Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	Y	R	H	S	F	H	A	G	N	H	A	D	V	L	K	H	T	V	Q	S	L	I	I	E	S	L	K	E	K	D	K	P	F	L	Y	L	D	T	H	A	G	A	G	R	Y	Q	L	G	S	E	H	A	E	R	T	G	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																															?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	L	E	G	I	A	R	I	W	Q	Q	D	D	L	P	A	E	L	E	A	Y	I	N	V	V	K	H	F	N	R	S	G	Q	L	R	Y	Y	P	G	S	P	L	I	A	R	L	L	L	R	E	Q	D	S	L	Q	L	T	E	L	H
Secondary structure
SS confidence
Disorder														?																	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	S	D	Y	P	L	L	R	S	E	F	Q	K	D	S	R	A	R	V	E	K	A	D	G	F	Q	Q	L	K	A	K	L	P	P	V	S	R	R	G	L	I	L	I	D	P	P	Y	E	M	K	T	D	Y	Q	A	V	V	S	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	E	G	Y	K	R	F	A	T	G	I	Y	A	L	W	Y	P	V	V	L	R	Q	Q	I	K	R	M	I	H	D	L	E	A	T	G	I	R	K	I	L	Q	I	E	L	A	V	L	P	D	S	D	R	R	G	M	T	A	S	G	M
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence		I	V	I	N	P	P	W	K	L	E	Q	Q	M	N	N	V	L	P	W	L	H	S	K	L	V	P	A	G	T	G	H	A	T	V	S	W	I	V	P	E
Secondary structure
SS confidence
Disorder																													?	?									?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2oo3 chain A domain 1 Region: 9 - 276 Aligned: 261 Modelled: 268 Confidence: 100.0% Identity: 40% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: LPG1296-like Phyre2 PDB 1wxw chain A Region: 94 - 236 Aligned: 143 Modelled: 143 Confidence: 97.5% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ttha1280; PDBTitle: crystal structure of tt1595, a putative sam-dependent2 methyltransferase from thermus thermophillus hb8 Phyre2 PDB 2igt chain A domain 1 Region: 83 - 241 Aligned: 157 Modelled: 159 Confidence: 97.4% Identity: 10% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 3c0k chain B Region: 79 - 230 Aligned: 152 Modelled: 152 Confidence: 97.2% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:upf0064 protein yccw; PDBTitle: crystal structure of a ribosomal rna methyltranferase Phyre2 PDB 2b78 chain A domain 2 Region: 94 - 223 Aligned: 130 Modelled: 130 Confidence: 97.0% Identity: 15% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 3ldu chain A Region: 6 - 197 Aligned: 181 Modelled: 192 Confidence: 97.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:putative methylase; PDBTitle: the crystal structure of a possible methylase from2 clostridium difficile 630. Phyre2 PDB 1wxx chain A domain 2 Region: 94 - 232 Aligned: 139 Modelled: 139 Confidence: 96.9% Identity: 14% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 2fhp chain A domain 1 Region: 77 - 181 Aligned: 105 Modelled: 102 Confidence: 96.8% Identity: 21% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 2avd chain A domain 1 Region: 74 - 243 Aligned: 153 Modelled: 170 Confidence: 96.2% Identity: 17% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 1yb2 chain A domain 1 Region: 98 - 243 Aligned: 132 Modelled: 146 Confidence: 96.2% Identity: 17% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: tRNA(1-methyladenosine) methyltransferase-like Phyre2 PDB 1yb2 chain A Region: 98 - 243 Aligned: 132 Modelled: 146 Confidence: 96.2% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ta0852; PDBTitle: structure of a putative methyltransferase from thermoplasma2 acidophilum. Phyre2 PDB 2as0 chain A domain 2 Region: 94 - 219 Aligned: 126 Modelled: 126 Confidence: 96.1% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 3k0b chain A Region: 110 - 194 Aligned: 80 Modelled: 85 Confidence: 96.0% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:predicted n6-adenine-specific dna methylase; PDBTitle: crystal structure of a predicted n6-adenine-specific dna methylase2 from listeria monocytogenes str. 4b f2365 Phyre2 PDB 2b2c chain A domain 1 Region: 99 - 213 Aligned: 101 Modelled: 109 Confidence: 95.9% Identity: 18% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Spermidine synthase Phyre2 PDB 1uir chain A Region: 99 - 216 Aligned: 115 Modelled: 118 Confidence: 95.9% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Spermidine synthase Phyre2 PDB 1ws6 chain A domain 1 Region: 79 - 194 Aligned: 114 Modelled: 116 Confidence: 