Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP23367
DateThu Jan 5 11:39:26 GMT 2012
Unique Job IDe19466b908b9e767

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3h4lB_
Top template information
PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
Confidence and coverage
Confidence:100.0% Coverage: 53%
323 residues ( 53% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
513 residues ( 83%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNG
Secondary structure 
SS confidence 
Disorder  ???????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  CGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEA
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  WQAYAEGRDMNVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIAL
Secondary structure 
SS confidence 
Disorder 
????
?????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  ARFDVTINLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWV
Secondary structure 
SS confidence 
Disorder 
????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  ADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
Secondary structure 
SS confidence 
Disorder 
?????
?
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRSIPENRVAAGR
Secondary structure 
SS confidence 
Disorder 
?????????????????????????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  NHFAEPAAREPVAPRYTPAPASGSRPAAPWPNAQPGYQKQQGEVYRQLLQTPAPMQKLKA
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????
??
??
??
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  PEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEAPVC
Secondary structure 
SS confidence 
Disorder 
??
???
?
???????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  AQPLLIPLRLKVSAEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIP
Secondary structure 
SS confidence 
Disorder  ???
?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  ELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLL
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........610.....
Sequence  QSVDLHPAIKALKDE
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3h4l chain B

3D model

Region: 5 - 333
Aligned: 323
Modelled: 329
Confidence: 100.0%
Identity: 24%
PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein

Phyre2

PDB 3na3 chain A

3D model

Region: 1 - 307
Aligned: 295
Modelled: 307
Confidence: 100.0%
Identity: 33%
PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens

Phyre2

PDB 1ea6 chain A

3D model

Region: 15 - 330
Aligned: 281
Modelled: 282
Confidence: 100.0%
Identity: 24%
PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp

Phyre2

PDB 1bkn chain A

3D model

Region: 20 - 331
Aligned: 272
Modelled: 278
Confidence: 100.0%
Identity: 92%
PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl

Phyre2

PDB 3ncv chain B

3D model

Region: 433 - 613
Aligned: 180
Modelled: 181
Confidence: 100.0%
Identity: 19%
PDB header:hydrolase
Chain: B: PDB Molecule:dna mismatch repair protein mutl;
PDBTitle: ngol

Phyre2

PDB 1b63 chain A domain 2

3D model

Region: 1 - 216
Aligned: 216
Modelled: 216
Confidence: 100.0%
Identity: 100%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1kij chain B

3D model

Region: 2 - 328
Aligned: 311
Modelled: 317
Confidence: 100.0%
Identity: 16%
PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin

Phyre2

PDB 3gab chain C

3D model

Region: 433 - 613
Aligned: 174
Modelled: 181
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: C: PDB Molecule:dna mismatch repair protein mutl;
PDBTitle: c-terminal domain of bacillus subtilis mutl crystal form i

Phyre2

PDB 1ei1 chain B

3D model

Region: 2 - 333
Aligned: 318
Modelled: 328
Confidence: 100.0%
Identity: 16%
PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center

Phyre2

PDB 1s16 chain B

3D model

Region: 19 - 333
Aligned: 302
Modelled: 313
Confidence: 100.0%
Identity: 16%
PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp

Phyre2

PDB 1x9z chain A

3D model

Region: 434 - 614
Aligned: 181
Modelled: 181
Confidence: 100.0%
Identity: 99%
Fold: DNA mismatch repair protein MutL
Superfamily: DNA mismatch repair protein MutL
Family: DNA mismatch repair protein MutL

Phyre2

PDB 1h7s chain A domain 2

3D model

Region: 17 - 216
Aligned: 190
Modelled: 190
Confidence: 100.0%
Identity: 29%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1bkn chain A domain 2

3D model

Region: 20 - 216
Aligned: 172
Modelled: 178
Confidence: 100.0%
Identity: 87%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1b63 chain A domain 1

3D model

Region: 217 - 331
Aligned: 115
Modelled: 115
Confidence: 100.0%
Identity: 100%
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Family: DNA gyrase/MutL, second domain

Phyre2

PDB 1ei1 chain A domain 2

3D model

Region: 2 - 204
Aligned: 192
Modelled: 197
Confidence: 100.0%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1s16 chain A domain 2

3D model

Region: 2 - 199
Aligned: 183
Modelled: 197
Confidence: 100.0%
Identity: 20%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1kij chain A domain 2

3D model

Region: 2 - 191
Aligned: 177
Modelled: 189
Confidence: 100.0%
Identity: 20%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 1mx0 chain D

3D model

Region: 22 - 199
Aligned: 175
Modelled: 178
Confidence: 100.0%
Identity: 19%
PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit

Phyre2

PDB 3g7b chain B

3D model

Region: 20 - 192
Aligned: 147
Modelled: 156
Confidence: 99.9%
Identity: 24%
PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor

