Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	E	Q	A	T	T	T	D	E	L	A	F	T	R	P	Y	G	E	Q	E	K	Q	I	L	T	A	E	A	V	E	F	L	T	E	L	V	T	H	F	T	P	Q	R	N	K	L	L	A	A	R	I	Q	Q	Q	Q	D	I	D	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																																																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	T	L	P	D	F	I	S	E	T	A	S	I	R	D	A	D	W	K	I	R	G	I	P	A	D	L	E	D	R	R	V	E	I	T	G	P	V	E	R	K	M	V	I	N	A	L	N	A	N	V	K	V	F	M	A	D	F	E	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	L	A	P	D	W	N	K	V	I	D	G	Q	I	N	L	R	D	A	V	N	G	T	I	S	Y	T	N	E	A	G	K	I	Y	Q	L	K	P	N	P	A	V	L	I	C	R	V	R	G	L	H	L	P	E	K	H	V	T	W	R
Secondary structure
SS confidence
Disorder																																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	E	A	I	P	G	S	L	F	D	F	A	L	Y	F	F	H	N	Y	Q	A	L	L	A	K	G	S	G	P	Y	F	Y	L	P	K	T	Q	S	W	Q	E	A	A	W	W	S	E	V	F	S	Y	A	E	D	R	F	N	L	P	R
Secondary structure
SS confidence
Disorder																									?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	T	I	K	A	T	L	L	I	E	T	L	P	A	V	F	Q	M	D	E	I	L	H	A	L	R	D	H	I	V	G	L	N	C	G	R	W	D	Y	I	F	S	Y	I	K	T	L	K	N	Y	P	D	R	V	L	P	D	R	Q	A
Secondary structure
SS confidence
Disorder																																																		?		?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	T	M	D	K	P	F	L	N	A	Y	S	R	L	L	I	K	T	C	H	K	R	G	A	F	A	M	G	G	M	A	A	F	I	P	S	K	D	E	E	H	N	N	Q	V	L	N	K	V	K	A	D	K	S	L	E	A	N	N	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		H	D	G	T	W	I	A	H	P	G	L	A	D	T	A	M	A	V	F	N	D	I	L	G	S	R	K	N	Q	L	E	V	M	R	E	Q	D	A	P	I	T	A	D	Q	L	L	A	P	C	D	G	E	R	T	E	E	G	M	R	A
Secondary structure
SS confidence
Disorder																										?		?	?					?		?	?									?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		N	I	R	V	A	V	Q	Y	I	E	A	W	I	S	G	N	G	C	V	P	I	Y	G	L	M	E	D	A	A	T	A	E	I	S	R	T	S	I	W	Q	W	I	H	H	Q	K	T	L	S	N	G	K	P	V	T	K	A	L	F	R
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.
Sequence		Q	M	L	G	E	E	M	K	V	I	A	S	E	L	G	E	E	R	F	S	Q	G	R	F	D	D	A	A	R	L	M	E	Q	I	T	T	S	D	E	L	I	D	F	L	T	L	P	G	Y	R	L	L	A
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?																												?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3cuz chain A Region: 5 - 533 Aligned: 529 Modelled: 529 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:malate synthase a; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 3cux chain A Region: 11 - 532 Aligned: 499 Modelled: 504 Confidence: 100.0% Identity: 55% PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 1n8i chain A Region: 113 - 529 Aligned: 396 Modelled: 416 Confidence: 100.0% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Malate synthase G Family: Malate synthase G Phyre2 PDB 1d8c chain A Region: 113 - 529 Aligned: 400 Modelled: 417 Confidence: 100.0% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Malate synthase G Family: Malate synthase G Phyre2 PDB 3pug chain A Region: 90 - 485 Aligned: 318 Modelled: 323 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate Phyre2 PDB 3r4i chain B Region: 98 - 458 Aligned: 274 Modelled: 289 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:citrate lyase; PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution Phyre2 PDB 3qqw chain C Region: 72 - 433 Aligned: 275 Modelled: 290 Confidence: 100.0% Identity: 15% PDB header:lyase Chain: C: PDB Molecule:putative citrate lyase; PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution Phyre2 PDB 1sgj chain B Region: 88 - 379 Aligned: 227 Modelled: 245 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: B: PDB Molecule:citrate lyase, beta subunit; PDBTitle: crystal structure of citrate lyase beta subunit Phyre2 PDB 1sgj chain A Region: 88 - 379 Aligned: 227 Modelled: 245 Confidence: 100.0% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 1u5v chain A Region: 87 - 380 Aligned: 218 Modelled: 241 Confidence: 100.0% Identity: 20% PDB header:lyase Chain: A: PDB Molecule:cite; PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis Phyre2 PDB 1u5h chain A Region: 89 - 380 Aligned: 216 