Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	K	L	F	S	A	F	R	K	N	K	I	W	D	F	N	G	G	I	H	P	P	E	M	K	T	Q	S	N	G	T	P	L	R	Q	V	P	L	A	Q	R	F	V	I	P	L	K	Q	H	I	G	A	E	G	E	L	C	V	S
Secondary structure
SS confidence
Disorder		?	?	?				?	?	?	?	?	?	?	?																			?	?	?	?				?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	D	K	V	L	R	G	Q	P	L	T	R	G	R	G	K	M	L	P	V	H	A	P	T	S	G	T	V	T	A	I	A	P	H	S	T	A	H	P	S	A	L	A	E	L	S	V	I	I	D	A	D	G	E	D	C	W	I	P
Secondary structure
SS confidence
Disorder																																				?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	D	G	W	A	D	Y	R	T	R	S	R	E	E	L	I	E	R	I	H	Q	F	G	V	A	G	L	G	G	A	G	F	P	T	G	V	K	L	Q	G	G	G	D	K	I	E	T	L	I	I	N	A	A	E	C	E	P	Y	I	T
Secondary structure
SS confidence
Disorder					?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	D	R	L	M	Q	D	C	A	A	Q	V	V	E	G	I	R	I	L	A	H	I	L	Q	P	R	E	I	L	I	G	I	E	D	N	K	P	Q	A	I	S	M	L	R	A	V	L	A	D	S	N	D	I	S	L	R	V	I	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	K	Y	P	S	G	G	A	K	Q	L	T	Y	I	L	T	G	K	Q	V	P	H	G	G	R	S	S	D	I	G	V	L	M	Q	N	V	G	T	A	Y	A	V	K	R	A	V	I	D	G	E	P	I	T	E	R	V	V	T	L	T
Secondary structure
SS confidence
Disorder																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	E	A	I	A	R	P	G	N	V	W	A	R	L	G	T	P	V	R	H	L	L	N	D	A	G	F	C	P	S	A	D	Q	M	V	I	M	G	G	P	L	M	G	F	T	L	P	W	L	D	V	P	V	V	K	I	T	N	C	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	A	P	S	A	N	E	L	G	E	P	Q	E	E	Q	S	C	I	R	C	S	A	C	A	D	A	C	P	A	D	L	L	P	Q	Q	L	Y	W	F	S	K	G	Q	Q	H	D	K	A	T	T	H	N	I	A	D	C	I	E	C	G
Secondary structure
SS confidence
Disorder									?	?	?		?		?		?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	C	A	W	V	C	P	S	N	I	P	L	V	Q	Y	F	R	Q	E	K	A	E	I	A	A	I	R	Q	E	E	K	R	A	A	E	A	K	A	R	F	E	A	R	Q	A	R	L	E	R	E	K	A	A	R	L	E	R	H	K	S
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	A	V	Q	P	A	A	K	D	K	D	A	I	A	A	A	L	A	R	V	K	E	K	Q	A	Q	A	T	Q	P	I	V	I	K	A	G	E	R	P	D	N	S	A	I	I	A	A	R	E	A	R	K	A	Q	A	R	A	K	Q	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?	?	?					?	?								?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		E	L	Q	Q	T	N	D	A	A	T	V	A	D	P	R	K	T	A	V	E	A	A	I	A	R	A	K	A	R	K	L	E	Q	Q	Q	A	N	A	E	P	E	Q	Q	V	D	P	R	K	A	A	V	E	A	A	I	A	R	A	K	A
Secondary structure
SS confidence
Disorder				?	?								?	?																					?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		R	K	L	E	Q	Q	Q	A	N	A	E	P	E	E	Q	V	D	P	R	K	A	A	V	E	A	A	I	A	R	A	K	A	R	K	L	E	Q	Q	Q	A	N	A	E	P	E	Q	Q	V	D	P	R	K	A	A	V	E	A	A	I	A
Secondary structure
SS confidence
Disorder		?	?	?			?	?	?	?	?	?	?									?									?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		R	A	K	A	R	K	R	E	Q	Q	P	A	N	A	E	P	E	E	Q	V	D	P	R	K	A	A	V	E	A	A	I	A	R	A	K	A	R	K	L	E	Q	Q	Q	A	N	A	V	P	E	E	Q	V	D	P	R	K	A	A	V	A
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?								?	?				?									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740
Sequence		A	A	I	A	R	A	Q	A	K	K	A	A	Q	Q	K	V	V	N	E	D
Secondary structure
SS confidence
