Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP08839
DateThu Jan 5 11:01:38 GMT 2012
Unique Job ID3546c154e9a788ac

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2hwgA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
Confidence and coverage
Confidence:100.0% Coverage: 99%
571 residues ( 99% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MISGILASPGIAFGKALLLKEDEIVIDRKKISADQVDQEVERFLSGRAKASAQLETIKTK
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Disorder  ???????















?

????
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   .........70.........80.........90.........100.........110.........120
Sequence  AGETFGEEKEAIFEGHIMLLEDEELEQEIIALIKDKHMTADAAAHEVIEGQASALEELDD
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Disorder 

??????
















































???
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   .........130.........140.........150.........160.........170.........180
Sequence  EYLKERAADVRDIGKRLLRNILGLKIIDLSAIQDEVILVAADLTPSETAQLNLKKVLGFI
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?
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   .........190.........200.........210.........220.........230.........240
Sequence  TDAGGRTSHTSIMARSLELPAIVGTGSVTSQVKNDDYLILDAVNNQVYVNPTNEVIDKMR
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   .........250.........260.........270.........280.........290.........300
Sequence  AVQEQVASEKAELAKLKDLPAITLDGHQVEVCANIGTVRDVEGAERNGAEGVGLYRTEFL
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   .........310.........320.........330.........340.........350.........360
Sequence  FMDRDALPTEEEQFAAYKAVAEACGSQAVIVRTMDIGGDKELPYMNFPKEENPFLGWRAI
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   .........370.........380.........390.........400.........410.........420
Sequence  RIAMDRREILRDQLRAILRASAFGKLRIMFPMIISVEEVRALRKEIEIYKQELRDEGKAF
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?????
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   .........430.........440.........450.........460.........470.........480
Sequence  DESIEIGVMVETPAAATIARHLAKEVDFFSIGTNDLTQYTLAVDRGNDMISHLYQPMSPS
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   .........490.........500.........510.........520.........530.........540
Sequence  VLNLIKQVIDASHAEGKWTGMCGELAGDERATLLLLGMGLDEFSMSAISIPRIKKIIRNT
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   .........550.........560.........570.....
Sequence  NFEDAKVLAEQALAQPTTDELMTLVNKFIEEKTIC
Secondary structure 








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????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2hwg chain A

3D model

Region: 2 - 573
Aligned: 571
Modelled: 566
Confidence: 100.0%
Identity: 97%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system

Phyre2

PDB 2hro chain A

3D model

Region: 2 - 570
Aligned: 550
Modelled: 566
Confidence: 100.0%
Identity: 52%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus

Phyre2

PDB 1h6z chain A

3D model

Region: 4 - 547
Aligned: 515
Modelled: 519
Confidence: 100.0%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei

Phyre2

PDB 1kbl chain A

3D model

Region: 67 - 539
Aligned: 456
Modelled: 460
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase

Phyre2

PDB 2bg5 chain C

3D model

Region: 251 - 571
Aligned: 321
Modelled: 321
Confidence: 100.0%
Identity: 58%
PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)

Phyre2

PDB 1vbh chain A

3D model

Region: 67 - 540
Aligned: 454
Modelled: 461
Confidence: 100.0%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize

Phyre2

PDB 2ols chain A

3D model

Region: 143 - 539
Aligned: 354
Modelled: 364
Confidence: 100.0%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis

Phyre2

PDB 1h6z chain A domain 1

3D model

Region: 251 - 547
Aligned: 293
Modelled: 297
Confidence: 100.0%
Identity: 28%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1vbg chain A domain 1

3D model

Region: 252 - 541
Aligned: 286
Modelled: 290
Confidence: 100.0%
Identity: 29%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1kbl chain A domain 1

3D model

Region: 251 - 539
Aligned: 285
Modelled: 289
Confidence: 100.0%
Identity: 31%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1eza chain A

3D model

Region: 1 - 259
Aligned: 259
Modelled: 259
Confidence: 100.0%
Identity: 100%
PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure

