1 d1vdda_
100.0
46
Fold: Recombination protein RecRSuperfamily: Recombination protein RecRFamily: Recombination protein RecR
2 c1vddC_
100.0
45
PDB header: recombinationChain: C: PDB Molecule: recombination protein recr;
PDBTitle: crystal structure of recombinational repair protein recr
3 c2h5xA_
96.3
41
PDB header: dna binding proteinChain: A: PDB Molecule: holliday junction atp-dependent dna helicase ruva;
PDBTitle: ruva from mycobacterium tuberculosis
4 d1bvsa2
95.9
32
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: DNA helicase RuvA subunit, middle domain
5 d1ixra1
95.9
36
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: DNA helicase RuvA subunit, middle domain
6 d1cuka2
95.7
41
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: DNA helicase RuvA subunit, middle domain
7 d1gkub3
95.4
23
Fold: Prokaryotic type I DNA topoisomeraseSuperfamily: Prokaryotic type I DNA topoisomeraseFamily: Prokaryotic type I DNA topoisomerase
8 c2o59B_
94.9
20
PDB header: isomerase/dnaChain: B: PDB Molecule: dna topoisomerase 3;
PDBTitle: structure of e. coli topoisomerase iii in complex with an 8-2 base single stranded oligonucleotide. frozen in glycerol3 ph 8.0
9 d1i7da_
94.8
22
Fold: Prokaryotic type I DNA topoisomeraseSuperfamily: Prokaryotic type I DNA topoisomeraseFamily: Prokaryotic type I DNA topoisomerase
10 c2hr5B_
94.8
27
PDB header: metal binding proteinChain: B: PDB Molecule: rubrerythrin;
PDBTitle: pf1283- rubrerythrin from pyrococcus furiosus iron bound form
11 c1hjpA_
94.4
42
PDB header: dna recombinationChain: A: PDB Molecule: ruva;
PDBTitle: holliday junction binding protein ruva from e. coli
12 c2au3A_
94.4
18
PDB header: transferaseChain: A: PDB Molecule: dna primase;
PDBTitle: crystal structure of the aquifex aeolicus primase (zinc binding and2 rna polymerase domains)
13 c1dvbA_
94.2
18
PDB header: electron transportChain: A: PDB Molecule: rubrerythrin;
PDBTitle: rubrerythrin
14 d1t6t1_
94.1
18
Fold: Toprim domainSuperfamily: Toprim domainFamily: Toprim domain
15 d2noha1
93.8
28
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: DNA repair glycosylase, 2 C-terminal domains
16 c1nuiA_
93.8
13
PDB header: replicationChain: A: PDB Molecule: dna primase/helicase;
PDBTitle: crystal structure of the primase fragment of bacteriophage t7 primase-2 helicase protein
17 d1nuia1
93.5
13
Fold: DNA primase coreSuperfamily: DNA primase coreFamily: Primase fragment of primase-helicase protein
18 c3f10A_
93.5
26
PDB header: hydrolase, lyaseChain: A: PDB Molecule: 8-oxoguanine-dna-glycosylase;
PDBTitle: crystal structure of clostridium acetobutylicum 8-2 oxoguanine dna glycosylase in complex with 8-oxoguanosine
19 c1yuzB_
93.0
20
PDB header: oxidoreductaseChain: B: PDB Molecule: nigerythrin;
PDBTitle: partially reduced state of nigerythrin
20 c1yqmA_
93.0
28
PDB header: hydrolase/dnaChain: A: PDB Molecule: n-glycosylase/dna lyase;
PDBTitle: catalytically inactive human 8-oxoguanine glycosylase2 crosslinked to 7-deazaguanine containing dna
21 c3n0uB_
not modelled
93.0
21
PDB header: hydrolase, lyaseChain: B: PDB Molecule: probable n-glycosylase/dna lyase;
PDBTitle: crystal structure of tm1821, the 8-oxoguanine dna glycosylase of2 thermotoga maritima
22 c3lpeF_
not modelled
92.9
25
PDB header: transferaseChain: F: PDB Molecule: dna-directed rna polymerase subunit e'';
PDBTitle: crystal structure of spt4/5ngn heterodimer complex from methanococcus2 jannaschii
23 d1pu6a_
not modelled
92.9
19
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: 3-Methyladenine DNA glycosylase III (MagIII)
24 c3s6iA_
not modelled
92.8
25
PDB header: hydrolase/dnaChain: A: PDB Molecule: dna-3-methyladenine glycosylase 1;
PDBTitle: schizosaccaromyces pombe 3-methyladenine dna glycosylase (mag1) in2 complex with abasic-dna.
