Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP08401
DateThu Jan 5 11:01:29 GMT 2012
Unique Job ID0e99a62ab29891d4

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3d36B_
Top template information
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
Confidence and coverage
Confidence:100.0% Coverage: 45%
214 residues ( 45% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
412 residues ( 87%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MRIGMRLLLGYFLLVAVAAWFVLAIFVKEVKPGVRRATEGTLIDTATLLAELARPDLLSG
Secondary structure 



SS confidence 



























































Disorder  ????



















































????
Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  DPTHGQLAQAFNQLQHRPFRANIGGINKVRNEYHVYMTDAQGKVLFDSANKAVGQDYSRW
Secondary structure 































SS confidence 



























































Disorder  ?????







??????????
????



















????????????
Disorder confidence 



























































 
   .........130.........140.........150.........160.........170.........180
Sequence  NDVWLTLRGQYGARSTLQNPADPESSVMYVAAPIMDGSRLIGVLSVGKPNAAMAPVIKRS
Secondary structure 

















SS confidence 



























































Disorder 





????

??


??








































Disorder confidence 



























































 
   .........190.........200.........210.........220.........230.........240
Sequence  ERRILWASAILLGIALVIGAGMVWWINRSIARLTRYADSVTDNKPVPLPDLGSSELRKLA
Secondary structure 














SS confidence 



























































Disorder 








































?????
??????






Disorder confidence 



























































 
   .........250.........260.........270.........280.........290.........300
Sequence  QALESMRVKLEGKNYIEQYVYALTHELKSPLAAIRGAAEILREGPPPEVVARFTDNILTQ
Secondary structure 






SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........310.........320.........330.........340.........350.........360
Sequence  NARMQALVETLLRQARLENRQEVVLTAVDVAALFRRVSEARTVQLAEKKITLHVTPTEVN
Secondary structure 

















SS confidence 



























































Disorder 















????????




















?













Disorder confidence 



























































 
   .........370.........380.........390.........400.........410.........420
Sequence  VAAEPALLEQALGNLLDNAIDFTPESGCITLSAEVDQEHVTLKVLDTGSGIPDYALSRIF
Secondary structure 













SS confidence 



























































Disorder 



























































Disorder confidence 



























































 
   .........430.........440.........450.........460.........470....
Sequence  ERFYSLPRANGQKSSGLGLAFVSEVARLFNGEVTLRNVQEGGVLASLRLHRHFT
Secondary structure 
























SS confidence 





















































Disorder 






????????


































????
Disorder confidence 





















































 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3d36 chain B

3D model

Region: 251 - 470
Aligned: 214
Modelled: 220
Confidence: 100.0%
Identity: 22%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 3d2r chain B

3D model

Region: 196 - 471
Aligned: 276
Modelled: 276
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2q8f chain A

3D model

Region: 237 - 474
Aligned: 238
Modelled: 238
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 2c2a chain A

3D model

Region: 244 - 472
Aligned: 222
Modelled: 229
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 2bu8 chain A

3D model

Region: 237 - 474
Aligned: 234
Modelled: 238
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 1y8o chain A

3D model

Region: 237 - 472
Aligned: 229
Modelled: 236
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 1gjv chain A

3D model

Region: 214 - 471
Aligned: 252
Modelled: 258
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 3a0r chain A

3D model

Region: 244 - 472
Aligned: 218
Modelled: 229
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 3a0t chain A

3D model

Region: 323 - 472
Aligned: 146
Modelled: 150
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 322 - 472
Aligned: 144
Modelled: 151
Confidence: 100.0%
Identity: 25%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 328 - 472
Aligned: 143
Modelled: 143
Confidence: 100.0%
Identity: 24%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1id0 chain A

3D model

Region: 325 - 472
Aligned: 144
Modelled: 146
Confidence: 100.0%
Identity: 25%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 326 - 471
Aligned: 143
Modelled: 146
Confidence: 100.0%
Identity: 20%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1bxd chain A

3D model

Region: 319 - 470
Aligned: 148
Modelled: 150
Confidence: 100.0%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1b3q chain A

3D model

Region: 264 - 474
Aligned: 204
Modelled: 211
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 2ch4 chain A

3D model

Region: 328 - 474
Aligned: 147
Modelled: 147
Confidence: 99.9%
Identity: 22%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 324 - 471
Aligned: 134
Modelled: 148
Confidence: 99.9%
Identity: 30%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1i58 chain A

3D model

Region: 328 - 470
Aligned: 143
Modelled: 143
Confidence: 99.9%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3jz3 chain B

3D model

Region: 288 - 471
Aligned: 153
Modelled: 157
Confidence: 99.9%
Identity: 25%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2

PDB 1r62 chain A

3D model

Region: 325 - 470
Aligned: 132
Modelled: 146
Confidence: 99.8%
Identity: 18%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1p0z chain A

3D model

Region: 36 - 173
Aligned: 122
Modelled: 122
Confidence: 95.8%
Identity: 16%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2

