Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	I	K	N	L	P	A	D	Y	L	L	A	A	Q	Q	G	D	I	D	K	V	K	T	C	L	A	L	G	V	D	I	N	T	C	D	R	Q	G	K	T	A	I	T	L	A	S	L	Y	Q	Q	Y	A	C	V	Q	A	L	I	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	A	D	I	N	K	Q	D	H	T	C	L	N	P	F	L	I	S	C	L	N	D	D	L	T	L	L	R	I	I	L	P	A	K	P	D	L	N	C	V	T	R	F	G	G	V	G	L	T	P	A	C	E	K	G	H	L	S	I
Secondary structure
SS confidence
Disorder											?																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	K	E	L	L	A	H	T	E	I	N	V	N	Q	T	N	H	V	G	W	T	P	L	L	E	A	I	V	L	N	D	G	G	I	K	Q	Q	A	I	V	Q	L	L	L	E	H	G	A	S	P	H	L	T	D	K	Y	G	K	T	P
Secondary structure
SS confidence
Disorder																		?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.
Sequence		L	E	L	A	R	E	R	G	F	E	E	I	A	Q	L	L	I	A	A	G	A
Secondary structure
SS confidence
Disorder																					?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1wdy chain A Region: 5 - 201 Aligned: 197 Modelled: 197 Confidence: 100.0% Identity: 25% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 3eu9 chain B Region: 4 - 198 Aligned: 195 Modelled: 195 Confidence: 100.0% Identity: 15% PDB header:protein binding, methyl-lysine-binding p Chain: B: PDB Molecule:huntingtin-interacting protein 14; PDBTitle: the ankyrin repeat domain of huntingtin interacting protein 14 Phyre2 PDB 3b7b chain B Region: 8 - 201 Aligned: 194 Modelled: 194 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:euchromatic histone-lysine n-methyltransferase 1; PDBTitle: euhmt1 (glp) ankyrin repeat domain (structure 1) Phyre2 PDB 1ikn chain D Region: 5 - 201 Aligned: 196 Modelled: 197 Confidence: 100.0% Identity: 15% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 1oy3 chain D Region: 4 - 201 Aligned: 198 Modelled: 198 Confidence: 100.0% Identity: 19% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 1oy3 chain D Region: 4 - 201 Aligned: 198 Modelled: 198 Confidence: 100.0% Identity: 19% PDB header:dna binding protein Chain: D: PDB Molecule:transcription factor inhibitor i-kappa-b-beta; PDBTitle: crystal structure of an ikbbeta/nf-kb p65 homodimer complex Phyre2 PDB 1n11 chain A Region: 8 - 201 Aligned: 194 Modelled: 194 Confidence: 100.0% Identity: 21% PDB header:structural protein Chain: A: PDB Molecule:ankyrin; PDBTitle: d34 region of human ankyrin-r and linker Phyre2 PDB 1n11 chain A Region: 8 - 201 Aligned: 194 Modelled: 194 Confidence: 100.0% Identity: 21% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 3d9h chain A Region: 4 - 199 Aligned: 194 Modelled: 196 Confidence: 99.9% Identity: 17% PDB header:structural protein, protein binding Chain: A: PDB Molecule:cdna flj77766, highly similar to homo sapiens PDBTitle: crystal structure of the splice variant of human asb92 (hasb9-2), an ankyrin repeat protein Phyre2 PDB 3hra chain A Region: 8 - 199 Aligned: 192 Modelled: 192 Confidence: 99.9% Identity: 35% PDB header:structural protein Chain: A: PDB Molecule:ankyrin repeat family protein; PDBTitle: crystal structure of ef0377 an ankyrin repeat protein Phyre2 PDB 1ixv chain A Region: 7 - 201 Aligned: 192 Modelled: 195 Confidence: 99.9% Identity: 12% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 2f8x chain K Region: 8 - 201 Aligned: 189 Modelled: 189 Confidence: 99.9% Identity: 22% PDB header:transcription/dna Chain: K: PDB Molecule:neurogenic locus notch homolog protein 1; PDBTitle: crystal structure of activated notch, csl and maml on hes-12 promoter dna sequence Phyre2 PDB 2xai chain D Region: 8 - 201 Aligned: 192 Modelled: 194 Confidence: 99.9% Identity: 17% PDB header:transcription Chain: D: PDB Molecule:ankyrin repeat and socs box protein 9; PDBTitle: crystal structure of ankyrin repeat and socs box-containing2 protein 9 (asb9) in complex with elonginb and elonginc Phyre2 PDB 1k1a chain A Region: 4 - 194 Aligned: 191 Modelled: 191 Confidence: 99.9% Identity: 19% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 1uoh chain A Region: 7 - 198 Aligned: 191 Modelled: 192 Confidence: 99.9% Identity: 18% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 1s70 chain B