Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	V	V	I	S	D	A	W	R	Q	R	F	G	G	T	A	R	L	Y	G	E	K	A	L	Q	L	F	A	D	A	H	I	C	V	V	G	I	G	G	V	G	S	W	A	A	E	A	L	A	R	T	G	I	G	A	I	T	L	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	M	D	D	V	C	V	T	N	T	N	R	Q	I	H	A	L	R	D	N	V	G	L	A	K	A	E	V	M	A	E	R	I	R	Q	I	N	P	E	C	R	V	T	V	V	D	D	F	V	T	P	D	N	V	A	Q	Y	M	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	Y	S	Y	V	I	D	A	I	D	S	V	R	P	K	A	A	L	I	A	Y	C	R	R	N	K	I	P	L	V	T	T	G	G	A	G	G	Q	I	D	P	T	Q	I	Q	V	T	D	L	A	K	T	I	Q	D	P	L	A	A	K
Secondary structure
SS confidence
Disorder																																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	R	E	R	L	K	S	D	F	G	V	V	K	N	S	K	G	K	L	G	V	D	C	V	F	S	T	E	A	L	V	Y	P	Q	S	D	G	T	V	C	A	M	K	A	T	A	E	G	P	K	R	M	D	C	A	S	G	F	G	A
Secondary structure
SS confidence
Disorder		?					?	?		?		?	?	?	?		?	?																?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.
Sequence		A	T	M	V	T	A	T	F	G	F	V	A	V	S	H	A	L	K	K	M	M	A	K	A	A	R	Q	G
Secondary structure
SS confidence
Disorder		?																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zfn chain A Region: 5 - 268 Aligned: 215 Modelled: 216 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:adenylyltransferase thif; PDBTitle: structural analysis of escherichia coli thif Phyre2 PDB 1y8q chain A Region: 5 - 266 Aligned: 260 Modelled: 262 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: A: PDB Molecule:ubiquitin-like 1 activating enzyme e1a; PDBTitle: sumo e1 activating enzyme sae1-sae2-mg-atp complex Phyre2 PDB 1jw9 chain B Region: 5 - 266 Aligned: 206 Modelled: 207 Confidence: 100.0% Identity: 26% Fold: Activating enzymes of the ubiquitin-like proteins Superfamily: Activating enzymes of the ubiquitin-like proteins Family: Molybdenum cofactor biosynthesis protein MoeB Phyre2 PDB 1yov chain B domain 1 Region: 12 - 267 Aligned: 208 Modelled: 210 Confidence: 100.0% Identity: 23% Fold: Activating enzymes of the ubiquitin-like proteins Superfamily: Activating enzymes of the ubiquitin-like proteins Family: Ubiquitin activating enzymes (UBA) Phyre2 PDB 3h9g chain A Region: 6 - 267 Aligned: 226 Modelled: 227 Confidence: 100.0% Identity: 21% PDB header:transferase/antibiotic Chain: A: PDB Molecule:mccb protein; PDBTitle: crystal structure of e. coli mccb + mcca-n7isoasn Phyre2 PDB 3gzn chain B Region: 12 - 266 Aligned: 207 Modelled: 209 Confidence: 100.0% Identity: 22% PDB header:protein binding/ligase Chain: B: PDB Molecule:nedd8-activating enzyme e1 catalytic subunit; PDBTitle: structure of nedd8-activating enzyme in complex with nedd82 and mln4924 Phyre2 PDB 3kyd chain B Region: 18 - 266 Aligned: 212 Modelled: 213 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: B: PDB Molecule:sumo-activating enzyme subunit 2; PDBTitle: human sumo e1~sumo1-amp tetrahedral intermediate mimic Phyre2 PDB 2nvu chain B Region: 22 - 266 Aligned: 197 Modelled: 199 Confidence: 100.0% Identity: 23% PDB header:protein turnover, ligase Chain: B: PDB Molecule:maltose binding protein/nedd8-activating enzyme PDBTitle: structure of appbp1-uba3~nedd8-nedd8-mgatp-ubc12(c111a), a2 trapped ubiquitin-like protein activation complex Phyre2 PDB 