95.9% Identity: 21% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 2cmg chain A Region: 99 - 243 Aligned: 127 Modelled: 145 Confidence: 95.8% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:spermidine synthase; PDBTitle: crystal structure of spermidine synthase from helicobacter2 pylori Phyre2 PDB 2b78 chain A Region: 82 - 223 Aligned: 142 Modelled: 142 Confidence: 95.8% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein smu.776; PDBTitle: a putative sam-dependent methyltransferase from2 streptococcus mutans Phyre2 PDB 3ldg chain A Region: 109 - 197 Aligned: 84 Modelled: 89 Confidence: 95.7% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein smu.472; PDBTitle: crystal structure of smu.472, a putative methyltransferase complexed2 with sah Phyre2 PDB 1uwv chain A Region: 94 - 166 Aligned: 73 Modelled: 73 Confidence: 95.6% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase Phyre2 1 d2oo3a1 2 c1wxwA_ 3 d2igta1 4 c3c0kB_ 5 d2b78a2 6 c3lduA_ 7 d1wxxa2 8 d2fhpa1 9 d2avda1 10 d1yb2a1 11 c1yb2A_ 12 d2as0a2 13 c3k0bA_ 14 d2b2ca1 15 d1uira_ 16 d1ws6a1 17 c2cmgA_ 18 c2b78A_ 19 c3ldgA_ 20 c1uwvA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2oo3a1 100.0 40 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:LPG1296-like 2 c1wxwA_ 97.5 14 PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ttha1280; PDBTitle: crystal structure of tt1595, a putative sam-dependent2 methyltransferase from thermus thermophillus hb8 3 d2igta1 97.4 10 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:hypothetical RNA methyltransferase 4 c3c0kB_ 97.2 13 PDB header:transferase Chain: B: PDB Molecule:upf0064 protein yccw; PDBTitle: crystal structure of a ribosomal rna methyltranferase 5 d2b78a2 97.0 15 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:hypothetical RNA methyltransferase 6 c3lduA_ 97.0 17 PDB header:transferase Chain: A: PDB Molecule:putative methylase; PDBTitle: the crystal structure of a possible methylase from2 clostridium difficile 630. 7 d1wxxa2 96.9 14 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:hypothetical RNA methyltransferase 8 d2fhpa1 96.8 21 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhhF-like 9 d2avda1 96.2 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 10 d1yb2a1 96.2 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:tRNA(1-methyladenosine) methyltransferase-like 11 c1yb2A_ 96.2 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ta0852; PDBTitle: structure of a putative methyltransferase from thermoplasma2 acidophilum. 12 d2as0a2 96.1 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:hypothetical RNA methyltransferase 13 c3k0bA_ 96.0 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:predicted n6-adenine-specific dna methylase; PDBTitle: crystal structure of a predicted n6-adenine-specific dna methylase2 from listeria monocytogenes str. 4b f2365 14 d2b2ca1 95.9 18 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 15 d1uira_ 95.9 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 16 d1ws6a1 95.9 21 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhhF-like 17 c2cmgA_ 95.8 12 PDB header:transferase Chain: A: PDB Molecule:spermidine synthase; PDBTitle: crystal structure of spermidine synthase from helicobacter2 pylori 18 c2b78A_ 95.8 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein smu.776; PDBTitle: a putative sam-dependent methyltransferase from2 streptococcus mutans 19 c3ldgA_ 95.7 11 PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein smu.472; PDBTitle: crystal structure of smu.472, a putative methyltransferase complexed2 with sah 20 c1uwvA_ 95.6 12 PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase 21 d1uwva2 not modelled 95.6 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:(Uracil-5-)-methyltransferase 22 c2as0A_ not modelled 95.4 13 PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ph1915; PDBTitle: crystal structure of ph1915 (apc 5817): a hypothetical rna2 methyltransferase 23 d1inla_ not modelled 95.4 20 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 24 c3bwbA_ not modelled 