Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	I	I	I	L	G	A	G	Q	V	G	G	T	L	A	E	N	L	V	G	E	N	N	D	I	T	V	V	D	T	N	G	E	R	L	R	T	L	Q	D	K	F	D	L	R	V	V	Q	G	H	G	S	H	P	R	V	L	R	E
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	A	D	D	A	D	M	L	V	A	V	T	S	S	D	E	T	N	M	V	A	C	Q	V	A	Y	S	L	F	N	T	P	N	R	I	A	R	I	R	S	P	D	Y	V	R	D	A	D	K	L	F	H	S	D	A	V	P	I	D
Secondary structure
SS confidence
Disorder																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	L	I	A	P	E	Q	L	V	I	D	N	I	Y	R	L	I	E	Y	P	G	A	L	Q	V	V	N	F	A	E	G	K	V	S	L	A	V	V	K	A	Y	Y	G	G	P	L	I	G	N	A	L	S	T	M	R	E	H	M	P	H
Secondary structure
SS confidence
Disorder																		?																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	D	T	R	V	A	A	I	F	R	H	D	R	P	I	R	P	Q	G	S	T	I	V	E	A	G	D	E	V	F	F	I	A	A	S	Q	H	I	R	A	V	M	S	E	L	Q	R	L	E	K	P	Y	K	R	I	M	L	V	G	G
Secondary structure
SS confidence
Disorder																																																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	N	I	G	A	G	L	A	R	R	L	E	K	D	Y	S	V	K	L	I	E	R	N	Q	Q	R	A	A	E	L	A	E	K	L	Q	N	T	I	V	F	F	G	D	A	S	D	Q	E	L	L	A	E	E	H	I	D	Q	V	D	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	I	A	V	T	N	D	D	E	A	N	I	M	S	A	M	L	A	K	R	M	G	A	K	K	V	M	V	L	I	Q	R	R	A	Y	V	D	L	V	Q	G	S	V	I	D	I	A	I	S	P	Q	Q	A	T	I	S	A	L	L	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		H	V	R	K	A	D	I	V	G	V	S	S	L	R	R	G	V	A	E	A	I	E	A	V	A	H	G	D	E	S	T	S	R	V	V	G	R	V	I	D	E	I	K	L	P	P	G	T	I	I	G	A	V	V	R	G	N	D	V	M
Secondary structure
SS confidence
Disorder								?																				?				?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.
Sequence		I	A	N	D	N	L	R	I	E	Q	G	D	H	V	I	M	F	L	T	D	K	K	F	I	T	D	V	E	R	L	F	Q	P	S	P	F	F	L
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3mt5 chain A Region: 2 - 438 Aligned: 437 Modelled: 437 Confidence: 100.0% Identity: 15% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:potassium large conductance calcium-activated channel, PDBTitle: crystal structure of the human bk gating apparatus Phyre2 PDB 3u6n chain C Region: 2 - 438 Aligned: 437 Modelled: 437 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: C: PDB Molecule:high-conductance ca2+-activated k+ channel protein; PDBTitle: open structure of the bk channel gating ring Phyre2 PDB 3l4b chain G Region: 1 - 225 Aligned: 210 Modelled: 225 Confidence: 100.0% Identity: 22% PDB header:transport protein Chain: G: PDB Molecule:trka k+ channel protien tm1088b; PDBTitle: crystal structure of an octomeric two-subunit trka k+ channel ring2 gating assembly, tm1088a:tm1088b, from thermotoga maritima Phyre2 PDB 2fy8 chain A Region: 2 - 226 Aligned: 216 Modelled: 225 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:calcium-gated potassium channel mthk; PDBTitle: crystal structure of mthk rck domain in its ligand-free gating-ring2 form Phyre2 PDB 3naf chain A Region: 2 - 438 Aligned: 437 Modelled: 437 Confidence: 100.0% Identity: 15% PDB header:ion transport Chain: A: PDB Molecule:calcium-activated potassium channel subunit alpha-1; PDBTitle: structure of the intracellular gating ring from the human high-2 conductance ca2+ gated k+ channel (bk channel) Phyre2 PDB 1lnq chain C Region: 2 - 226 Aligned: 216 Modelled: 225 Confidence: 100.0% Identity: 15% PDB header:metal transport Chain: C: PDB Molecule:potassium channel related protein; PDBTitle: crystal structure of mthk at 3.3 a Phyre2 PDB 3eyw chain A Region: 1 - 138 Aligned: 131 Modelled: 132 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:c-terminal domain of glutathione-regulated