Region: 5 - 201 Aligned: 197 Modelled: 197 Confidence: 99.9% Identity: 23% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 PDB 3ljn chain A Region: 4 - 201 Aligned: 198 Modelled: 198 Confidence: 99.9% Identity: 15% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: ankyrin repeat protein from leishmania major Phyre2 PDB 2rfa chain A Region: 6 - 201 Aligned: 196 Modelled: 196 Confidence: 99.9% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:transient receptor potential cation channel subfamily v PDBTitle: crystal structure of the mouse trpv6 ankyrin repeat domain Phyre2 PDB 2fo1 chain E Region: 2 - 198 Aligned: 196 Modelled: 196 Confidence: 99.9% Identity: 14% PDB header:gene regulation/signalling protein/dna Chain: E: PDB Molecule:lin-12 protein; PDBTitle: crystal structure of the csl-notch-mastermind ternary2 complex bound to dna Phyre2 PDB 2fo1 chain E domain 1 Region: 7 - 198 Aligned: 191 Modelled: 192 Confidence: 99.9% Identity: 14% Fold: beta-hairpin-alpha-hairpin repeat Superfamily: Ankyrin repeat Family: Ankyrin repeat Phyre2 1 d1wdya_ 2 c3eu9B_ 3 c3b7bB_ 4 d1iknd_ 5 d1oy3d_ 6 c1oy3D_ 7 c1n11A_ 8 d1n11a_ 9 c3d9hA_ 10 c3hraA_ 11 d1ixva_ 12 c2f8xK_ 13 c2xaiD_ 14 d1k1aa_ 15 d1uoha_ 16 d1s70b_ 17 c3ljnA_ 18 c2rfaA_ 19 c2fo1E_ 20 d2fo1e1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1wdya_ 100.0 25 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 2 c3eu9B_ 100.0 15 PDB header:protein binding, methyl-lysine-binding p Chain: B: PDB Molecule:huntingtin-interacting protein 14; PDBTitle: the ankyrin repeat domain of huntingtin interacting protein 14 3 c3b7bB_ 100.0 15 PDB header:transferase Chain: B: PDB Molecule:euchromatic histone-lysine n-methyltransferase 1; PDBTitle: euhmt1 (glp) ankyrin repeat domain (structure 1) 4 d1iknd_ 100.0 15 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 5 d1oy3d_ 100.0 19 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 6 c1oy3D_ 100.0 19 PDB header:dna binding protein Chain: D: PDB Molecule:transcription factor inhibitor i-kappa-b-beta; PDBTitle: crystal structure of an ikbbeta/nf-kb p65 homodimer complex 7 c1n11A_ 100.0 21 PDB header:structural protein Chain: A: PDB Molecule:ankyrin; PDBTitle: d34 region of human ankyrin-r and linker 8 d1n11a_ 100.0 21 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 9 c3d9hA_ 99.9 17 PDB header:structural protein, protein binding Chain: A: PDB Molecule:cdna flj77766, highly similar to homo sapiens PDBTitle: crystal structure of the splice variant of human asb92 (hasb9-2), an ankyrin repeat protein 10 c3hraA_ 99.9 35 PDB header:structural protein Chain: A: PDB Molecule:ankyrin repeat family protein; PDBTitle: crystal structure of ef0377 an ankyrin repeat protein 11 d1ixva_ 99.9 12 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 12 c2f8xK_ 99.9 22 PDB header:transcription/dna Chain: K: PDB Molecule:neurogenic locus notch homolog protein 1; PDBTitle: crystal structure of activated notch, csl and maml on hes-12 promoter dna sequence 13 c2xaiD_ 99.9 17 PDB header:transcription Chain: D: PDB Molecule:ankyrin repeat and socs box protein 9; PDBTitle: crystal structure of ankyrin repeat and socs box-containing2 protein 9 (asb9) in complex with elonginb and elonginc 14 d1k1aa_ 99.9 19 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 15 d1uoha_ 99.9 18 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 16 d1s70b_ 99.9 23 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 17 c3ljnA_ 99.9 15 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: ankyrin repeat protein from leishmania major 18 c2rfaA_ 99.9 15 PDB header:membrane protein Chain: A: PDB Molecule:transient receptor potential cation channel subfamily v PDBTitle: crystal structure of the mouse trpv6 ankyrin repeat domain 19 c2fo1E_ 99.9 14 PDB header:gene regulation/signalling protein/dna Chain: E: PDB Molecule:lin-12 protein; PDBTitle: crystal structure of the csl-notch-mastermind ternary2 complex bound to dna 20 d2fo1e1 99.9 14 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 