Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	N	S	A	F	T	F	Q	T	L	H	P	D	T	I	M	D	A	L	F	E	H	G	I	R	V	D	S	G	L	T	P	L	N	S	Y	E	N	R	V	Y	Q	F	Q	D	E	D	R	R	R	F	V	V	K	F	Y	R	P	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	W	T	A	D	Q	I	L	E	E	H	Q	F	A	L	Q	L	V	N	D	E	V	P	V	A	A	P	V	A	F	N	G	Q	T	L	L	N	H	Q	G	F	Y	F	A	V	F	P	S	V	G	G	R	Q	F	E	A	D	N	I	D
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	M	E	A	V	G	R	Y	L	G	R	M	H	Q	T	G	R	K	Q	L	F	I	H	R	P	T	I	G	L	N	E	Y	L	I	E	P	R	K	L	F	E	D	A	T	L	I	P	S	G	L	K	A	A	F	L	K	A	T	D	E
Secondary structure
SS confidence
Disorder																		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	I	A	A	V	T	A	H	W	R	E	D	F	T	V	L	R	L	H	G	D	C	H	A	G	N	I	L	W	R	D	G	P	M	F	V	D	L	D	D	A	R	N	G	P	A	V	Q	D	L	W	M	L	L	N	G	D	K	A	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	R	M	Q	L	E	T	I	I	E	A	Y	E	E	F	S	E	F	D	T	A	E	I	G	L	I	E	P	L	R	A	M	R	L	V	Y	Y	L	A	W	L	M	R	R	W	A	D	P	A	F	P	K	N	F	P	W	L	T	G	E
Secondary structure
SS confidence
Disorder																																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.
Sequence		D	Y	W	L	R	Q	T	A	T	F	I	E	Q	A	K	V	L	Q	E	P	P	L	Q	L	T	P	M	Y
Secondary structure
SS confidence
Disorder																					?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zyl chain A domain 1 Region: 4 - 328 Aligned: 325 Modelled: 325 Confidence: 100.0% Identity: 100% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: APH phosphotransferases Phyre2 PDB 2ppq chain A domain 1 Region: 9 - 311 Aligned: 288 Modelled: 299 Confidence: 100.0% Identity: 18% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: APH phosphotransferases Phyre2 PDB 2q83 chain A Region: 14 - 271 Aligned: 250 Modelled: 252 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:ytaa protein; PDBTitle: crystal structure of ytaa (2635576) from bacillus subtilis at 2.50 a2 resolution Phyre2 PDB 3i0o chain A Region: 11 - 290 Aligned: 273 Modelled: 280 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:spectinomycin phosphotransferase; PDBTitle: crystal structure of spectinomycin phosphotransferase,2 aph(9)-ia, in complex with adp and spectinomcyin Phyre2 PDB 3dxp chain A Region: 10 - 285 Aligned: 265 Modelled: 270 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:putative acyl-coa dehydrogenase; PDBTitle: crystal structure of a putative aminoglycoside phosphotransferase2 (reut_a1007) from ralstonia eutropha jmp134 at 2.32 a resolution Phyre2 PDB 3dxq chain B Region: 14 - 312 Aligned: 269 Modelled: 290 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:choline/ethanolamine kinase family protein; PDBTitle: crystal structure of choline/ethanolamine kinase family protein2 (np_106042.1) from mesorhizobium loti at 2.55 a resolution Phyre2 PDB 3csv chain A Region: 14 - 295 Aligned: 261 Modelled: 282 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:aminoglycoside phosphotransferase; PDBTitle: crystal structure of a putative aminoglycoside phosphotransferase2 (yp_614837.1) from silicibacter sp. tm1040 at 2.15 a resolution Phyre2 PDB 3jr1 chain A Region: 14 - 278 Aligned: 248 Modelled: 264 Confidence: 100.0% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:putative fructosamine-3-kinase; PDBTitle: crystal structure of putative fructosamine-3-kinase2 (yp_719053.1) from haemophilus somnus 129pt at 2.32 a3 resolution Phyre2 PDB 3ovc chain A Region: 15 - 279 Aligned: 254 Modelled: 265 Confidence: 99.9% Identity: 11% PDB header:transferase/antibiotic Chain: A: PDB Molecule:hygromycin-b 4-o-kinase; PDBTitle: crystal structure of aminoglycoside phosphotransferase aph(4)-ia Phyre2 PDB 3f7w chain A Region: 14 - 285 Aligned: 256 Modelled: 271 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:putative