Email l.a.kelley@imperial.ac.uk Description P28903 Date Thu Jan 5 11:45:16 GMT 2012 Unique Job ID a3d84c41e8b53620

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1hk8A_ 100.0 57 PDB header:oxidoreductase Chain: A: PDB Molecule:anaerobic ribonucleotide-triphosphate reductase; PDBTitle: structural basis for allosteric substrate specificity2 regulation in class iii ribonucleotide reductases:3 nrdd in complex with dgtp 2 d1hk8a_ 100.0 57 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:Class III anaerobic ribonucleotide reductase NRDD subunit 3 c3r1rB_ 99.9 13 PDB header:complex (oxidoreductase/peptide) Chain: B: PDB Molecule:ribonucleotide reductase r1 protein; PDBTitle: ribonucleotide reductase r1 protein with amppnp occupying2 the activity site from escherichia coli 4 c3hnfA_ 99.8 14 PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large subunit; PDBTitle: crystal structure of human ribonucleotide reductase 1 bound to the2 effectors ttp and datp 5 c2cvuA_ 99.8 15 PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large chain PDBTitle: structures of yeast ribonucleotide reductase i 6 c2wghA_ 99.8 14 PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase large PDBTitle: human ribonucleotide reductase r1 subunit (rrm1) in complex2 with datp and mg. 7 c1xjeA_ 99.7 14 PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase, b12-dependent; PDBTitle: structural mechanism of allosteric substrate specificity in a2 ribonucleotide reductase: dttp-gdp complex 8 c1pemA_ 99.6 15 PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase 2 alpha PDBTitle: ribonucleotide reductase protein r1e from salmonella2 typhimurium 9 d1r9da_ 99.5 18 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:PFL-like 10 d1h16a_ 99.3 16 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:PFL-like 11 c2f3oB_ 99.3 18 PDB header:unknown function Chain: B: PDB Molecule:pyruvate formate-lyase 2; PDBTitle: crystal structure of a glycyl radical enzyme from archaeoglobus2 fulgidus 12 d1l1la_ 99.3 13 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:B12-dependent (class II) ribonucleotide reductase 13 d1peqa2 99.1 14 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:R1 subunit of ribonucleotide reductase, C-terminal domain 14 c2y8nC_ 98.9 16 PDB header:lyase Chain: C: PDB Molecule:4-hydroxyphenylacetate decarboxylase large subunit; PDBTitle: crystal structure of glycyl radical enzyme 15 d1rlra2 98.8 15 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:R1 subunit of ribonucleotide reductase, C-terminal domain 16 d1qhma_ 98.8 15 Fold:PFL-like glycyl radical enzymes Superfamily:PFL-like glycyl radical enzymes Family:PFL-like 17 d1rlra1 98.7 12 Fold:R1 subunit of ribonucleotide reductase, N-terminal domain Superfamily:R1 subunit of ribonucleotide reductase, N-terminal domain Family:R1 subunit of ribonucleotide reductase, N-terminal domain 18 c3a44D_ 96.0 17 PDB header:metal binding protein Chain: D: PDB Molecule:hydrogenase nickel incorporation protein hypa; PDBTitle: crystal structure of hypa in the dimeric form 19 c2kdxA_ 95.9 11 PDB header:metal-binding protein Chain: A: PDB Molecule:hydrogenase/urease nickel incorporation protein PDBTitle: solution structure of hypa protein 20 c1dvbA_ 95.1 20 PDB header:electron transport Chain: A: PDB Molecule:rubrerythrin; PDBTitle: rubrerythrin 21 c1yuzB_ not modelled 94.1 26 PDB header:oxidoreductase Chain: B: PDB Molecule:nigerythrin; PDBTitle: partially reduced state of nigerythrin 22 c2hr5B_ not modelled 93.8 30 PDB header:metal binding protein Chain: B: PDB Molecule:rubrerythrin; PDBTitle: pf1283- rubrerythrin from pyrococcus furiosus iron bound form 23 d2gmga1 not modelled 89.2 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:PF0610-like 