: 14%
PDB header:kinase
Chain: A: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains

Phyre2

PDB 3d9v chain A

3D model

Region: 31 - 222
Aligned: 180
Modelled: 180
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil

Phyre2

PDB 2fo0 chain A

3D model

Region: 27 - 222
Aligned: 180
Modelled: 180
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2vwi chain C

3D model

Region: 27 - 222
Aligned: 182
Modelled: 182
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: C: PDB Molecule:serine/threonine-protein kinase osr1;
PDBTitle: structure of the osr1 kinase, a hypertension drug target

Phyre2

PDB 3soa chain A

3D model

Region: 29 - 222
Aligned: 179
Modelled: 179
Confidence: 100.0%
Identity: 12%
PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit
PDBTitle: full-length human camkii

Phyre2

PDB 1opl chain A

3D model

Region: 27 - 222
Aligned: 180
Modelled: 180
Confidence: 99.9%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 3ckx chain A

3D model

Region: 30 - 222
Aligned: 177
Modelled: 177
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 24;
PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine

Phyre2

PDB 3q5i chain A

3D model

Region: 17 - 222
Aligned: 186
Modelled: 188
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase;
PDBTitle: crystal structure of pbanka_031420

Phyre2

PDB 2ozo chain A

3D model

Region: 30 - 222
Aligned: 175
Modelled: 176
Confidence: 99.9%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 3q60 chain A

3D model

Region: 30 - 222
Aligned: 192
Modelled: 193
Confidence: 99.9%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:rop5b;
PDBTitle: crystal structure of virulent allele rop5b pseudokinase domain bound2 to atp

Phyre2

PDB 3byv chain A

3D model

Region: 30 - 222
Aligned: 193
Modelled: 193
Confidence: 99.9%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:rhoptry kinase;
PDBTitle: crystal structure of toxoplasma gondii specific rhoptry2 antigen kinase domain

Phyre2

PDB 2j4z chain A domain 1

3D model

Region: 31 - 222
Aligned: 180
Modelled: 192
Confidence: 99.9%
Identity: 16%
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Family: Protein kinases, catalytic subunit

Phyre2
1

c3qa8A_
2

c1ym7C_
3

c2acxB_
4

c3pfqA_
5

c3c4yA_
6

c2pziA_
7

c3e7eA_
8

c2j0kB_
9

c1koaA_
10

c3d9vA_
11

c2fo0A_
12

c2vwiC_
13

c3soaA_
14

c1oplA_
15

c3ckxA_
16

c3q5iA_
17

c2ozoA_
18

c3q60A_
19

c3byvA_
20

d2j4za1
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3qa8A_



100.0 15 PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta
2c1ym7C_



100.0 14 PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)
3c2acxB_



100.0 17 PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp
4c3pfqA_



100.0 17 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
5c3c4yA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a
6c2pziA_



100.0 14 PDB header:transferase
Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng;
PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017
7c3e7eA_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:mitotic checkpoint serine/threonine-protein kinase bub1;
PDBTitle: structure and substrate recruitment of the human spindle checkpoint2 kinase bub
8c2j0kB_



100.0 12 PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.
9c1koaA_



100.0 14 PDB header:kinase
Chain: A: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains
10c3d9vA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil
11c2fo0A_



100.0 14 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
12c2vwiC_



100.0 15 PDB header:transferase
Chain: C: PDB Molecule:serine/threonine-protein kinase osr1;
PDBTitle: structure of the osr1 kinase, a hypertension drug target
13c3soaA_



100.0 12 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit
PDBTitle: full-length human camkii
14c1oplA_



99.9 14 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
15c3ckxA_



99.9 15 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 24;
PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine
16c3q5iA_



99.9 18 PDB header:transferase
Chain: A: PDB Molecule:protein kinase;
PDBTitle: crystal structure of pbanka_031420
17c2ozoA_



99.9 10 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
18c3q60A_



99.9 14 PDB header:transferase
Chain: A: PDB Molecule:rop5b;
PDBTitle: crystal structure of virulent allele rop5b pseudokinase domain bound2 to atp
19c3byvA_



99.9 10 PDB header:transferase
Chain: A: PDB Molecule:rhoptry kinase;
PDBTitle: crystal structure of toxoplasma gondii specific rhoptry2 antigen kinase domain
20d2j4za1



