Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP21865
DateThu Jan 5 11:38:35 GMT 2012
Unique Job IDa1475795e71ae0df

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2r8rB_
Top template information
PDB header:transferase
Chain: B: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the n-terminal region (19..243) of sensor protein2 kdpd from pseudomonas syringae pv. tomato str. dc3000
Confidence and coverage
Confidence:100.0% Coverage: 23%
207 residues ( 23% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
811 residues ( 91%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MNNEPLRPDPDRLLEQTAAPHRGKLKVFFGACAGVGKTWAMLAEAQRLRAQGLDIVVGVV
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   .........70.........80.........90.........100.........110.........120
Sequence  ETHGRKDTAAMLEGLAVLPLKRQAYRGRHISEFDLDAALARRPALILMDELAHSNAPGSR
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   .........130.........140.........150.........160.........170.........180
Sequence  HPKRWQDIEELLEAGIDVFTTVNVQHLESLNDVVSGVTGIQVRETVPDPFFDAADDVVLV
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   .........190.........200.........210.........220.........230.........240
Sequence  DLPPDDLRQRLKEGKVYIAGQAERAIEHFFRKGNLIALRELALRRTADRVDEQMRAWRGH
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??
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   .........250.........260.........270.........280.........290.........300
Sequence  PGEEKVWHTRDAILLCIGHNTGSEKLVRAAARLASRLGSVWHAVYVETPALHRLPEKKRR
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   .........310.........320.........330.........340.........350.........360
Sequence  AILSALRLAQELGAETATLSDPAEEKAVVRYAREHNLGKIILGRPASRRWWRRETFADRL
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   .........370.........380.........390.........400.........410.........420
Sequence  ARIAPDLDQVLVALDEPPARTINNAPDNRSFKDKWRVQIQGCVVAAALCAVITLIAMQWL
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   .........430.........440.........450.........460.........470.........480
Sequence  MAFDAANLVMLYLLGVVVVALFYGRWPSVVATVINVVSFDLFFIAPRGTLAVSDVQYLLT
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   .........490.........500.........510.........520.........530.........540
Sequence  FAVMLTVGLVIGNLTAGVRYQARVARYREQRTRHLYEMSKALAVGRSPQDIAATSEQFIA
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   .........550.........560.........570.........580.........590.........600
Sequence  STFHARSQVLLPDDNGKLQPLTHPQGMTPWDDAIAQWSFDKGLPAGAGTDTLPGVPYQIL
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   .........610.........620.........630.........640.........650.........660
Sequence  PLKSGEKTYGLVVVEPGNLRQLMIPEQQRLLETFTLLVANALERLTLTASEEQARMASER
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   .........670.........680.........690.........700.........710.........720
Sequence  EQIRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQHVLNTTRLVNN
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   .........730.........740.........750.........760.........770.........780
Sequence  LLDMARIQSGGFNLKKEWLTLEEVVGSALQMLEPGLSSPINLSLPEPLTLIHVDGPLFER
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   .........790.........800.........810.........820.........830.........840
Sequence  VLINLLENAVKYAGAQAEIGIDAHVEGENLQLDVWDNGPGLPPGQEQTIFDKFARGNKES
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?????
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   .........850.........860.........870.........880.........890....
Sequence  AVPGVGLGLAICRAIVDVHGGTITAFNRPEGGACFRVTLPQQTAPELEEFHEDM
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2r8r chain B

3D model

Region: 20 - 231
Aligned: 207
Modelled: 212
Confidence: 100.0%
Identity: 61%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the n-terminal region (19..243) of sensor protein2 kdpd from pseudomonas syringae pv. tomato str. dc3000

Phyre2

PDB 2c2a chain A

3D model

Region: 649 - 882
Aligned: 227
Modelled: 234
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 3d36 chain B

3D model

Region: 662 - 883
Aligned: 214
Modelled: 222
Confidence: 99.9%
Identity: 17%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 3d2r chain B

