Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP76393
DateThu Jan 5 12:22:31 GMT 2012
Unique Job ID5ad4a4f128b5400a

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2pziA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng;
PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017
Confidence and coverage
Confidence:100.0% Coverage: 65%
420 residues ( 65% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
472 residues ( 73%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKTNIKVFTSTGELTTLGRELGKGGEGAVYDIEEFVDSVAKIYHTPPPALKQDKLAFMAA
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Disorder  ?????
?????








?
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???








?
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   .........70.........80.........90.........100.........110.........120
Sequence  TADAQLLNYVAWPQATLHGGRGGKVIGFMMPKVSGKEPIHMIYSPAHRRQSYPHCAWDFL
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Disorder  ???????




































????????







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   .........130.........140.........150.........160.........170.........180
Sequence  LYVARNIASSFATVHEHGHVVGDVNQNSFMVGRDSKVVLIDSDSFQINANGTLHLCEVGV
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?????





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   .........190.........200.........210.........220.........230.........240
Sequence  SHFTPPELQTLPSFVGFERTENHDNFGLALLIFHVLFGGRHPYSGVPLISDAGNALETDI
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????????



























???????????



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   .........250.........260.........270.........280.........290.........300
Sequence  THFRYAYASDNQRRGLKPPPRSIPLSMLPSDVEAMFQQAFTESGVATGRPTAKAWVAALD
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????????
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?
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   .........310.........320.........330.........340.........350.........360
Sequence  SLRQQLKKCIVSAMHVYPAHLTDCPWCALDNQGVIYFIDLGEEVITTGGNFVLAKVWAMV
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Disorder 






??


?













?
???????????????????????????????
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   .........370.........380.........390.........400.........410.........420
Sequence  MASVAPPALQLPLPDHFQPTGRPLPLGLLRREYIILLEIALSALSLLLCGLQAEPRYIIL
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Disorder  ?????????????????????
???????????????????????????????

?????
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   .........430.........440.........450.........460.........470.........480
Sequence  VPVLAAIWIIGSLTSKAYKAEVQQRREAFNRAKMDYDHLVRQIQQVGGLEGFIAKRTMLE
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Disorder  ??






?
??????????






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   .........490.........500.........510.........520.........530.........540
Sequence  KMKDEILGLPEEEKRALAALHDTARERQKQKFLEGFFIDVASIPGVGPARKAALRSFGIE
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?????
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   .........550.........560.........570.........580.........590.........600
Sequence  TAADVTRRGVKQVKGFGDHLTQAVIDWKASCERRFVFRPNEAITPADRQAVMAKMTAKRH
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   .........610.........620.........630.........640........
Sequence  RLESALTVGATELQRFRLHAPARTMPLMEPLRQAAEKLAQAQADLSRC
Secondary structure 

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???
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2pzi chain A

3D model

Region: 9 - 483
Aligned: 420
Modelled: 447
Confidence: 100.0%
Identity: 11%
PDB header:transferase
Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng;
PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017

Phyre2

PDB 3qa8 chain A

3D model

Region: 16 - 291
Aligned: 253
Modelled: 265
Confidence: 100.0%
Identity: 14%
PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta

Phyre2

PDB 1ym7 chain C

3D model

Region: 15 - 298
Aligned: 250
Modelled: 264
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)

Phyre2

PDB 2acx chain B

3D model

Region: 15 - 298
Aligned: 247
Modelled: 263
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp

Phyre2

PDB 3pfq chain A

3D model

Region: 15 - 298
Aligned: 247
Modelled: 262
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii

Phyre2

PDB 1koa chain A

3D model

Region: 15 - 298
Aligned: 245
Modelled: 266
Confidence: 100.0%
Identity: 18%
PDB header:kinase
Chain: A: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains

Phyre2

PDB 2fo0 chain A

3D model

Region: 15 - 300
Aligned: 248
Modelled: 265
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 3c4y chain A

3D model

Region: 15 - 298
Aligned: 245
Modelled: 262
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a

Phyre2

PDB 1opl chain A

3D model

Region: 15 - 302
Aligned: 250
Modelled: 267
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 3q5i chain A

3D model

Region: 15 - 300
Aligned: 243
Modelled: 260
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase;
PDBTitle: crystal structure of pbanka_031420

Phyre2

PDB 3ckx chain A

3D model

Region: 13 - 300
Aligned: 244
Modelled: 259
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 24;
PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine

Phyre2

PDB 2j0k chain B

3D model

Region: 15 - 303
Aligned: 235
Modelled: 251
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.