99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
21c2c30A_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6;
PDBTitle: crystal structure of the human p21-activated kinase 6
22c2jiiA_



not modelled 99.9 12 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase vrk3 molecule: vaccinia
PDBTitle: structure of vaccinia related kinase 3
23c3p23B_



not modelled 99.9 15 PDB header:hydrolase, transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1;
PDBTitle: crystal structure of the human kinase and rnase domains in complex2 with adp
24c3hztA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase 3;
PDBTitle: crystal structure of toxoplasma gondii cdpk3, tgme49_105860
25c3fbvL_



not modelled 99.9 14 PDB header:transferase, hydrolase
Chain: L: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1;
PDBTitle: crystal structure of the oligomer formed by the kinase-ribonuclease2 domain of ire1
26c1k9aB_



not modelled 99.9 13 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
27c2h8hA_



not modelled 99.9 13 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
28c2bmcD_



not modelled 99.9 16 PDB header:transferase
Chain: D: PDB Molecule:serine threonine-protein kinase 6;
PDBTitle: aurora-2 t287d t288d complexed with pha-680632
29c2y7jB_



not modelled 99.9 12 PDB header:transferase
Chain: B: PDB Molecule:phosphorylase b kinase gamma catalytic chain,
PDBTitle: structure of human phosphorylase kinase, gamma 2
30c2vd5A_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:dmpk protein;
PDBTitle: structure of human myotonic dystrophy protein kinase in2 complex with the bisindoylmaleide inhibitor bim viii
31c2qg5D_



not modelled 99.9 14 PDB header:transferase
Chain: D: PDB Molecule:calcium/calmodulin-dependent protein kinase;
PDBTitle: cryptosporidium parvum calcium dependent protein kinase cgd7_1840
32c1y57A_



not modelled 99.9 13 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
33c2wtkC_



not modelled 99.9 20 PDB header:transferase/metal-binding protein
Chain: C: PDB Molecule:serine/threonine-protein kinase 11;
PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
34c3lijA_



not modelled 99.9 20 PDB header:transferase
Chain: A: PDB Molecule:calcium/calmodulin dependent protein kinase with
PDBTitle: crystal structure of full length cpcdpk3 (cgd5_820) in2 complex with ca2+ and amppnp
35c2a1aB_



not modelled 99.9 14 PDB header:protein synthesis/transferase
Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein
PDBTitle: pkr kinase domain-eif2alpha complex
36d1phka_



not modelled 99.9 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
37c2cgvA_



not modelled 99.9 18 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk1;
PDBTitle: identification of chemically diverse chk1 inhibitors by2 receptor-based virtual screening
38c2bujA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 16;
PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine
39d1yhwa1



not modelled 99.9 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
40c2clqA_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 5;
PDBTitle: structure of mitogen-activated protein kinase kinase kinase2 5
41c3kvwA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:dual specificity tyrosine-phosphorylation-regulated kinase
PDBTitle: crystal structure of dual-specificity tyrosine phosphorylation2 regulated kinase 2 (dyrk2) in complex with an indirubin ligand
42c3g0eA_



not modelled 99.9 13 PDB header:transferase
Chain: A: PDB Molecule:mast/stem cell growth factor receptor;
PDBTitle: kit kinase domain in complex with sunitinib
43c3op5B_



not modelled 99.9 14 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase vrk1;
PDBTitle: human vaccinia-related kinase 1
44c3dzoA_



not modelled 99.9 11 PDB header:transferase
Chain: A: PDB Molecule:rhoptry kinase domain;
PDBTitle: crystal structure of a rhoptry kinase from toxoplasma gondii
45c2vuwA_



not modelled 99.9 10 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase haspin;
PDBTitle: structure of human haspin kinase domain
46d1qcfa3



not modelled 99.9 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
47c2c0iA_



not modelled 99.9 12 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
48d1xjda_



not modelled 99.9 17 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
49c1xjdA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, theta type;
PDBTitle: crystal structure of pkc-theta complexed with staurosporine2 at 2a resolution
50c2a27B_



not modelled 99.9 14 PDB header:transferase
Chain: B: PDB Molecule:death-associated protein kinase 2;
PDBTitle: human drp-1 kinase, w305s s308a d40 mutant, crystal form with 82 monomers in the asymmetric unit
51d1nvra_



not modelled 99.9 17 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
52c2zv2A_



not modelled 99.9 14 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase kinase 2;
PDBTitle: crystal structure of human calcium/calmodulin-dependent protein kinase2 kinase 2, beta, camkk2 kinase domain in complex with sto-609
53d1opja_



not modelled 99.9 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
54c2y94A_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit alpha-1;
PDBTitle: structure of an active form of mammalian ampk
55c3dfaA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920;
PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum
56c2wtkB_