95.4 20 PDB header:transferase Chain: A: PDB Molecule:spermidine synthase; PDBTitle: crystal structure of the apo form of spermidine synthase from2 trypanosoma cruzi at 2.5 a resolution 25 c2esrB_ not modelled 95.3 19 PDB header:transferase Chain: B: PDB Molecule:methyltransferase; PDBTitle: conserved hypothetical protein- streptococcus pyogenes 26 c2pssC_ not modelled 94.8 17 PDB header:transferase Chain: C: PDB Molecule:spermidine synthase; PDBTitle: the structure of plasmodium falciparum spermidine synthase in its apo-2 form 27 d2ifta1 not modelled 94.8 18 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhhF-like 28 c3ll7A_ not modelled 94.8 13 PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase; PDBTitle: crystal structure of putative methyltransferase pg_1098 from2 porphyromonas gingivalis w83 29 d2fpoa1 not modelled 94.7 16 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhhF-like 30 c3c3yB_ not modelled 94.7 15 PDB header:transferase Chain: B: PDB Molecule:o-methyltransferase; PDBTitle: crystal structure of pfomt, phenylpropanoid and flavonoid o-2 methyltransferase from m. crystallinum 31 d2pkwa1 not modelled 94.6 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhiQ-like 32 d1nv8a_ not modelled 94.6 16 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N5-glutamine methyltransferase, HemK 33 d2esra1 not modelled 94.6 20 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhhF-like 34 c3gdhC_ not modelled 94.4 12 PDB header:transferase Chain: C: PDB Molecule:trimethylguanosine synthase homolog; PDBTitle: methyltransferase domain of human trimethylguanosine2 synthase 1 (tgs1) bound to m7gtp and adenosyl-homocysteine3 (active form) 35 c2hnkC_ not modelled 94.4 17 PDB header:transferase Chain: C: PDB Molecule:sam-dependent o-methyltransferase; PDBTitle: crystal structure of sam-dependent o-methyltransferase from2 pathogenic bacterium leptospira interrogans 36 c3tr6A_ not modelled 94.3 15 PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase; PDBTitle: structure of a o-methyltransferase from coxiella burnetii 37 d1eg2a_ not modelled 94.3 28 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Type II DNA methylase 38 d1o54a_ not modelled 94.3 20 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:tRNA(1-methyladenosine) methyltransferase-like 39 d1xj5a_ not modelled 94.3 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 40 c2r6zA_ not modelled 94.0 16 PDB header:transferase Chain: A: PDB Molecule:upf0341 protein in rsp 3' region; PDBTitle: crystal structure of the sam-dependent methyltransferase2 ngo1261 from neisseria gonorrhoeae, northeast structural3 genomics consortium target ngr48 41 c3a4tA_ not modelled 94.0 14 PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase mj0026; PDBTitle: crystal structure of atrm4 from m.jannaschii with sinefungin 42 d1iy9a_ not modelled 94.0 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 43 c3cbgA_ not modelled 93.9 17 PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase; PDBTitle: functional and structural characterization of a2 cationdependent o-methyltransferase from the3 cyanobacterium synechocystis sp. strain pcc 6803 44 c3bt7A_ not modelled 93.8 16 PDB header:transferase/rna Chain: A: PDB Molecule:trna (uracil-5-)-methyltransferase; PDBTitle: structure of e. coli 5-methyluridine methyltransferase trma2 in complex with 19 nucleotide t-arm analogue 45 c2ozvA_ not modelled 93.8 21 PDB header:transferase Chain: A: PDB Molecule:hypothetical protein atu0636; PDBTitle: crystal structure of a predicted o-methyltransferase, protein atu6362 from agrobacterium tumefaciens. 