Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	A	K	R	I	I	P	C	L	D	V	R	D	G	Q	V	V	K	G	V	Q	F	R	N	H	E	I	I	G	D	I	V	P	L	A	K	R	Y	A	E	E	G	A	D	E	L	V	F	Y	D	I	T	A	S	S	D	G	R	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?															?				?	?	?	?																														?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	D	K	S	W	V	S	R	V	A	E	V	I	D	I	P	F	C	V	A	G	G	I	K	S	L	E	D	A	A	K	I	L	S	F	G	A	D	K	I	S	I	N	S	P	A	L	A	D	P	T	L	I	T	R	L	A	D	R	F
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	V	Q	C	I	V	V	G	I	D	T	W	Y	D	A	E	T	G	K	Y	H	V	N	Q	Y	T	G	D	E	S	R	T	R	V	T	Q	W	E	T	L	D	W	V	Q	E	V	Q	K	R	G	A	G	E	I	V	L	N	M	M	N
Secondary structure
SS confidence
Disorder																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	D	G	V	R	N	G	Y	D	L	E	Q	L	K	K	V	R	E	V	C	H	V	P	L	I	A	S	G	G	A	G	T	M	E	H	F	L	E	A	F	R	D	A	D	V	D	G	A	L	A	A	S	V	F	H	K	Q	I	I	N
Secondary structure
SS confidence
Disorder				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.
Sequence		I	G	E	L	K	A	Y	L	A	T	Q	G	V	E	I	R	I	C
Secondary structure
SS confidence
Disorder																?			?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1jvn chain A domain 1 Region: 2 - 257 Aligned: 254 Modelled: 256 Confidence: 100.0% Identity: 33% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1jvn chain B Region: 2 - 257 Aligned: 254 Modelled: 256 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:bifunctional histidine biosynthesis protein hishf; PDBTitle: crystal structure of imidazole glycerol phosphate synthase: a tunnel2 through a (beta/alpha)8 barrel joins two active sites Phyre2 PDB 1thf chain D Region: 1 - 257 Aligned: 250 Modelled: 257 Confidence: 100.0% Identity: 52% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1qo2 chain A Region: 6 - 249 Aligned: 230 Modelled: 244 Confidence: 100.0% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1ka9 chain F Region: 2 - 257 Aligned: 249 Modelled: 256 Confidence: 100.0% Identity: 51% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1h5y chain A Region: 2 - 257 Aligned: 249 Modelled: 256 Confidence: 100.0% Identity: 45% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 2y85 chain D Region: 2 - 249 Aligned: 232 Modelled: 241 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: D: PDB Molecule:phosphoribosyl isomerase a; PDBTitle: crystal structure of mycobacterium tuberculosis phosphoribosyl2 isomerase with bound rcdrp Phyre2 PDB 2w6r chain A Region: 4 - 235 Aligned: 220 Modelled: 232 Confidence: 100.0% Identity: 34% PDB header:lyase Chain: A: PDB Molecule:imidazole glycerol phosphate synthase subunit PDBTitle: crystal structure of an artificial (ba)8-barrel protein2 designed from identical half barrels Phyre2 PDB 2agk chain A Region: 5 - 252 Aligned: 223 Modelled: 242 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) PDBTitle: structure of s. cerevisiae his6 protein Phyre2 PDB 1vzw chain A domain 1 Region: 3 - 248 Aligned: 220 Modelled: 246 Confidence: 100.0% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1znn chain A domain 1 Region: 31 - 250 Aligned: 207 Modelled: 220 Confidence: 100.0% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: PdxS-like Phyre2 PDB 1znn chain F Region: 31 - 250 Aligned: 207 Modelled: 220 Confidence: 100.0% Identity: 17% PDB header:biosynthetic protein Chain: F: PDB Molecule:plp synthase; PDBTitle: structure of the synthase subunit of plp synthase Phyre2 PDB 3qja chain A Region: 31 - 255 Aligned: 190 Modelled: 196 Confidence: 99.9% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form Phyre2 PDB 1vc4 chain A Region: 31 - 248 Aligned: 184 Modelled: 189 Confidence: 99.9% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 1a53 chain A Region: 31 - 244 Aligned: 178 Modelled: 185 Confidence: 99.9% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 2c3z chain A Region: 31 - 244 Aligned: 178 Modelled: 185 Confidence: 99.9% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus Phyre2 PDB 3tdm chain D Region: 122 - 246 Aligned: 118 Modelled: 125 Confidence: 99.9% Identity: 39% PDB header:de novo protein Chain: D: PDB Molecule:computationally designed two-fold symmetric tim-barrel PDBTitle: computationally designed tim-barrel protein, halfflr Phyre2 PDB 1pii chain A Region: 31 - 258 Aligned: 188 Modelled: 199 Confidence: 99.8% Identity: 18% PDB header:bifunctional(isomerase and synthase) Chain: A: PDB Molecule:n-(5'phosphoribosyl)anthranilate isomerase; PDBTitle: three-dimensional structure of the bifunctional enzyme2 phosphoribosylanthranilate isomerase:3 indoleglycerolphosphate synthase from escherichia coli4 refined at 2.0 angstroms resolution Phyre2 PDB 3igs chain B Region: 13 - 250 Aligned: 199 Modelled: 201 Confidence: 99.8% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2; PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase Phyre2 PDB 3q58 chain A Region: 14 - 250 Aligned: 198 Modelled: 200 Confidence: 99.8% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase; PDBTitle: structure of n-acetylmannosamine-6-phosphate epimerase from salmonella2 enterica Phyre2 1 d1jvna1 2 c1jvnB_ 3 d1thfd_ 4 d1qo2a_ 5 d1ka9f_ 6 d1h5ya_ 7 c2y85D_ 8 c2w6rA_ 9 c2agkA_ 10 d1vzwa1 11 d1znna1 12 c1znnF_ 13 c3qjaA_ 14 d1vc4a_ 15 d1a53a_ 16 c2c3zA_ 17 c3tdmD_ 18 c1piiA_ 19 c3igsB_ 20 c3q58A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499