Phyre2

PDB 1zym chain A domain 2

3D model

Region: 140 - 249
Aligned: 110
Modelled: 110
Confidence: 99.9%
Identity: 96%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Family: N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system

Phyre2

PDB 1zym chain A domain 1

3D model

Region: 22 - 143
Aligned: 122
Modelled: 122
Confidence: 99.9%
Identity: 100%
Fold: SAM domain-like
Superfamily: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain

Phyre2

PDB 1dxe chain A

3D model

Region: 264 - 540
Aligned: 211
Modelled: 244
Confidence: 99.9%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: HpcH/HpaI aldolase

Phyre2

PDB 3qz6 chain A

3D model

Region: 269 - 549
Aligned: 215
Modelled: 245
Confidence: 99.9%
Identity: 22%
PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2

Phyre2

PDB 1izc chain A

3D model

Region: 264 - 551
Aligned: 227
Modelled: 250
Confidence: 99.8%
Identity: 21%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: HpcH/HpaI aldolase

Phyre2

PDB 1izc chain A

3D model

Region: 264 - 551
Aligned: 227
Modelled: 255
Confidence: 99.8%
Identity: 21%
PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase

Phyre2

PDB 1vbg chain A domain 2

3D model

Region: 148 - 236
Aligned: 87
Modelled: 89
Confidence: 99.8%
Identity: 21%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Family: Pyruvate phosphate dikinase, central domain

Phyre2

PDB 2v5j chain B

3D model

Region: 264 - 536
Aligned: 208
Modelled: 231
Confidence: 99.8%
Identity: 24%
PDB header:lyase
Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
PDBTitle: apo class ii aldolase hpch

Phyre2

PDB 1h6z chain A domain 2

3D model

Region: 116 - 230
Aligned: 111
Modelled: 115
Confidence: 99.8%
Identity: 23%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Family: Pyruvate phosphate dikinase, central domain

Phyre2
1

c2hwgA_
2

c2hroA_
3

c1h6zA_
4

c1kblA_
5

c2bg5C_
6

c1vbhA_
7

c2olsA_
8

d1h6za1
9

d1vbga1
10

d1kbla1
11

c1ezaA_
12

d1zyma2
13

d1zyma1
14

d1dxea_
15

c3qz6A_
16

d1izca_
17

c1izcA_
18

d1vbga2
19

c2v5jB_
20

d1h6za2
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2hwgA_



100.0 97 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
2c2hroA_



100.0 52 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus
3c1h6zA_



100.0 23 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei
4c1kblA_



100.0 26 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase
5c2bg5C_



100.0 58 PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)
6c1vbhA_



100.0 24 PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize
7c2olsA_



100.0 27 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis
8d1h6za1



100.0 28 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
9d1vbga1



100.0 29 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
10d1kbla1



100.0 31 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
11c1ezaA_



100.0 100 PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure
12d1zyma2



99.9 96 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system
13d1zyma1



99.9 100 Fold:SAM domain-like
Superfamily:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
14d1dxea_



99.9 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
15c3qz6A_



99.9 22 PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2
16d1izca_



99.8 21 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
17c1izcA_



99.8 21 PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase
18d1vbga2



99.8 21 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
19c2v5jB_



99.8 24 PDB header:lyase
Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
PDBTitle: apo class ii aldolase hpch
20d1h6za2



99.8 23 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
21d1kbla2



not modelled 99.8 26 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
22c2vwtA_



not modelled 99.8 21 PDB header:lyase
Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase;
PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex
23c3t07D_



not modelled 99.5 18 PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid
24c2e28A_



not modelled 99.4 28 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus
25c3qqwC_



not modelled 99.4 15 PDB header:lyase
Chain: C: PDB Molecule:putative citrate lyase;
PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution
26c1sgjB_



not modelled 99.3 21 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase, beta subunit;
PDBTitle: crystal structure of citrate lyase beta subunit
27d1sgja_