24 c2lcqA_ not modelled 88.3 38 PDB header:metal binding protein Chain: A: PDB Molecule:putative toxin vapc6; PDBTitle: solution structure of the endonuclease nob1 from p.horikoshii 25 d1lkoa2 not modelled 85.6 33 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 26 d1yuza2 not modelled 85.1 29 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 27 c3lpeF_ not modelled 84.8 27 PDB header:transferase Chain: F: PDB Molecule:dna-directed rna polymerase subunit e''; PDBTitle: crystal structure of spt4/5ngn heterodimer complex from methanococcus2 jannaschii 28 d1nnqa2 not modelled 84.6 30 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 29 d1ryqa_ not modelled 82.5 28 Fold:Rubredoxin-like Superfamily:RNA polymerase subunits Family:RpoE2-like 30 d1dx8a_ not modelled 82.2 40 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 31 d2j0151 not modelled 82.0 30 Fold:Rubredoxin-like Superfamily:Zn-binding ribosomal proteins Family:Ribosomal protein L32p 32 d2zjrz1 not modelled 81.7 25 Fold:Rubredoxin-like Superfamily:Zn-binding ribosomal proteins Family:Ribosomal protein L32p 33 c1s24A_ not modelled 81.6 38 PDB header:electron transport Chain: A: PDB Molecule:rubredoxin 2; PDBTitle: rubredoxin domain ii from pseudomonas oleovorans 34 d1s24a_ not modelled 81.6 38 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 35 d2apob1 not modelled 81.5 45 Fold:Rubredoxin-like Superfamily:Nop10-like SnoRNP Family:Nucleolar RNA-binding protein Nop10-like 36 d4rxna_ not modelled 81.3 32 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 37 c2v3bB_ not modelled 81.2 35 PDB header:oxidoreductase Chain: B: PDB Molecule:rubredoxin 2; PDBTitle: crystal structure of the electron transfer complex2 rubredoxin - rubredoxin reductase from pseudomonas3 aeruginosa. 38 d1iroa_ not modelled 81.0 32 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 39 d1rb9a_ not modelled 80.8 32 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 40 d2ey4e1 not modelled 80.4 40 Fold:Rubredoxin-like Superfamily:Nop10-like SnoRNP Family:Nucleolar RNA-binding protein Nop10-like 41 c2gb5B_ not modelled 80.4 20 PDB header:hydrolase Chain: B: PDB Molecule:nadh pyrophosphatase; PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution 42 d1h7va_ not modelled 80.3 30 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 43 d2gnra1 not modelled 80.3 23 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:SSO2064-like 44 d1qcva_ not modelled 80.3 19 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 45 d1iu5a_ not modelled 79.8 36 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 46 c3axtA_ not modelled 79.7 26 PDB header:transferase Chain: A: PDB Molecule:probable n(2),n(2)-dimethylguanosine trna methyltransferase PDBTitle: complex structure of trna methyltransferase trm1 from aquifex aeolicus2 with s-adenosyl-l-methionine 47 d2dsxa1 not modelled 79.2 36 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 48 c2k2dA_ not modelled 78.4 20 PDB header:metal binding protein Chain: A: PDB Molecule:ring finger and chy zinc finger domain- PDBTitle: solution nmr structure of c-terminal domain of human pirh2.2 northeast structural genomics consortium (nesg) target ht2c 49 d1brfa_ not modelled 76.9 36 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 50 c2ba1B_ not modelled 76.9 25 PDB header:rna binding protein Chain: B: PDB Molecule:archaeal exosome rna binding protein csl4; PDBTitle: archaeal exosome core 51 d6rxna_ not modelled 76.5 32 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 52 d2cona1 not modelled 73.9 35 Fold:Rubredoxin-like Superfamily:NOB1 zinc finger-like Family:NOB1 zinc finger-like 53 c2qkdA_ not modelled 72.8 23 PDB header:signaling protein, cell cycle Chain: A: PDB Molecule:zinc finger