PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c2fllA_

Fold library id	PDB Header	Molecule	Title
c2fllA_	PDB header: replication/dna	Chain: A: PDB Molecule: dna polymerase iota;	PDBTitle: ternary complex of human dna polymerase iota with dna and2 dttp

Links to external resources
Added to library: Tue Mar 16 13:58:32 2010

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence A S S R V I V H V D L D C F Y A Q V E M I S N P E L K D K P L G V Q Q K Y L V V T C N Y E A R K L G V K K L M N V R D A K E K C P Q L V L V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
G G G T T S
T T
T T
T T S S
S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence N G E D L T R Y R E M S Y K V T E L L E E F S P V V E R L G F D E N F V D L T E M V E K R L Q Q L Q S D E L S A V T V S G H V Y N N Q S I N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
T T T
S
T T G G G G
S G G G

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence L L D V L H I R L L V G S Q I A A E M R E A M Y N Q L G L T G C A G V A S N K L L A K L V S G V F K P N Q Q T V L L P E S C Q H L I H S L N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S S T S S
S S
G G G
S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence H I K E I P G I G Y K T A K C L E A L G I N S V R D L Q T F S P K I L E K E L G I S V A Q R I Q K L S F G E D N S P V I L S G P P Q S F S E

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S G G G S T T
T T
S S
T T
S
S

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence E D S F K K C S S E V E A K N K I E E L L A S L L N R V C Q D G R K P H T V R L I I R R Y S S E K H Y G R E S R Q C P I P S H V I Q V M T P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
S S T T S S
S S S
T T
T T T T

. . . . . . . . . 360 . . . . . . . . . 370 . . .

Sequence M V D I L M K L F R N M T L L S V C F C N L K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	A	S	S	R	V	I	V	H	V	D	L	D	C	F	Y	A	Q	V	E	M	I	S	N	P	E	L	K	D	K	P	L	G	V	Q	Q	K	Y	L	V	V	T	C	N	Y	E	A	R	K	L	G	V	K	K	L	M	N	V	R	D	A	K	E	K	C	P	Q	L	V	L	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												S	S											G	G	G	T	T	S							T	T												T	T			T	T								S	S		S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	N	G	E	D	L	T	R	Y	R	E	M	S	Y	K	V	T	E	L	L	E	E	F	S	P	V	V	E	R	L	G	F	D	E	N	F	V	D	L	T	E	M	V	E	K	R	L	Q	Q	L	Q	S	D	E	L	S	A	V	T	V	S	G	H	V	Y	N	N	Q	S	I	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)																								S						T	T	T																	S		T	T	G	G	G	G					S			G	G	G
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	L	L	D	V	L	H	I	R	L	L	V	G	S	Q	I	A	A	E	M	R	E	A	M	Y	N	Q	L	G	L	T	G	C	A	G	V	A	S	N	K	L	L	A	K	L	V	S	G	V	F	K	P	N	Q	Q	T	V	L	L	P	E	S	C	Q	H	L	I	H	S	L	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T																																			S	S									T	S	S		S	S							G	G	G									S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	H	I	K	E	I	P	G	I	G	Y	K	T	A	K	C	L	E	A	L	G	I	N	S	V	R	D	L	Q	T	F	S	P	K	I	L	E	K	E	L	G	I	S	V	A	Q	R	I	Q	K	L	S	F	G	E	D	N	S	P	V	I	L	S	G	P	P	Q	S	F	S	E
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	G	G	G	S	T	T												T	T			S							S																						T	T											S		S
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	E	D	S	F	K	K	C	S	S	E	V	E	A	K	N	K	I	E	E	L	L	A	S	L	L	N	R	V	C	Q	D	G	R	K	P	H	T	V	R	L	I	I	R	R	Y	S	S	E	K	H	Y	G	R	E	S	R	Q	C	P	I	P	S	H	V	I	Q	V	M	T	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)					S	S				S	S	T	T	S																		S														S	S	S		T	T											T	T	T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.
Sequence	M	V	D	I	L	M	K	L	F	R	N	M	T	L	L	S	V	C	F	C	N	L	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)											T