not modelled 99.3 21 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
28d1e0ta2



not modelled 99.2 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
29d2g50a2



not modelled 99.2 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
30d1a3xa2



not modelled 99.2 17 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
31d1pkla2



not modelled 99.1 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
32c3r4iB_



not modelled 99.0 27 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase;
PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution
33d1liua2



not modelled 99.0 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
34c1u5vA_



not modelled 99.0 18 PDB header:lyase
Chain: A: PDB Molecule:cite;
PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis
35d1u5ha_



not modelled 99.0 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
36c3cuzA_



not modelled 98.8 13 PDB header:transferase
Chain: A: PDB Molecule:malate synthase a;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
37c3qllB_



not modelled 98.7 14 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase;
PDBTitle: crystal structure of ripc from yersinia pestis
38c3cuxA_



not modelled 98.3 16 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
39c2vgbB_



not modelled 98.3 18 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase isozymes r/l;
PDBTitle: human erythrocyte pyruvate kinase
40c3ma8A_



not modelled 98.1 17 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum
41c3eoeC_



not modelled 98.1 16 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007
42c3pugA_



not modelled 97.9 17 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate
43c1e0tD_



not modelled 97.9 15 PDB header:phosphotransferase
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: r292d mutant of e. coli pyruvate kinase
44c1aqfB_



not modelled 97.7 15 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate
45c1t5aB_



not modelled 97.7 17 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme;
PDBTitle: human pyruvate kinase m2
46c3e0vB_



not modelled 97.6 20 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions
47c1a3wB_



not modelled 97.6 18 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+
48c1pklB_



not modelled 97.6 20 PDB header:transferase
Chain: B: PDB Molecule:protein (pyruvate kinase);
PDBTitle: the structure of leishmania pyruvate kinase
49d1d8ca_



not modelled 97.5 14 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
50c3khdC_



not modelled 96.7 24 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pff1300w.
51c2zbtB_



not modelled 95.3 21 PDB header:lyase
Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: crystal structure of pyridoxine biosynthesis protein from thermus2 thermophilus hb8
52c2nv2U_



not modelled 94.8 23 PDB header:lyase/transferase
Chain: U: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: structure of the plp synthase complex pdx1/2 (yaad/e) from bacillus2 subtilis
53c3femB_



not modelled 94.6 22 PDB header:biosynthetic protein, transferase
Chain: B: PDB Molecule:pyridoxine biosynthesis protein snz1;
PDBTitle: structure of the synthase subunit pdx1.1 (snz1) of plp synthase from2 saccharomyces cerevisiae
54d1eepa_



not modelled 94.4 20 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
55c2a7rD_



not modelled 93.6 18 PDB header:oxidoreductase
Chain: D: PDB Molecule:gmp reductase 2;
PDBTitle: crystal structure of human guanosine monophosphate2 reductase 2 (gmpr2)
56d1vrda1



not modelled 92.7 21 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
57d1jr1a1



not modelled 92.0 16 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
58c3odmE_



not modelled 92.0 15 PDB header:lyase
Chain: E: PDB Molecule:phosphoenolpyruvate carboxylase;
PDBTitle: archaeal-type phosphoenolpyruvate carboxylase
59d1n8ia_



not modelled 91.9 13 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
60d2hi6a1



not modelled 91.7 25 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:AF0055-like
61c3r2gA_



not modelled 91.0 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila
62c1vrdA_



not modelled 90.8 21 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase (tm1347)2 from thermotoga maritima at 2.18 a resolution
63d1zfja1



not modelled 89.7 16 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
64c3khjE_



not modelled 88.5 22 PDB header:oxidoreductase
Chain: E: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: c. parvum inosine monophosphate dehydrogenase bound by inhibitor c64
65c1jcnA_



not modelled 87.7 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase i;
PDBTitle: binary complex of human type-i inosine monophosphate dehydrogenase2 with 6-cl-imp
66d1tb3a1



not modelled 87.6 24 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
67c3qjaA_



