Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP0AD14
DateThu Jan 5 11:19:40 GMT 2012
Unique Job IDf94be540cf14ac5a

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2c2aA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
Confidence and coverage
Confidence:100.0% Coverage: 35%
199 residues ( 35% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
320 residues ( 57%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MYDFNLVLLLLQQMCVFLVIAWLMSKTPLFIPLMQVTVRLPHKFLCYIVFSIFCIMGTWF
Secondary structure 
SS confidence 
Disorder  ???
????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  GLHIDDSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGGMTALSCMISTIVEGLL
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  GGLVHSILIRRGRTDKVFNPITAGAVTFVAEMVQMLIILAIARPYEDAVRLVSNIAAPMM
Secondary structure 
SS confidence 
Disorder 
??????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  VTNTVGAALFMRILLDKRAMFEKYTSAFSATALKVAASTEGILRQGFNEVNSMKVAQVLY
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  QELDIGAVAITDREKLLAFTGIGDDHHLPGKPISSTYTLKAIETGEVVYADGNEVPYRCS
Secondary structure 
SS confidence 
Disorder 
?
??
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  LHPQCKLGSTLVIPLRGENQRVMGTIKLYEAKNRLFSSINRTLGEGIAQLLSAQILAGQY
Secondary structure 
SS confidence 
Disorder 
?
?
???
?
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  ERQKAMLTQSEIKLLHAQVNPHFLFNALNTIKAVIRRDSEQASQLVQYLSTFFRKNLKRP
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  SEFVTLADEIEHVNAYLQIEKARFQSRLQVNIAIPQELSQQQLPAFTLQPIVENAIKHGT
Secondary structure 
SS confidence 
Disorder  ?
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  SQLLDTGRVAISARREGQHLMLEIEDNAGLYQPVTNASGLGMNLVDKRLRERFGDDYGIS
Secondary structure 
SS confidence 
Disorder 
???
???????????
Disorder confidence 
 
   .........550.........560.
Sequence  VACEPDSYTRITLRLPWRDEA
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2c2a chain A

3D model

Region: 356 - 558
Aligned: 199
Modelled: 203
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 3d36 chain B

3D model

Region: 376 - 557
Aligned: 174
Modelled: 182
Confidence: 100.0%
Identity: 20%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 2q8f chain A

3D model

Region: 370 - 557
Aligned: 184
Modelled: 188
Confidence: 100.0%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 3d2r chain B

3D model

Region: 370 - 561
Aligned: 189
Modelled: 192
Confidence: 99.9%
Identity: 12%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 1y8o chain A

3D model

Region: 370 - 560
Aligned: 188
Modelled: 191
Confidence: 99.9%
Identity: 13%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 1gjv chain A

3D model

Region: 345 - 557
Aligned: 209
Modelled: 213
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 2bu8 chain A

3D model

Region: 371 - 561
Aligned: 188
Modelled: 191
Confidence: 99.9%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 3a0r chain A

3D model

Region: 239 - 560
Aligned: 314
Modelled: 322
Confidence: 99.9%
Identity: 8%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 1b3q chain A

3D model

Region: 381 - 558
Aligned: 169
Modelled: 178
Confidence: 99.9%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 418 - 558
Aligned: 137
Modelled: 141
Confidence: 99.9%
Identity: 15%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3a0t chain A

3D model

Region: 419 - 560
Aligned: 137
Modelled: 142
Confidence: 99.9%
Identity: 12%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 424 - 561
Aligned: 134
Modelled: 138
Confidence: 99.9%
Identity: 17%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1id0 chain A

3D model

Region: 421 - 558
Aligned: 130
Modelled: 138
Confidence: 99.9%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3jz3 chain B

3D model

Region: 395 - 557
Aligned: 144
Modelled: 163
Confidence: 99.8%
Identity: 13%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2

PDB 2ch4 chain A

3D model

Region: 422 - 558
Aligned: 133
Modelled: 137
Confidence: 99.8%
Identity: 19%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1bxd chain A

3D model

Region: 418 - 561
Aligned: 133
Modelled: 144
Confidence: 99.8%
Identity: 18%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 425 - 561
Aligned: 134
Modelled: 137
Confidence: 99.8%
Identity: 10%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1i58 chain A

3D model

Region: 422 - 557
Aligned: 132
Modelled: 136
Confidence: 99.8%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 419 - 557
Aligned: 130
Modelled: 139
Confidence: 99.8%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3gie chain A

3D model

Region: 349 - 556
Aligned: 191
Modelled: 208
Confidence: 99.8%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp

Phyre2

PDB 3p5n chain A

3D model

Region: 39 - 202
Aligned: 164
Modelled: 164
Confidence: 78.7%
Identity: 9%
PDB header:transport protein
Chain: A: PDB Molecule:riboflavin uptake protein;
PDBTitle: structure and mechanism of the s component of a bacterial ecf2 transporter

Phyre2

PDB 1mc0 chain A

3D model

Region: 183 - 368
Aligned: 186
Modelled: 186
Confidence: 65.6%
Identity: 10%
PDB header:hydrolase
Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a;
PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains

Phyre2
1
c2c2aA_
2
c3d36B_
3
c2q8fA_
4
c3d2rB_
5
c1y8oA_
6
c1gjvA_
7
c2bu8A_
8
c3a0rA_
9
c1b3qA_
10
d2c2aa2
11
c3a0tA_
12
d1gkza2
13
d1id0a_
14
c3jz3B_
15
c2ch4A_
16
d1bxda_
17
d1jm6a2
18
d1i58a_
19
d1ysra1
20
c3gieA_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
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63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
c3p5nA_
84
85
86
87
c1mc0A_
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
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107
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122



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2c2aA_
100.0 17 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
2c3d36B_
100.0 20 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
3c2q8fA_
100.0 14 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
4c3d2rB_
99.9 12 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
5c1y8oA_
99.9 13 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
6c1gjvA_
99.9 15 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
7c2bu8A_
99.9 10 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
8c3a0rA_
99.9 8 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
9c1b3qA_
99.9 17 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
10d2c2aa2
99.9 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
11c3a0tA_
99.9 12 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
12d1gkza2
99.9 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
13d1id0a_
99.9 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
14c3jz3B_
99.8 13 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
15c2ch4A_
99.8 19 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
16d1bxda_
99.8 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
17d1jm6a2
99.8 10 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
18d1i58a_
99.8 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
19d1ysra1
99.8 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
20c3gieA_
99.8 15 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
21d1r62a_
not modelled 99.7 14 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
22c3ehgA_
not modelled 99.7 14 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
23c3zxqA_
not modelled 99.6 18 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
24c3zxoB_
not modelled 99.6 20 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
25d2hkja3
not modelled 99.5 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
26d1ixma_
not modelled 99.4 9 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
27d1th8a_
not modelled 99.3 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
28c2zbkB_
not modelled 99.3 24 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
29c1mx0D_
not modelled 99.3 23 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
30c2q2eB_
not modelled 99.3 14 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
31d1h7sa2
not modelled 99.0 8 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
32d1y8oa2
not modelled 98.9 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
33d1bkna2
not modelled 98.7 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
34d1b63a2
not modelled 98.6 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
35c3h4lB_
not modelled 98.0 21 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
36c3na3A_
not modelled 98.0 13 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
37c1ea6A_
not modelled 98.0 12 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
38d1pvga2
not modelled 97.9 12 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
39c3ke6A_
not modelled 97.9 21 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
40c1zxnB_
not modelled 97.9 18 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
41d1kija2
not modelled 97.8 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
42d1ei1a2
not modelled 97.7 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
43c1qzrA_
not modelled 97.7 12 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
44c1bknA_
not modelled 97.6 19 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
45c2iopD_
not modelled 97.6 21 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
46c1ei1B_
not modelled 97.6 15 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
47c1s16B_
not modelled 97.6 16 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
48c1y4sA_
not modelled 97.6 23 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
49d1s16a2
not modelled 97.5 12 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
50c1kijB_
not modelled 97.5 18 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
51c3lnuA_
not modelled 97.5 11 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
52c3g7bB_