Phyre2

PDB 2hkj chain A domain 3

3D model

Region: 20 - 205
Aligned: 182
Modelled: 186
Confidence: 99.9%
Identity: 18%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2
1
c3h4lB_
2
c3na3A_
3
c1ea6A_
4
c1bknA_
5
c3ncvB_
6
d1b63a2
7
c1kijB_
8
c3gabC_
9
c1ei1B_
10
c1s16B_
11
d1x9za_
12
d1h7sa2
13
d1bkna2
14
d1b63a1
15
d1ei1a2
16
d1s16a2
17
d1kija2
18
c1mx0D_
19
c3g7bB_
20
d2hkja3
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
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53
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63
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3h4lB_
100.0 24 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
2c3na3A_
100.0 33 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
3c1ea6A_
100.0 24 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
4c1bknA_
100.0 92 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
5c3ncvB_
100.0 19 PDB header:hydrolase
Chain: B: PDB Molecule:dna mismatch repair protein mutl;
PDBTitle: ngol
6d1b63a2
100.0 100 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
7c1kijB_
100.0 16 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
8c3gabC_
100.0 16 PDB header:hydrolase
Chain: C: PDB Molecule:dna mismatch repair protein mutl;
PDBTitle: c-terminal domain of bacillus subtilis mutl crystal form i
9c1ei1B_
100.0 16 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
10c1s16B_
100.0 16 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
11d1x9za_
100.0 99 Fold:DNA mismatch repair protein MutL
Superfamily:DNA mismatch repair protein MutL
Family:DNA mismatch repair protein MutL
12d1h7sa2
100.0 29 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
13d1bkna2
100.0 87 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
14d1b63a1
100.0 100 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:DNA gyrase/MutL, second domain
15d1ei1a2
100.0 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
16d1s16a2
100.0 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
17d1kija2
100.0 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
18c1mx0D_
100.0 19 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
19c3g7bB_
99.9 24 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
20d2hkja3
99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
21d1s14a_
not modelled 99.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
22c2zbkB_
not modelled 99.9 18 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
23d1pvga2
not modelled 99.9 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
24c2q2eB_
not modelled 99.9 25 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
25d1h7sa1
not modelled 99.9 16 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:DNA gyrase/MutL, second domain
26c3lnuA_
not modelled 99.9 18 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
27c3iedA_
not modelled 99.9 25 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
28d2iwxa1
not modelled 99.9 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
29c1zwhA_
not modelled 99.9 28 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
30d1uyma_
not modelled 99.8 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
31c1y4sA_
not modelled 99.8 21 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
32d1uyla_
not modelled 99.8 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
33c2fwyA_
not modelled 99.8 24 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
34c2iorA_
not modelled 99.8 22 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
35d1qy5a_
not modelled 99.8 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
36c2o1wB_
not modelled 99.8 19 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
37c2akpA_
not modelled 99.7 26 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
38d2gqpa1
not modelled 99.7 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
39c2iopD_
not modelled 99.7 20 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
40c2cg9A_
not modelled 99.6 19 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
41c2o1uA_
not modelled 99.6 17 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
42c3pehB_
not modelled 99.5 19 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
43c1zxnB_
not modelled 99.4 22 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
44c1qzrA_
not modelled 99.3 17 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
45c3cwvB_
not modelled 99.1 10 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
46c2q8fA_
not modelled 98.9 17 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
47c1y8oA_
not modelled 98.9 24 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
48c3d2rB_
not modelled 98.9 20 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
49c1gjvA_
not modelled 98.7 27 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
50c2bu8A_
not modelled 98.7 19 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
51c3d36B_
not modelled 98.4 25 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
52c1b3qA_
not modelled 98.3 20 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
53c2ch4A_
not modelled 98.3 21 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
54d1jm6a2
not modelled 98.2 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
55c2c2aA_
not modelled 98.1 22 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
56d1gkza2
not modelled 98.0 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
57d1y8oa2
not modelled 98.0 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
58c3a0rA_
not modelled 98.0 20 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