3D model

Region: 659 - 891
Aligned: 233
Modelled: 233
Confidence: 99.9%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2q8f chain A

3D model

Region: 659 - 891
Aligned: 229
Modelled: 229
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 2bu8 chain A

3D model

Region: 659 - 891
Aligned: 229
Modelled: 233
Confidence: 99.9%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 1gjv chain A

3D model

Region: 661 - 886
Aligned: 220
Modelled: 226
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 1y8o chain A

3D model

Region: 644 - 891
Aligned: 241
Modelled: 248
Confidence: 99.9%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 3a0r chain A

3D model

Region: 657 - 885
Aligned: 213
Modelled: 229
Confidence: 99.8%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 3a0t chain A

3D model

Region: 734 - 886
Aligned: 149
Modelled: 153
Confidence: 99.7%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 733 - 882
Aligned: 143
Modelled: 150
Confidence: 99.7%
Identity: 32%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1bxd chain A

3D model

Region: 729 - 892
Aligned: 160
Modelled: 163
Confidence: 99.7%
Identity: 28%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1b3q chain A

3D model

Region: 672 - 885
Aligned: 206
Modelled: 214
Confidence: 99.7%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 1id0 chain A

3D model

Region: 736 - 882
Aligned: 142
Modelled: 145
Confidence: 99.7%
Identity: 30%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 737 - 891
Aligned: 153
Modelled: 153
Confidence: 99.7%
Identity: 20%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 737 - 886
Aligned: 147
Modelled: 150
Confidence: 99.6%
Identity: 16%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 735 - 883
Aligned: 136
Modelled: 149
Confidence: 99.6%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3jz3 chain B

3D model

Region: 704 - 880
Aligned: 146
Modelled: 150
Confidence: 99.6%
Identity: 29%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2

PDB 2ch4 chain A

3D model

Region: 745 - 884
Aligned: 140
Modelled: 140
Confidence: 99.6%
Identity: 21%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1i58 chain A

3D model

Region: 745 - 881
Aligned: 137
Modelled: 134
Confidence: 99.5%
Identity: 23%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 2ksf chain A

3D model

Region: 398 - 502
Aligned: 105
Modelled: 105
Confidence: 98.8%
Identity: 98%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein kdpd;
PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor kdpd, center for structures of3 membrane proteins (csmp) target 4312c

Phyre2

PDB 3hgm chain D

3D model

Region: 251 - 372
Aligned: 121
Modelled: 121
Confidence: 98.2%
Identity: 21%
PDB header:signaling protein
Chain: D: PDB Molecule:universal stress protein tead;
PDBTitle: universal stress protein tead from the trap transporter2 teaabc of halomonas elongata

Phyre2

PDB 3dlo chain C

3D model

Region: 251 - 372
Aligned: 121
Modelled: 120
Confidence: 98.2%
Identity: 17%
PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:universal stress protein;
PDBTitle: structure of universal stress protein from archaeoglobus fulgidus

Phyre2

PDB 3s3t chain D

3D model

Region: 251 - 372
Aligned: 121
Modelled: 120
Confidence: 98.2%
Identity: 15%
PDB header:chaperone
Chain: D: PDB Molecule:nucleotide-binding protein, universal stress protein uspa
PDBTitle: universal stress protein uspa from lactobacillus plantarum

Phyre2

PDB 2z3v chain A domain 1

3D model

Region: 251 - 372
Aligned: 121
Modelled: 121
Confidence: 98.1%
Identity: 21%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Adenine nucleotide alpha hydrolases-like
Family: Universal stress protein-like

Phyre2

PDB 3loq chain A

3D model

Region: 244 - 378
Aligned: 129
Modelled: 125
Confidence: 98.0%
Identity: 13%
PDB header:structure genomics, unknown function
Chain: A: PDB Molecule:universal stress protein;
PDBTitle: the crystal structure of a universal stress protein from2 archaeoglobus fulgidus dsm 4304