Modelled: 230 Confidence: 100.0% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 1dxe chain A Region: 98 - 380 Aligned: 202 Modelled: 233 Confidence: 99.9% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 2v5j chain B Region: 98 - 380 Aligned: 198 Modelled: 233 Confidence: 99.8% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PDBTitle: apo class ii aldolase hpch Phyre2 PDB 1izc chain A Region: 98 - 380 Aligned: 203 Modelled: 240 Confidence: 99.8% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase; PDBTitle: crystal structure analysis of macrophomate synthase Phyre2 PDB 1izc chain A Region: 98 - 380 Aligned: 203 Modelled: 246 Confidence: 99.8% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: HpcH/HpaI aldolase Phyre2 PDB 2vwt chain A Region: 98 - 362 Aligned: 182 Modelled: 204 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase; PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex Phyre2 PDB 3qz6 chain A Region: 94 - 326 Aligned: 167 Modelled: 175 Confidence: 99.7% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:hpch/hpai aldolase; PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2 Phyre2 PDB 1e0t chain A domain 2 Region: 90 - 327 Aligned: 171 Modelled: 184 Confidence: 99.7% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Pyruvate kinase Phyre2 PDB 1a3x chain A domain 2 Region: 90 - 380 Aligned: 221 Modelled: 235 Confidence: 99.6% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Pyruvate kinase Phyre2 PDB 1pkl chain A domain 2 Region: 79 - 327 Aligned: 180 Modelled: 199 Confidence: 99.4% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Pyruvate kinase Phyre2 1 c3cuzA_ 2 c3cuxA_ 3 d1n8ia_ 4 d1d8ca_ 5 c3pugA_ 6 c3r4iB_ 7 c3qqwC_ 8 c1sgjB_ 9 d1sgja_ 10 c1u5vA_ 11 d1u5ha_ 12 d1dxea_ 13 c2v5jB_ 14 c1izcA_ 15 d1izca_ 16 c2vwtA_ 17 c3qz6A_ 18 d1e0ta2 19 d1a3xa2 20 d1pkla2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3cuzA_ 100.0 100 PDB header:transferase Chain: A: PDB Molecule:malate synthase a; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design 2 c3cuxA_ 100.0 55 PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design 3 d1n8ia_ 100.0 21 Fold:TIM beta/alpha-barrel Superfamily:Malate synthase G Family:Malate synthase G 4 d1d8ca_ 100.0 19 Fold:TIM beta/alpha-barrel Superfamily:Malate synthase G Family:Malate synthase G 5 c3pugA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate 6 c3r4iB_ 100.0 17 PDB header:lyase Chain: B: PDB Molecule:citrate lyase; PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution 7 c3qqwC_ 100.0 15 PDB header:lyase Chain: C: PDB Molecule:putative citrate lyase; PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution 8 c1sgjB_ 100.0 16 PDB header:lyase Chain: B: PDB Molecule:citrate lyase, beta subunit; PDBTitle: crystal structure of citrate lyase beta subunit 9 d1sgja_ 100.0 16 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:HpcH/HpaI aldolase 10 c1u5vA_ 100.0 20 PDB header:lyase Chain: A: PDB Molecule:cite; PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis 11 d1u5ha_ 100.0 20 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:HpcH/HpaI aldolase 12 d1dxea_ 99.9 19 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:HpcH/HpaI aldolase 13 c2v5jB_ 99.8 20 PDB header:lyase Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PDBTitle: apo class ii aldolase hpch 14 c1izcA_ 99.8 16 PDB header:lyase Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase; PDBTitle: crystal structure analysis of macrophomate synthase 15 d1izca_ 99.8 16 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:HpcH/HpaI aldolase 16 c2vwtA_ 99.8 18 PDB header:lyase Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase; PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex 17 c3qz6A_ 99.7 19 PDB header:lyase Chain: A: PDB Molecule:hpch/hpai aldolase; PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2 18 d1e0ta2 99.7 22 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 19 d1a3xa2 99.6 19 