fructosamine-3-kinase; PDBTitle: crystal structure of putative fructosamine-3-kinase (yp_290396.1) from2 thermobifida fusca yx-er1 at 1.85 a resolution Phyre2 PDB 3c5i chain D Region: 30 - 317 Aligned: 274 Modelled: 288 Confidence: 99.9% Identity: 11% PDB header:transferase Chain: D: PDB Molecule:choline kinase; PDBTitle: crystal structure of plasmodium knowlesi choline kinase, pkh_134520 Phyre2 PDB 1nd4 chain A Region: 27 - 257 Aligned: 222 Modelled: 231 Confidence: 99.9% Identity: 14% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: APH phosphotransferases Phyre2 PDB 3lzh chain A Region: 14 - 280 Aligned: 257 Modelled: 267 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:aph(2")-id/aph(2")-iva; PDBTitle: crystal structure of aminoglycoside phosphotransferase aph(2")-2 id/aph(2")-iva Phyre2 PDB 3mes chain B Region: 30 - 317 Aligned: 266 Modelled: 288 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: B: PDB Molecule:choline kinase; PDBTitle: crystal structure of choline kinase from cryptosporidium2 parvum iowa ii, cgd3_2030 Phyre2 PDB 3att chain A Region: 13 - 308 Aligned: 293 Modelled: 295 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of rv3168 with atp Phyre2 PDB 1j7l chain A Region: 13 - 269 Aligned: 243 Modelled: 257 Confidence: 99.9% Identity: 14% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: APH phosphotransferases Phyre2 PDB 2ig7 chain A Region: 30 - 280 Aligned: 233 Modelled: 251 Confidence: 99.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:choline/ethanolamine kinase; PDBTitle: crystal structure of human choline kinase b Phyre2 PDB 1nw1 chain A Region: 30 - 317 Aligned: 275 Modelled: 287 Confidence: 99.9% Identity: 13% Fold: Protein kinase-like (PK-like) Superfamily: Protein kinase-like (PK-like) Family: Choline kinase Phyre2 PDB 1nw1 chain A Region: 30 - 317 Aligned: 275 Modelled: 287 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:choline kinase (49.2 kd); PDBTitle: crystal structure of choline kinase Phyre2 PDB 3ham chain A Region: 35 - 284 Aligned: 236 Modelled: 250 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:aminoglycoside phosphotransferase; PDBTitle: structure of the gentamicin-aph(2")-iia complex Phyre2 1 d1zyla1 2 d2ppqa1 3 c2q83A_ 4 c3i0oA_ 5 c3dxpA_ 6 c3dxqB_ 7 c3csvA_ 8 c3jr1A_ 9 c3ovcA_ 10 c3f7wA_ 11 c3c5iD_ 12 d1nd4a_ 13 c3lzhA_ 14 c3mesB_ 15 c3attA_ 16 d1j7la_ 17 c2ig7A_ 18 d1nw1a_ 19 c1nw1A_ 20 c3hamA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1zyla1 100.0 100 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:APH phosphotransferases 2 d2ppqa1 100.0 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:APH phosphotransferases 3 c2q83A_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:ytaa protein; PDBTitle: crystal structure of ytaa (2635576) from bacillus subtilis at 2.50 a2 resolution 4 c3i0oA_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:spectinomycin phosphotransferase; PDBTitle: crystal structure of spectinomycin phosphotransferase,2 aph(9)-ia, in complex with adp and spectinomcyin 5 c3dxpA_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:putative acyl-coa dehydrogenase; PDBTitle: crystal structure of a putative aminoglycoside phosphotransferase2 (reut_a1007) from ralstonia eutropha jmp134 at 2.32 a resolution 6 c3dxqB_ 100.0 16 PDB header:transferase Chain: B: PDB Molecule:choline/ethanolamine kinase family protein; PDBTitle: crystal structure of choline/ethanolamine kinase family protein2 (np_106042.1) from mesorhizobium loti at 2.55 a resolution 7 c3csvA_ 100.0 20 PDB header:transferase Chain: A: PDB Molecule:aminoglycoside phosphotransferase; PDBTitle: crystal structure of