protein zpr1; PDBTitle: crystal structure of tandem zpr1 domains 54 c2nn6I_ not modelled 72.6 13 PDB header:hydrolase/transferase Chain: I: PDB Molecule:3'-5' exoribonuclease csl4 homolog; PDBTitle: structure of the human rna exosome composed of rrp41, rrp45,2 rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 55 d2rdva_ not modelled 72.4 48 Fold:Rubredoxin-like Superfamily:Rubredoxin-like Family:Rubredoxin 56 d2fiya1 not modelled 70.3 30 Fold:FdhE-like Superfamily:FdhE-like Family:FdhE-like 57 c2kn9A_ not modelled 70.2 42 PDB header:electron transport Chain: A: PDB Molecule:rubredoxin; PDBTitle: solution structure of zinc-substituted rubredoxin b (rv3250c) from2 mycobacterium tuberculosis. seattle structural genomics center for3 infectious disease target mytud.01635.a 58 c2f9iD_ not modelled 69.1 22 PDB header:transferase Chain: D: PDB Molecule:acetyl-coenzyme a carboxylase carboxyl PDBTitle: crystal structure of the carboxyltransferase subunit of acc2 from staphylococcus aureus 59 d2ct7a1 not modelled 66.0 28 Fold:RING/U-box Superfamily:RING/U-box Family:IBR domain 60 d2qam01 not modelled 65.2 23 Fold:Rubredoxin-like Superfamily:Zn-binding ribosomal proteins Family:Ribosomal protein L32p 61 c1u5kA_ not modelled 65.0 19 PDB header:recombination,replication Chain: A: PDB Molecule:hypothetical protein; PDBTitle: recombinational repair protein reco 62 d2dkta1 not modelled 63.6 24 Fold:CHY zinc finger-like Superfamily:CHY zinc finger-like Family:CHY zinc finger 63 d1pfva3 not modelled 62.7 30 Fold:Rubredoxin-like Superfamily:Methionyl-tRNA synthetase (MetRS), Zn-domain Family:Methionyl-tRNA synthetase (MetRS), Zn-domain 64 c3ir9A_ not modelled 62.2 35 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:peptide chain release factor subunit 1; PDBTitle: c-terminal domain of peptide chain release factor from2 methanosarcina mazei. 65 c2ktvA_ not modelled 61.3 19 PDB header:translation Chain: A: PDB Molecule:eukaryotic peptide chain release factor subunit 1; PDBTitle: human erf1 c-domain, "open" conformer 66 d1nuia2 not modelled 60.5 36 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:DNA primase zinc finger 67 c2f9yB_ not modelled 59.8 32 PDB header:ligase Chain: B: PDB Molecule:acetyl-coenzyme a carboxylase carboxyl transferase subunit PDBTitle: the crystal structure of the carboxyltransferase subunit of acc from2 escherichia coli 68 d2f9yb1 not modelled 59.8 32 Fold:ClpP/crotonase Superfamily:ClpP/crotonase Family:Biotin dependent carboxylase carboxyltransferase domain 69 d1ltla_ not modelled 59.6 22 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:DNA replication initiator (cdc21/cdc54) N-terminal domain 70 c2aklA_ not modelled 56.1 21 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:phna-like protein pa0128; PDBTitle: solution structure for phn-a like protein pa0128 from2 pseudomonas aeruginosa 71 c3f2cA_ not modelled 56.0 40 PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn 72 d2nn6i1 not modelled 55.0 13 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 73 c3cngC_ not modelled 54.5 29 PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea 74 c1ltlE_ not modelled 54.1 22 PDB header:replication Chain: E: PDB Molecule:dna replication initiator (cdc21/cdc54); PDBTitle: the dodecamer structure of mcm from archaeal m.2 thermoautotrophicum 75 c3bjiA_ not modelled 53.7 38 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: structural basis of promiscuous guanine nucleotide exchange2 by the t-cell essential vav1 76 d2akla2 not modelled 53.6 23 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:PhnA zinc-binding domain 77 c1m2oA_ not modelled 53.0 13 PDB header:protein transport/signaling protein Chain: A: PDB Molecule:protein transport protein