Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP21599
DateThu Jan 5 11:38:29 GMT 2012
Unique Job ID84b4199246729433

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2e28A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus
Confidence and coverage
Confidence:100.0% Coverage: 98%
469 residues ( 98% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSRRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAK
Secondary structure 
SS confidence 
Disorder  ???????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  LGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPAD
Secondary structure 
SS confidence 
Disorder 
?
?
?
??????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  VVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKA
Secondary structure 
SS confidence 
Disorder 
?
???
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  DIKTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDII
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  LASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAE
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  VMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDN
Secondary structure 
SS confidence 
Disorder 
??????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  VEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALY
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  RGVTPVHFDSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTVE
Secondary structure 
SS confidence 
Disorder 
???????
?
Disorder confidence 
 
  
Sequence 
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2e28 chain A

3D model

Region: 5 - 479
Aligned: 469
Modelled: 475
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus

Phyre2

PDB 3t07 chain D

3D model

Region: 5 - 479
Aligned: 469
Modelled: 475
Confidence: 100.0%
Identity: 40%
PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid

Phyre2

PDB 1t5a chain B

3D model

Region: 1 - 479
Aligned: 474
Modelled: 479
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme;
PDBTitle: human pyruvate kinase m2

Phyre2

PDB 1aqf chain B

3D model

Region: 1 - 479
Aligned: 474
Modelled: 479
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate

Phyre2

PDB 3e0v chain B

3D model

Region: 2 - 480
Aligned: 470
Modelled: 479
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions

Phyre2

PDB 3ma8 chain A

3D model

Region: 4 - 479
Aligned: 462
Modelled: 476
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum

Phyre2

PDB 1a3w chain B

3D model

Region: 3 - 479
Aligned: 470
Modelled: 476
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+

Phyre2

PDB 3eoe chain C

3D model

Region: 4 - 480
Aligned: 461
Modelled: 477
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007

Phyre2

PDB 1pkl chain B

3D model

Region: 2 - 464
Aligned: 459
Modelled: 463
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: B: PDB Molecule:protein (pyruvate kinase);
PDBTitle: the structure of leishmania pyruvate kinase

Phyre2

PDB 2vgb chain B

3D model

Region: 1 - 479
Aligned: 452
Modelled: 470
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase isozymes r/l;
PDBTitle: human erythrocyte pyruvate kinase

Phyre2

PDB 1e0t chain D

3D model

Region: 5 - 479
Aligned: 444
Modelled: 475
Confidence: 100.0%
Identity: 36%
PDB header:phosphotransferase
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: r292d mutant of e. coli pyruvate kinase

Phyre2

PDB 3khd chain C

3D model

Region: 1 - 479
Aligned: 358
Modelled: 389
Confidence: 100.0%
Identity: 42%
PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pff1300w.

Phyre2

PDB 1pkl chain A domain 2

3D model

Region: 2 - 345
Aligned: 244
Modelled: 247
Confidence: 100.0%
Identity: 48%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate kinase

Phyre2

PDB 2g50 chain A domain 2

3D model

Region: 2 - 352
Aligned: 256
Modelled: 259
Confidence: 100.0%
Identity: 43%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate kinase

Phyre2

PDB 1a3x chain A domain 2

3D model

Region: 2 - 352
Aligned: 250
Modelled: 253
Confidence: 100.0%
Identity: 51%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate kinase

Phyre2

PDB 1liu chain A domain 2

3D model

Region: 2 - 352
Aligned: 256
Modelled: 260
Confidence: 100.0%
Identity: 40%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate kinase

Phyre2

PDB 1e0t chain A domain 2

3D model

Region: 5 - 348
Aligned: 228
Modelled: 246
Confidence: 100.0%
Identity: 51%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate kinase

Phyre2

PDB 1liu chain A domain 3

3D model

Region: 351 - 479
Aligned: 127
Modelled: 129
Confidence: 100.0%
Identity: 29%
Fold: Pyruvate kinase C-terminal domain-like
Superfamily: PK C-terminal domain-like
Family: Pyruvate kinase, C-terminal domain

Phyre2

PDB 2g50 chain A domain 3

3D model

Region: 352 - 479
Aligned: 126
Modelled: 128
Confidence: 100.0%
Identity: 35%
Fold: Pyruvate kinase C-terminal domain-like
Superfamily: PK C-terminal domain-like
Family: Pyruvate kinase, C-terminal domain

Phyre2

PDB 1e0t chain A domain 3

3D model

Region: 361 - 479
Aligned: 117
Modelled: 119
Confidence: 100.0%
Identity: 23%
Fold: Pyruvate kinase C-terminal domain-like
Superfamily: PK C-terminal domain-like
Family: Pyruvate kinase, C-terminal domain

