Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	P	K	I	M	N	D	E	N	F	F	K	K	A	A	A	H	G	E	E	P	P	L	T	P	Q	N	E	H	Q	R	S	G	L	R	F	A	R	R	V	R	L	P	R	A	V	G	L	A	G	M	F	L	P	I	A	S	T	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	S	H	P	P	P	G	W	W	W	L	V	L	V	G	W	A	F	V	W	P	H	L	A	W	Q	I	A	S	R	A	V	D	P	L	S	R	E	I	Y	N	L	K	T	D	A	V	L	A	G	M	W	V	G	V	M	G	V	N	V
Secondary structure
SS confidence
Disorder																															?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	P	S	T	A	M	L	M	I	M	C	L	N	L	M	G	A	G	G	P	R	L	F	V	A	G	L	V	L	M	V	V	S	C	L	V	T	L	E	L	T	G	I	T	V	S	F	N	S	A	P	L	E	W	W	L	S	L	P	I
Secondary structure
SS confidence
Disorder																?																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	V	I	Y	P	L	L	F	G	W	V	S	Y	Q	T	A	T	K	L	A	E	H	K	R	R	L	Q	V	M	S	T	R	D	G	M	T	G	V	Y	N	R	R	H	W	E	T	M	L	R	N	E	F	D	N	C	R	R	H	N	R
Secondary structure
SS confidence
Disorder																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	A	T	L	L	I	I	D	I	D	H	F	K	S	I	N	D	T	W	G	H	D	V	G	D	E	A	I	V	A	L	T	R	Q	L	Q	I	T	L	R	G	S	D	V	I	G	R	F	G	G	D	E	F	A	V	I	M	S	G	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	A	E	S	A	I	T	A	M	L	R	V	H	E	G	L	N	T	L	R	L	P	N	T	P	Q	V	T	L	R	I	S	V	G	V	A	P	L	N	P	Q	M	S	H	Y	R	E	W	L	K	S	A	D	L	A	L	Y	K	A	K
Secondary structure
SS confidence
Disorder																					?	?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.
Sequence		K	A	G	R	N	R	T	E	V	A	A
Secondary structure
SS confidence
Disorder						?					?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1w25 chain B Region: 182 - 371 Aligned: 190 Modelled: 190 Confidence: 100.0% Identity: 28% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 3ezu chain A Region: 188 - 369 Aligned: 174 Modelled: 182 Confidence: 100.0% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution Phyre2 PDB 3bre chain A Region: 192 - 369 Aligned: 178 Modelled: 178 Confidence: 100.0% Identity: 35% PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 Phyre2 PDB 3i5c chain A Region: 193 - 369 Aligned: 177 Modelled: 177 Confidence: 100.0% Identity: 35% PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa Phyre2 PDB 3ign chain A Region: 208 - 370 Aligned: 163 Modelled: 159 Confidence: 100.0% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a Phyre2 PDB 3i5a chain A Region: 191 - 367 Aligned: 177 Modelled: 177 Confidence: 100.0% Identity: 32% PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae Phyre2 PDB 3hva chain A Region: 209 - 368 Aligned: 160 Modelled: 160 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa Phyre2 PDB 3i5b chain A Region: 209 - 370 Aligned: 162 Modelled: 162 Confidence: 100.0% Identity: 35% PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa Phyre2 PDB 3icl chain A Region: 212 - 369 Aligned: 158 Modelled: 157 Confidence: 100.0% Identity: 29% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c Phyre2 PDB 3qyy chain B Region: 205 - 367 Aligned: 153 Modelled: 163 Confidence: 100.0% Identity: 32% PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp Phyre2 PDB 1w25 chain A domain 3 Region: 215 - 368 Aligned: 154 Modelled: 154 Confidence: 100.0% Identity: 33% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: GGDEF domain Phyre2 PDB 3mtk chain A Region: 205 - 369 Aligned: 156 Modelled: 165 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c Phyre2 PDB 3pjw chain A Region: 195 - 369 Aligned: 173 Modelled: 175 Confidence: 99.9% Identity: 25% PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 Phyre2 PDB 3hvw chain A Region: 219 - 365 Aligned: 145 Modelled: 147 Confidence: 99.9% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c Phyre2 PDB 3gfz chain B Region: 206 - 366 Aligned: 132 Modelled: 134 Confidence: 99.4% Identity: 14% PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex Phyre2 PDB 3p7n chain B Region: 195 - 267 Aligned: 73 Modelled: 73 Confidence: 98.2% Identity: 8% PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis Phyre2 PDB 2qv6 chain D Region: 238 - 365 Aligned: 113 Modelled: 120 Confidence: 96.0% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions Phyre2 PDB 1cjk chain A Region: 240 - 337 Aligned: 98 Modelled: 97 Confidence: 95.0% Identity: 13% PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn Phyre2 PDB 1azs chain A Region: 237 - 335 Aligned: 99 Modelled: 99 Confidence: 94.8% Identity: 13% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 