Disorder																?		?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2fug chain A Region: 110 - 453 Aligned: 343 Modelled: 344 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:nadh-quinone oxidoreductase chain 1; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus Phyre2 PDB 2fug chain 1 domain 2 Region: 110 - 289 Aligned: 180 Modelled: 180 Confidence: 100.0% Identity: 24% Fold: Nqo1 FMN-binding domain-like Superfamily: Nqo1 FMN-binding domain-like Family: Nqo1 FMN-binding domain-like Phyre2 PDB 2fug chain 1 domain 3 Region: 295 - 365 Aligned: 70 Modelled: 71 Confidence: 99.1% Identity: 26% Fold: beta-Grasp (ubiquitin-like) Superfamily: Nqo1 middle domain-like Family: Nqo1 middle domain-like Phyre2 PDB 1kf6 chain B domain 1 Region: 363 - 449 Aligned: 87 Modelled: 87 Confidence: 98.5% Identity: 22% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 PDB 2b76 chain N Region: 363 - 445 Aligned: 83 Modelled: 83 Confidence: 98.4% Identity: 20% PDB header:oxidoreductase Chain: N: PDB Molecule:fumarate reductase iron-sulfur protein; PDBTitle: e. coli quinol fumarate reductase frda e49q mutation Phyre2 PDB 1nek chain B Region: 363 - 446 Aligned: 84 Modelled: 84 Confidence: 98.4% Identity: 17% PDB header:oxidoreductase/electron transport Chain: B: PDB Molecule:succinate dehydrogenase iron-sulfur protein; PDBTitle: complex ii (succinate dehydrogenase) from e. coli with2 ubiquinone bound Phyre2 PDB 2h89 chain B Region: 363 - 448 Aligned: 86 Modelled: 86 Confidence: 98.4% Identity: 19% PDB header:oxidoreductase Chain: B: PDB Molecule:succinate dehydrogenase ip subunit; PDBTitle: avian respiratory complex ii with malonate bound Phyre2 PDB 3cf4 chain A Region: 377 - 448 Aligned: 71 Modelled: 72 Confidence: 98.4% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex Phyre2 PDB 1nek chain B domain 1 Region: 363 - 446 Aligned: 84 Modelled: 84 Confidence: 98.3% Identity: 17% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 PDB 2bs2 chain B domain 1 Region: 363 - 443 Aligned: 81 Modelled: 81 Confidence: 98.2% Identity: 23% Fold: Globin-like Superfamily: alpha-helical ferredoxin Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain Phyre2 PDB 2bs2 chain E Region: 363 - 445 Aligned: 83 Modelled: 83 Confidence: 98.1% Identity: 23% PDB header:oxidoreductase Chain: E: PDB Molecule:quinol-fumarate reductase iron-sulfur subunit b; PDBTitle: quinol:fumarate reductase from wolinella succinogenes Phyre2 PDB 2fug chain G Region: 347 - 452 Aligned: 102 Modelled: 102 Confidence: 98.0% Identity: 27% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase chain 9; PDBTitle: crystal structure of the hydrophilic domain of respiratory complex i2 from thermus thermophilus Phyre2 PDB 2fug chain 9 domain 1 Region: 347 - 452 Aligned: 102 Modelled: 106 Confidence: 98.0% Identity: 27% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 1jb0 chain C Region: 377 - 440 Aligned: 62 Modelled: 64 Confidence: 97.7% Identity: 26% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: 7-Fe ferredoxin Phyre2 PDB 1xer chain A Region: 339 - 429 Aligned: 82 Modelled: 91 Confidence: 97.6% Identity: 27% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Archaeal ferredoxins Phyre2 PDB 1rgv chain A Region: 377 - 448 Aligned: 68 Modelled: 72 Confidence: 97.6% Identity: 22% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Short-chain ferredoxins Phyre2 PDB 1gte chain A domain 5 Region: 288 - 427 Aligned: 131 Modelled: 140 Confidence: 97.5% Identity: 18% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: Ferredoxin domains from multidomain proteins Phyre2 PDB 1hfe chain L Region: 341 - 427 