not modelled 99.9 14 PDB header:transferase/metal-binding protein
Chain: B: PDB Molecule:ste20-related kinase adapter protein alpha;
PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
57c2v62A_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase vrk2;
PDBTitle: structure of vaccinia-related kinase 2
58c3en9B_



not modelled 99.9 19 PDB header:hydrolase
Chain: B: PDB Molecule:o-sialoglycoprotein endopeptidase/protein kinase;
PDBTitle: structure of the methanococcus jannaschii kae1-bud32 fusion2 protein
59c2j2iB_



not modelled 99.9 13 PDB header:transferase
Chain: B: PDB Molecule:proto-oncogene serine/threonine-protein kinase pim-1;
PDBTitle: crystal structure of the humab pim1 in complex with2 ly333531
60d1xwsa_



not modelled 99.9 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
61c1mruB_



not modelled 99.9 19 PDB header:transferase
Chain: B: PDB Molecule:probable serine/threonine-protein kinase pknb;
PDBTitle: intracellular ser/thr protein kinase domain of2 mycobacterium tuberculosis pknb.
62c3dpkA_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:macrophage colony-stimulating factor 1 receptor;
PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor
63c2h6dA_



not modelled 99.9 16 PDB header:signaling protein,transferase
Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit
PDBTitle: protein kinase domain of the human 5'-amp-activated protein2 kinase catalytic subunit alpha-2 (ampk alpha-2 chain)
64d1jksa_



not modelled 99.9 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
65c3is5E_



not modelled 99.9 13 PDB header:transferase
Chain: E: PDB Molecule:calcium-dependent protein kinase;
PDBTitle: crystal structure of cdpk kinase domain from toxoplasma gondii,2 tgme49_018720
66c3igoA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:calmodulin-domain protein kinase 1;
PDBTitle: crystal structure of cryptosporidium parvum cdpk1, cgd3_920
67d2jfla1



not modelled 99.9 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
68c3zzwA_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2;
PDBTitle: crystal structure of the kinase domain of ror2
69c3i6uA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk2;
PDBTitle: structure and activation mechanism of the chk2 dna-damage checkpoint2 kinase
70c2j51A_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:ste20-like serine/threonine-protein kinase;
PDBTitle: crystal structure of human ste20-like kinase bound to 5-2 amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6-3 difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
71d1o6ya_



not modelled 99.9 20 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
72c2ivsA_



not modelled 99.9 18 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor
PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain
73c2r7bA_



not modelled 99.9 12 PDB header:signaling protein, transferase
Chain: A: PDB Molecule:phosphoinositide-dependent protein kinase 1;
PDBTitle: crystal structure of the phosphoinositide-dependent kinase-2 1 (pdk-1)catalytic domain bound to a dibenzonaphthyridine3 inhibitor
74c2chlA_



not modelled 99.9 11 PDB header:transferase
Chain: A: PDB Molecule:casein kinase i isoform gamma-3;
PDBTitle: structure of casein kinase 1 gamma 3
75c3cokB_



not modelled 99.9 14 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase plk4;
PDBTitle: crystal structure of plk4 kinase
76c3cblA_



not modelled 99.9 10 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
77c1zrzA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, iota;
PDBTitle: crystal structure of the catalytic domain of atypical2 protein kinase c-iota
78c2pvfA_



not modelled 99.9 13 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of tyrosine phosphorylated activated fgf2 receptor 2 (fgfr2) kinase domain in complex with atp3 analog and substrate peptide
79c3p1aA_



not modelled 99.9 11 PDB header:transferase
Chain: A: PDB Molecule:membrane-associated tyrosine- and threonine-specific cdc2-
PDBTitle: structure of human membrane-associated tyrosine- and threonine-2 specific cdc2-inhibitory kinase myt1 (pkmyt1)
80c2ya9A_



not modelled 99.9 14 PDB header:transferase
Chain: A: PDB Molecule:death-associated protein kinase 2;
PDBTitle: crystal structure of the autoinhibited form of mouse dapk2
81c2zmcA_



not modelled 99.9 16 PDB header:transferase
Chain: A: PDB Molecule:dual specificity protein kinase ttk;
PDBTitle: crystal structure of human mitotic checkpoint kinase mps1 catalytic2 domain apo form
82c3i6wB_



not modelled 99.9 16 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase chk2;
PDBTitle: structure and activation mechanism of the chk2 dna-damage checkpoint2 kinase
83d1uu3a_



not modelled 99.9 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
84c2x4fA_



not modelled 99.9 18 PDB header:transferase
Chain: A: PDB Molecule:myosin light chain kinase family member 4;
PDBTitle: the crystal structure of the human myosin light chain2 kinase loc340156.
85c1kobB_