3mr7 chain B Region: 240 - 337 Aligned: 96 Modelled: 98 Confidence: 94.7% Identity: 13% PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi Phyre2 1 c1w25B_ 2 c3ezuA_ 3 c3breA_ 4 c3i5cA_ 5 c3ignA_ 6 c3i5aA_ 7 c3hvaA_ 8 c3i5bA_ 9 c3iclA_ 10 c3qyyB_ 11 d1w25a3 12 c3mtkA_ 13 c3pjwA_ 14 c3hvwA_ 15 c3gfzB_ 16 c3p7nB_ 17 c2qv6D_ 18 c1cjkA_ 19 d1azsa_ 20 c3mr7B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1w25B_ 100.0 28 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 2 c3ezuA_ 100.0 27 PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution 3 c3breA_ 100.0 35 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 4 c3i5cA_ 100.0 35 PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa 5 c3ignA_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a 6 c3i5aA_ 100.0 32 PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae 7 c3hvaA_ 100.0 23 PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa 8 c3i5bA_ 100.0 35 PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa 9 c3iclA_ 100.0 29 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c 10 c3qyyB_ 100.0 32 PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp 11 d1w25a3 100.0 33 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:GGDEF domain 12 c3mtkA_ 100.0 22 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c 13 c3pjwA_ 99.9 25 PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 14 c3hvwA_ 99.9 14 PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c 15 c3gfzB_ 99.4 14 PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex 16 c3p7nB_ 98.2 8 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 17 c2qv6D_ 96.0 18 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 18 c1cjkA_ 95.0 13 PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn 19 d1azsa_ 94.8 13 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 20 c3mr7B_ 94.7 13 PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi 21 d1wc1a_ not modelled 94.0 19 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 22 c2w01C_ not modelled 93.9 14 PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 23 c1y10C_ not modelled 92.5 13 PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state 24 c1wc6B_ not modelled 91.0 19 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate 25 c3uvjC_ not modelled 90.9 19 PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. 26 d1fx2a_ not modelled 90.4 14 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 27 c1ybuA_ not modelled 89.7 14 PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. 28 c2wz1B_ not modelled 89.5 9 PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble2 guanylate cyclase 1 beta 3. 29 d1fx4a_ not modelled 89.0 17 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 30 c3et6A_ not modelled 88.4 11 PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase 31 c1yk9A_ not modelled 87.2 16 PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c 32 c2aq4A_ not modelled 81.6 18 PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. 33 c3gqcB_ not modelled 76.2 22 PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex 34 d1azsb_ not modelled 73.6 12 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 35 c3onqB_ not modelled 67.3 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:regulator of polyketide synthase expression; PDBTitle: crystal structure of regulator of polyketide synthase expression2 bad_0249 from bifidobacterium adolescentis 36 d1im4a_ not modelled 61.1 19 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 37 c1s97D_ not modelled 57.2 16 PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch 38 c1k1qA_ not modelled 52.1 17 PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus 39 c1jihA_ not modelled 46.2 22 PDB header:translation Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: yeast dna polymerase eta 40 c2oh2B_ not modelled 39.5 20 PDB header:transferase/dna Chain: B: PDB Molecule:dna polymerase kappa; PDBTitle: ternary complex of human dna polymerase 41 c3mr2A_ not modelled 38.4 22 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: human dna polymerase eta in complex with normal dna and incoming2 nucleotide (nrm) 42 c2r8kB_ not modelled 36.0 20 PDB header:replication, transferase/dna Chain: B: PDB Molecule:dna polymerase eta; PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna 43 d1xxaa_ not