Phyre2

PDB 1mjh chain A

3D model

Region: 251 - 377
Aligned: 126
Modelled: 126
Confidence: 98.0%
Identity: 11%
Fold: Adenine nucleotide alpha hydrolase-like
Superfamily: Adenine nucleotide alpha hydrolases-like
Family: Universal stress protein-like

Phyre2

PDB 3ibj chain B

3D model

Region: 483 - 659
Aligned: 176
Modelled: 176
Confidence: 97.9%
Identity: 11%
PDB header:hydrolase
Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase;
PDBTitle: x-ray structure of pde2a

Phyre2

PDB 3p01 chain A

3D model

Region: 495 - 646
Aligned: 151
Modelled: 148
Confidence: 97.8%
Identity: 15%
PDB header:signaling protein
Chain: A: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120

Phyre2

PDB 3p01 chain C

3D model

Region: 499 - 648
Aligned: 149
Modelled: 146
Confidence: 97.8%
Identity: 14%
PDB header:signaling protein
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120

Phyre2

PDB 1mc0 chain A

3D model

Region: 481 - 655
Aligned: 175
Modelled: 175
Confidence: 97.8%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a;
PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains

Phyre2

PDB 3mmh chain A

3D model

Region: 507 - 648
Aligned: 141
Modelled: 141
Confidence: 97.6%
Identity: 12%
PDB header:oxidoreductase
Chain: A: PDB Molecule:methionine-r-sulfoxide reductase;
PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate

Phyre2

PDB 2o9c chain A domain 1

3D model

Region: 513 - 646
Aligned: 133
Modelled: 133
Confidence: 97.6%
Identity: 15%
Fold: Profilin-like
Superfamily: GAF domain-like
Family: GAF domain

Phyre2

PDB 1ihu chain A domain 2

3D model

Region: 6 - 57
Aligned: 52
Modelled: 52
Confidence: 89.5%
Identity: 31%
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Family: Nitrogenase iron protein-like

Phyre2
1

c2r8rB_
2

c2c2aA_
3

c3d36B_
4

c3d2rB_
5

c2q8fA_
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c2bu8A_
7

c1gjvA_
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c1y8oA_
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c3a0rA_
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c3a0tA_
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d2c2aa2
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d1bxda_
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c1b3qA_
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d1id0a_
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d1jm6a2
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d1gkza2
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d1ysra1
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c3jz3B_
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c2ch4A_
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d1i58a_
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c2ksfA_
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c3hgmD_
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c3dloC_
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c3s3tD_
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d2z3va1
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c3loqA_
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d1mjha_
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c3ibjB_
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c3p01A_
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c3p01C_
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c1mc0A_
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c3mmhA_
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d2o9ca1
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d1ihua2
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2r8rB_



100.0 61 PDB header:transferase
Chain: B: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the n-terminal region (19..243) of sensor protein2 kdpd from pseudomonas syringae pv. tomato str. dc3000
2c2c2aA_



99.9 28 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
3c3d36B_



99.9 17 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
4c3d2rB_



99.9 16 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
5c2q8fA_



99.9 15 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
6c2bu8A_



99.9 17 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
7c1gjvA_



99.9 15 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
8c1y8oA_



99.9 15 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
9c3a0rA_



99.8 25 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
10c3a0tA_



99.7 24 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
11d2c2aa2



99.7 32 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
12d1bxda_



99.7 28 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
13c1b3qA_



99.7 17 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
14d1id0a_



99.7 30 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
15d1jm6a2



99.7 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
16d1gkza2



99.6 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
17d1ysra1



99.6 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
18c3jz3B_



99.6 29 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
19c2ch4A_



99.6 21 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
20d1i58a_



99.5 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
21c3gieA_



not modelled 99.4 15 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
22d1r62a_



not modelled 99.3 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
23c3ehgA_



not modelled 99.1 20 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
24d2hkja3



not modelled 99.1 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
25c3zxqA_



not modelled 99.0 28 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
26c3zxoB_



not modelled 98.9 25 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
27c1mx0D_



not modelled 98.9 19 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
28c2zbkB_



not modelled 98.9 21 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
29d1ixma_



not modelled 98.8 16 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
30c2ksfA_