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 20 d1pkla2 99.4 19 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 21 d2g50a2 not modelled 99.3 15 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 22 d1liua2 not modelled 99.3 19 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 23 c2hwgA_ not modelled 98.9 10 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system 24 c2hroA_ not modelled 98.8 10 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus 25 c2bg5C_ not modelled 98.8 14 PDB header:transferase Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase; PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts) 26 d1h6za1 not modelled 98.7 12 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate phosphate dikinase, C-terminal domain 27 d1vbga1 not modelled 98.6 18 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate phosphate dikinase, C-terminal domain 28 c1vbhA_ not modelled 98.6 17 PDB header:transferase Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase; PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize 29 c1t5aB_ not modelled 98.4 18 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme; PDBTitle: human pyruvate kinase m2 30 c2vgbB_ not modelled 98.3 14 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase isozymes r/l; PDBTitle: human erythrocyte pyruvate kinase 31 c1aqfB_ not modelled 98.3 18 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase; PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate 32 c3khdC_ not modelled 98.3 20 PDB header:transferase Chain: C: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pff1300w. 33 c1h6zA_ not modelled 98.3 13 PDB header:transferase Chain: A: PDB Molecule:pyruvate phosphate dikinase; PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei 34 d1kbla1 not modelled 98.1 12 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate phosphate dikinase, C-terminal domain 35 c1e0tD_ not modelled 98.1 19 PDB header:phosphotransferase Chain: D: PDB Molecule:pyruvate kinase; PDBTitle: r292d mutant of e. coli pyruvate kinase 36 c1kblA_ not modelled 98.1 15 PDB header:transferase Chain: A: PDB Molecule:pyruvate phosphate dikinase; PDBTitle: pyruvate phosphate dikinase 37 c1a3wB_ not modelled 98.0 20 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase; PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+ 38 c3ma8A_ not modelled 98.0 18 PDB header:transferase Chain: A: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum 39 c1pklB_ not modelled 97.9 17 PDB header:transferase Chain: B: PDB Molecule:protein (pyruvate kinase); PDBTitle: the structure of leishmania pyruvate kinase 40 c2olsA_ not modelled 97.9 14 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate synthase; PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis 41 c3e0vB_ not modelled 97.8 19 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions 42 c2e28A_ not modelled 97.7 21 PDB header:transferase Chain: A: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus 43 c3eoeC_ not modelled 97.7 18 PDB header:transferase Chain: C: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007 44 c3t07D_ not modelled 97.6 20 PDB header:transferase/transferase inhibitor Chain: D: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid 45 c3odmE_ not modelled 97.6 19 PDB header:lyase Chain: E: PDB Molecule:phosphoenolpyruvate carboxylase; PDBTitle: archaeal-type phosphoenolpyruvate carboxylase 46 d1jqoa_ not modelled 76.0 10 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate carboxylase 47 c1jqoA_ not modelled 76.0 10 PDB header:lyase Chain: A: PDB Molecule:phosphoenolpyruvate carboxylase; PDBTitle: crystal structure of c4-form phosphoenolpyruvate carboxylase from2 maize 48 d1jqna_ not modelled 71.4 19 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate carboxylase 49 c3r3sD_ not modelled 62.3 17 PDB header:oxidoreductase Chain: D: PDB Molecule:oxidoreductase; PDBTitle: structure of the ygha oxidoreductase from salmonella