PDB 3by8 chain A domain 1

3D model

Region: 34 - 178
Aligned: 129
Modelled: 129
Confidence: 94.1%
Identity: 17%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2
1

c3d36B_
2

c3d2rB_
3

c2q8fA_
4

c2c2aA_
5

c2bu8A_
6

c1y8oA_
7

c1gjvA_
8

c3a0rA_
9

c3a0tA_
10

d2c2aa2
11

d1jm6a2
12

d1id0a_
13

d1gkza2
14

d1bxda_
15

c1b3qA_
16

c2ch4A_
17

d1ysra1
18

d1i58a_
19

c3jz3B_
20

d1r62a_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58



59



60



61



62



63



64



65



66



67



68



69



70



71



72



73

d1p0za_
74



75

d3by8a1
76



77



78



79



80



81



82



83



84



85



86



87



88



89



90



91



92



93



94



95



96



97



98



99



100



101



102



103






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3d36B_



100.0 22 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
2c3d2rB_



100.0 17 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
3c2q8fA_



100.0 16 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
4c2c2aA_



100.0 25 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
5c2bu8A_



100.0 18 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
6c1y8oA_



100.0 18 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
7c1gjvA_



100.0 17 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
8c3a0rA_



100.0 20 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
9c3a0tA_



100.0 25 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
10d2c2aa2



100.0 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
11d1jm6a2



100.0 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
12d1id0a_



100.0 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
13d1gkza2



100.0 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
14d1bxda_



100.0 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
15c1b3qA_



100.0 17 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
16c2ch4A_



99.9 22 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
17d1ysra1



99.9 30 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
18d1i58a_



99.9 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
19c3jz3B_



99.9 25 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
20d1r62a_



99.8 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
21c3gieA_



not modelled 99.8 13 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
22d2hkja3



not modelled 99.8 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
23c3ehgA_



not modelled 99.7 14 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
24c1mx0D_



not modelled 99.7 17 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
25c2zbkB_



not modelled 99.7 20 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
26c3zxqA_



not modelled 99.7 19 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
27c2q2eB_



not modelled 99.7 21 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
28c3zxoB_



not modelled 99.6 19 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
29d1h7sa2



not modelled 99.6 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
30d1ixma_



not modelled 99.6 13 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
31d1th8a_



not modelled 99.5 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
32d1bkna2



not modelled 99.5 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
33d1b63a2



not modelled 99.4 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
34d1y8oa2



not modelled 99.4 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
35c3na3A_



not modelled 99.0 24 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
36c3zrwB_



not modelled 98.7 22 PDB header:signaling protein
Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz;
PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant
37c3h4lB_



not modelled 98.7 17 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
38d1kija2



not modelled 98.5 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
39d1pvga2



not modelled 98.4 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
40d1s16a2



not modelled 98.3 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
41c1bknA_



not modelled 98.3 18 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
42d1ei1a2



not modelled 98.3 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
43c1ei1B_



not modelled 98.2 22 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
44c1kijB_



not modelled 98.2 18 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
45c1y4sA_



not modelled 98.2 27 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
46c1zxnB_



not modelled 98.1 18 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
47c3iedA_



not modelled 98.1 21 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
48c1s16B_



not modelled 98.1 18 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
49d1uyla_



not modelled 98.0 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
50c2cg9A_



not modelled 98.0 24 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
51c1ea6A_



not modelled 98.0 23 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
52c2fwyA_



not modelled 98.0 19 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
53d2iwxa1



not modelled 98.0 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
54c1zwhA_



not modelled 98.0 21 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
55c1qzrA_



not modelled 97.9 20 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
56c2iopD_



not modelled 97.9 26 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
57c3g7bB_



not modelled 97.9 15 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
58c2akpA_



not modelled 97.8 20 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
59c2o1wB_



not modelled 97.8 26 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
60c3pehB_



not modelled 97.8 24 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
61d1s14a_



not modelled 97.8 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
62d1uyma_



not modelled 97.7 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
63c3ke6A_



not modelled 97.7 27 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
64c3lnrA_



not modelled 97.7 13 PDB header:signaling protein
Chain: A: PDB Molecule:aerotaxis transducer aer2;
PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2
65c2iorA_



not modelled 97.7 20 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
66d2gqpa1



not modelled 97.5 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
67d1joya_



not modelled 97.5 21 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
68c3lnuA_



not modelled 97.5 22 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
69d2c2aa1



not modelled 97.5 23 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
70d1qy5a_



not modelled 97.2 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
71c2o1uA_



not modelled 97.1 34 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
72d2asxa1



not modelled 96.6 24 Fold:HAMP domain-like
Superfamily:HAMP domain-like
Family:HAMP domain
73d1p0za_



95.8 16 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:Sensory domain of two-component sensor kinase
74c3cwvB_



not modelled 94.4 22 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
75d3by8a1