Phyre2
1
c2e28A_
2
c3t07D_
3
c1t5aB_
4
c1aqfB_
5
c3e0vB_
6
c3ma8A_
7
c1a3wB_
8
c3eoeC_
9
c1pklB_
10
c2vgbB_
11
c1e0tD_
12
c3khdC_
13
d1pkla2
14
d2g50a2
15
d1a3xa2
16
d1liua2
17
d1e0ta2
18
d1liua3
19
d2g50a3
20
d1e0ta3
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2e28A_
100.0 41 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus
2c3t07D_
100.0 40 PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid
3c1t5aB_
100.0 37 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme;
PDBTitle: human pyruvate kinase m2
4c1aqfB_
100.0 38 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate
5c3e0vB_
100.0 37 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions
6c3ma8A_
100.0 36 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum
7c1a3wB_
100.0 38 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+
8c3eoeC_
100.0 36 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007
9c1pklB_
100.0 36 PDB header:transferase
Chain: B: PDB Molecule:protein (pyruvate kinase);
PDBTitle: the structure of leishmania pyruvate kinase
10c2vgbB_
100.0 38 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase isozymes r/l;
PDBTitle: human erythrocyte pyruvate kinase
11c1e0tD_
100.0 36 PDB header:phosphotransferase
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: r292d mutant of e. coli pyruvate kinase
12c3khdC_
100.0 42 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pff1300w.
13d1pkla2
100.0 48 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
14d2g50a2
100.0 43 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
15d1a3xa2
100.0 51 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
16d1liua2
100.0 40 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
17d1e0ta2
100.0 51 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
18d1liua3
100.0 29 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:Pyruvate kinase, C-terminal domain
19d2g50a3
100.0 35 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:Pyruvate kinase, C-terminal domain
20d1e0ta3
100.0 23 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:Pyruvate kinase, C-terminal domain
21d1pkla3
not modelled 100.0 26 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:Pyruvate kinase, C-terminal domain
22d1a3xa3
not modelled 99.9 28 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:Pyruvate kinase, C-terminal domain
23d2g50a1
not modelled 99.8 30 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
24d1e0ta1
not modelled 99.8 31 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
25d1pkma1
not modelled 99.8 32 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
26d1liua1
not modelled 99.8 29 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
27d1pkla1
not modelled 99.8 27 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
28d1a3xa1
not modelled 99.8 22 Fold:PK beta-barrel domain-like
Superfamily:PK beta-barrel domain-like
Family:Pyruvate kinase beta-barrel domain
29c2v5jB_
not modelled 99.0 24 PDB header:lyase
Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
PDBTitle: apo class ii aldolase hpch
30d1dxea_
not modelled 99.0 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
31c2vwtA_
not modelled 98.9 27 PDB header:lyase
Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase;
PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex
32c3qz6A_
not modelled 98.9 23 PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2
33c1sgjB_
not modelled 98.8 15 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase, beta subunit;
PDBTitle: crystal structure of citrate lyase beta subunit
34d1sgja_
not modelled 98.8 15 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
35c1izcA_
not modelled 98.7 19 PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase
36d1izca_
not modelled 98.7 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
37c3qqwC_
not modelled 98.2 17 PDB header:lyase
Chain: C: PDB Molecule:putative citrate lyase;
PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution
38c1u5vA_
not modelled 98.2 17 PDB header:lyase
Chain: A: PDB Molecule:cite;
PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis
39d1u5ha_
not modelled 98.1 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
40c3r4iB_
not modelled 97.9 15 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase;
PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution
41c3cuzA_
not modelled 97.4 20 PDB header:transferase
Chain: A: PDB Molecule:malate synthase a;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
42c3pugA_
not modelled 97.3 14 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate
43c1zfjA_
not modelled 97.3 19 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from2 streptococcus pyogenes
44c2bg5C_
not modelled 97.3 16 PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)
45c2hroA_
not modelled 97.2 14 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus
46c2olsA_
not modelled 97.2 15 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis
47c2hwgA_
not modelled 97.1 15 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
48c1h6zA_
not modelled 97.0 16 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei
49c1kblA_
not modelled 97.0 12 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase
50d1kbla1
not modelled 96.7 13 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
51d1vbga1
not modelled 96.7 22 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
52d1h6za1
not modelled 96.5 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
53d1jr1a1
not modelled 96.4 20 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
54c3cuxA_
not modelled 96.4 19 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
55c1vbhA_
not modelled 96.4 20 PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize
56c1jcnA_
not modelled 96.1 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase i;
PDBTitle: binary complex of human type-i inosine monophosphate dehydrogenase2 with 6-cl-imp
57d1zfja1
not modelled 95.9 19 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
58d2flia1
not modelled 93.7 12 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
59d2tpsa_
not modelled 93.5 24 Fold:TIM beta/alpha-barrel
Superfamily:Thiamin phosphate synthase
Family:Thiamin phosphate synthase
60c3r2gA_
not modelled 93.4 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila
61d1t57a_
not modelled 92.3 18 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:MTH1675-like
62c3odmE_
not modelled 91.9 16 PDB header:lyase
Chain: E: PDB Molecule:phosphoenolpyruvate carboxylase;
PDBTitle: archaeal-type phosphoenolpyruvate carboxylase
63c3pg8B_
not modelled 91.2 16 PDB header:transferase
Chain: B: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase;
PDBTitle: truncated form of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase2 from thermotoga maritima
64c3gndC_
not modelled 90.9 19 PDB header:lyase
Chain: C: PDB Molecule:aldolase lsrf;
PDBTitle: crystal structure of e. coli lsrf in complex with ribulose-5-phosphate
65c3f4wA_
not modelled 90.2 14 PDB header:synthase, lyase
Chain: A: PDB Molecule:putative hexulose 6 phosphate synthase;
PDBTitle: the 1.65a crystal structure of 3-hexulose-6-phosphate2 synthase from salmonella typhimurium
66c1vrdA_
not modelled 90.0 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase (tm1347)2 from thermotoga maritima at 2.18 a resolution
67c3ffsC_
not modelled 89.7 17 PDB header:oxidoreductase
Chain: C: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: the crystal structure of cryptosporidium parvum inosine-5'-2 monophosphate dehydrogenase
68d1h1ya_
not modelled 89.6 11 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
69c3inpA_
not modelled 89.1 14 PDB header:isomerase
Chain: A: PDB Molecule:d-ribulose-phosphate 3-epimerase;
PDBTitle: 2.05 angstrom resolution crystal structure of d-ribulose-phosphate 3-2 epimerase from francisella tularensis.
70d1vp8a_
not modelled 89.1 17 Fold:Pyruvate kinase C-terminal domain-like
Superfamily:PK C-terminal domain-like
Family:MTH1675-like
71c2vp8A_
not modelled 89.1 11 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase 2;
PDBTitle: structure of mycobacterium tuberculosis rv1207
72c1xuzA_
not modelled 89.0 16 PDB header:biosynthetic protein
Chain: A: PDB Molecule:polysialic acid capsule biosynthesis protein siac;
PDBTitle: crystal structure analysis of sialic acid synthase (neub)from2 neisseria meningitidis, bound to mn2+, phosphoenolpyruvate, and n-3 acetyl mannosaminitol
73d1vrda1
not modelled 89.0 17 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
74c3b0vD_
not modelled 88.9 17 PDB header:oxidoreductase/rna
Chain: D: PDB Molecule:trna-dihydrouridine synthase;
PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna
75d1rpxa_
not modelled 88.1 13 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
76d1kbia1
not modelled 88.0 19 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
77c2gjlA_
not modelled 87.9 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:hypothetical protein pa1024;
PDBTitle: crystal structure of 2-nitropropane dioxygenase
78d1o4ua1
not modelled 87.1 15 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
79c2qr6A_
not modelled 85.6 16 PDB header:oxidoreductase
Chain: A: PDB Molecule:imp dehydrogenase/gmp reductase;
PDBTitle: crystal structure of imp dehydrogenase/gmp reductase-like protein2 (np_599840.1) from corynebacterium glutamicum atcc 13032 kitasato at3 1.50 a resolution
80c2z6jB_
not modelled 85.5 15 PDB header:oxidoreductase
Chain: B: PDB Molecule:trans-2-enoyl-acp reductase ii;
PDBTitle: crystal structure of s. pneumoniae enoyl-acyl carrier2 protein reductase (fabk) in complex with an inhibitor
81d1y0ea_
not modelled 85.5 14 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:NanE-like
82c3bo9B_
not modelled 85.0 16 PDB header:oxidoreductase
Chain: B: PDB Molecule:putative nitroalkan dioxygenase;
PDBTitle: crystal structure of putative nitroalkan dioxygenase (tm0800) from2 thermotoga maritima at 2.71 a resolution
83c2y0fD_
not modelled 84.2 17 PDB header:oxidoreductase
Chain: D: PDB Molecule:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase;
PDBTitle: structure of gcpe (ispg) from thermus thermophilus hb27
84d1vcva1
not modelled 83.3 19 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