a putative aminoglycoside phosphotransferase2 (yp_614837.1) from silicibacter sp. tm1040 at 2.15 a resolution 8 c3jr1A_ 100.0 11 PDB header:transferase Chain: A: PDB Molecule:putative fructosamine-3-kinase; PDBTitle: crystal structure of putative fructosamine-3-kinase2 (yp_719053.1) from haemophilus somnus 129pt at 2.32 a3 resolution 9 c3ovcA_ 99.9 11 PDB header:transferase/antibiotic Chain: A: PDB Molecule:hygromycin-b 4-o-kinase; PDBTitle: crystal structure of aminoglycoside phosphotransferase aph(4)-ia 10 c3f7wA_ 99.9 17 PDB header:transferase Chain: A: PDB Molecule:putative fructosamine-3-kinase; PDBTitle: crystal structure of putative fructosamine-3-kinase (yp_290396.1) from2 thermobifida fusca yx-er1 at 1.85 a resolution 11 c3c5iD_ 99.9 11 PDB header:transferase Chain: D: PDB Molecule:choline kinase; PDBTitle: crystal structure of plasmodium knowlesi choline kinase, pkh_134520 12 d1nd4a_ 99.9 14 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:APH phosphotransferases 13 c3lzhA_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:aph(2")-id/aph(2")-iva; PDBTitle: crystal structure of aminoglycoside phosphotransferase aph(2")-2 id/aph(2")-iva 14 c3mesB_ 99.9 13 PDB header:transferase Chain: B: PDB Molecule:choline kinase; PDBTitle: crystal structure of choline kinase from cryptosporidium2 parvum iowa ii, cgd3_2030 15 c3attA_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of rv3168 with atp 16 d1j7la_ 99.9 14 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:APH phosphotransferases 17 c2ig7A_ 99.9 14 PDB header:transferase Chain: A: PDB Molecule:choline/ethanolamine kinase; PDBTitle: crystal structure of human choline kinase b 18 d1nw1a_ 99.9 13 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Choline kinase 19 c1nw1A_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:choline kinase (49.2 kd); PDBTitle: crystal structure of choline kinase 20 c3hamA_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:aminoglycoside phosphotransferase; PDBTitle: structure of the gentamicin-aph(2")-iia complex 21 c3r78B_ not modelled 99.9 12 PDB header:transferase Chain: B: PDB Molecule:aminoglycoside 3'-phosphotransferase apha1-iab; PDBTitle: crystal structure of the aminoglycoside phosphotransferase aph(3')-ia,2 atp-bound 22 c2pywA_ not modelled 99.9 14 PDB header:transferase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of a. thaliana 5-methylthioribose kinase in complex with adp2 and mtr 23 d2pula1 not modelled 99.9 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:APH phosphotransferases 24 c3f2rA_ not modelled 99.9 16 PDB header:transferase Chain: A: PDB Molecule:choline kinase alpha; PDBTitle: crystal structure of human choline kinase alpha in complex2 with hemicholinium-3 25 c2qg7A_ not modelled 99.8 16 PDB header:transferase Chain: A: PDB Molecule:ethanolamine kinase pv091845; PDBTitle: plasmodium vivax ethanolamine kinase pv091845 26 c3en9B_ not modelled 99.6 15 PDB header:hydrolase Chain: B: PDB Molecule:o-sialoglycoprotein endopeptidase/protein kinase; PDBTitle: structure of the methanococcus jannaschii kae1-bud32 fusion2 protein 27 c2pziA_ not modelled 98.7 22 PDB header:transferase Chain: A: PDB Molecule:probable serine/threonine-protein kinase pkng; PDBTitle: crystal structure of protein kinase pkng from mycobacterium2 tuberculosis in complex with tetrahydrobenzothiophene ax20017 28 c1tqmA_ not modelled 98.7 18 PDB header:ribosome Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of a. fulgidus rio2 serine protein kinase bound to2 amppnp 29 c1zp9A_ not modelled 98.5 22 PDB header:transferase Chain: A: PDB Molecule:rio1 kinase; PDBTitle: crystal structure of