1y8q chain D Region: 18 - 175 Aligned: 157 Modelled: 158 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: D: PDB Molecule:ubiquitin-like 2 activating enzyme e1b; PDBTitle: sumo e1 activating enzyme sae1-sae2-mg-atp complex Phyre2 PDB 3vh3 chain A Region: 3 - 268 Aligned: 225 Modelled: 227 Confidence: 100.0% Identity: 17% PDB header:metal binding protein/protein transport Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of atg7ctd-atg8 complex Phyre2 PDB 3cmm chain A Region: 12 - 175 Aligned: 163 Modelled: 164 Confidence: 100.0% Identity: 25% PDB header:ligase/protein binding Chain: A: PDB Molecule:ubiquitin-activating enzyme e1 1; PDBTitle: crystal structure of the uba1-ubiquitin complex Phyre2 PDB 3vh1 chain A Region: 18 - 268 Aligned: 199 Modelled: 201 Confidence: 100.0% Identity: 17% PDB header:metal binding protein Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of saccharomyces cerevisiae atg7 (1-595) Phyre2 PDB 1yov chain A domain 1 Region: 10 - 164 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 19% Fold: Activating enzymes of the ubiquitin-like proteins Superfamily: Activating enzymes of the ubiquitin-like proteins Family: Ubiquitin activating enzymes (UBA) Phyre2 PDB 3guc chain B Region: 26 - 266 Aligned: 181 Modelled: 187 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:ubiquitin-like modifier-activating enzyme 5; PDBTitle: human ubiquitin-activating enzyme 5 in complex with amppnp Phyre2 PDB 1e5l chain A Region: 29 - 151 Aligned: 96 Modelled: 104 Confidence: 98.5% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine reductase; PDBTitle: apo saccharopine reductase from magnaporthe grisea Phyre2 PDB 2axq chain A Region: 30 - 155 Aligned: 99 Modelled: 100 Confidence: 98.5% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine dehydrogenase; PDBTitle: apo histidine-tagged saccharopine dehydrogenase (l-glu2 forming) from saccharomyces cerevisiae Phyre2 PDB 1pjq chain A domain 1 Region: 28 - 149 Aligned: 91 Modelled: 97 Confidence: 98.4% Identity: 18% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Siroheme synthase N-terminal domain-like Phyre2 PDB 1vi2 chain A domain 1 Region: 28 - 129 Aligned: 83 Modelled: 83 Confidence: 98.2% Identity: 13% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 3ic5 chain A Region: 29 - 154 Aligned: 98 Modelled: 98 Confidence: 98.2% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative saccharopine dehydrogenase; PDBTitle: n-terminal domain of putative saccharopine dehydrogenase from ruegeria2 pomeroyi. Phyre2 PDB 1pjt chain B Region: 28 - 192 Aligned: 134 Modelled: 140 Confidence: 98.1% Identity: 22% PDB header:transferase/oxidoreductase/lyase Chain: B: PDB Molecule:siroheme synthase; PDBTitle: the structure of the ser128ala point-mutant variant of cysg,2 the multifunctional3 methyltransferase/dehydrogenase/ferrochelatase for4 siroheme synthesis Phyre2 1 c1zfnA_ 2 c1y8qA_ 3 d1jw9b_ 4 d1yovb1 5 c3h9gA_ 6 c3gznB_ 7 c3kydB_ 8 c2nvuB_ 9 c1y8qD_ 10 c3vh3A_ 11 c3cmmA_ 12 c3vh1A_ 13 d1yova1 14 c3gucB_ 15 c1e5lA_ 16 c2axqA_ 17 d1pjqa1 18 d1vi2a1 19 c3ic5A_ 20 c1pjtB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499