25 d1mw9x_
not modelled
92.5
33
Fold: Prokaryotic type I DNA topoisomeraseSuperfamily: Prokaryotic type I DNA topoisomeraseFamily: Prokaryotic type I DNA topoisomerase
26 d1mpga1
not modelled
92.5
29
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: DNA repair glycosylase, 2 C-terminal domains
27 c3fhgA_
not modelled
92.4
21
PDB header: dna repair, hydrolase, lyaseChain: A: PDB Molecule: n-glycosylase/dna lyase;
PDBTitle: crystal structure of sulfolobus solfataricus 8-oxoguanine dna2 glycosylase (ssogg)
28 c1q57G_
not modelled
92.4
11
PDB header: transferaseChain: G: PDB Molecule: dna primase/helicase;
PDBTitle: the crystal structure of the bifunctional primase-helicase of2 bacteriophage t7
29 c1ko9A_
not modelled
92.2
31
PDB header: hydrolaseChain: A: PDB Molecule: 8-oxoguanine dna glycosylase;
PDBTitle: native structure of the human 8-oxoguanine dna glycosylase2 hogg1
30 d2fcja1
not modelled
92.0
21
Fold: Toprim domainSuperfamily: Toprim domainFamily: Toprim domain
31 c2yg8B_
not modelled
91.9
25
PDB header: hydrolaseChain: B: PDB Molecule: dna-3-methyladenine glycosidase ii, putative;
PDBTitle: structure of an unusual 3-methyladenine dna glycosylase ii (2 alka) from deinococcus radiodurans
32 c1mpgB_
not modelled
91.8
30
PDB header: hydrolaseChain: B: PDB Molecule: 3-methyladenine dna glycosylase ii;
PDBTitle: 3-methyladenine dna glycosylase ii from escherichia coli
33 c2jhnB_
not modelled
91.7
21
PDB header: hydrolaseChain: B: PDB Molecule: 3-methyladenine dna-glycosylase;
PDBTitle: 3-methyladenine dna-glycosylase from archaeoglobus fulgidus
34 c1gl9B_
not modelled
91.6
25
PDB header: topoisomeraseChain: B: PDB Molecule: reverse gyrase;
PDBTitle: archaeoglobus fulgidus reverse gyrase complexed with adpnp
35 d2fmpa1
not modelled
90.9
24
Fold: SAM domain-likeSuperfamily: DNA polymerase beta, N-terminal domain-likeFamily: DNA polymerase beta, N-terminal domain-like
36 d2abka_
not modelled
90.6
38
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Endonuclease III
37 d1rrqa1
not modelled
90.3
20
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Mismatch glycosylase
38 d1kg2a_
not modelled
90.1
31
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Mismatch glycosylase
39 c3kntC_
not modelled
89.7
16
PDB header: hydrolase, lyase/dnaChain: C: PDB Molecule: n-glycosylase/dna lyase;
PDBTitle: crystal structure of methanocaldococcus jannaschii 8-2 oxoguanine glycosylase/lyase in complex with 15mer dna3 containing 8-oxoguanine
40 d1orna_
not modelled
89.6
31
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Endonuclease III
41 c2w9mB_
not modelled
89.5
12
PDB header: dna replicationChain: B: PDB Molecule: polymerase x;
PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans
42 d1keaa_
not modelled
89.4
23
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Mismatch glycosylase
43 c3n5nX_
not modelled
89.3
28
PDB header: hydrolaseChain: X: PDB Molecule: a/g-specific adenine dna glycosylase;
PDBTitle: crystal structure analysis of the catalytic domain and interdomain2 connector of human muty homologue
44 d2a1jb1
not modelled
89.1
17
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Hef domain-like
45 c8iczA_
not modelled
88.9
21
PDB header: transferase/dnaChain: A: PDB Molecule: protein (dna polymerase beta (e.c.2.7.7.7));
PDBTitle: dna polymerase beta (pol b) (e.c.2.7.7.7) complexed with2 seven base pairs of dna; soaked in the presence of of datp3 (1 millimolar), mncl2 (5 millimolar), and lithium sulfate4 (75 millimolar)
46 c1rrqA_
not modelled
88.4
19
PDB header: hydrolase/dnaChain: A: PDB Molecule: muty;
PDBTitle: muty adenine glycosylase in complex with dna containing an2 a:oxog pair
47 d2bcqa1
not modelled
88.0
23