full-legnth a.fulgidus rio1 serine kinase bound2 to atp and mn2+ ions. 30 d1zara2 not modelled 98.5 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:RIO1-like kinases 31 c1ym7C_ not modelled 97.9 16 PDB header:transferase Chain: C: PDB Molecule:beta-adrenergic receptor kinase 1; PDBTitle: g protein-coupled receptor kinase 2 (grk2) 32 c3e7eA_ not modelled 97.8 20 PDB header:transferase Chain: A: PDB Molecule:mitotic checkpoint serine/threonine-protein kinase bub1; PDBTitle: structure and substrate recruitment of the human spindle checkpoint2 kinase bub 33 c3q60A_ not modelled 97.8 19 PDB header:transferase Chain: A: PDB Molecule:rop5b; PDBTitle: crystal structure of virulent allele rop5b pseudokinase domain bound2 to atp 34 c3dzoA_ not modelled 97.4 17 PDB header:transferase Chain: A: PDB Molecule:rhoptry kinase domain; PDBTitle: crystal structure of a rhoptry kinase from toxoplasma gondii 35 c2acxB_ not modelled 97.4 20 PDB header:transferase Chain: B: PDB Molecule:g protein-coupled receptor kinase 6; PDBTitle: crystal structure of g protein coupled receptor kinase 6 bound to2 amppnp 36 c3ckxA_ not modelled 97.4 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 24; PDBTitle: crystal structure of sterile 20-like kinase 3 (mst3, stk24)2 in complex with staurosporine 37 c3qa8A_ not modelled 97.4 23 PDB header:immune system, signaling protein Chain: A: PDB Molecule:mgc80376 protein; PDBTitle: crystal structure of inhibitor of kappa b kinase beta 38 c2vwiC_ not modelled 97.3 21 PDB header:transferase Chain: C: PDB Molecule:serine/threonine-protein kinase osr1; PDBTitle: structure of the osr1 kinase, a hypertension drug target 39 c3c4yA_ not modelled 97.2 17 PDB header:transferase Chain: A: PDB Molecule:rhodopsin kinase; PDBTitle: crystal structure of apo form of g protein coupled receptor kinase 12 at 7.51a 40 c2fo0A_ not modelled 97.2 13 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 41 c3pfqA_ not modelled 97.1 11 PDB header:transferase Chain: A: PDB Molecule:protein kinase c beta type; PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii 42 c2h8hA_ not modelled 96.8 19 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 43 c3p23B_ not modelled 96.7 21 PDB header:hydrolase, transferase Chain: B: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1; PDBTitle: crystal structure of the human kinase and rnase domains in complex2 with adp 44 d1qcfa3 not modelled 96.7 14 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 45 d1qpca_ not modelled 96.7 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 46 c1oplA_ not modelled 96.7 14 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 47 c2c0iA_ not modelled 96.7 14 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 48 c2zv2A_ not modelled 96.6 19 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase kinase 2; PDBTitle: crystal structure of human calcium/calmodulin-dependent protein kinase2 kinase 2, beta, camkk2 kinase domain in complex with sto-609 49 c1k9aB_ not modelled 96.6 19 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 50 c3fbvL_ not modelled 96.6 19 PDB header:transferase, hydrolase Chain: L: PDB Molecule:serine/threonine-protein kinase/endoribonuclease ire1; PDBTitle: crystal structure of the oligomer formed by the kinase-ribonuclease2 domain of ire1 51 c1y57A_ not modelled 96.5 20 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 52 c3kvwA_ not modelled 96.5 19 PDB header:transferase Chain: A: PDB Molecule:dual specificity tyrosine-phosphorylation-regulated kinase PDBTitle: crystal structure of dual-specificity tyrosine phosphorylation2 regulated kinase 2 (dyrk2) in complex with an indirubin ligand 53 