Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	L	L	A	L	G	I	N	H	K	T	A	P	V	S	L	R	E	R	V	S	F	S	P	D	K	L	D	Q	A	L	D	S	L	L	A	Q	P	M	V	Q	G	G	V	V	L	S	T	C	N	R	T	E	L	Y	L	S	V	E
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	Q	D	N	L	Q	E	A	L	I	R	W	L	C	D	Y	H	N	L	N	E	E	D	L	R	K	S	L	Y	W	H	Q	D	N	D	A	V	S	H	L	M	R	V	A	S	G	L	D	S	L	V	L	G	E	P	Q	I	L	G	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	K	K	A	F	A	D	S	Q	K	G	H	M	K	A	S	E	L	E	R	M	F	Q	K	S	F	S	V	A	K	R	V	R	T	E	T	D	I	G	A	S	A	V	S	V	A	F	A	A	C	T	L	A	R	Q	I	F	E	S	L
Secondary structure
SS confidence
Disorder														?																								?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	T	V	T	V	L	L	V	G	A	G	E	T	I	E	L	V	A	R	H	L	R	E	H	K	V	Q	K	M	I	I	A	N	R	T	R	E	R	A	Q	I	L	A	D	E	V	G	A	E	V	I	A	L	S	D	I	D	E	R	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	E	A	D	I	I	I	S	S	T	A	S	P	L	P	I	I	G	K	G	M	V	E	R	A	L	K	S	R	R	N	Q	P	M	L	L	V	D	I	A	V	P	R	D	V	E	P	E	V	G	K	L	A	N	A	Y	L	Y	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		D	D	L	Q	S	I	I	S	H	N	L	A	Q	R	K	A	A	A	V	E	A	E	T	I	V	A	Q	E	T	S	E	F	M	A	W	L	R	A	Q	S	A	S	E	T	I	R	E	Y	R	S	Q	A	E	Q	V	R	D	E	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.
Sequence		A	K	A	L	A	A	L	E	Q	G	G	D	A	Q	A	I	M	Q	D	L	A	W	K	L	T	N	R	L	I	H	A	P	T	K	S	L	Q	Q	A	A	R	D	G	D	N	E	R	L	N	I	L	R	D	S	L	G	L	E
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?																											?		?	?		?												?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1gpj chain A Region: 1 - 418 Aligned: 396 Modelled: 411 Confidence: 100.0% Identity: 34% PDB header:reductase Chain: A: PDB Molecule:glutamyl-trna reductase; PDBTitle: glutamyl-trna reductase from methanopyrus kandleri Phyre2 PDB 1gpj chain A domain 3 Region: 1 - 158 Aligned: 142 Modelled: 145 Confidence: 100.0% Identity: 37% Fold: Ferredoxin-like Superfamily: Glutamyl tRNA-reductase catalytic, N-terminal domain Family: Glutamyl tRNA-reductase catalytic, N-terminal domain Phyre2 PDB 1gpj chain A domain 2 Region: 159 - 316 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 40% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 3oj0 chain A Region: 161 - 317 Aligned: 138 Modelled: 157 Confidence: 99.9% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:glutamyl-trna reductase; PDBTitle: crystal structure of glutamyl-trna reductase from thermoplasma2 volcanium (nucleotide binding domain) Phyre2 PDB 1lua chain A Region: 88 - 298 Aligned: 204 Modelled: 211 Confidence: 99.8% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:methylene tetrahydromethanopterin dehydrogenase; PDBTitle: structure of methylene-tetrahydromethanopterin dehydrogenase from2 methylobacterium extorquens am1 complexed with nadp Phyre2 PDB 3pgj chain B Region: 95 - 353 Aligned: 234 Modelled: 242 Confidence: 99.8% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:shikimate dehydrogenase; PDBTitle: 2.49 angstrom resolution crystal structure of shikimate 5-2 dehydrogenase (aroe) from vibrio cholerae o1 biovar eltor str. n169613 in complex with shikimate Phyre2 PDB 2nlo chain A Region: 95 - 347 Aligned: 231 Modelled: 234 Confidence: 99.7% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate dehydrogenase; PDBTitle: crystal structure of the quinate dehydrogenase from corynebacterium2 