not modelled 86.9 16 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form
68d1pvna1



not modelled 86.7 15 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
69c3pm6B_



not modelled 86.1 13 PDB header:lyase
Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase;
PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr
70d1jcna1



not modelled 83.3 20 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
71c2yzrB_



not modelled 82.9 21 PDB header:lyase
Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: crystal structure of pyridoxine biosynthesis protein from2 methanocaldococcus jannaschii
72c2vc6A_



not modelled 82.3 26 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: structure of mosa from s. meliloti with pyruvate bound
73d2cu0a1



not modelled 79.8 22 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
74d2gp4a1



not modelled 77.4 19 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:IlvD/EDD C-terminal domain-like
75c1ypfB_



not modelled 77.1 18 PDB header:oxidoreductase
Chain: B: PDB Molecule:gmp reductase;
PDBTitle: crystal structure of guac (ba5705) from bacillus anthracis at 1.8 a2 resolution
76c2e77B_



not modelled 75.2 17 PDB header:oxidoreductase
Chain: B: PDB Molecule:lactate oxidase;
PDBTitle: crystal structure of l-lactate oxidase with pyruvate complex
77c2zrvC_



not modelled 74.9 22 PDB header:isomerase
Chain: C: PDB Molecule:isopentenyl-diphosphate delta-isomerase;
PDBTitle: crystal structure of sulfolobus shibatae isopentenyl2 diphosphate isomerase in complex with reduced fmn.
78d1goxa_



not modelled 74.7 24 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
79d1o5ka_



not modelled 74.5 24 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
80c2f7fA_



not modelled 73.7 17 PDB header:transferase
Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase, putative;
PDBTitle: crystal structure of enterococcus faecalis putative nicotinate2 phosphoribosyltransferase, new york structural genomics consortium
81c2rduA_



not modelled 72.3 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:hydroxyacid oxidase 1;
PDBTitle: crystal structure of human glycolate oxidase in complex with2 glyoxylate
82c2gp4A_



not modelled 71.8 21 PDB header:lyase
Chain: A: PDB Molecule:6-phosphogluconate dehydratase;
PDBTitle: structure of [fes]cluster-free apo form of 6-phosphogluconate2 dehydratase from shewanella oneidensis
83c3n2xB_



not modelled 70.9 15 PDB header:lyase
Chain: B: PDB Molecule:uncharacterized protein yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to the2 dihydrodipicolinic acid synthase family from e. coli k12 in complex3 with pyruvate
84d1j93a_



not modelled 70.8 12 Fold:TIM beta/alpha-barrel
Superfamily:UROD/MetE-like
Family:Uroporphyrinogen decarboxylase, UROD
85c2qr6A_



not modelled 69.4 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:imp dehydrogenase/gmp reductase;
PDBTitle: crystal structure of imp dehydrogenase/gmp reductase-like protein2 (np_599840.1) from corynebacterium glutamicum atcc 13032 kitasato at3 1.50 a resolution
86c1me9A_



not modelled 68.7 16 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh) from2 tritrichomonas foetus with imp bound
87c3s5oA_



not modelled 68.6 14 PDB header:lyase
Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase, mitochondrial;
PDBTitle: crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to2 pyruvate
88c3lerA_



not modelled 68.5 23 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168
89d1a53a_



not modelled 68.3 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
90c3pueA_



not modelled 68.3 21 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of the complex of dhydrodipicolinate synthase from2 acinetobacter baumannii with lysine at 2.6a resolution
91d1qapa1



not modelled 67.9 14 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
92c2cu0B_



not modelled 66.8 22 PDB header:oxidoreductase
Chain: B: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase from2 pyrococcus horikoshii ot3
93c3lciA_



not modelled 64.8 20 PDB header:lyase
Chain: A: PDB Molecule:n-acetylneuraminate lyase;
PDBTitle: the d-sialic acid aldolase mutant v251w
94c2ehhE_