c2vuwA_ not modelled 96.3 20 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase haspin; PDBTitle: structure of human haspin kinase domain 54 c2a1aB_ not modelled 96.1 13 PDB header:protein synthesis/transferase Chain: B: PDB Molecule:interferon-induced, double-stranded rna-activated protein PDBTitle: pkr kinase domain-eif2alpha complex 55 d1phka_ not modelled 96.0 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 56 d1k2pa_ not modelled 95.7 20 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 57 c3d9vA_ not modelled 95.7 16 PDB header:transferase Chain: A: PDB Molecule:rho-associated protein kinase 1; PDBTitle: crystal structure of rock i bound to h-1152p a di-2 methylated variant of fasudil 58 c3q5iA_ not modelled 95.6 19 PDB header:transferase Chain: A: PDB Molecule:protein kinase; PDBTitle: crystal structure of pbanka_031420 59 c2jiiA_ not modelled 95.4 18 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase vrk3 molecule: vaccinia PDBTitle: structure of vaccinia related kinase 3 60 c3byvA_ not modelled 95.4 15 PDB header:transferase Chain: A: PDB Molecule:rhoptry kinase; PDBTitle: crystal structure of toxoplasma gondii specific rhoptry2 antigen kinase domain 61 d1opja_ not modelled 95.4 15 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 62 c3g0eA_ not modelled 95.3 17 PDB header:transferase Chain: A: PDB Molecule:mast/stem cell growth factor receptor; PDBTitle: kit kinase domain in complex with sunitinib 63 d2j4za1 not modelled 95.3 13 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 64 c2y7jB_ not modelled 95.2 19 PDB header:transferase Chain: B: PDB Molecule:phosphorylase b kinase gamma catalytic chain, PDBTitle: structure of human phosphorylase kinase, gamma 2 65 c2wu6A_ not modelled 95.1 11 PDB header:transferase Chain: A: PDB Molecule:dual specificity protein kinase clk3; PDBTitle: crystal structure of the human clk3 in complex with dki 66 c2pvfA_ not modelled 95.1 13 PDB header:transferase Chain: A: PDB Molecule:fibroblast growth factor receptor 2; PDBTitle: crystal structure of tyrosine phosphorylated activated fgf2 receptor 2 (fgfr2) kinase domain in complex with atp3 analog and substrate peptide 67 c2c30A_ not modelled 95.1 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: crystal structure of the human p21-activated kinase 6 68 c3dfaA_ not modelled 94.8 16 PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase cgd3_920; PDBTitle: crystal structure of kinase domain of calcium-dependent protein kinase2 cgd3_920 from cryptosporidium parvum 69 d1yhwa1 not modelled 94.5 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 70 c1mruB_ not modelled 94.4 18 PDB header:transferase Chain: B: PDB Molecule:probable serine/threonine-protein kinase pknb; PDBTitle: intracellular ser/thr protein kinase domain of2 mycobacterium tuberculosis pknb. 71 c3soaA_ not modelled 94.3 15 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:calcium/calmodulin-dependent protein kinase type ii subunit PDBTitle: full-length human camkii 72 c2qg5D_ not modelled 94.1 16 PDB header:transferase Chain: D: PDB Molecule:calcium/calmodulin-dependent protein kinase; PDBTitle: cryptosporidium parvum calcium dependent protein kinase cgd7_1840 73 c3comB_ not modelled 94.0 21 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase 4; PDBTitle: crystal structure of mst1 kinase 74 d1jksa_ not modelled 94.0 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 75 c2clqA_ not modelled 94.0 18 PDB header:transferase Chain: A: PDB Molecule:mitogen-activated protein kinase kinase kinase 5; PDBTitle: structure of mitogen-activated protein kinase kinase kinase2 5 76 c1koaA_ not modelled 93.8 10 