21 c2kbxA_ not modelled 99.9 21 PDB header:cell adhesion Chain: A: PDB Molecule:integrin-linked protein kinase; PDBTitle: solution structure of ilk-pinch complex 22 d1blxb_ not modelled 99.9 22 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 23 c3keaB_ not modelled 99.9 13 PDB header:viral protein Chain: B: PDB Molecule:k1l; PDBTitle: structure function studies of vaccinia virus host-range protein k12 reveal a novel ankyrin repeat interaction surface for k1s function 24 d1ihba_ not modelled 99.9 19 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 25 d1ot8a_ not modelled 99.9 19 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 26 c1ycsB_ not modelled 99.9 35 PDB header:complex (anti-oncogene/ankyrin repeats) Chain: B: PDB Molecule:53bp2; PDBTitle: p53-53bp2 complex 27 d1awcb_ not modelled 99.9 19 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 28 d1bd8a_ not modelled 99.9 23 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 29 c3twtD_ not modelled 99.9 27 PDB header:signaling protein/peptide Chain: D: PDB Molecule:tankyrase-2; PDBTitle: crystal structure of arc4 from human tankyrase 2 in complex with2 peptide from human mcl1 (chimeric peptide) 30 c2rfmB_ not modelled 99.9 22 PDB header:protein binding Chain: B: PDB Molecule:putative ankyrin repeat protein tv1425; PDBTitle: structure of a thermophilic ankyrin repeat protein 31 c2jabC_ not modelled 99.9 37 PDB header:de novo protein Chain: C: PDB Molecule:h10-2-g3; PDBTitle: a designed ankyrin repeat protein evolved to picomolar2 affinity to her2 32 c3ui2A_ not modelled 99.9 29 PDB header:transport protein Chain: A: PDB Molecule:signal recognition particle 43 kda protein, chloroplastic; PDBTitle: crystal structure of the cpsrp54 tail bound to cpsrp43 33 d1bi7b_ not modelled 99.9 31 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 34 c2ajaA_ not modelled 99.9 12 PDB header:protein binding Chain: A: PDB Molecule:ankyrin repeat family protein; PDBTitle: x-ray structure of an ankyrin repeat family protein q5zsv02 from legionella pneumophila. northeast structural genomics3 consortium target lgr21. 35 c2v5qC_ not modelled 99.9 35 PDB header:transferase Chain: C: PDB Molecule:design ankyrin repeat protein; PDBTitle: crystal structure of wild-type plk-1 kinase domain in2 complex with a selective darpin 36 d2a5ea_ not modelled 99.9 23 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 37 c3jueA_ not modelled 99.8 41 PDB header:protein transport/endocytosis Chain: A: PDB Molecule:arfgap with coiled-coil, ank repeat and ph domain- PDBTitle: crystal structure of arfgap and ank repeat domain of acap1 38 d2ajaa1 not modelled 99.8 15 Fold:alpha-alpha superhelix Superfamily:Pseudo ankyrin repeat-like Family:Pseudo ankyrin repeat 39 c1dcqA_ not modelled 99.8 30 PDB header:metal binding protein Chain: A: PDB Molecule:pyk2-associated protein beta; PDBTitle: crystal structure of the arf-gap domain and ankyrin repeats2 of papbeta. 40 c2nyjA_ not modelled 99.8 14 PDB header:transport protein Chain: A: PDB Molecule:transient receptor potential cation channel PDBTitle: crystal structure of the ankyrin repeat domain of trpv1 41 d1myoa_ not modelled 99.8 32 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 42 c3deoA_ not modelled 99.8 39 PDB header:protein transport, membrane protein Chain: A: PDB Molecule:signal recognition particle 43 kda protein; PDBTitle: structural basis for specific substrate recognition by the2 chloroplast signal recognition particle protein cpsrp43 43 c2xenA_ not modelled 99.8 53 PDB header:de novo protein Chain: A: PDB Molecule:ni1c mut4; PDBTitle: structural determinants for improved thermal stability of2 designed ankyrin repeat proteins with a redesigned c-3 capping module. 