85c1o4uA_
not modelled 83.1 15 PDB header:transferase
Chain: A: PDB Molecule:type ii quinolic acid phosphoribosyltransferase;
PDBTitle: crystal structure of a nicotinate nucleotide pyrophosphorylase2 (tm1645) from thermotoga maritima at 2.50 a resolution
86d1xcfa_
not modelled 83.0 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
87d1vpea_
not modelled 82.6 14 Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
88c2v82A_
not modelled 81.4 16 PDB header:lyase
Chain: A: PDB Molecule:2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
PDBTitle: kdpgal complexed to kdpgal
89c3cwcB_
not modelled 81.2 18 PDB header:transferase
Chain: B: PDB Molecule:putative glycerate kinase 2;
PDBTitle: crystal structure of putative glycerate kinase 2 from salmonella2 typhimurium lt2
90d1n7ka_
not modelled 81.2 13 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
91d16pka_
not modelled 81.1 16 Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
92c3khjE_
not modelled 81.1 18 PDB header:oxidoreductase
Chain: E: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: c. parvum inosine monophosphate dehydrogenase bound by inhibitor c64
93d1tqja_
not modelled 81.1 12 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
94d1tx2a_
not modelled 80.6 15 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
95c1tx2A_
not modelled 80.6 15 PDB header:transferase
Chain: A: PDB Molecule:dhps, dihydropteroate synthase;
PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis
96c1kbiB_
not modelled 79.1 20 PDB header:oxidoreductase
Chain: B: PDB Molecule:cytochrome b2;
PDBTitle: crystallographic study of the recombinant flavin-binding domain of2 baker's yeast flavocytochrome b2: comparison with the intact wild-3 type enzyme
97d1ub3a_
not modelled 78.8 22 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
98d1eepa_
not modelled 77.6 17 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
99c2p10D_
not modelled 77.2 17 PDB header:hydrolase
Chain: D: PDB Molecule:mll9387 protein;
PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution
100c3ct7E_
not modelled 76.5 15 PDB header:isomerase
Chain: E: PDB Molecule:d-allulose-6-phosphate 3-epimerase;
PDBTitle: crystal structure of d-allulose 6-phosphate 3-epimerase2 from escherichia coli k-12
101d1dvja_
not modelled 76.0 12 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Decarboxylase
102d1pvna1
not modelled 75.7 14 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
103d1ajza_
not modelled 75.2 23 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Dihydropteroate synthetase
104c1yadD_
not modelled 74.2 14 PDB header:transcription
Chain: D: PDB Molecule:regulatory protein teni;
PDBTitle: structure of teni from bacillus subtilis
105c2c3zA_
not modelled 74.1 13 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus
106c3tr9A_
not modelled 73.8 17 PDB header:transferase
Chain: A: PDB Molecule:dihydropteroate synthase;
PDBTitle: structure of a dihydropteroate synthase (folp) in complex with pteroic2 acid from coxiella burnetii
107c3o63B_
not modelled 73.6 19 PDB header:transferase
Chain: B: PDB Molecule:probable thiamine-phosphate pyrophosphorylase;
PDBTitle: crystal structure of thiamin phosphate synthase from mycobacterium2 tuberculosis
108c2cdh1_
not modelled 73.4 18 PDB header:transferase
Chain: 1: PDB Molecule:enoyl reductase;
PDBTitle: architecture of the thermomyces lanuginosus fungal fatty2 acid synthase at 5 angstrom resolution.
109c3ipwA_
not modelled 72.4 14 PDB header:hydrolase
Chain: A: PDB Molecule:hydrolase tatd family protein;
PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica
110c2qjhH_
not modelled 72.3 17 PDB header:lyase
Chain: H: PDB Molecule:putative aldolase mj0400;
PDBTitle: m. jannaschii adh synthase covalently bound to2 dihydroxyacetone phosphate
111d3bofa1
not modelled 72.0 21 Fold:TIM beta/alpha-barrel
Superfamily:Dihydropteroate synthetase-like
Family:Methyltetrahydrofolate-utiluzing methyltransferases
112c3igsB_
not modelled 71.8 14 PDB header:isomerase
Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2;
PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase
113d1qpga_
not modelled 71.2 18 Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
114c3bleA_
not modelled 70.6 14 PDB header:transferase
Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans;
PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate
115d1jqoa_
not modelled 69.9 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Phosphoenolpyruvate carboxylase
116c1jqoA_
not modelled 69.9 19 PDB header:lyase
Chain: A: PDB Molecule:phosphoenolpyruvate carboxylase;
PDBTitle: crystal structure of c4-form phosphoenolpyruvate carboxylase from2 maize
117d1vjda_
not modelled 69.0 16 Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
118d1ltka_
not modelled 69.0 14 Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
119d1jqna_
not modelled 68.8 20 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Phosphoenolpyruvate carboxylase
120d1ps9a1
not modelled 68.3 19 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0