98.8 98 PDB header:transferase
Chain: A: PDB Molecule:sensor protein kdpd;
PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor kdpd, center for structures of3 membrane proteins (csmp) target 4312c
31c2q2eB_



not modelled 98.8 17 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
32d1th8a_



not modelled 98.7 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
33d1y8oa2



not modelled 98.6 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
34d1h7sa2



not modelled 98.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
35d1bkna2



not modelled 98.3 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
36d2c2aa1



not modelled 98.3 22 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
37c3hgmD_



98.2 21 PDB header:signaling protein
Chain: D: PDB Molecule:universal stress protein tead;
PDBTitle: universal stress protein tead from the trap transporter2 teaabc of halomonas elongata
38d1b63a2



not modelled 98.2 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
39c3dloC_



98.2 17 PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:universal stress protein;
PDBTitle: structure of universal stress protein from archaeoglobus fulgidus
40c3s3tD_



98.2 15 PDB header:chaperone
Chain: D: PDB Molecule:nucleotide-binding protein, universal stress protein uspa
PDBTitle: universal stress protein uspa from lactobacillus plantarum
41d2z3va1



98.1 21 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
42c3loqA_



98.0 13 PDB header:structure genomics, unknown function
Chain: A: PDB Molecule:universal stress protein;
PDBTitle: the crystal structure of a universal stress protein from2 archaeoglobus fulgidus dsm 4304
43d1mjha_



98.0 11 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
44c2pfsA_



not modelled 97.9 21 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:universal stress protein;
PDBTitle: crystal structure of universal stress protein from nitrosomonas2 europaea
45c3ibjB_



97.9 11 PDB header:hydrolase
Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase;
PDBTitle: x-ray structure of pde2a
46c3mt0A_



not modelled 97.9 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein pa1789;
PDBTitle: the crystal structure of a functionally unknown protein pa1789 from2 pseudomonas aeruginosa pao1
47d1tq8a_



not modelled 97.9 18 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
48c3p01A_



97.8 15 PDB header:signaling protein
Chain: A: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
49c3olqA_



not modelled 97.8 14 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:universal stress protein e;
PDBTitle: the crystal structure of a universal stress protein e from proteus2 mirabilis hi4320
50c3na3A_



not modelled 97.8 21 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
51d1jmva_



not modelled 97.8 13 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
52c3p01C_



97.8 14 PDB header:signaling protein
Chain: C: PDB Molecule:two-component response regulator;
PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
53c1mc0A_



97.8 12 PDB header:hydrolase
Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a;
PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains
54c3fh0A_



not modelled 97.7 11 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative universal stress protein kpn_01444;
PDBTitle: crystal structure of putative universal stress protein kpn_01444 -2 atpase
55d2gm3a1



not modelled 97.6 8 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
56c3mmhA_



97.6 12 PDB header:oxidoreductase
Chain: A: PDB Molecule:methionine-r-sulfoxide reductase;
PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate
57d2o9ca1