Fold: SAM domain-likeSuperfamily: DNA polymerase beta, N-terminal domain-likeFamily: DNA polymerase beta, N-terminal domain-like
48 d1jmsa1
not modelled
87.6
15
Fold: SAM domain-likeSuperfamily: DNA polymerase beta, N-terminal domain-likeFamily: DNA polymerase beta, N-terminal domain-like
49 c2csdB_
not modelled
87.5
29
PDB header: isomeraseChain: B: PDB Molecule: topoisomerase v;
PDBTitle: crystal structure of topoisomerase v (61 kda fragment)
50 c2ihmA_
not modelled
87.5
38
PDB header: transferase/dnaChain: A: PDB Molecule: dna polymerase mu;
PDBTitle: polymerase mu in ternary complex with gapped 11mer dna2 duplex and bound incoming nucleotide
51 c2gb5B_
not modelled
87.5
18
PDB header: hydrolaseChain: B: PDB Molecule: nadh pyrophosphatase;
PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution
52 d2edua1
not modelled
87.2
38
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: ComEA-like
53 d1nzpa_
not modelled
86.4
23
Fold: SAM domain-likeSuperfamily: DNA polymerase beta, N-terminal domain-likeFamily: DNA polymerase beta, N-terminal domain-like
54 d2bgwa1
not modelled
86.3
24
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Hef domain-like
55 c1ixrA_
not modelled
85.9
43
PDB header: hydrolaseChain: A: PDB Molecule: holliday junction dna helicase ruva;
PDBTitle: ruva-ruvb complex
56 d1kfta_
not modelled
84.9
23
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Excinuclease UvrC C-terminal domain
57 c1kftA_
not modelled
84.9
23
PDB header: dna binding proteinChain: A: PDB Molecule: excinuclease abc subunit c;
PDBTitle: solution structure of the c-terminal domain of uvrc from e-2 coli
58 c1kdhA_
not modelled
84.2
22
PDB header: transferase/dnaChain: A: PDB Molecule: terminal deoxynucleotidyltransferase short
PDBTitle: binary complex of murine terminal deoxynucleotidyl2 transferase with a primer single stranded dna
59 d1x2ia1
not modelled
83.3
20
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Hef domain-like
60 c2gajA_
not modelled
83.0
28
PDB header: isomeraseChain: A: PDB Molecule: dna topoisomerase i;
PDBTitle: structure of full length topoisomerase i from thermotoga maritima in2 monoclinic crystal form
61 c1nomA_
not modelled
82.9
25
PDB header: nucleotidyltransferaseChain: A: PDB Molecule: dna polymerase beta;
PDBTitle: dna polymerase beta (pol b) (e.c.2.7.7.7), 31-kd domain; soaked in the2 presence of mncl2 (5 millimolar)
62 c2kp7A_
not modelled
82.2
14
PDB header: hydrolaseChain: A: PDB Molecule: crossover junction endonuclease mus81;
PDBTitle: solution nmr structure of the mus81 n-terminal hhh.2 northeast structural genomics consortium target mmt1a
63 d2duya1
not modelled
81.8
43
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: ComEA-like
64 d2aq0a1
not modelled
81.6
24
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Hef domain-like
65 c2bcuA_
not modelled
81.6
20
PDB header: transferase, lyase/dnaChain: A: PDB Molecule: dna polymerase lambda;
PDBTitle: dna polymerase lambda in complex with a dna duplex2 containing an unpaired damp and a t:t mismatch
66 d1dk2a_
not modelled
81.3
36
Fold: SAM domain-likeSuperfamily: DNA polymerase beta, N-terminal domain-likeFamily: DNA polymerase beta, N-terminal domain-like
67 c1s5lu_
not modelled
81.3
21
PDB header: photosynthesisChain: U: PDB Molecule: photosystem ii 12 kda extrinsic protein;
PDBTitle: architecture of the photosynthetic oxygen evolving center
68 d2axtu1
not modelled
80.5
21
Fold: SAM domain-likeSuperfamily: PsbU/PolX domain-likeFamily: PsbU-like
69 d1ngna_
not modelled
80.3
20
Fold: DNA-glycosylaseSuperfamily: DNA-glycosylaseFamily: Mismatch glycosylase
70 d1a77a1
not modelled
78.5
33
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
71 d1pzna1
not modelled
78.5
27