enterica 50 c3i1jB_ not modelled 61.0 18 PDB header:oxidoreductase Chain: B: PDB Molecule:oxidoreductase, short chain PDBTitle: structure of a putative short chain dehydrogenase from2 pseudomonas syringae 51 c2x3mA_ not modelled 52.0 36 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein orf239; PDBTitle: crystal structure of hypothetical protein orf239 from pyrobaculum2 spherical virus 52 c3g5oC_ not modelled 40.9 13 PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis 53 d1yxma1 not modelled 40.9 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 54 d1qasa3 not modelled 35.5 28 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 55 d1g0oa_ not modelled 30.2 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 56 d2zkmx4 not modelled 28.4 18 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 57 c3iv6C_ not modelled 26.6 29 PDB header:oxidoreductase Chain: C: PDB Molecule:putative zn-dependent alcohol dehydrogenase; PDBTitle: crystal structure of putative zn-dependent alcohol dehydrogenases from2 rhodobacter sphaeroides. 58 c2gjmA_ not modelled 26.1 16 PDB header:oxidoreductase Chain: A: PDB Molecule:lactoperoxidase; PDBTitle: crystal structure of buffalo lactoperoxidase at 2.75a resolution 59 c3qkbB_ not modelled 25.4 10 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a protein with unknown function which belongs to2 pfam duf74 family (pepe_0654) from pediococcus pentosaceus atcc 257453 at 2.73 a resolution 60 d1q45a_ not modelled 24.2 14 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 61 c3ohmB_ not modelled 22.4 18 PDB header:signaling protein / hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3 62 c1djyB_ not modelled 22.0 28 PDB header:lipid degradation Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c, PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate 63 c3bbnD_ not modelled 22.0 27 PDB header:ribosome Chain: D: PDB Molecule:ribosomal protein s4; PDBTitle: homology model for the spinach chloroplast 30s subunit2 fitted to 9.4a cryo-em map of the 70s chlororibosome. 64 d1mn3a_ not modelled 20.6 23 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:CUE domain 65 c1bknA_ not modelled 20.4 25 PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl 66 d1geea_ not modelled 19.9 30 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 67 d1gtea2 not modelled 19.8 11 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 68 c1ddxA_ not modelled 19.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:protein (prostaglandin h2 synthase-2); PDBTitle: crystal structure of a mixture of arachidonic acid and prostaglandin2 bound to the cyclooxygenase active site of cox-2: prostaglandin3 structure 69 c3pghD_ not modelled 19.4 19 PDB header:oxidoreductase Chain: D: PDB Molecule:cyclooxygenase-2; PDBTitle: cyclooxygenase-2 (prostaglandin synthase-2) complexed with a non-2 selective inhibitor, flurbiprofen 70 c2fjuB_ not modelled 18.9 18 PDB header:signaling protein,apoptosis/hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2 71 c3gdbA_ not modelled 18.9 27 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein spr0440; PDBTitle: crystal structure of spr0440 glycoside hydrolase domain,2 endo-d from streptococcus pneumoniae r6 72 d1cvua1 not modelled 18.3 19 Fold:Heme-dependent peroxidases Superfamily:Heme-dependent peroxidases Family:Myeloperoxidase-like 73 c3ivuB_ not modelled 18.3 12 PDB header:transferase Chain: B: PDB Molecule:homocitrate synthase, mitochondrial; PDBTitle: homocitrate synthase lys4 bound to 2-og 74 d1vyua2 not modelled 18.2 13 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 75 c1pggB_ not modelled 18.2 14 PDB header:oxidoreductase Chain: B: PDB Molecule:prostaglandin h2 synthase-1; PDBTitle: prostaglandin h2 synthase-1 complexed with 1-(4-iodobenzoyl)-5-2 methoxy-2-methylindole-3-acetic acid (iodoindomethacin), trans model 76 c1ht8B_ not modelled 18.2 14 PDB header:oxidoreductase Chain: B: PDB Molecule:prostaglandin h2 