Phyre2

PDB 2c30 chain A

3D model

Region: 15 - 298
Aligned: 242
Modelled: 265
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6;
PDBTitle: crystal structure of the human p21-activated kinase 6

Phyre2

PDB 3soa chain A

3D model

Region: 15 - 298
Aligned: 245
Modelled: 259
Confidence: 100.0%
Identity: 13%
PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit
PDBTitle: full-length human camkii

Phyre2

PDB 1k9a chain B

3D model

Region: 15 - 305
Aligned: 244
Modelled: 257
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 2vwi chain C

3D model

Region: 8 - 298
Aligned: 257
Modelled: 271
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: C: PDB Molecule:serine/threonine-protein kinase osr1;
PDBTitle: structure of the osr1 kinase, a hypertension drug target

Phyre2

PDB 2ozo chain A

3D model

Region: 10 - 315
Aligned: 254
Modelled: 270
Confidence: 100.0%
Identity: 11%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 2h8h chain A

3D model

Region: 15 - 311
Aligned: 258
Modelled: 276
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2

PDB 1y57 chain A

3D model

Region: 15 - 315
Aligned: 262
Modelled: 280
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2

PDB 1phk chain A

3D model

Region: 15 - 298
Aligned: 249
Modelled: 259
Confidence: 100.0%
Identity: 12%
Fold: Protein kinase-like (PK-like)
Superfamily: Protein kinase-like (PK-like)
Family: Protein kinases, catalytic subunit

Phyre2
1

c2pziA_
2

c3qa8A_
3

c1ym7C_
4

c2acxB_
5

c3pfqA_
6

c1koaA_
7

c2fo0A_
8

c3c4yA_
9

c1oplA_
10

c3q5iA_
11

c3ckxA_
12

c2j0kB_
13

c2c30A_
14

c3soaA_
15

c1k9aB_
16

c2vwiC_
17

c2ozoA_
18

c2h8hA_
19

c1y57A_
20

d1phka_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2pziA_



100.0 11 PDB header:transferase
Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng;
PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017
2c3qa8A_



100.0 14 PDB header:immune system, signaling protein
Chain: A: PDB Molecule:mgc80376 protein;
PDBTitle: crystal structure of inhibitor of kappa b kinase beta
3c1ym7C_



100.0 16 PDB header:transferase
Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1;
PDBTitle: g protein-coupled receptor kinase 2 (grk2)
4c2acxB_



100.0 14 PDB header:transferase
Chain: B: PDB Molecule:g protein-coupled receptor kinase 6;
PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp
5c3pfqA_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
6c1koaA_



100.0 18 PDB header:kinase
Chain: A: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains
7c2fo0A_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
8c3c4yA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:rhodopsin kinase;
PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a
9c1oplA_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
10c3q5iA_



100.0 14 PDB header:transferase
Chain: A: PDB Molecule:protein kinase;
PDBTitle: crystal structure of pbanka_031420
11c3ckxA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 24;
PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine
12c2j0kB_



100.0 16 PDB header:transferase
Chain: B: PDB Molecule:focal adhesion kinase 1;
PDBTitle: crystal structure of a fragment of focal adhesion kinase2 containing the ferm and kinase domains.
13c2c30A_



100.0 15 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6;
PDBTitle: crystal structure of the human p21-activated kinase 6
14c3soaA_



100.0 13 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit
PDBTitle: full-length human camkii
15c1k9aB_



100.0 16 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
16c2vwiC_



100.0 14 PDB header:transferase
Chain: C: PDB Molecule:serine/threonine-protein kinase osr1;
PDBTitle: structure of the osr1 kinase, a hypertension drug target
17c2ozoA_



100.0 11 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
18c2h8hA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
19c1y57A_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
20d1phka_