potassium-efflux PDBTitle: crystal structure of the c-terminal domain of e. coli kefc in complex2 with keff Phyre2 PDB 1lss chain A Region: 1 - 139 Aligned: 132 Modelled: 139 Confidence: 100.0% Identity: 35% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Potassium channel NAD-binding domain Phyre2 PDB 3fwz chain A Region: 2 - 140 Aligned: 132 Modelled: 139 Confidence: 99.9% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:inner membrane protein ybal; PDBTitle: crystal structure of trka-n domain of inner membrane protein ybal from2 escherichia coli Phyre2 PDB 1id1 chain A Region: 2 - 146 Aligned: 139 Modelled: 145 Confidence: 99.9% Identity: 15% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Potassium channel NAD-binding domain Phyre2 PDB 2g1u chain A Region: 2 - 140 Aligned: 132 Modelled: 138 Confidence: 99.9% Identity: 30% PDB header:transport protein Chain: A: PDB Molecule:hypothetical protein tm1088a; PDBTitle: crystal structure of a putative transport protein (tm1088a) from2 thermotoga maritima at 1.50 a resolution Phyre2 PDB 2hmv chain A domain 1 Region: 2 - 141 Aligned: 133 Modelled: 140 Confidence: 99.9% Identity: 15% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Potassium channel NAD-binding domain Phyre2 PDB 3llv chain A Region: 2 - 138 Aligned: 129 Modelled: 137 Confidence: 99.9% Identity: 18% PDB header:nad(p) binding protein Chain: A: PDB Molecule:exopolyphosphatase-related protein; PDBTitle: the crystal structure of the nad(p)-binding domain of an2 exopolyphosphatase-related protein from archaeoglobus fulgidus to3 1.7a Phyre2 PDB 2fy8 chain A domain 1 Region: 2 - 137 Aligned: 127 Modelled: 136 Confidence: 99.9% Identity: 15% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Potassium channel NAD-binding domain Phyre2 PDB 3c85 chain A Region: 2 - 148 Aligned: 140 Modelled: 147 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:putative glutathione-regulated potassium-efflux system PDBTitle: crystal structure of trka domain of putative glutathione-regulated2 potassium-efflux kefb from vibrio parahaemolyticus Phyre2 PDB 1e5q chain A domain 1 Region: 1 - 179 Aligned: 171 Modelled: 179 Confidence: 99.7% Identity: 13% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 3jxo chain B Region: 366 - 451 Aligned: 81 Modelled: 86 Confidence: 99.3% Identity: 28% PDB header:transport protein Chain: B: PDB Molecule:trka-n domain protein; PDBTitle: crystal structure of an octomeric two-subunit trka k+ channel ring2 gating assembly, tm1088a:tm1088b, from thermotoga maritima Phyre2 PDB 2fy8 chain A domain 2 Region: 148 - 227 Aligned: 80 Modelled: 80 Confidence: 99.1% Identity: 16% Fold: TrkA C-terminal domain-like Superfamily: TrkA C-terminal domain-like Family: TrkA C-terminal domain-like Phyre2 PDB 2bkn chain A Region: 128 - 230 Aligned: 103 Modelled: 103 Confidence: 99.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:hypothetical protein ph0236; PDBTitle: structure analysis of unknown function protein Phyre2 PDB 1vct chain A domain 2 Region: 148 - 233 Aligned: 86 Modelled: 86 Confidence: 99.0% Identity: 13% Fold: TrkA C-terminal domain-like Superfamily: TrkA C-terminal domain-like Family: TrkA C-terminal domain-like Phyre2 1 c3mt5A_ 2 c3u6nC_ 3 c3l4bG_ 4 c2fy8A_ 5 c3nafA_ 6 c1lnqC_ 7 c3eywA_ 8 d1lssa_ 9 c3fwzA_ 10 d1id1a_ 11 c2g1uA_ 12 d2hmva1 13 c3llvA_ 14 d2fy8a1 15 c3c85A_ 16 d1e5qa1 17 c3jxoB_ 18 d2fy8a2 19 c2bknA_ 20 d1vcta2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499