not modelled 97.4 11 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
53d1s14a_
not modelled 97.4 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
54c2o1uA_
not modelled 97.4 26 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
55c2w1tB_
not modelled 97.4 18 PDB header:transcription
Chain: B: PDB Molecule:stage v sporulation protein t;
PDBTitle: crystal structure of b. subtilis spovt
56c3iedA_
not modelled 97.4 21 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
57c2w1rA_
not modelled 97.2 17 PDB header:transcription
Chain: A: PDB Molecule:stage v sporulation protein t;
PDBTitle: crystal structure of the c-terminal domain of b. subtilis2 spovt
58d2c2aa1
not modelled 97.1 24 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
59d1qy5a_
not modelled 97.1 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
60c2fwyA_
not modelled 97.0 18 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
61c2cg9A_
not modelled 96.9 21 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
62c2akpA_
not modelled 96.8 19 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
63c3pehB_
not modelled 96.6 24 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
64d1uyla_
not modelled 96.5 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
65d2gqpa1
not modelled 96.4 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
66d1uyma_
not modelled 96.4 14 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
67c1zwhA_
not modelled 96.3 20 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
68d2iwxa1
not modelled 96.3 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
69c2iorA_
not modelled 96.2 20 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
70d1joya_
not modelled 96.0 19 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
71c2o1wB_
not modelled 96.0 12 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
72c3zrwB_
not modelled 95.7 13 PDB header:signaling protein
Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz;
PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant
73c3cwvB_
not modelled 94.1 7 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
74c3lmmA_
not modelled 89.3 10 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
75c1vhmB_
not modelled 87.6 14 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein yebr;
PDBTitle: crystal structure of an hypothetical protein
76c3eeaB_
not modelled 86.9 12 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:gaf domain/hd domain protein;
PDBTitle: the crystal structure of the gaf domain/hd domain protein2 from geobacter sulfurreducens
77c3hcyB_
not modelled 86.5 13 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:putative two-component sensor histidine kinase protein;
PDBTitle: the crystal structure of the domain of putative two-component sensor2 histidine kinase protein from sinorhizobium meliloti 1021
78d1vhma_
not modelled 84.1 11 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
79c3mmhA_
not modelled 82.0 16 PDB header:oxidoreductase
Chain: A: PDB Molecule:methionine-r-sulfoxide reductase;
PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate
80d1f5ma_
not modelled 81.8 15 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
81c2zmfA_
not modelled 80.5 12 PDB header:hydrolase
Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase
PDBTitle: crystal structure of the c-terminal gaf domain of human2 phosphodiesterase 10a
82c2vjwA_
not modelled 80.2 17 PDB header:hydrolase
Chain: A: PDB Molecule:gaf family protein;
PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis
83c3p5nA_
78.7 9 PDB header:transport protein
Chain: A: PDB Molecule:riboflavin uptake protein;
PDBTitle: structure and mechanism of the s component of a bacterial ecf2 transporter
84c3ksiA_
not modelled 70.7 12 PDB header:oxidoreductase
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: structure of frmsr of staphylococcus aureus (complex with 2-propanol)
85c3oovA_
not modelled 67.9 14 PDB header:signaling protein
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein, putative;
PDBTitle: crystal structure of a methyl-accepting chemotaxis protein, residues2 122 to 287
86c2w3gA_
not modelled 66.6 11 PDB header:transferase
Chain: A: PDB Molecule:two component sensor histidine kinase devs (gaf
PDBTitle: air-oxidized structure of the first gaf domain of2 mycobacterium tuberculosis doss
87c1mc0A_
65.6 10 PDB header:hydrolase
Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a;
PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains
88c3o5yA_
not modelled 64.1 14 PDB header:transcription regulator
Chain: A: PDB Molecule:sensor protein;
PDBTitle: the crystal structure of the gaf domain of a two-component sensor2 histidine kinase from bacillus halodurans to 2.45a
89c3ibjB_
not modelled 59.4 14 PDB header:hydrolase
Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase;
PDBTitle: x-ray structure of pde2a
90c3p01C_
not modelled 55.5 14 PDB header:signaling protein
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
91c2oolA_
not modelled 54.7 25 PDB header:signaling protein
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the chromophore-binding domain of an unusual2 bacteriophytochrome rpbphp3 from r. palustris
92c3k2nB_