sec23; PDBTitle: crystal structure of the sec23-sar1 complex 78 c2vl6C_ not modelled 51.4 30 PDB header:dna binding protein Chain: C: PDB Molecule:minichromosome maintenance protein mcm; PDBTitle: structural analysis of the sulfolobus solfataricus mcm2 protein n-terminal domain 79 c1vddC_ not modelled 51.4 19 PDB header:recombination Chain: C: PDB Molecule:recombination protein recr; PDBTitle: crystal structure of recombinational repair protein recr 80 d1pfta_ not modelled 51.2 25 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 81 c2k5cA_ not modelled 48.1 56 PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein pf0385; PDBTitle: nmr structure for pf0385 82 d1u5ka2 not modelled 48.0 19 Fold:ArfGap/RecO-like zinc finger Superfamily:ArfGap/RecO-like zinc finger Family:RecO C-terminal domain-like 83 d1dl6a_ not modelled 47.9 29 Fold:Rubredoxin-like Superfamily:Zinc beta-ribbon Family:Transcriptional factor domain 84 d2dlqa2 not modelled 47.0 75 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 85 c3ky9B_ not modelled 47.0 38 PDB header:apoptosis Chain: B: PDB Molecule:proto-oncogene vav; PDBTitle: autoinhibited vav1 86 d1ynjd1 not modelled 44.9 35 Fold:beta and beta-prime subunits of DNA dependent RNA-polymerase Superfamily:beta and beta-prime subunits of DNA dependent RNA-polymerase Family:RNA-polymerase beta-prime 87 c3gn5B_ not modelled 44.5 36 PDB header:dna binding protein Chain: B: PDB Molecule:hth-type transcriptional regulator mqsa (ygit/b3021); PDBTitle: structure of the e. coli protein mqsa (ygit/b3021) 88 c3eswA_ not modelled 43.4 23 PDB header:hydrolase Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine PDBTitle: complex of yeast pngase with glcnac2-iac. 89 d2ctda2 not modelled 43.3 50 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 90 d1x6ma_ not modelled 42.6 28 Fold:Mss4-like Superfamily:Mss4-like Family:Glutathione-dependent formaldehyde-activating enzyme, Gfa 91 c1ee8A_ not modelled 42.5 26 PDB header:dna binding protein Chain: A: PDB Molecule:mutm (fpg) protein; PDBTitle: crystal structure of mutm (fpg) protein from thermus thermophilus hb8 92 c3eh2B_ not modelled 42.5 19 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24c; PDBTitle: crystal structure of the human copii-coat protein sec24c 93 c1m2vB_ not modelled 42.2 20 PDB header:protein transport Chain: B: PDB Molecule:protein transport protein sec24; PDBTitle: crystal structure of the yeast sec23/24 heterodimer 94 c2owoA_ not modelled 41.0 44 PDB header:ligase/dna Chain: A: PDB Molecule:dna ligase; PDBTitle: last stop on the road to repair: structure of e.coli dna ligase bound2 to nicked dna-adenylate 95 c3k7aM_ not modelled 40.3 29 PDB header:transcription Chain: M: PDB Molecule:transcription initiation factor iib; PDBTitle: crystal structure of an rna polymerase ii-tfiib complex 96 c3h0gN_ not modelled 40.0 21 PDB header:transcription Chain: N: PDB Molecule:dna-directed rna polymerase ii subunit rpb2; PDBTitle: rna polymerase ii from schizosaccharomyces pombe 97 c2ysaA_ not modelled 39.7 21 PDB header:metal binding protein Chain: A: PDB Molecule:retinoblastoma-binding protein 6; PDBTitle: solution structure of the zinc finger cchc domain from the2 human retinoblastoma-binding protein 6 (retinoblastoma-3 binding q protein 1, rbq-1) 98 c3cw2M_ not modelled 39.2 22 PDB header:translation Chain: M: PDB Molecule:translation initiation factor 2 subunit beta; PDBTitle: crystal structure of the intact archaeal translation2 initiation factor 2 from sulfolobus solfataricus . 