not modelled 63.8 15 PDB header:lyase
Chain: E: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 aquifex aeolicus
95d1hl2a_



not modelled 62.9 18 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
96c3na8A_



not modelled 62.5 24 PDB header:lyase
Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase;
PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa
97c2a7nA_



not modelled 61.5 19 PDB header:oxidoreductase
Chain: A: PDB Molecule:l(+)-mandelate dehydrogenase;
PDBTitle: crystal structure of the g81a mutant of the active chimera of (s)-2 mandelate dehydrogenase
98c3dz1A_



not modelled 60.4 14 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 1.87a resolution
99c2c3zA_



not modelled 60.1 18 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus
100c2pkpA_



not modelled 60.0 17 PDB header:lyase
Chain: A: PDB Molecule:homoaconitase small subunit;
PDBTitle: crystal structure of 3-isopropylmalate dehydratase (leud)2 from methhanocaldococcus jannaschii dsm2661 (mj1271)
101c3cprB_



not modelled 58.7 25 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthetase;
PDBTitle: the crystal structure of corynebacterium glutamicum2 dihydrodipicolinate synthase to 2.2 a resolution
102d1xxxa1



not modelled 58.1 27 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
103c3iz5H_



not modelled 57.9 34 PDB header:ribosome
Chain: H: PDB Molecule:60s ribosomal protein l7a (l7ae);
PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
104d1qpoa1



not modelled 57.6 17 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
105c2rfgB_



not modelled 57.2 21 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from hahella2 chejuensis at 1.5a resolution
106c2r8wB_



not modelled 56.9 18 PDB header:lyase
Chain: B: PDB Molecule:agr_c_1641p;
PDBTitle: the crystal structure of dihydrodipicolinate synthase (atu0899) from2 agrobacterium tumefaciens str. c58
107c2v9dB_



not modelled 56.4 15 PDB header:lyase
Chain: B: PDB Molecule:yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to2 the dihydrodipicolinic acid synthase family from e. coli3 k12
108c3daqB_



not modelled 55.6 15 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus
109c1zfjA_



not modelled 55.0 16 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from2 streptococcus pyogenes
110d1v7la_



not modelled 55.0 13 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:LeuD-like
111c1kbiB_



not modelled 54.6 24 PDB header:oxidoreductase
Chain: B: PDB Molecule:cytochrome b2;
PDBTitle: crystallographic study of the recombinant flavin-binding domain of2 baker's yeast flavocytochrome b2: comparison with the intact wild-3 type enzyme
112c3ke8A_



not modelled 54.2 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:4-hydroxy-3-methylbut-2-enyl diphosphate
PDBTitle: crystal structure of isph:hmbpp-complex
113c2yxgD_



not modelled 54.1 18 PDB header:lyase
Chain: D: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihyrodipicolinate synthase (dapa)
114c2cdh1_



not modelled 54.0 18 PDB header:transferase
Chain: 1: PDB Molecule:enoyl reductase;
PDBTitle: architecture of the thermomyces lanuginosus fungal fatty2 acid synthase at 5 angstrom resolution.
115c2zkrf_



not modelled 54.0 29 PDB header:ribosomal protein/rna
Chain: F: PDB Molecule:rna expansion segment es7 part iii;
PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map
116c1x1oC_



not modelled 52.5 17 PDB header:transferase
Chain: C: PDB Molecule:nicotinate-nucleotide pyrophosphorylase;
PDBTitle: crystal structure of project id tt0268 from thermus thermophilus hb8
117c2vy9A_



not modelled 52.4 16 PDB header:gene regulation
Chain: A: PDB Molecule:anti-sigma-factor antagonist;
PDBTitle: molecular architecture of the stressosome, a signal2 integration and transduction hub
118c3noeA_



not modelled 52.1 22 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa
119d1o4ua1



not modelled 50.6 25 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
120c3izcH_



not modelled 50.1 29 PDB header:ribosome
Chain: H: PDB Molecule:60s ribosomal protein rpl8 (l7ae);
PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0