97.6 15 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
58c3fg9B_



not modelled 97.6 20 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein of universal stress protein uspa family;
PDBTitle: the crystal structure of an universal stress protein uspa2 family protein from lactobacillus plantarum wcfs1
59c3trcA_



not modelled 97.5 10 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the gaf domain from a phosphoenolpyruvate-protein2 phosphotransferase (ptsp) from coxiella burnetii
60c3ci6B_



not modelled 97.5 11 PDB header:transferase
Chain: B: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: crystal structure of the gaf domain from acinetobacter2 phosphoenolpyruvate-protein phosphotransferase
61d2oola1



not modelled 97.5 10 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
62d2veaa1



not modelled 97.5 18 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
63d1joya_



not modelled 97.3 29 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
64c3oovA_



not modelled 97.3 12 PDB header:signaling protein
Chain: A: PDB Molecule:methyl-accepting chemotaxis protein, putative;
PDBTitle: crystal structure of a methyl-accepting chemotaxis protein, residues2 122 to 287
65c3h4lB_



not modelled 97.3 16 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
66c3mf0A_



not modelled 97.3 12 PDB header:hydrolase
Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase;
PDBTitle: crystal structure of pde5a gaf domain (89-518)
67c2dumD_



not modelled 97.3 14 PDB header:structural genomics, unknown function
Chain: D: PDB Molecule:hypothetical protein ph0823;
PDBTitle: crystal structure of hypothetical protein, ph0823
68c3zrwB_



not modelled 97.2 25 PDB header:signaling protein
Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz;
PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant
69c1vhmB_



not modelled 97.2 10 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein yebr;
PDBTitle: crystal structure of an hypothetical protein
70c3ab8B_



not modelled 97.2 18 PDB header:unknown function
Chain: B: PDB Molecule:putative uncharacterized protein ttha0350;
PDBTitle: crystal structure of the hypothetical tandem-type universal stress2 protein ttha0350 complexed with atps.
71c3k2nB_



not modelled 97.2 17 PDB header:transcription regulator
Chain: B: PDB Molecule:sigma-54-dependent transcriptional regulator;
PDBTitle: the crystal structure of sigma-54-dependent transcriptional2 regulator domain from chlorobium tepidum tls
72d1pvga2



not modelled 97.1 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
73c2vjwA_



not modelled 97.1 13 PDB header:hydrolase
Chain: A: PDB Molecule:gaf family protein;
PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis
74c3e98B_



not modelled 97.1 13 PDB header:unknown function
Chain: B: PDB Molecule:gaf domain of unknown function;
PDBTitle: crystal structure of a gaf domain containing protein that belongs to2 pfam duf484 family (pa5279) from pseudomonas aeruginosa at 2.43 a3 resolution
75d1kija2



not modelled 97.1 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
76d1vhma_



not modelled 97.1 10 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
77d1q77a_



not modelled 97.0 13 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:Universal stress protein-like
78c3e0yA_



not modelled 97.0 11 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:conserved domain protein;
PDBTitle: the crystal structure of a conserved domain from a protein of2 geobacter sulfurreducens pca
79c2zmfA_



not modelled 96.9 15 PDB header:hydrolase
Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase
PDBTitle: crystal structure of the c-terminal gaf domain of human2 phosphodiesterase 10a
80c2e21A_



not modelled 96.8 16 PDB header:ligase
Chain: A: PDB Molecule:trna(ile)-lysidine synthase;
PDBTitle: crystal structure of tils in a complex with amppnp from aquifex2 aeolicus.
81c3eeaB_



not modelled 96.8 8 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:gaf domain/hd domain protein;
PDBTitle: the crystal structure of the gaf domain/hd domain protein2 from geobacter sulfurreducens
82c3a2kB_



not modelled 96.8 14 PDB header:ligase/rna
Chain: B: PDB Molecule:trna(ile)-lysidine synthase;
PDBTitle: crystal structure of tils complexed with trna
83d1ei1a2



not modelled 96.8 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
84c1zxnB_



not modelled 96.8 22 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
85c1ea6A_



not modelled 96.8 19 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
86c1y4sA_



not modelled 96.7 19 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
87d1s16a2



not modelled 96.7 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
88d1mc0a1



not modelled 96.7 12 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
89c1bknA_



not modelled 96.7 23 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
90c3idfA_