Fold: SAM domain-likeSuperfamily: Rad51 N-terminal domain-likeFamily: DNA repair protein Rad51, N-terminal domain
72 d3bzka1
not modelled
78.4
19
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Tex HhH-containing domain-like
73 c1d8lA_
not modelled
78.1
28
PDB header: gene regulationChain: A: PDB Molecule: protein (holliday junction dna helicase ruva);
PDBTitle: e. coli holliday junction binding protein ruva nh2 region2 lacking domain iii
74 d2vana1
not modelled
77.3
21
Fold: SAM domain-likeSuperfamily: PsbU/PolX domain-likeFamily: DNA polymerase beta-like, second domain
75 d1dgsa1
not modelled
77.0
36
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: NAD+-dependent DNA ligase, domain 3
76 c1b22A_
not modelled
77.0
17
PDB header: dna binding proteinChain: A: PDB Molecule: dna repair protein rad51;
PDBTitle: rad51 (n-terminal domain)
77 d1b22a_
not modelled
77.0
17
Fold: SAM domain-likeSuperfamily: Rad51 N-terminal domain-likeFamily: DNA repair protein Rad51, N-terminal domain
78 d1mc8a1
not modelled
75.6
42
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
79 c2h56C_
not modelled
74.8
17
PDB header: hydrolaseChain: C: PDB Molecule: dna-3-methyladenine glycosidase;
PDBTitle: crystal structure of dna-3-methyladenine glycosidase (10174367) from2 bacillus halodurans at 2.55 a resolution
80 d1rxwa1
not modelled
74.8
42
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
81 d1o98a1
not modelled
74.6
21
Fold: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domainSuperfamily: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domainFamily: 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain
82 d2a1ja1
not modelled
74.5
17
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Hef domain-like
83 d2i1qa1
not modelled
74.5
28
Fold: SAM domain-likeSuperfamily: Rad51 N-terminal domain-likeFamily: DNA repair protein Rad51, N-terminal domain
84 c3cngC_
not modelled
74.3
14
PDB header: hydrolaseChain: C: PDB Molecule: nudix hydrolase;
PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea
85 d2csba3
not modelled
73.8
29
Fold: SAM domain-likeSuperfamily: RuvA domain 2-likeFamily: Topoisomerase V repeat domain
86 c3qeaZ_
not modelled
73.6
12
PDB header: hydrolase/dnaChain: Z: PDB Molecule: exonuclease 1;
PDBTitle: crystal structure of human exonuclease 1 exo1 (wt) in complex with dna2 (complex ii)
87 d2fmpa2
not modelled
73.5
28
Fold: SAM domain-likeSuperfamily: PsbU/PolX domain-likeFamily: DNA polymerase beta-like, second domain
88 d1b43a1
not modelled
72.4
33
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
89 d1szpa1
not modelled
72.3
18
Fold: SAM domain-likeSuperfamily: Rad51 N-terminal domain-likeFamily: DNA repair protein Rad51, N-terminal domain
90 d1xo1a1
not modelled
70.6
25
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
91 c2r8kB_
not modelled
70.2
7
PDB header: replication, transferase/dnaChain: B: PDB Molecule: dna polymerase eta;
PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna
92 d1ul1x1
not modelled
69.2
42
Fold: SAM domain-likeSuperfamily: 5' to 3' exonuclease, C-terminal subdomainFamily: 5' to 3' exonuclease, C-terminal subdomain
93 d2i5ha1
not modelled
69.1
44
Fold: AF1531-likeSuperfamily: AF1531-likeFamily: AF1531-like
94 c2i5hA_
not modelled
69.1
44
PDB header: structural genomics, unknown functionChain: A: PDB Molecule: hypothetical protein af1531;
PDBTitle: crystal structure of af1531 from archaeoglobus fulgidus,2 pfam duf655
95 c2nrzB_
not modelled
68.5
24
PDB header: hydrolaseChain: B: PDB Molecule: uvrabc system protein c;
PDBTitle: crystal structure of the c-terminal half of uvrc bound to2 its catalytic divalent cation
96 d2apob1
not modelled
67.8
24
Fold: Rubredoxin-likeSuperfamily: Nop10-like SnoRNPFamily: Nucleolar RNA-binding protein Nop10-like