not modelled 99.9 18 PDB header:kinase
Chain: B: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (aplysia), autoregulated protein2 kinase domain
86c2in6A_



not modelled 99.9 14 PDB header:transferase
Chain: A: PDB Molecule:wee1-like protein kinase;
PDBTitle: wee1 kinase complex with inhibitor pd311839
87d1rdqe_



not modelled 99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
88c3comB_



not modelled 99.9 12 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase 4;
PDBTitle: crystal structure of mst1 kinase
89c2wqmA_



not modelled 99.9 19 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase nek7;
PDBTitle: structure of apo human nek7
90d1o6la_



not modelled 99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
91d1ckia_



not modelled 99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
92d1koba_



not modelled 99.9 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
93c3rp9A_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase;
PDBTitle: crystal structure of the apo mapk from toxoplasma gondii, 25.m01780 or2 tgme49_007820
94c2r5tA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase sgk1;
PDBTitle: crystal structure of inactive serum and glucocorticoid-2 regulated kinase 1 in complex with amp-pnp
95c1zp9A_



not modelled 99.9 11 PDB header:transferase
Chain: A: PDB Molecule:rio1 kinase;
PDBTitle: crystal structure of full-legnth a.fulgidus rio1 serine kinase bound2 to atp and mn2+ ions.
96d1koaa2



not modelled 99.9 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
97d1fota_



not modelled 99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
98c2c47D_



not modelled 99.9 13 PDB header:transferase
Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform;
PDBTitle: structure of casein kinase 1 gamma 2
99d1gzka_



not modelled 99.9 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
100d1qpca_



not modelled 99.9 11 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
101d1xh6a1



not modelled 99.9 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
102c2z7qA_



not modelled 99.9 15 PDB header:transferase
Chain: A: PDB Molecule:ribosomal protein s6 kinase alpha-1;
PDBTitle: crystal structure of the n-terminal kinase domain of human2 rsk-1 bound to amp-pcp
103c2qhnA_



not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk1;
PDBTitle: crystal structure of chek1 in complex with inhibitor 1a
104c3an0A_



not modelled 99.9 18 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:dual specificity mitogen-activated protein kinase kinase 6;
PDBTitle: crystal structure of non-phosphorylated map2k6 as a putative auto2 inhibition state
105d2psqa1



not modelled 99.9 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
106c2psqA_



not modelled 99.9 12 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain
107c3c0hB_



not modelled 99.9 13 PDB header:transferase
Chain: B: PDB Molecule:peripheral plasma membrane protein cask;
PDBTitle: cask cam-kinase domain- amppnp complex, p1 form
108c1tqmA_



not modelled 99.9 15 PDB header:ribosome
Chain: A: PDB Molecule:conserved hypothetical protein;
PDBTitle: crystal structure of a. fulgidus rio2 serine protein kinase bound to2 amppnp
109d1tkia_



not modelled 99.8 17 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
110d1u59a_



not modelled 99.8 9 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
111c1lufA_



not modelled 99.8 13 PDB header:transferase
Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk;
PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation
112d1lufa_



not modelled 99.8 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
113c2i0eB_



not modelled 99.8 15 PDB header:transferase
Chain: B: PDB Molecule:protein kinase c-beta ii;
PDBTitle: structure of catalytic domain of human protein kinase c2 beta ii complexed with a bisindolylmaleimide inhibitor
114c2bdwB_



not modelled 99.8 15 PDB header:transferase
Chain: B: PDB Molecule:hypothetical protein k11e8.1d;
PDBTitle: crystal structure of the auto-inhibited kinase domain of2 calcium/calmodulin activated kinase ii
115c3ku2A_



not modelled 99.8 16 PDB header:transferase
Chain: A: PDB Molecule:calmodulin-domain protein kinase 1;
PDBTitle: crystal structure of inactivated form of cdpk1 from toxoplasma gondii,2 tgme49.101440
116c2cn5A_



not modelled 99.8 17 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk2;
PDBTitle: crystal structure of human chk2 in complex with adp
117c3lxkA_



not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
118d1omwa3



not modelled 99.8 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
119c2wu6A_



not modelled 99.8 13 PDB header:transferase
Chain: A: PDB Molecule:dual specificity protein kinase clk3;
PDBTitle: crystal structure of the human clk3 in complex with dki
120c3plsA_



not modelled 99.8 13 PDB header:transferase
Chain: A: PDB Molecule:macrophage-stimulating protein receptor;
PDBTitle: ron in complex with ligand amp-pnp

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0