100.0 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
21d1qcfa3



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
22c3lijA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:calcium/calmodulin dependent protein kinase with
PDBTitle: crystal structure of full length cpcdpk3 (cgd5_820) in2 complex with ca2+ and amppnp
23d2j4za1



not modelled 100.0 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
24d2jfla1



not modelled 100.0 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
25c2y7jB_



not modelled 100.0 13 PDB header:transferase
Chain: B: PDB Molecule:phosphorylase b kinase gamma catalytic chain,
PDBTitle: structure of human phosphorylase kinase, gamma 2
26c2j51A_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:ste20-like serine/threonine-protein kinase;
PDBTitle: crystal structure of human ste20-like kinase bound to 5-2 amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6-3 difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
27c3zzwA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase transmembrane receptor ror2;
PDBTitle: crystal structure of the kinase domain of ror2
28c3q60A_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:rop5b;
PDBTitle: crystal structure of virulent allele rop5b pseudokinase domain bound2 to atp
29c3d9vA_



not modelled 100.0 12 PDB header:transferase
Chain: A: PDB Molecule:rho-associated protein kinase 1;
PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil
30c3fbvL_



not modelled 100.0 15 PDB header:transferase, hydrolase
Chain: L: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1;
PDBTitle: crystal structure of the oligomer formed by the kinase-ribonuclease2 domain of ire1
31c2qg5D_



not modelled 100.0 17 PDB header:transferase
Chain: D: PDB Molecule:calcium/calmodulin-dependent protein kinase;
PDBTitle: cryptosporidium parvum calcium dependent protein kinase cgd7_1840
32c2c0iA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
33c2bujA_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase 16;
PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine
34c2a1aB_



not modelled 100.0 12 PDB header:protein synthesis/transferase
Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein
PDBTitle: pkr kinase domain-eif2alpha complex
35d1opja_



not modelled 100.0 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
36d1yhwa1



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
37c1mruB_



not modelled 100.0 18 PDB header:transferase
Chain: B: PDB Molecule:probable serine/threonine-protein kinase pknb;
PDBTitle: intracellular ser/thr protein kinase domain of2 mycobacterium tuberculosis pknb.
38c2a27B_



not modelled 100.0 14 PDB header:transferase
Chain: B: PDB Molecule:death-associated protein kinase 2;
PDBTitle: human drp-1 kinase, w305s s308a d40 mutant, crystal form with 82 monomers in the asymmetric unit
39d1qpca_



not modelled 100.0 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
40c2wtkC_



not modelled 100.0 12 PDB header:transferase/metal-binding protein
Chain: C: PDB Molecule:serine/threonine-protein kinase 11;
PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
41d1jksa_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
42c3dfaA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920;
PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum
43c3p23B_



not modelled 100.0 14 PDB header:hydrolase, transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1;
PDBTitle: crystal structure of the human kinase and rnase domains in complex2 with adp
44c3g0eA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:mast/stem cell growth factor receptor;
PDBTitle: kit kinase domain in complex with sunitinib
45c3hztA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:calcium-dependent protein kinase 3;
PDBTitle: crystal structure of toxoplasma gondii cdpk3, tgme49_105860
46c2pvfA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of tyrosine phosphorylated activated fgf2 receptor 2 (fgfr2) kinase domain in complex with atp3 analog and substrate peptide
47c2zv2A_



not modelled 100.0 12 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase kinase 2;
PDBTitle: crystal structure of human calcium/calmodulin-dependent protein kinase2 kinase 2, beta, camkk2 kinase domain in complex with sto-609
48c3byvA_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:rhoptry kinase;
PDBTitle: crystal structure of toxoplasma gondii specific rhoptry2 antigen kinase domain
49c2ya9A_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:death-associated protein kinase 2;
PDBTitle: crystal structure of the autoinhibited form of mouse dapk2
50c3dzoA_



not modelled 100.0 12 PDB header:transferase
Chain: A: PDB Molecule:rhoptry kinase domain;
PDBTitle: crystal structure of a rhoptry kinase from toxoplasma gondii
51c2vd5A_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:dmpk protein;
PDBTitle: structure of human myotonic dystrophy protein kinase in2 complex with the bisindoylmaleide inhibitor bim viii
52c2ivsA_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor
PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain
53c2jiiA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase vrk3 molecule: vaccinia
PDBTitle: structure of vaccinia related kinase 3
54c1xjdA_



not modelled 100.0 18 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, theta type;
PDBTitle: crystal structure of pkc-theta complexed with staurosporine2 at 2a resolution
55d1xjda_