46 c3egiA_ not modelled 93.7 13 PDB header:transferase Chain: A: PDB Molecule:trimethylguanosine synthase homolog; PDBTitle: methyltransferase domain of human trimethylguanosine2 synthase tgs1 bound to m7gpppa (inactive form) 47 d1qyra_ not modelled 93.7 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA adenine dimethylase-like 48 c3dmgA_ not modelled 93.7 20 PDB header:transferase Chain: A: PDB Molecule:probable ribosomal rna small subunit methyltransferase; PDBTitle: t. thermophilus 16s rrna n2 g1207 methyltransferase (rsmc) in complex2 with adohcy 49 c2hteB_ not modelled 93.6 16 PDB header:transferase Chain: B: PDB Molecule:spermidine synthase; PDBTitle: the crystal structure of spermidine synthase from p. falciparum in2 complex with 5'-methylthioadenosine 50 d1susa1 not modelled 93.5 16 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 51 c3tqsB_ not modelled 93.3 15 PDB header:transferase Chain: B: PDB Molecule:ribosomal rna small subunit methyltransferase a; PDBTitle: structure of the dimethyladenosine transferase (ksga) from coxiella2 burnetii 52 d2oyra1 not modelled 92.7 21 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:YhiQ-like 53 c2zifB_ not modelled 92.6 19 PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine 54 d2o07a1 not modelled 92.6 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 55 d1zq9a1 not modelled 92.4 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA adenine dimethylase-like 56 c3mb5A_ not modelled 92.2 17 PDB header:transferase Chain: A: PDB Molecule:sam-dependent methyltransferase; PDBTitle: crystal structure of p. abyssi trna m1a58 methyltransferase in complex2 with s-adenosyl-l-methionine 57 d1booa_ not modelled 92.0 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Type II DNA methylase 58 c2q41D_ not modelled 91.4 13 PDB header:transferase Chain: D: PDB Molecule:spermidine synthase 1; PDBTitle: ensemble refinement of the protein crystal structure of spermidine2 synthase from arabidopsis thaliana gene at1g23820 59 d1dusa_ not modelled 91.3 18 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Hypothetical protein MJ0882 60 c2vs1A_ not modelled 91.0 14 PDB header:transferase Chain: A: PDB Molecule:uncharacterized rna methyltransferase pyrab10780; PDBTitle: the crystal structure of pyrococcus abyssi trna (uracil-54,2 c5)-methyltransferase in complex with s-adenosyl-l-3 homocysteine 61 d2frna1 not modelled 90.9 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Met-10+ protein-like 62 c1nw6A_ not modelled 90.7 28 PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin 63 c3p9nA_ not modelled 90.1 18 PDB header:transferase Chain: A: PDB Molecule:possible methyltransferase (methylase); PDBTitle: rv2966c of m. tuberculosis is a rsmd-like methyltransferase 64 c3r3hA_ not modelled 89.0 15 PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase, sam-dependent; PDBTitle: crystal structure of o-methyltransferase from legionella pneumophila 65 c3grrA_ not modelled 88.8 12 PDB header:transferase Chain: A: PDB Molecule:dimethyladenosine transferase; PDBTitle: crystal structure of the complex between s-adenosyl homocysteine and2 methanocaldococcus jannaschi dim1. 66 d2cl5a1 not modelled 88.6 11 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:COMT-like 67 c3gjyA_ not modelled 88.3 14 PDB header:transferase Chain: A: PDB Molecule:spermidine synthase; PDBTitle: crystal structure of a probable spermidine synthase from2 corynebacterium glutamicum atcc 13032 68 c3fydA_ not modelled 87.9 12 PDB header:transferase Chain: A: PDB Molecule:probable dimethyladenosine transferase; PDBTitle: crystal structure of dim1 from the thermophilic archeon,2 methanocaldococcus jannaschi 69 c3adnB_ not modelled 87.8 15 PDB header:transferase Chain: B: PDB Molecule:spermidine synthase; PDBTitle: crystal structure of spermidine synthase from e. coli. 70 c1sqgA_ not modelled 87.3 17 PDB header:transferase Chain: A: PDB Molecule:sun protein; PDBTitle: the crystal structure of the e. coli fmu apoenzyme at 1.652 a resolution 71 d1mjfa_ not modelled 87.1 15 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Spermidine synthase 72 c2pwyB_ not modelled 86.9 17 PDB header:transferase Chain: B: PDB Molecule:trna (adenine-n(1)-)-methyltransferase; PDBTitle: crystal structure of a m1a58 trna methyltransferase 73 c3axtA_ not modelled 86.6 16 PDB header:transferase Chain: A: PDB Molecule:probable n(2),n(2)-dimethylguanosine trna methyltransferase PDBTitle: complex structure of trna methyltransferase trm1 from aquifex aeolicus2 