99 c1pd0A_ not modelled 39.2 20 PDB header:transport protein Chain: A: PDB Molecule:protein transport protein sec24; PDBTitle: crystal structure of the copii coat subunit, sec24,2 complexed with a peptide from the snare protein sed53 (yeast syntaxin-5) 100 d1vdda_ not modelled 39.1 23 Fold:Recombination protein RecR Superfamily:Recombination protein RecR Family:Recombination protein RecR 101 c2opfA_ not modelled 38.5 33 PDB header:hydrolase/dna Chain: A: PDB Molecule:endonuclease viii; PDBTitle: crystal structure of the dna repair enzyme endonuclease-viii (nei)2 from e. coli (r252a) in complex with ap-site containing dna substrate 102 c3eg9B_ not modelled 38.4 16 PDB header:protein transport Chain: B: PDB Molecule:sec24 related gene family, member d; PDBTitle: crystal structure of the mammalian copii-coat protein2 sec23/24 bound to the transport signal sequence of membrin 103 c2yqqA_ not modelled 38.1 29 PDB header:protein binding Chain: A: PDB Molecule:zinc finger hit domain-containing protein 3; PDBTitle: solution structure of the zf-hit domain in zinc finger hit2 domain-containing protein 3 (trip-3) 104 d1j6wa_ not modelled 38.1 57 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 105 c3h7hA_ not modelled 38.1 19 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt4; PDBTitle: crystal structure of the human transcription elongation factor dsif,2 hspt4/hspt5 (176-273) 106 c2pmzB_ not modelled 38.0 28 PDB header:translation, transferase Chain: B: PDB Molecule:dna-directed rna polymerase subunit b; PDBTitle: archaeal rna polymerase from sulfolobus solfataricus 107 c2ja6L_ not modelled 37.7 21 PDB header:transferase Chain: L: PDB Molecule:dna-directed rna polymerases i, ii, and iii 7.7 PDBTitle: cpd lesion containing rna polymerase ii elongation complex2 b 108 c2bx9J_ not modelled 37.3 35 PDB header:transcription regulation Chain: J: PDB Molecule:tryptophan rna-binding attenuator protein-inhibitory PDBTitle: crystal structure of b.subtilis anti-trap protein, an2 antagonist of trap-rna interactions 109 c3na7A_ not modelled 37.3 20 PDB header:gene regulation, chaperone Chain: A: PDB Molecule:hp0958; PDBTitle: 2.2 angstrom structure of the hp0958 protein from helicobacter pylori2 ccug 17874 110 c3h0gL_ not modelled 36.8 21 PDB header:transcription Chain: L: PDB Molecule:dna-directed rna polymerases i, ii, and iii PDBTitle: rna polymerase ii from schizosaccharomyces pombe 111 d1x3za1 not modelled 36.7 22 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Transglutaminase core 112 c1nnjA_ not modelled 36.6 24 PDB header:hydrolase Chain: A: PDB Molecule:formamidopyrimidine-dna glycosylase; PDBTitle: crystal structure complex between the lactococcus lactis fpg and an2 abasic site containing dna 113 c2f5qA_ not modelled 35.9 32 PDB header:hydrolase/dna Chain: A: PDB Molecule:formamidopyrimidine-dna glycosidase; PDBTitle: catalytically inactive (e3q) mutm crosslinked to oxog:c2 containing dna cc2 114 c3pkiF_ not modelled 35.5 28 PDB header:hydrolase Chain: F: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: human sirt6 crystal structure in complex with adp ribose 115 d1j6xa_ not modelled 35.3 43 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:Autoinducer-2 production protein LuxS 116 c1v9pB_ not modelled 35.3 56 PDB header:ligase Chain: B: PDB Molecule:dna ligase; PDBTitle: crystal structure of nad+-dependent dna ligase 117 d2dula1 not modelled 35.1 17 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:TRM1-like 118 d1srka_ not modelled 35.0 33 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 119 c3pfqA_ not modelled 35.0 29 PDB header:transferase Chain: A: PDB Molecule:protein kinase c beta type; PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii 120 c3f9vA_ not modelled 34.9 30 PDB header:hydrolase Chain: A: PDB Molecule:minichromosome maintenance protein mcm; PDBTitle: crystal structure of a near full-length archaeal mcm: functional2 insights for an aaa+ hexameric helicase