not modelled 96.7 17 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:usp-like protein;
PDBTitle: the crystal structure of a usp-like protein from wolinella2 succinogenes to 2.0a
91c2jaxA_



not modelled 96.6 17 PDB header:protein binding
Chain: A: PDB Molecule:hypothetical protein tb31.7;
PDBTitle: universal stress protein rv2623 from mycobaterium2 tuberculosis
92c3ke6A_



not modelled 96.6 29 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
93c3ksiA_



not modelled 96.6 9 PDB header:oxidoreductase
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: structure of frmsr of staphylococcus aureus (complex with 2-propanol)
94c3dbaB_



not modelled 96.6 13 PDB header:hydrolase
Chain: B: PDB Molecule:cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit
PDBTitle: crystal structure of the cgmp-bound gaf a domain from the2 photoreceptor phosphodiesterase 6c
95c1ei1B_



not modelled 96.5 23 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
96c1ykdB_



not modelled 96.5 13 PDB header:lyase
Chain: B: PDB Molecule:adenylate cyclase;
PDBTitle: crystal structure of the tandem gaf domains from a cyanobacterial2 adenylyl cyclase: novel modes of ligand-binding and dimerization
97c1kijB_



not modelled 96.4 26 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
98c3iedA_



not modelled 96.4 18 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
99c2w3gA_



not modelled 96.4 15 PDB header:transferase
Chain: A: PDB Molecule:two component sensor histidine kinase devs (gaf
PDBTitle: air-oxidized structure of the first gaf domain of2 mycobacterium tuberculosis doss
100c2ja1A_



not modelled 96.3 16 PDB header:transferase
Chain: A: PDB Molecule:thymidine kinase;
PDBTitle: thymidine kinase from b. cereus with ttp bound as phosphate2 donor.
101c1qzrA_



not modelled 96.2 21 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
102c3o5yA_



not modelled 96.2 16 PDB header:transcription regulator
Chain: A: PDB Molecule:sensor protein;
PDBTitle: the crystal structure of the gaf domain of a two-component sensor2 histidine kinase from bacillus halodurans to 2.45a
103d1uyla_



not modelled 96.2 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
104c1s16B_



not modelled 96.1 23 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
105c2iopD_



not modelled 96.1 20 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
106c2qybA_



not modelled 96.0 14 PDB header:membrane protein
Chain: A: PDB Molecule:membrane protein, putative;
PDBTitle: crystal structure of the gaf domain region of putative membrane2 protein from geobacter sulfurreducens pca
107c2fwyA_



not modelled 96.0 17 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
108d1wy5a1



not modelled 95.9 17 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Adenine nucleotide alpha hydrolases-like
Family:PP-loop ATPase
109c3hcyB_



not modelled 95.9 11 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:putative two-component sensor histidine kinase protein;
PDBTitle: the crystal structure of the domain of putative two-component sensor2 histidine kinase protein from sinorhizobium meliloti 1021
110c2akpA_



not modelled 95.8 16 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
111c2cg9A_



not modelled 95.8 27 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
112d1mc0a2



not modelled 95.7 13 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
113c2o1wB_



not modelled 95.7 20 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
114d1xp8a1



not modelled 95.6 13 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:RecA protein-like (ATPase-domain)
115d2k2na1



not modelled 95.6 13 Fold:Profilin-like
Superfamily:GAF domain-like
Family:GAF domain
116d1xbta1



not modelled 95.6 24 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:Type II thymidine kinase
117c2lb5A_



not modelled 95.6 14 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: refined structural basis for the photoconversion of a phytochrome to2 the activated far-red light-absorbing form
118c1xx6B_



not modelled 95.5 16 PDB header:transferase
Chain: B: PDB Molecule:thymidine kinase;
PDBTitle: x-ray structure of clostridium acetobutylicum thymidine kinase with2 adp. northeast structural genomics target car26.
119c3g7bB_



not modelled 95.5 24 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
120d2iwxa1



not modelled 95.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0