not modelled 53.8 19 PDB header:transcription regulator
Chain: B: PDB Molecule:sigma-54-dependent transcriptional regulator;
PDBTitle: the crystal structure of sigma-54-dependent transcriptional2 regulator domain from chlorobium tepidum tls
93d2veaa1
not modelled 52.8 12 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
94c3dbaB_
not modelled 51.5 11 PDB header:hydrolase
Chain: B: PDB Molecule:cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit
PDBTitle: crystal structure of the cgmp-bound gaf a domain from the2 photoreceptor phosphodiesterase 6c
95d1mc0a1
not modelled 46.6 11 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
96d2k2na1
not modelled 46.3 19 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
97c3ci6B_
not modelled 46.0 9 PDB header:transferase
Chain: B: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: crystal structure of the gaf domain from acinetobacter2 phosphoenolpyruvate-protein phosphotransferase
98c1ykdB_
not modelled 45.9 16 PDB header:lyase
Chain: B: PDB Molecule:adenylate cyclase;
PDBTitle: crystal structure of the tandem gaf domains from a cyanobacterial2 adenylyl cyclase: novel modes of ligand-binding and dimerization
99c2qybA_
not modelled 45.8 15 PDB header:membrane protein
Chain: A: PDB Molecule:membrane protein, putative;
PDBTitle: crystal structure of the gaf domain region of putative membrane2 protein from geobacter sulfurreducens pca
100c3trcA_
not modelled 44.0 13 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the gaf domain from a phosphoenolpyruvate-protein2 phosphotransferase (ptsp) from coxiella burnetii
101c3k7pA_
not modelled 41.6 18 PDB header:isomerase
Chain: A: PDB Molecule:ribose 5-phosphate isomerase;
PDBTitle: structure of mutant of ribose 5-phosphate isomerase type b from2 trypanosoma cruzi.
102c3m1pA_
not modelled 41.6 18 PDB header:isomerase
Chain: A: PDB Molecule:ribose 5-phosphate isomerase;
PDBTitle: structure of ribose 5-phosphate isomerase type b from trypanosoma2 cruzi, soaked with allose-6-phosphate
103c2lb5A_
not modelled 40.4 25 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: refined structural basis for the photoconversion of a phytochrome to2 the activated far-red light-absorbing form
104c3s6fA_
not modelled 38.1 20 PDB header:transferase
Chain: A: PDB Molecule:hypothetical acetyltransferase;
PDBTitle: crystal structure of a hypotetical acetyltransferase (dr_1678) from2 deinococcus radiodurans at 1.19 a resolution
105d2o9ca1
not modelled 37.9 12 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
106d1xmta_
not modelled 33.4 12 Fold:Acyl-CoA N-acyltransferases (Nat)
Superfamily:Acyl-CoA N-acyltransferases (Nat)
Family:N-acetyl transferase, NAT
107d1hh2p2
not modelled 31.0 23 Fold:Alpha-lytic protease prodomain-like
Superfamily:Prokaryotic type KH domain (KH-domain type II)
Family:Prokaryotic type KH domain (KH-domain type II)
108d1mc0a2
not modelled 30.4 6 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
109d1b74a1
not modelled 29.9 17 Fold:ATC-like
Superfamily:Aspartate/glutamate racemase
Family:Aspartate/glutamate racemase
110c3mf0A_
not modelled 28.5 15 PDB header:hydrolase
Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase;
PDBTitle: crystal structure of pde5a gaf domain (89-518)
111c3p01A_
not modelled 27.7 15 PDB header:signaling protein
Chain: A: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
112d2asba2
not modelled 26.9 19 Fold:Alpha-lytic protease prodomain-like
Superfamily:Prokaryotic type KH domain (KH-domain type II)
Family:Prokaryotic type KH domain (KH-domain type II)
113c3mxqC_
not modelled 26.6 10 PDB header:transferase
Chain: C: PDB Molecule:sensor protein;
PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae
114c2crqA_
not modelled 24.0 15 PDB header:translation
Chain: A: PDB Molecule:mitochondrial translational initiation factor 3;
PDBTitle: solution structure of c-terminal domain of riken cdna2 2810012l14
115c2o9bA_
not modelled 24.0 23 PDB header:transferase
Chain: A: PDB Molecule:bacteriophytochrome;
PDBTitle: crystal structure of bacteriophytochrome chromophore binding domain
116d1p0ha_
not modelled 22.2 19 Fold:Acyl-CoA N-acyltransferases (Nat)
Superfamily:Acyl-CoA N-acyltransferases (Nat)
Family:N-acetyl transferase, NAT
117c3c26A_
not modelled 21.9 15 PDB header:transferase
Chain: A: PDB Molecule:putative acetyltransferase ta0821;
PDBTitle: crystal structure of a putative acetyltransferase (np_394282.1) from2 thermoplasma acidophilum at 2.00 a resolution
118c3e0yA_
not modelled 21.8 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:conserved domain protein;
PDBTitle: the crystal structure of a conserved domain from a protein of2 geobacter sulfurreducens pca
119c3onoA_
not modelled 21.6 16 PDB header:isomerase
Chain: A: PDB Molecule:ribose/galactose isomerase;
PDBTitle: crystal structure of ribose-5-phosphate isomerase lacab_rpib from2 vibrio parahaemolyticus
120c2pc1A_
not modelled 21.4 9 PDB header:transferase
Chain: A: PDB Molecule:acetyltransferase, gnat family;
PDBTitle: crystal structure of acetyltransferase gnat family (np_688560.1) from2 streptococcus agalactiae 2603 at 1.28 a resolution

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0