with s-adenosyl-l-methionine 74 d1qama_ not modelled 86.0 18 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA adenine dimethylase-like 75 c2yxlA_ not modelled 85.7 11 PDB header:transferase Chain: A: PDB Molecule:450aa long hypothetical fmu protein; PDBTitle: crystal structure of ph0851 76 c2pjdA_ not modelled 85.5 15 PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase c; PDBTitle: crystal structure of 16s rrna methyltransferase rsmc 77 c3c6kC_ not modelled 85.3 13 PDB header:transferase Chain: C: PDB Molecule:spermine synthase; PDBTitle: crystal structure of human spermine synthase in complex2 with spermidine and 5-methylthioadenosine 78 c3dr5A_ not modelled 85.3 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative o-methyltransferase; PDBTitle: crystal structure of the q8nrd3_corgl protein from2 corynebacterium glutamicum. northeast structural genomics3 consortium target cgr117. 79 c3fuxB_ not modelled 84.3 19 PDB header:transferase Chain: B: PDB Molecule:dimethyladenosine transferase; PDBTitle: t. thermophilus 16s rrna a1518 and a1519 methyltransferase (ksga) in2 complex with 5'-methylthioadenosine in space group p212121 80 d1g60a_ not modelled 84.3 24 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Type II DNA methylase 81 c3duwB_ not modelled 83.5 13 PDB header:transferase Chain: B: PDB Molecule:o-methyltransferase, putative; PDBTitle: crystal structural analysis of the o-methyltransferase from2 bacillus cereus in complex sah 82 c2yvlB_ not modelled 83.5 12 PDB header:transferase Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of trna (m1a58) methyltransferase trmi from aquifex2 aeolicus 83 c3njrB_ not modelled 83.0 12 PDB header:transferase Chain: B: PDB Molecule:precorrin-6y methylase; PDBTitle: crystal structure of c-terminal domain of precorrin-6y c5,15-2 methyltransferase from rhodobacter capsulatus 84 c2g1pB_ not modelled 82.4 14 PDB header:transferase/dna Chain: B: PDB Molecule:dna adenine methylase; PDBTitle: structure of e. coli dna adenine methyltransferase (dam) 85 c3m4xA_ not modelled 81.9 18 PDB header:transferase Chain: A: PDB Molecule:nol1/nop2/sun family protein; PDBTitle: structure of a ribosomal methyltransferase 86 c3a26A_ not modelled 80.9 12 PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein ph0793; PDBTitle: crystal structure of p. horikoshii tyw2 in complex with2 mesado 87 d1l3ia_ not modelled 80.9 9 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Precorrin-6Y methyltransferase (CbiT) 88 d2h00a1 not modelled 80.6 14 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Methyltransferase 10 domain 89 c2yx1A_ not modelled 79.5 11 PDB header:transferase Chain: A: PDB Molecule:hypothetical protein mj0883; PDBTitle: crystal structure of m.jannaschii trna m1g37 methyltransferase 90 d2b9ea1 not modelled 78.6 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:NOL1/NOP2/sun 91 c3m6wA_ not modelled 76.9 17 PDB header:transferase Chain: A: PDB Molecule:rrna methylase; PDBTitle: multi-site-specific 16s rrna methyltransferase rsmf from thermus2 thermophilus in space group p21212 in complex with s-adenosyl-l-3 methionine 92 d1o9ga_ not modelled 75.8 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA methyltransferase AviRa 93 d1sqga2 not modelled 75.5 16 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:NOL1/NOP2/sun 94 c2frxD_ not modelled 75.4 21 PDB header:transferase Chain: D: PDB Molecule:hypothetical protein yebu; PDBTitle: crystal structure of yebu, a m5c rna methyltransferase from e.coli 95 c3uzuA_ not modelled 74.5 15 PDB header:transferase Chain: A: PDB Molecule:ribosomal rna small subunit methyltransferase a; PDBTitle: the structure of the ribosomal rna small subunit methyltransferase a2 from burkholderia pseudomallei 96 d2b25a1 not modelled 74.5 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:tRNA(1-methyladenosine) methyltransferase-like 97 c3tfwB_ not modelled 74.2 15 PDB header:transferase Chain: B: PDB Molecule:putative o-methyltransferase; PDBTitle: crystal structure of a putative o-methyltransferase from klebsiella2 