PDB header:kinase Chain: A: PDB Molecule:twitchin; PDBTitle: twitchin kinase fragment (c.elegans), autoregulated protein2 kinase and immunoglobulin domains 77 c2bmcD_ not modelled 93.8 16 PDB header:transferase Chain: D: PDB Molecule:serine threonine-protein kinase 6; PDBTitle: aurora-2 t287d t288d complexed with pha-680632 78 c2ozoA_ not modelled 93.8 20 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 79 c2zmcA_ not modelled 93.8 19 PDB header:transferase Chain: A: PDB Molecule:dual specificity protein kinase ttk; PDBTitle: crystal structure of human mitotic checkpoint kinase mps1 catalytic2 domain apo form 80 c3cokB_ not modelled 93.6 17 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase plk4; PDBTitle: crystal structure of plk4 kinase 81 c2chlA_ not modelled 93.5 17 PDB header:transferase Chain: A: PDB Molecule:casein kinase i isoform gamma-3; PDBTitle: structure of casein kinase 1 gamma 3 82 c3lijA_ not modelled 93.3 21 PDB header:transferase Chain: A: PDB Molecule:calcium/calmodulin dependent protein kinase with PDBTitle: crystal structure of full length cpcdpk3 (cgd5_820) in2 complex with ca2+ and amppnp 83 d1sm2a_ not modelled 92.8 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 84 c2wtkB_ not modelled 92.6 13 PDB header:transferase/metal-binding protein Chain: B: PDB Molecule:ste20-related kinase adapter protein alpha; PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex 85 d1fmka3 not modelled 92.5 16 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 86 c2cgvA_ not modelled 92.5 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase chk1; PDBTitle: identification of chemically diverse chk1 inhibitors by2 receptor-based virtual screening 87 d1u59a_ not modelled 91.8 21 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 88 c2r7bA_ not modelled 91.7 13 PDB header:signaling protein, transferase Chain: A: PDB Molecule:phosphoinositide-dependent protein kinase 1; PDBTitle: crystal structure of the phosphoinositide-dependent kinase-2 1 (pdk-1)catalytic domain bound to a dibenzonaphthyridine3 inhibitor 89 c2j51A_ not modelled 91.7 17 PDB header:transferase Chain: A: PDB Molecule:ste20-like serine/threonine-protein kinase; PDBTitle: crystal structure of human ste20-like kinase bound to 5-2 amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6-3 difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide 90 d1iasa_ not modelled 91.5 15 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 91 c2in6A_ not modelled 91.4 13 PDB header:transferase Chain: A: PDB Molecule:wee1-like protein kinase; PDBTitle: wee1 kinase complex with inhibitor pd311839 92 c2qluA_ not modelled 91.1 14 PDB header:transferase Chain: A: PDB Molecule:activin receptor type iib; PDBTitle: crystal structure of activin receptor type ii kinase domain2 from human 93 c2v62A_ not modelled 91.0 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase vrk2; PDBTitle: structure of vaccinia-related kinase 2 94 c3op5B_ not modelled 90.8 23 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase vrk1; PDBTitle: human vaccinia-related kinase 1 95 c2h6dA_ not modelled 90.7 14 PDB header:signaling protein,transferase Chain: A: PDB Molecule:5'-amp-activated protein kinase catalytic subunit PDBTitle: protein kinase domain of the human 5'-amp-activated protein2 kinase catalytic subunit alpha-2 (ampk alpha-2 chain) 96 c3lltA_ not modelled 90.3 17 PDB header:transferase Chain: A: PDB Molecule:serine/threonine kinase-1, pflammer; PDBTitle: crystal structure of pf14_0431, kinase domain. 