94.1 17 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:Sensory domain of two-component sensor kinase
76c3lmmA_



not modelled 89.3 16 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
77c2rm8A_



not modelled 88.2 15 PDB header:signaling protein
Chain: A: PDB Molecule:sensory rhodopsin ii transducer;
PDBTitle: the solution structure of phototactic transducer protein2 htrii linker region from natronomonas pharaonis
78c3fosA_



not modelled 67.8 8 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of two-component sensor histidine kinase domain from2 bacillus subtilis subsp. subtilis str. 168
79d2p7ja2



not modelled 52.7 12 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:YkuI C-terminal domain-like
80d1g0oa_



not modelled 49.1 19 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
81c3by9A_



not modelled 46.4 15 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the v. cholerae histidine kinase dctb2 sensor domain
82c3e4pB_



not modelled 43.5 10 PDB header:transferase
Chain: B: PDB Molecule:c4-dicarboxylate transport sensor protein dctb;
PDBTitle: crystal structure of malonate occupied dctb
83c3n0rA_



not modelled 43.0 15 PDB header:signaling protein
Chain: A: PDB Molecule:response regulator;
PDBTitle: structure of the phyr stress response regulator at 1.25 angstrom2 resolution
84c3o38D_



not modelled 43.0 17 PDB header:oxidoreductase
Chain: D: PDB Molecule:short chain dehydrogenase;
PDBTitle: crystal structure of a short chain dehydrogenase from mycobacterium2 smegmatis
85c3s8mA_



not modelled 41.7 27 PDB header:oxidoreductase
Chain: A: PDB Molecule:enoyl-acp reductase;
PDBTitle: the crystal structure of fabv
86c3ctmH_



not modelled 35.1 22 PDB header:oxidoreductase
Chain: H: PDB Molecule:carbonyl reductase;
PDBTitle: crystal structure of a carbonyl reductase from candida2 parapsilosis with anti-prelog stereo-specificity
87c3rd5A_



not modelled 30.8 30 PDB header:oxidoreductase
Chain: A: PDB Molecule:mypaa.01249.c;
PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium paratuberculosis
88c1ybyB_



not modelled 30.2 17 PDB header:translation
Chain: B: PDB Molecule:translation elongation factor p;
PDBTitle: conserved hypothetical protein cth-95 from clostridium2 thermocellum
89c3i1jB_



not modelled 28.4 22 PDB header:oxidoreductase
Chain: B: PDB Molecule:oxidoreductase, short chain
PDBTitle: structure of a putative short chain dehydrogenase from2 pseudomonas syringae
90d1yxma1



not modelled 26.6 22 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
91c3pt5A_



not modelled 26.4 9 PDB header:hydrolase
Chain: A: PDB Molecule:nans (yjhs), a 9-o-acetyl n-acetylneuraminic acid esterase;
PDBTitle: crystal structure of nans
92c3clwF_



not modelled 25.3 12 PDB header:structural genomics, unknown function
Chain: F: PDB Molecule:conserved exported protein;
PDBTitle: crystal structure of conserved exported protein from bacteroides2 fragilis
93d1efub3



not modelled 24.6 21 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
94c3nnhA_



not modelled 23.0 15 PDB header:rna binding protein/rna
Chain: A: PDB Molecule:cugbp elav-like family member 1;
PDBTitle: crystal structure of the cugbp1 rrm1 with guuguuuuguuu rna
95c1qr0A_



not modelled 22.8 18 PDB header:transferase
Chain: A: PDB Molecule:4'-phosphopantetheinyl transferase sfp;
PDBTitle: crystal structure of the 4'-phosphopantetheinyl transferase sfp-2 coenzyme a complex
96d1aipc1



not modelled 22.6 16 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
97c3gdfA_



not modelled 22.6 17 PDB header:oxidoreductase
Chain: A: PDB Molecule:probable nadp-dependent mannitol dehydrogenase;
PDBTitle: crystal structure of the nadp-dependent mannitol dehydrogenase from2 cladosporium herbarum.
98d1xb2b1



not modelled 22.5 11 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
99c3k31B_



not modelled 22.2 21 PDB header:oxidoreductase
Chain: B: PDB Molecule:enoyl-(acyl-carrier-protein) reductase;
PDBTitle: crystal structure of eonyl-(acyl-carrier-protein) reductase from2 anaplasma phagocytophilum in complex with nad at 1.9a resolution
100c1vr7A_



not modelled 22.1 17 PDB header:lyase
Chain: A: PDB Molecule:s-adenosylmethionine decarboxylase proenzyme;
PDBTitle: crystal structure of s-adenosylmethionine decarboxylase proenzyme2 (tm0655) from thermotoga maritima at 1.2 a resolution
101d2cp9a1



not modelled 21.9 11 Fold:RuvA C-terminal domain-like
Superfamily:UBA-like
Family:TS-N domain
102d1vr7a1



not modelled 21.8 16 Fold:S-adenosylmethionine decarboxylase
Superfamily:S-adenosylmethionine decarboxylase
Family:Bacterial S-adenosylmethionine decarboxylase
103d1w6ua_



not modelled 20.8 11 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0