synthase-1; PDBTitle: the 2.7 angstrom resolution model of ovine cox-1 complexed with2 alclofenac 77 c3kvoB_ not modelled 18.1 20 PDB header:oxidoreductase Chain: B: PDB Molecule:hydroxysteroid dehydrogenase-like protein 2; PDBTitle: crystal structure of the catalytic domain of human hydroxysteroid2 dehydrogenase like 2 (hsdl2) 78 c1y2iC_ not modelled 17.2 11 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:hypothetical protein s0862; PDBTitle: crystal structure of mcsg target apc27401 from shigella2 flexneri 79 d1y2ia_ not modelled 17.2 11 Fold:Dodecin subunit-like Superfamily:YbjQ-like Family:YbjQ-like 80 c2w91A_ not modelled 16.8 26 PDB header:hydrolase Chain: A: PDB Molecule:endo-beta-n-acetylglucosaminidase d; PDBTitle: structure of a streptococcus pneumoniae family 85 glycoside2 hydrolase, endo-d. 81 c2oyuP_ not modelled 16.7 14 PDB header:oxidoreductase Chain: P: PDB Molecule:prostaglandin g/h synthase 1; PDBTitle: indomethacin-(s)-alpha-ethyl-ethanolamide bound to cyclooxygenase-1 82 c2qr6A_ not modelled 16.6 14 PDB header:oxidoreductase Chain: A: PDB Molecule:imp dehydrogenase/gmp reductase; PDBTitle: crystal structure of imp dehydrogenase/gmp reductase-like protein2 (np_599840.1) from corynebacterium glutamicum atcc 13032 kitasato at3 1.50 a resolution 83 c3qr0A_ not modelled 16.5 17 PDB header:hydrolase Chain: A: PDB Molecule:phospholipase c-beta (plc-beta); PDBTitle: crystal structure of s. officinalis plc21 84 c1zfjA_ not modelled 16.1 16 PDB header:oxidoreductase Chain: A: PDB Molecule:inosine monophosphate dehydrogenase; PDBTitle: inosine monophosphate dehydrogenase (impdh; ec 1.1.1.205) from2 streptococcus pyogenes 85 d1o70a2 not modelled 16.1 9 Fold:FAS1 domain Superfamily:FAS1 domain Family:FAS1 domain 86 c3mdoB_ not modelled 15.7 15 PDB header:ligase Chain: B: PDB Molecule:putative phosphoribosylformylglycinamidine cyclo-ligase; PDBTitle: crystal structure of a putative phosphoribosylformylglycinamidine2 cyclo-ligase (bdi_2101) from parabacteroides distasonis atcc 8503 at3 1.91 a resolution 87 c2a7rD_ not modelled 15.7 22 PDB header:oxidoreductase Chain: D: PDB Molecule:gmp reductase 2; PDBTitle: crystal structure of human guanosine monophosphate2 reductase 2 (gmpr2) 88 c3gafF_ not modelled 15.2 23 PDB header:oxidoreductase Chain: F: PDB Molecule:7-alpha-hydroxysteroid dehydrogenase; PDBTitle: 2.2a crystal structure of 7-alpha-hydroxysteroid2 dehydrogenase from brucella melitensis 89 d2cu0a1 not modelled 14.9 17 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 90 c2kheA_ not modelled 14.9 12 PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 91 d1w6ua_ not modelled 14.8 20 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 92 d1uzma1 not modelled 14.6 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 93 d1q4ga1 not modelled 14.4 14 Fold:Heme-dependent peroxidases Superfamily:Heme-dependent peroxidases Family:Myeloperoxidase-like 94 d1pvna1 not modelled 14.2 17 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 95 d2jn4a1 not modelled 14.1 21 Fold:NifT/FixU barrel-like Superfamily:NifT/FixU-like Family:NifT/FixU 96 c2jn4A_ not modelled 14.1 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein fixu, nift; PDBTitle: solution nmr structure of protein rp4601 from2 rhodopseudomonas palustris. northeast structural genomics3 consortium target rpt2; ontario center for structural4 proteomics target rp4601. 97 d1zfja1 not modelled 14.0 16 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 98 c3rihB_ not modelled 14.0 28 PDB header:oxidoreductase Chain: B: PDB Molecule:short chain dehydrogenase or reductase; PDBTitle: crystal structure of a putative short chain dehydrogenase or reductase2 from mycobacterium abscessus 99 c1d2vD_ not modelled 14.0 19 PDB header:oxidoreductase Chain: D: PDB Molecule:myeloperoxidase; PDBTitle: crystal structure of bromide-bound human myeloperoxidase isoform c at2 ph 5.5

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0