97 c2wqmA_ not modelled 89.3 19 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase nek7; PDBTitle: structure of apo human nek7 98 c3is5E_ not modelled 89.3 22 PDB header:transferase Chain: E: PDB Molecule:calcium-dependent protein kinase; PDBTitle: crystal structure of cdpk kinase domain from toxoplasma gondii,2 tgme49_018720 99 d1o6ya_ not modelled 88.6 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 100 c3dpkA_ not modelled 88.6 20 PDB header:transferase Chain: A: PDB Molecule:macrophage colony-stimulating factor 1 receptor; PDBTitle: cfms tyrosine kinase in complex with a pyridopyrimidinone2 inhibitor 101 c2a27B_ not modelled 88.4 19 PDB header:transferase Chain: B: PDB Molecule:death-associated protein kinase 2; PDBTitle: human drp-1 kinase, w305s s308a d40 mutant, crystal form with 82 monomers in the asymmetric unit 102 c2bujA_ not modelled 88.1 18 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase 16; PDBTitle: crystal structure of the human serine-threonine kinase 162 in complex with staurosporine 103 d1ckia_ not modelled 88.0 15 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 104 d1nvra_ not modelled 87.9 18 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 105 c2wtkC_ not modelled 87.1 17 PDB header:transferase/metal-binding protein Chain: C: PDB Molecule:serine/threonine-protein kinase 11; PDBTitle: structure of the heterotrimeric lkb1-stradalpha-mo25alpha2 complex 106 c3hztA_ not modelled 86.1 19 PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase 3; PDBTitle: crystal structure of toxoplasma gondii cdpk3, tgme49_105860 107 d2jfla1 not modelled 85.8 19 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 108 c2i0eB_ not modelled 85.6 11 PDB header:transferase Chain: B: PDB Molecule:protein kinase c-beta ii; PDBTitle: structure of catalytic domain of human protein kinase c2 beta ii complexed with a bisindolylmaleimide inhibitor 109 c3sxrA_ not modelled 85.6 18 PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: crystal structure of bmx non-receptor tyrosine kinase complex with2 dasatinib 110 c3lxkA_ not modelled 84.5 16 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase jak3; PDBTitle: structural and thermodynamic characterization of the tyk2 and jak32 kinase domains in complex with cp-690550 and cmp-6 111 c2y3aA_ not modelled 83.7 23 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 112 c2qhnA_ not modelled 82.7 19 PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase chk1; PDBTitle: crystal structure of chek1 in complex with inhibitor 1a 113 c2x4fA_ not modelled 82.0 19 PDB header:transferase Chain: A: PDB Molecule:myosin light chain kinase family member 4; PDBTitle: the crystal structure of the human myosin light chain2 kinase loc340156. 114 c3cekA_ not modelled 81.9 13 PDB header:transferase Chain: A: PDB Molecule:dual specificity protein kinase ttk; PDBTitle: crystal structure of human dual specificity protein kinase (ttk) 115 d1t46a_ not modelled 81.6 19 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 116 c2ivsA_ not modelled 80.8 19 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase receptor PDBTitle: crystal structure of non-phosphorylated ret tyrosine kinase2 domain 117 d1e7ua4 not modelled 80.6 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Phoshoinositide 3-kinase (PI3K), catalytic domain 118 d1ob3a_ not modelled 79.7 17 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 119 d1xwsa_ not modelled 78.1 15 Fold:Protein kinase-like (PK-like) Superfamily:Protein kinase-like (PK-like) Family:Protein kinases, catalytic subunit 120 c2c47D_ not modelled 76.6 17 PDB header:transferase Chain: D: PDB Molecule:casein kinase 1 gamma 2 isoform; PDBTitle: structure of casein kinase 1 gamma 2

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0