glutamicum Phyre2 PDB 1gpj chain A domain 1 Region: 317 - 404 Aligned: 88 Modelled: 88 Confidence: 99.7% Identity: 15% Fold: Glutamyl tRNA-reductase dimerization domain Superfamily: Glutamyl tRNA-reductase dimerization domain Family: Glutamyl tRNA-reductase dimerization domain Phyre2 PDB 3don chain A Region: 95 - 360 Aligned: 233 Modelled: 246 Confidence: 99.7% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate dehydrogenase; PDBTitle: crystal structure of shikimate dehydrogenase from staphylococcus2 epidermidis Phyre2 PDB 2egg chain A Region: 171 - 354 Aligned: 158 Modelled: 166 Confidence: 99.7% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:shikimate 5-dehydrogenase; PDBTitle: crystal structure of shikimate 5-dehydrogenase (aroe) from2 geobacillus kaustophilus Phyre2 PDB 3gvp chain B Region: 54 - 376 Aligned: 301 Modelled: 307 Confidence: 99.6% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:adenosylhomocysteinase 3; PDBTitle: human sahh-like domain of human adenosylhomocysteinase 3 Phyre2 PDB 1leh chain B Region: 164 - 359 Aligned: 185 Modelled: 196 Confidence: 99.6% Identity: 16% PDB header:oxidoreductase Chain: B: PDB Molecule:leucine dehydrogenase; PDBTitle: leucine dehydrogenase from bacillus sphaericus Phyre2 PDB 3o8q chain B Region: 95 - 353 Aligned: 233 Modelled: 241 Confidence: 99.6% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:shikimate 5-dehydrogenase i alpha; PDBTitle: 1.45 angstrom resolution crystal structure of shikimate 5-2 dehydrogenase (aroe) from vibrio cholerae Phyre2 PDB 1nvt chain A domain 1 Region: 166 - 352 Aligned: 165 Modelled: 169 Confidence: 99.6% Identity: 24% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 2rir chain A Region: 161 - 338 Aligned: 160 Modelled: 178 Confidence: 99.5% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase, a chain; PDBTitle: crystal structure of dipicolinate synthase, a chain, from bacillus2 subtilis Phyre2 PDB 2i99 chain A Region: 167 - 311 Aligned: 139 Modelled: 145 Confidence: 99.5% Identity: 27% PDB header:oxidoreductase Chain: A: PDB Molecule:mu-crystallin homolog; PDBTitle: crystal structure of human mu_crystallin at 2.6 angstrom Phyre2 PDB 1l7d chain A domain 1 Region: 166 - 305 Aligned: 134 Modelled: 140 Confidence: 99.5% Identity: 16% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Formate/glycerate dehydrogenases, NAD-domain Phyre2 PDB 3d4o chain A Region: 137 - 333 Aligned: 179 Modelled: 197 Confidence: 99.5% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:dipicolinate synthase subunit a; PDBTitle: crystal structure of dipicolinate synthase subunit a (np_243269.1)2 from bacillus halodurans at 2.10 a resolution Phyre2 PDB 1nyt chain A domain 1 Region: 166 - 352 Aligned: 164 Modelled: 169 Confidence: 99.4% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 1npy chain A domain 1 Region: 167 - 352 Aligned: 164 Modelled: 168 Confidence: 99.4% Identity: 21% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 1 c1gpjA_ 2 d1gpja3 3 d1gpja2 4 c3oj0A_ 5 c1luaA_ 6 c3pgjB_ 7 c2nloA_ 8 d1gpja1 9 c3donA_ 10 c2eggA_ 11 c3gvpB_ 12 c1lehB_ 13 c3o8qB_ 14 d1nvta1 15 c2rirA_ 16 c2i99A_ 17 d1l7da1 18 c3d4oA_ 19 d1nyta1 20 d1npya1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499