44 d1sw6a_ not modelled 99.8 13 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 45 c1sw6A_ not modelled 99.8 13 PDB header:transcription regulation Chain: A: PDB Molecule:regulatory protein swi6; PDBTitle: s. cerevisiae swi6 ankyrin-repeat fragment 46 c1n0qB_ not modelled 99.8 50 PDB header:structural protein Chain: B: PDB Molecule:3 ankyrin repeats; PDBTitle: 3ank: a designed ankyrin repeat protein with three identical consensus2 repeats 47 c2f37B_ not modelled 99.8 15 PDB header:membrane protein Chain: B: PDB Molecule:transient receptor potential cation channel PDBTitle: crystal structure of the ankyrin repeat domain of human2 trpv2 48 d1dcqa1 not modelled 99.8 27 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 49 c2vgeA_ not modelled 99.8 17 PDB header:transcription Chain: A: PDB Molecule:rela-associated inhibitor; PDBTitle: crystal structure of the c-terminal region of human iaspp 50 c3ehrB_ not modelled 99.8 27 PDB header:signaling protein Chain: B: PDB Molecule:osteoclast-stimulating factor 1; PDBTitle: crystal structure of human osteoclast stimulating factor 51 d1ycsb1 not modelled 99.8 24 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 52 c3c5rB_ not modelled 99.8 32 PDB header:protein binding Chain: B: PDB Molecule:brca1-associated ring domain protein 1; PDBTitle: crystal structure of the bard1 ankyrin repeat domain and its2 functional consequences 53 c3t8kB_ not modelled 99.8 14 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of a functionally unknown protein lebu_0176 from2 leptotrichia buccalis c-1013-b 54 c1ympB_ not modelled 99.8 28 PDB header:transcription Chain: B: PDB Molecule:notch 1 protein; PDBTitle: the crystal structure of a partial mouse notch-1 ankyrin2 domain: repeats 4 through 7 preserve an ankyrin fold 55 c1ympA_ not modelled 99.8 28 PDB header:transcription Chain: A: PDB Molecule:notch 1 protein; PDBTitle: the crystal structure of a partial mouse notch-1 ankyrin2 domain: repeats 4 through 7 preserve an ankyrin fold 56 c2zgdA_ not modelled 99.8 53 PDB header:de novo protein Chain: A: PDB Molecule:3 repeat synthetic ankyrin; PDBTitle: asn-hydroxylation stabilises the ankyrin repeat domain fold 57 c1n0rA_ not modelled 99.8 42 PDB header:structural protein Chain: A: PDB Molecule:4 ankyrin repeats; PDBTitle: 4ank: a designed ankyrin repeat protein with four identical2 consensus repeats 58 c3jxiA_ not modelled 99.7 13 PDB header:membrane protein Chain: A: PDB Molecule:vanilloid receptor-related osmotically activated channel PDBTitle: crystal structure of the chicken trpv4 ankyrin repeat domain 59 c2b0oF_ not modelled 99.7 21 PDB header:metal binding protein Chain: F: PDB Molecule:uplc1; PDBTitle: crystal structure of uplc1 gap domain 60 c2l6bA_ not modelled 99.7 44 PDB header:de novo protein Chain: A: PDB Molecule:nr1c; PDBTitle: nrc consensus ankyrin repeat protein solution structure 61 c3lvrE_ not modelled 99.6 22 PDB header:protein transport Chain: E: PDB Molecule:arf-gap with sh3 domain, ank repeat and ph domain- PDBTitle: the crystal structure of asap3 in complex with arf6 in transition2 state soaked with calcium 62 c2xumS_ not modelled 90.7 33 PDB header:oxidoreductase/peptide Chain: S: PDB Molecule:asp-substrate peptide 2; PDBTitle: factor inhibiting hif (fih) q239h mutant in complex with zn(ii), nog2 and asp-substrate peptide (20-mer) 63 c2y0iS_ not modelled 57.1 31 PDB header:oxidoreductase/peptide Chain: S: PDB Molecule:tankyrase-2; PDBTitle: factor inhibiting hif-1 alpha in complex with tankyrase-2 (tnks2)2 fragment peptide (21-mer) 64 c3zrhA_ not modelled 10.7 16 PDB header:hydrolase Chain: A: PDB Molecule:ubiquitin thioesterase zranb1; PDBTitle: crystal structure of the lys29, lys33-linkage-specific trabid otu2 deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding3 domain (ankubd) 65 c2do6A_ not modelled 6.8 17 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase cbl-b; PDBTitle: solution structure of rsgi ruh-065, a uba domain from human2 cdna 66 d2hoea1 not modelled 6.4 40 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:ROK associated domain 67 c2d9sA_ not modelled 6.2 26 PDB header:ligase Chain: A: PDB Molecule:cbl e3 ubiquitin protein ligase; PDBTitle: solution structure of rsgi ruh-049, a uba domain from mouse2 cdna

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0