97 d1ryqa_
not modelled
67.8
17
Fold: Rubredoxin-likeSuperfamily: RNA polymerase subunitsFamily: RpoE2-like
98 d2bcqa2
not modelled
67.6
30
Fold: SAM domain-likeSuperfamily: PsbU/PolX domain-likeFamily: DNA polymerase beta-like, second domain
99 c1jihA_
not modelled
67.1
7
PDB header: translationChain: A: PDB Molecule: dna polymerase eta;
PDBTitle: yeast dna polymerase eta
100 d1jiha2
not modelled
67.0
7
Fold: DNA/RNA polymerasesSuperfamily: DNA/RNA polymerasesFamily: Lesion bypass DNA polymerase (Y-family), catalytic domain
101 c1ut8B_
not modelled
66.5
25
PDB header: hydrolaseChain: B: PDB Molecule: exodeoxyribonuclease;
PDBTitle: divalent metal ions (zinc) bound to t5 5'-exonuclease
102 d2ey4e1
not modelled
66.2
32
Fold: Rubredoxin-likeSuperfamily: Nop10-like SnoRNPFamily: Nucleolar RNA-binding protein Nop10-like
103 d1jmsa3
not modelled
64.6
25
Fold: SAM domain-likeSuperfamily: PsbU/PolX domain-likeFamily: DNA polymerase beta-like, second domain
104 d1nnqa2
not modelled
64.5
23
Fold: Rubredoxin-likeSuperfamily: Rubredoxin-likeFamily: Rubredoxin
105 c1dd9A_
not modelled
64.2
26
PDB header: transferaseChain: A: PDB Molecule: dna primase;
PDBTitle: structure of the dnag catalytic core
106 d1dd9a_
not modelled
64.2
26
Fold: DNA primase coreSuperfamily: DNA primase coreFamily: DNA primase DnaG catalytic core
107 d2gy9m1
not modelled
63.5
18
Fold: S13-like H2TH domainSuperfamily: S13-like H2TH domainFamily: Ribosomal protein S13
108 c1jr3E_
not modelled
62.4
18
PDB header: transferaseChain: E: PDB Molecule: dna polymerase iii, delta' subunit;
PDBTitle: crystal structure of the processivity clamp loader gamma2 complex of e. coli dna polymerase iii
109 d1vk2a_
not modelled
61.9
10
Fold: Uracil-DNA glycosylase-likeSuperfamily: Uracil-DNA glycosylase-likeFamily: Mug-like
110 c2aq4A_
not modelled
61.6
44
PDB header: transferaseChain: A: PDB Molecule: dna repair protein rev1;
PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp.
111 d1d8ba_
not modelled
61.4
23
Fold: SAM domain-likeSuperfamily: HRDC-likeFamily: HRDC domain from helicases
112 c2izoA_
not modelled
60.3
33
PDB header: hydrolaseChain: A: PDB Molecule: flap structure-specific endonuclease;
PDBTitle: structure of an archaeal pcna1-pcna2-fen1 complex
113 c3fblA_
not modelled
59.7
18
PDB header: structural proteinChain: A: PDB Molecule: putative uncharacterized protein;
PDBTitle: crystal structure of orf132 of the archaeal virus acidianus2 filamentous virus 1 (afv1)
114 c1o98A_
not modelled
59.6
21
PDB header: isomeraseChain: A: PDB Molecule: 2,3-bisphosphoglycerate-independent
PDBTitle: 1.4a crystal structure of phosphoglycerate mutase from2 bacillus stearothermophilus complexed with3 2-phosphoglycerate
115 c2owoA_
not modelled
57.0
33
PDB header: ligase/dnaChain: A: PDB Molecule: dna ligase;
PDBTitle: last stop on the road to repair: structure of e.coli dna ligase bound2 to nicked dna-adenylate
116 d1yuza2
not modelled
57.0
27
Fold: Rubredoxin-likeSuperfamily: Rubredoxin-likeFamily: Rubredoxin
117 c1a77A_
not modelled
56.8
33
PDB header: 5'-3' exo/endo nucleaseChain: A: PDB Molecule: flap endonuclease-1 protein;
PDBTitle: flap endonuclease-1 from methanococcus jannaschii
118 c3q8lA_
not modelled
55.4
42
PDB header: hydrolase/dnaChain: A: PDB Molecule: flap endonuclease 1;
PDBTitle: crystal structure of human flap endonuclease fen1 (wt) in complex with2 substrate 5'-flap dna, sm3+, and k+
119 d1lb2b_
not modelled
54.8
29
Fold: SAM domain-likeSuperfamily: C-terminal domain of RNA polymerase alpha subunitFamily: C-terminal domain of RNA polymerase alpha subunit
120 d1gm5a2
not modelled
54.3
25
Fold: OB-foldSuperfamily: Nucleic acid-binding proteinsFamily: RecG "wedge" domain