pneumoniae 98 d1i4wa_ not modelled 73.2 25 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA adenine dimethylase-like 99 c1i4wA_ not modelled 73.2 25 PDB header:transcription Chain: A: PDB Molecule:mitochondrial replication protein mtf1; PDBTitle: the crystal structure of the transcription factor sc-mttfb2 offers intriguing insights into mitochondrial transcription 100 c2yxdA_ not modelled 72.7 10 PDB header:transferase Chain: A: PDB Molecule:probable cobalt-precorrin-6y c(15)-methyltransferase PDBTitle: crystal structure of cobalamin biosynthesis precorrin 8w decarboxylase2 (cbit) 101 d1yuba_ not modelled 67.7 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:rRNA adenine dimethylase-like 102 d2dpma_ not modelled 66.7 15 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N6 adenine-specific DNA methylase, DAM 103 c3lpmA_ not modelled 60.8 15 PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase; PDBTitle: crystal structure of putative methyltransferase small domain protein2 from listeria monocytogenes 104 c1dl5A_ not modelled 59.5 9 PDB header:transferase Chain: A: PDB Molecule:protein-l-isoaspartate o-methyltransferase; PDBTitle: protein-l-isoaspartate o-methyltransferase 105 d2iv2x1 not modelled 59.3 16 Fold:Double psi beta-barrel Superfamily:ADC-like Family:Formate dehydrogenase/DMSO reductase, C-terminal domain 106 c3hm2G_ not modelled 58.2 11 PDB header:transferase Chain: G: PDB Molecule:precorrin-6y c5,15-methyltransferase; PDBTitle: crystal structure of putative precorrin-6y c5,15-2 methyltransferase targeted domain from corynebacterium3 diphtheriae 107 d1vbfa_ not modelled 58.0 13 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Protein-L-isoaspartyl O-methyltransferase 108 c3fteA_ not modelled 57.8 14 PDB header:transferase/rna Chain: A: PDB Molecule:dimethyladenosine transferase; PDBTitle: crystal structure of a. aeolicus ksga in complex with rna 109 d1yf3a1 not modelled 57.2 14 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:N6 adenine-specific DNA methylase, DAM 110 c3e05B_ not modelled 56.6 17 PDB header:transferase Chain: B: PDB Molecule:precorrin-6y c5,15-methyltransferase (decarboxylating); PDBTitle: crystal structure of precorrin-6y c5,15-methyltransferase from2 geobacter metallireducens gs-15 111 c1y5iA_ not modelled 55.7 15 PDB header:oxidoreductase Chain: A: PDB Molecule:respiratory nitrate reductase 1 alpha chain; PDBTitle: the crystal structure of the narghi mutant nari-k86a 112 c2advB_ not modelled 55.7 16 PDB header:hydrolase Chain: B: PDB Molecule:glutaryl 7- aminocephalosporanic acid acylase; PDBTitle: crystal structures of glutaryl 7-aminocephalosporanic acid acylase:2 mutational study of activation mechanism 113 d1y5ia1 not modelled 55.2 15 Fold:Double psi beta-barrel Superfamily:ADC-like Family:Formate dehydrogenase/DMSO reductase, C-terminal domain 114 d1g8ka1 not modelled 52.6 17 Fold:Double psi beta-barrel Superfamily:ADC-like Family:Formate dehydrogenase/DMSO reductase, C-terminal domain 115 c3hy5A_ not modelled 52.2 34 PDB header:transport protein Chain: A: PDB Molecule:retinaldehyde-binding protein 1; PDBTitle: crystal structure of cralbp 116 c2ki8A_ not modelled 52.1 27 PDB header:oxidoreductase Chain: A: PDB Molecule:tungsten formylmethanofuran dehydrogenase, PDBTitle: solution nmr structure of tungsten formylmethanofuran2 dehydrogenase subunit d from archaeoglobus fulgidus,3 northeast structural genomics consortium target att7 117 d2dula1 not modelled 50.8 12 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:TRM1-like 118 d2bm8a1 not modelled 50.6 19 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:CmcI-like 119 c3evzA_ not modelled 50.1 14 PDB header:transferase Chain: A: PDB Molecule:methyltransferase; PDBTitle: crystal strucure of methyltransferase from pyrococcus furiosus 120 c3ntvB_ not modelled 47.0 11 PDB header:transferase Chain: B: PDB Molecule:mw1564 protein; PDBTitle: crystal structure of a putative caffeoyl-coa o-methyltransferase from2 staphylococcus aureus

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0