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
56c2bmcD_



not modelled 100.0 13 PDB header:transferase
Chain: D: PDB Molecule:serine threonine-protein kinase 6;
PDBTitle: aurora-2 t287d t288d complexed with pha-680632
57d1uwha_



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
58c2bdwB_



not modelled 100.0 15 PDB header:transferase
Chain: B: PDB Molecule:hypothetical protein k11e8.1d;
PDBTitle: crystal structure of the auto-inhibited kinase domain of2 calcium/calmodulin activated kinase ii
59d1o6ya_



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
60d1ckia_



not modelled 100.0 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
61c3plsA_



not modelled 100.0 17 PDB header:transferase
Chain: A: PDB Molecule:macrophage-stimulating protein receptor;
PDBTitle: ron in complex with ligand amp-pnp
62c2clqA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 5;
PDBTitle: structure of mitogen-activated protein kinase kinase kinase2 5
63c2wtkB_



not modelled 100.0 13 PDB header:transferase/metal-binding protein
Chain: B: PDB Molecule:ste20-related kinase adapter protein alpha;
PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex
64c3dpkA_



not modelled 100.0 17 PDB header:transferase
Chain: A: PDB Molecule:macrophage colony-stimulating factor 1 receptor;
PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor
65c2cgvA_



not modelled 100.0 12 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk1;
PDBTitle: identification of chemically diverse chk1 inhibitors by2 receptor-based virtual screening
66c3d4qA_



not modelled 100.0 17 PDB header:transferase
Chain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase;
PDBTitle: pyrazole-based inhibitors of b-raf kinase
67d1k2pa_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
68d2psqa1



not modelled 100.0 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
69c2psqA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:fibroblast growth factor receptor 2;
PDBTitle: crystal structure of unphosphorylated unactivated wild type2 fgf receptor 2 (fgfr2) kinase domain
70c3cblA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
71d1koaa2



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
72d1nvra_



not modelled 100.0 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
73c3e7eA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:mitotic checkpoint serine/threonine-protein kinase bub1;
PDBTitle: structure and substrate recruitment of the human spindle checkpoint2 kinase bub
74c1lufA_



not modelled 100.0 18 PDB header:transferase
Chain: A: PDB Molecule:muscle-specific tyrosine kinase receptor musk;
PDBTitle: crystal structure of the musk tyrosine kinase: insights2 into receptor autoregulation
75d1lufa_



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
76c2x4fA_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:myosin light chain kinase family member 4;
PDBTitle: the crystal structure of the human myosin light chain2 kinase loc340156.
77d1u59a_



not modelled 100.0 11 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
78d1o6la_



not modelled 100.0 17 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
79d1koba_



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
80c1kobB_



not modelled 100.0 19 PDB header:kinase
Chain: B: PDB Molecule:twitchin;
PDBTitle: twitchin kinase fragment (aplysia), autoregulated protein2 kinase domain
81c3lxkA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6
82c2chlA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:casein kinase i isoform gamma-3;
PDBTitle: structure of casein kinase 1 gamma 3
83c2vz6A_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:calcium calmodulin dependent protein kinase type ii alpha
PDBTitle: structure of human calcium calmodulin dependent protein2 kinase type ii alpha (camk2a) in complex with indirubin3 e804
84c1zrzA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, iota;
PDBTitle: crystal structure of the catalytic domain of atypical2 protein kinase c-iota
85c3is5E_



not modelled 100.0 18 PDB header:transferase
Chain: E: PDB Molecule:calcium-dependent protein kinase;
PDBTitle: crystal structure of cdpk kinase domain from toxoplasma gondii,2 tgme49_018720
86c3c0hB_



not modelled 100.0 14 PDB header:transferase
Chain: B: PDB Molecule:peripheral plasma membrane protein cask;
PDBTitle: cask cam-kinase domain- amppnp complex, p1 form
87c2c47D_



not modelled 100.0 14 PDB header:transferase
Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform;
PDBTitle: structure of casein kinase 1 gamma 2
88d1t46a_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
89d3bu3a1



not modelled 100.0 18 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
90c3an0A_



not modelled 100.0 14 PDB header:transferase/transferase inhibitor
Chain: A: PDB Molecule:dual specificity mitogen-activated protein kinase kinase 6;
PDBTitle: crystal structure of non-phosphorylated map2k6 as a putative auto2 inhibition state
91d1xwsa_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
92c2r7bA_