modelled 35.3 12 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 44 d1k1sa2 not modelled 34.6 17 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 45 d1jiha2 not modelled 34.1 12 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 46 d1gx1a_ not modelled 33.2 17 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 47 d1jx4a2 not modelled 29.8 15 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 48 d1w5sa2 not modelled 29.6 12 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Extended AAA-ATPase domain 49 d1vh8a_ not modelled 29.5 15 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 50 d1w55a2 not modelled 24.1 13 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 51 d1j27a_ not modelled 24.0 12 Fold:Ferredoxin-like Superfamily:Hypothetical protein TT1725 Family:Hypothetical protein TT1725 52 d1t0aa_ not modelled 23.3 15 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 53 c1xaxA_ not modelled 22.5 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical upf0054 protein hi0004; PDBTitle: nmr structure of hi0004, a putative essential gene product2 from haemophilus influenzae 54 c3af5A_ not modelled 21.7 10 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein ph1404; PDBTitle: the crystal structure of an archaeal cpsf subunit, ph1404 from2 pyrococcus horikoshii 55 c3i24B_ not modelled 21.3 18 PDB header:hydrolase Chain: B: PDB Molecule:hit family hydrolase; PDBTitle: crystal structure of a hit family hydrolase protein from2 vibrio fischeri. northeast structural genomics consortium3 target id vfr176 56 c2zztA_ not modelled 20.8 16 PDB header:transport protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the cytosolic domain of the cation2 diffusion facilitator family protein 57 d1wdia_ not modelled 20.4 25 Fold:QueA-like Superfamily:QueA-like Family:QueA-like 58 c3b6nA_ not modelled 20.3 14 PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate PDBTitle: crystal structure of 2c-methyl-d-erythritol 2,4-2 cyclodiphosphate synthase pv003920 from plasmodium vivax 59 c2pmpA_ not modelled 20.0 13 PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase from2 the isoprenoid biosynthetic pathway of arabidopsis thaliana 60 c2jroA_ not modelled 19.1 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of so0334 from shewanella oneidensis. northeast2 structural genomics target sor75 61 d1xm5a_ not modelled 18.5 17 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 62 c3f0gA_ not modelled 18.5 16 PDB header:lyase Chain: A: PDB Molecule:2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase; PDBTitle: co-crystal structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate2 synthase with cmp 63 d3bypa1 not modelled 18.4 20 Fold:Alpha-lytic protease prodomain-like Superfamily:Cation efflux protein cytoplasmic domain-like Family:Cation efflux protein cytoplasmic domain-like 64 d1oz9a_ not modelled 18.4 15 Fold:Zincin-like Superfamily:Metalloproteases ("zincins"), catalytic domain Family:Predicted metal-dependent hydrolase 65 d1iv3a_ not modelled 18.1 18 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 66 c1qgeE_ not modelled 17.4 23 PDB header:hydrolase Chain: E: PDB Molecule:protein (triacylglycerol hydrolase); PDBTitle: new crystal form of pseudomonas glumae (formerly chromobacterium2 viscosum atcc 6918) lipase 67 c3v4gA_ not modelled 17.1 18 PDB header:dna binding protein Chain: A: PDB Molecule:arginine repressor; PDBTitle: 1.60 angstrom resolution crystal structure of an arginine repressor2 from vibrio vulnificus cmcp6 68 c3mc6C_ not modelled 17.0 11 PDB header:lyase Chain: C: PDB Molecule:sphingosine-1-phosphate lyase; PDBTitle: crystal structure of scdpl1 69 c3oheA_ not modelled 16.3 14 PDB header:hydrolase Chain: A: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad protein (maqu_1709) from2 marinobacter aquaeolei vt8 at 1.20 a resolution 70 d2ox6a1 not modelled 16.3 19 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:YdiL-like 71 d2o5aa1 not modelled 15.9 11 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 72 d1y4ia1 not modelled 14.6 33 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 73 d2qfia1 not modelled 14.5 13 Fold:Alpha-lytic protease prodomain-like Superfamily:Cation efflux protein cytoplasmic domain-like Family:Cation efflux protein cytoplasmic domain-like 74 c1t3nB_ not modelled 14.1 