59d2c2aa2
not modelled 97.7 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
60d1i58a_
not modelled 97.7 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
61c3a0tA_
not modelled 97.7 21 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
62d1id0a_
not modelled 97.6 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
63c3rbnB_
not modelled 97.5 20 PDB header:protein binding
Chain: B: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens]
64d1ysra1
not modelled 97.5 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
65c3ehgA_
not modelled 97.2 22 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
66d1bxda_
not modelled 97.2 15 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
67d1th8a_
not modelled 97.0 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
68d1ixma_
not modelled 96.6 11 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
69c3zxqA_
not modelled 96.3 30 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
70c3jz3B_
not modelled 95.9 23 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
71c3gieA_
not modelled 95.4 25 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
72c2it0A_
not modelled 95.3 9 PDB header:transcription/dna
Chain: A: PDB Molecule:iron-dependent repressor ider;
PDBTitle: crystal structure of a two-domain ider-dna complex crystal2 form ii
73c3zxoB_
not modelled 95.1 26 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
74d1g3wa2
not modelled 94.0 10 Fold:Iron-dependent repressor protein, dimerization domain
Superfamily:Iron-dependent repressor protein, dimerization domain
Family:Iron-dependent repressor protein, dimerization domain
75c2x4hA_
not modelled 93.3 8 PDB header:transcription
Chain: A: PDB Molecule:hypothetical protein sso2273;
PDBTitle: crystal structure of the hypothetical protein sso2273 from2 sulfolobus solfataricus
76d2isya2
not modelled 92.2 13 Fold:Iron-dependent repressor protein, dimerization domain
Superfamily:Iron-dependent repressor protein, dimerization domain
Family:Iron-dependent repressor protein, dimerization domain
77c1fx7C_
not modelled 91.8 8 PDB header:signaling protein
Chain: C: PDB Molecule:iron-dependent repressor ider;
PDBTitle: crystal structure of the iron-dependent regulator (ider)2 from mycobacterium tuberculosis
78c1g3wA_
not modelled 91.6 10 PDB header:gene regulation
Chain: A: PDB Molecule:diphtheria toxin repressor;
PDBTitle: cd-cys102ser dtxr
79c3hruA_
not modelled 90.3 13 PDB header:transcription
Chain: A: PDB Molecule:metalloregulator scar;
PDBTitle: crystal structure of scar with bound zn2+
80c1qw1A_
not modelled 61.8 11 PDB header:gene regulation
Chain: A: PDB Molecule:diphtheria toxin repressor;
PDBTitle: solution structure of the c-terminal domain of dtxr2 residues 110-226
81d1to6a_
not modelled 60.0 31 Fold:Glycerate kinase I
Superfamily:Glycerate kinase I
Family:Glycerate kinase I
82c3cwcB_
not modelled 53.4 44 PDB header:transferase
Chain: B: PDB Molecule:putative glycerate kinase 2;
PDBTitle: crystal structure of putative glycerate kinase 2 from salmonella2 typhimurium lt2
83d1jjcb2
not modelled 51.8 20 Fold:Putative DNA-binding domain
Superfamily:Putative DNA-binding domain
Family:Domains B1 and B5 of PheRS-beta, PheT
84c3iswB_
not modelled 39.0 27 PDB header:structural protein
Chain: B: PDB Molecule:filamin-a;
PDBTitle: crystal structure of filamin-a immunoglobulin-like repeat 21 bound to2 an n-terminal peptide of cftr
85c2brqA_
not modelled 38.3 26 PDB header:structural protein
Chain: A: PDB Molecule:filamin a;
PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the integrin beta7 cytoplasmic tail peptide
86c2w0pB_
not modelled 38.3 26 PDB header:cell adhesion
Chain: B: PDB Molecule:filamin-a;
PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the migfilin peptide
87c2j3sB_
not modelled 34.0 27 PDB header:structural protein
Chain: B: PDB Molecule:filamin-a;
PDBTitle: crystal structure of the human filamin a ig domains 19 to2 21
88c2brqB_
not modelled 31.8 27 PDB header:structural protein
Chain: B: PDB Molecule:filamin a;
PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the integrin beta7 cytoplasmic tail peptide
89d2dica1
not modelled 29.2 30 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
90c1djyB_
not modelled 28.9 33 PDB header:lipid degradation
Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c,
PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate
91d2w0pa1
not modelled 28.9 27 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:Filamin repeat (rod domain)
92c3lmmA_
not modelled 28.0 19 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
93d1r62a_
not modelled 26.7 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
94d1k82a1
not modelled 24.2 30 Fold:S13-like H2TH domain
Superfamily:S13-like H2TH domain
Family:Middle domain of MutM-like DNA repair proteins
95d1jkwa2
not modelled 23.2 19 Fold:Cyclin-like
Superfamily:Cyclin-like
Family:Cyclin
96d1tdza1
not modelled 23.2 13 Fold:S13-like H2TH domain
Superfamily:S13-like H2TH domain
Family:Middle domain of MutM-like DNA repair proteins
97d2j7ja2
not modelled 23.1 17 Fold:beta-beta-alpha zinc fingers
Superfamily:beta-beta-alpha zinc fingers
Family:Classic zinc finger, C2H2
98c2ee6A_
not modelled 21.8 26 PDB header:structural protein
Chain: A: PDB Molecule:filamin-b;
PDBTitle: solution structure of the 21th filamin domain from human2 filamin-b
99c3ke6A_
not modelled 21.0 17 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0