not modelled 100.0 14 PDB header:signaling protein, transferase
Chain: A: PDB Molecule:phosphoinositide-dependent protein kinase 1;
PDBTitle: crystal structure of the phosphoinositide-dependent kinase-2 1 (pdk-1)catalytic domain bound to a dibenzonaphthyridine3 inhibitor
93c3comB_



not modelled 100.0 12 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase 4;
PDBTitle: crystal structure of mst1 kinase
94d1tkia_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
95c2j2iB_



not modelled 100.0 14 PDB header:transferase
Chain: B: PDB Molecule:proto-oncogene serine/threonine-protein kinase pim-1;
PDBTitle: crystal structure of the humab pim1 in complex with2 ly333531
96c2r5tA_



not modelled 100.0 17 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase sgk1;
PDBTitle: crystal structure of inactive serum and glucocorticoid-2 regulated kinase 1 in complex with amp-pnp
97c3lvpD_



not modelled 100.0 16 PDB header:transferase
Chain: D: PDB Molecule:insulin-like growth factor 1 receptor;
PDBTitle: crystal structure of bisphosphorylated igf1-r kinase domain (2p) in2 complex with a bis-azaindole inhibitor
98d1fmka3



not modelled 100.0 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
99c2cn5A_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase chk2;
PDBTitle: crystal structure of human chk2 in complex with adp
100d1uu3a_



not modelled 100.0 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
101c2h6dA_



not modelled 100.0 15 PDB header:signaling protein,transferase
Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit
PDBTitle: protein kinase domain of the human 5'-amp-activated protein2 kinase catalytic subunit alpha-2 (ampk alpha-2 chain)
102c2i0eB_



not modelled 100.0 15 PDB header:transferase
Chain: B: PDB Molecule:protein kinase c-beta ii;
PDBTitle: structure of catalytic domain of human protein kinase c2 beta ii complexed with a bisindolylmaleimide inhibitor
103d1csna_



not modelled 100.0 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
104c2qluA_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:activin receptor type iib;
PDBTitle: crystal structure of activin receptor type ii kinase domain2 from human
105c2wqmA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase nek7;
PDBTitle: structure of apo human nek7
106c1yvjA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase jak3;
PDBTitle: crystal structure of the jak3 kinase domain in complex with2 a staurosporine analogue
107d1xbba_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
108d1fota_



not modelled 100.0 14 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
109c3ku2A_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:calmodulin-domain protein kinase 1;
PDBTitle: crystal structure of inactivated form of cdpk1 from toxoplasma gondii,2 tgme49.101440
110d1sm2a_



not modelled 100.0 13 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
111c2v62A_



not modelled 100.0 16 PDB header:transferase
Chain: A: PDB Molecule:serine/threonine-protein kinase vrk2;
PDBTitle: structure of vaccinia-related kinase 2
112c2y94A_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit alpha-1;
PDBTitle: structure of an active form of mammalian ampk
113d1iasa_



not modelled 100.0 12 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
114c3l9pA_



not modelled 100.0 15 PDB header:transferase
Chain: A: PDB Molecule:anaplastic lymphoma kinase;
PDBTitle: crystal structure of the anaplastic lymphoma kinase catalytic domain
115c2x7fA_



not modelled 100.0 14 PDB header:transferase
Chain: A: PDB Molecule:traf2 and nck-interacting protein kinase;
PDBTitle: crystal structure of the kinase domain of human traf2- and2 nck-interacting kinase with wee1chk1 inhibitor
116d1gzka_



not modelled 100.0 19 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
117c3op5B_



not modelled 100.0 15 PDB header:transferase
Chain: B: PDB Molecule:serine/threonine-protein kinase vrk1;
PDBTitle: human vaccinia-related kinase 1
118d1p4oa_



not modelled 100.0 15 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit
119c3eygA_



not modelled 100.0 13 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase;
PDBTitle: crystal structures of jak1 and jak2 inhibitor complexes
120d1mp8a_



not modelled 100.0 16 Fold:Protein kinase-like (PK-like)
Superfamily:Protein kinase-like (PK-like)
Family:Protein kinases, catalytic subunit

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0