26 PDB header:replication/dna Chain: B: PDB Molecule:polymerase (dna directed) iota; PDBTitle: structure of the catalytic core of dna polymerase iota in2 complex with dna and dttp 75 d1n8pa_ not modelled 13.6 35 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 76 d2phcb2 not modelled 13.1 11 Fold:DCoH-like Superfamily:PH0987 N-terminal domain-like Family:PH0987 N-terminal domain-like 77 c3upsA_ not modelled 12.6 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:iojap-like protein; PDBTitle: crystal structure of iojap-like protein from zymomonas mobilis 78 c3l5aA_ not modelled 12.5 15 PDB header:oxidoreductase Chain: A: PDB Molecule:nadh/flavin oxidoreductase/nadh oxidase; PDBTitle: crystal structure of a probable nadh-dependent flavin oxidoreductase2 from staphylococcus aureus 79 c2htfA_ not modelled 12.4 27 PDB header:transferase Chain: A: PDB Molecule:dna polymerase mu; PDBTitle: the solution structure of the brct domain from human2 polymerase reveals homology with the tdt brct domain 80 d1t94a2 not modelled 12.2 21 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 81 d2fsqa1 not modelled 12.1 12 Fold:LigT-like Superfamily:LigT-like Family:Atu0111-like 82 c1t94B_ not modelled 12.0 21 PDB header:replication Chain: B: PDB Molecule:polymerase (dna directed) kappa; PDBTitle: crystal structure of the catalytic core of human dna2 polymerase kappa 83 d2c0ra1 not modelled 11.6 12 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:GABA-aminotransferase-like 84 c3k30B_ not modelled 11.4 18 PDB header:oxidoreductase Chain: B: PDB Molecule:histamine dehydrogenase; PDBTitle: histamine dehydrogenase from nocardiodes simplex 85 c2qfiB_ not modelled 11.3 14 PDB header:transport protein Chain: B: PDB Molecule:ferrous-iron efflux pump fief; PDBTitle: structure of the zinc transporter yiip 86 c3nrdB_ not modelled 11.2 19 PDB header:nucleotide binding protein Chain: B: PDB Molecule:histidine triad (hit) protein; PDBTitle: crystal structure of a histidine triad (hit) protein (smc02904) from2 sinorhizobium meliloti 1021 at 2.06 a resolution 87 c3l7xA_ not modelled 11.2 16 PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 88 c3nj2B_ not modelled 11.0 10 PDB header:unknown function Chain: B: PDB Molecule:duf269-containing protein; PDBTitle: crystal structure of cce_0566 from the cyanobacterium cyanothece2 51142, a protein associated with nitrogen fixation from the duf2693 family 89 d2p5ma1 not modelled 11.0 20 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 90 d1zaka2 not modelled 10.7 43 Fold:Rubredoxin-like Superfamily:Microbial and mitochondrial ADK, insert "zinc finger" domain Family:Microbial and mitochondrial ADK, insert "zinc finger" domain 91 c3jurA_ not modelled 10.7 18 PDB header:hydrolase Chain: A: PDB Molecule:exo-poly-alpha-d-galacturonosidase; PDBTitle: the crystal structure of a hyperthermoactive exopolygalacturonase from2 thermotoga maritima 92 c1x31A_ not modelled 10.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:sarcosine oxidase alpha subunit; PDBTitle: crystal structure of heterotetrameric sarcosine oxidase from2 corynebacterium sp. u-96 93 c2fllA_ not modelled 10.6 24 PDB header:replication/dna Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: ternary complex of human dna polymerase iota with dna and dttp 94 c3kmlB_ not modelled 10.6 55 PDB header:viral protein Chain: B: PDB Molecule:coat protein; PDBTitle: circular permutant of the tobacco mosaic virus 95 d1ei7a_ not modelled 10.6 55 Fold:Four-helical up-and-down bundle Superfamily:TMV-like viral coat proteins Family:TMV-like viral coat proteins 96 d1iwga2 not modelled 10.1 12 Fold:Ferredoxin-like Superfamily:Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Family:Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 97 d1b4ba_ not modelled 10.1 18 Fold:DCoH-like Superfamily:C-terminal domain of arginine repressor Family:C-terminal domain of arginine repressor 98 c2uzhB_ not modelled 10.0 15 PDB header:lyase Chain: B: PDB Molecule:2c-methyl-d-erythritol 2,4-cyclodiphosphate PDBTitle: mycobacterium smegmatis 2c-methyl-d-erythritol-2,4-2 cyclodiphosphate synthase (ispf) 99 d1vtmp_ not modelled 9.9 40 Fold:Four-helical up-and-down bundle Superfamily:TMV-like viral coat proteins Family:TMV-like viral coat proteins

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0