Aligned: 70 Modelled: 87 Confidence: 97.3% Identity: 23% PDB header:hydrogenase Chain: L: PDB Molecule:protein (fe-only hydrogenase (e.c.1.18.99.1) PDBTitle: 1.6 a resolution structure of the fe-only hydrogenase from2 desulfovibrio desulfuricans Phyre2 PDB 7fd1 chain A Region: 374 - 452 Aligned: 69 Modelled: 79 Confidence: 97.3% Identity: 25% Fold: Ferredoxin-like Superfamily: 4Fe-4S ferredoxins Family: 7-Fe ferredoxin Phyre2 PDB 1gx7 chain A Region: 372 - 427 Aligned: 48 Modelled: 56 Confidence: 97.2% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:periplasmic [fe] hydrogenase large subunit; PDBTitle: best model of the electron transfer complex between2 cytochrome c3 and [fe]-hydrogenase Phyre2 PDB 2q8i chain B Region: 38 - 127 Aligned: 85 Modelled: 85 Confidence: 96.3% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase component of PDBTitle: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug2 radicicol Phyre2 PDB 1bdo chain A Region: 34 - 92 Aligned: 55 Modelled: 55 Confidence: 96.3% Identity: 29% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1qjo chain A Region: 39 - 115 Aligned: 76 Modelled: 76 Confidence: 96.1% Identity: 25% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 3mxu chain A Region: 58 - 130 Aligned: 73 Modelled: 73 Confidence: 95.8% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from bartonella2 henselae Phyre2 PDB 1o78 chain A Region: 52 - 92 Aligned: 41 Modelled: 41 Confidence: 95.7% Identity: 29% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 1dcz chain A Region: 40 - 92 Aligned: 50 Modelled: 50 Confidence: 95.6% Identity: 28% Fold: Barrel-sandwich hybrid Superfamily: Single hybrid motif Family: Biotinyl/lipoyl-carrier proteins and domains Phyre2 PDB 2zv4 chain O Region: 579 - 740 Aligned: 162 Modelled: 162 Confidence: 92.4% Identity: 9% PDB header:structural protein Chain: O: PDB Molecule:major vault protein; PDBTitle: the structure of rat liver vault at 3.5 angstrom resolution Phyre2 PDB 3oja chain B Region: 597 - 739 Aligned: 142 Modelled: 142 Confidence: 90.5% Identity: 11% PDB header:protein binding Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein PDBTitle: crystal structure of lrim1/apl1c complex Phyre2 PDB 2dfs chain A Region: 421 - 735 Aligned: 313 Modelled: 313 Confidence: 84.3% Identity: 8% PDB header:contractile protein/transport protein Chain: A: PDB Molecule:myosin-5a; PDBTitle: 3-d structure of myosin-v inhibited state Phyre2 PDB 2qf7 chain A Region: 21 - 92 Aligned: 57 Modelled: 57 Confidence: 81.9% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase protein; PDBTitle: crystal structure of a complete multifunctional pyruvate carboxylase2 from rhizobium etli Phyre2 1 c2fugA_ 2 d2fug12 3 d2fug13 4 d1kf6b1 5 c2b76N_ 6 c1nekB_ 7 c2h89B_ 8 c3cf4A_ 9 d1nekb1 10 d2bs2b1 11 c2bs2E_ 12 c2fugG_ 13 d2fug91 14 d1jb0c_ 15 d1xera_ 16 d1rgva_ 17 d1gtea5 18 c1hfeL_ 19 d7fd1a_ 20 c1gx7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 c2q8iB_ 42 d1bdoa_ 43 44 45 d1qjoa_ 46 47 48 c3mxuA_ 49 50 d1o78a_ 51 52 d1dcza_ 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 c2zv4O_ 92 93 94 95 96 97 98 c3ojaB_ 99 100 101 102 103 104 105 106 107 108 109 c2dfsA_ 110 111 c2qf7A_ 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278