Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	N	L	V	I	V	S	H	S	S	R	L	G	E	G	V	G	E	L	A	R	Q	M	L	M	S	D	S	C	K	I	A	I	A	A	G	I	D	D	P	Q	N	P	I	G	T	D	A	V	K	V	M	E	A	I	E	S	V	A
Secondary structure
SS confidence
Disorder		?	?																																					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	A	D	H	V	L	V	M	M	D	M	G	S	A	L	L	S	A	E	T	A	L	E	L	L	A	P	E	I	A	A	K	V	R	L	C	A	A	P	L	V	E	G	T	L	A	A	T	V	S	A	A	S	G	A	D	I	D	K	V
Secondary structure
SS confidence
Disorder																									?																												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	F	D	A	M	H	A	L	E	A	K	R	E	Q	L	G	L	P	S	S	D	T	E	I	S	D	T	C	P	A	Y	D	E	E	A	R	S	L	A	V	V	I	K	N	R	N	G	L	H	V	R	P	A	S	R	L	V	Y	T	L
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	T	F	N	A	D	M	L	L	E	K	N	G	K	C	V	T	P	E	S	I	N	Q	I	A	L	L	Q	V	R	Y	N	D	T	L	R	L	I	A	K	G	P	E	A	E	E	A	L	I	A	F	R	Q	L	A	E	D	N	F	G
Secondary structure
SS confidence
Disorder																			?									?																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	T	E	E	V	A	P	P	T	L	R	P	V	P	P	V	S	G	K	A	F	Y	Y	Q	P	V	L	C	T	V	Q	A	K	S	T	L	T	V	E	E	E	Q	D	R	L	R	Q	A	I	D	F	T	L	L	D	L	M	T	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	K	A	E	A	S	G	L	D	D	I	A	A	I	F	S	G	H	H	T	L	L	D	D	P	E	L	L	A	A	A	S	E	L	L	Q	H	E	H	C	T	A	E	Y	A	W	Q	Q	V	L	K	E	L	S	Q	Q	Y	Q	Q	L
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	D	E	Y	L	Q	A	R	Y	I	D	V	D	D	L	L	H	R	T	L	V	H	L	T	Q	T	K	E	E	L	P	Q	F	N	S	P	T	I	L	L	A	E	N	I	Y	P	S	T	V	L	Q	L	D	P	A	V	V	K	G	I
Secondary structure
SS confidence
Disorder		?	?																									?	?	?	?	?	?	?																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.
Sequence		C	L	S	A	G	S	P	V	S	H	S	A	L	I	A	R	E	L	G	I	G	W	I	C	Q	Q	G	E	K	L	Y	A	I	Q	P	E	E	T	L	T	L	D	V	K	T	Q	R	F	N	R	Q	G
Secondary structure
SS confidence
Disorder																																															?			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1eza chain A Region: 250 - 471 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 28% PDB header:phosphotransferase Chain: A: PDB Molecule:enzyme i; PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure Phyre2 PDB 2hro chain A Region: 250 - 471 Aligned: 213 Modelled: 221 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus Phyre2 PDB 2hwg chain A Region: 250 - 469 Aligned: 219 Modelled: 220 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system Phyre2 PDB 3ct6 chain A domain 1 Region: 1 - 131 Aligned: 122 Modelled: 131 Confidence: 100.0% Identity: 30% Fold: PTS system fructose IIA component-like Superfamily: PTS system fructose IIA component-like Family: DhaM-like Phyre2 PDB 1zym chain A domain 1 Region: 266 - 386 Aligned: 121 Modelled: 121 Confidence: 99.9% Identity: 30% Fold: SAM domain-like Superfamily: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Family: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phyre2 PDB 3b48 chain A domain 1 Region: 2 - 127 Aligned: 121 Modelled: 126 Confidence: 99.9% Identity: 30% Fold: PTS system fructose IIA component-like Superfamily: PTS system fructose IIA component-like Family: DhaM-like Phyre2 PDB 2hpr chain A Region: 156 - 241 Aligned: 86 Modelled: 86 Confidence: 99.9% Identity: 31% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 3gdw chain A Region: 2 - 128 Aligned: 119 Modelled: 113 Confidence: 99.8% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sigma-54 interaction domain protein; PDBTitle: crystal structure of sigma-54 interaction domain protein from2 enterococcus faecalis Phyre2 PDB 1ka5 chain A Region: 156 - 241 Aligned: 86 Modelled: 86 Confidence: 99.8% Identity: 31% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1pch chain A Region: 156 - 241 Aligned: 86 Modelled: 86 Confidence: 99.8% Identity: 24% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 3le1 chain B Region: 156 - 239 Aligned: 84 Modelled: 84 Confidence: 99.8% Identity: 38% PDB header:transferase Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins; PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis Phyre2 PDB 1qr5 chain A Region: 156 - 241 Aligned: 86 Modelled: 86 Confidence: 99.8% Identity: 31% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1mo1 chain A Region: 156 - 239 Aligned: 84 Modelled: 84 Confidence: 99.8% Identity: 31% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 3ihs chain B Region: 153 - 236 Aligned: 84 Modelled: 84 Confidence: 99.8% Identity: 32% PDB header:transport protein Chain: B: PDB Molecule:phosphocarrier protein hpr; PDBTitle: crystal structure of a phosphocarrier protein hpr from2 bacillus anthracis str. ames Phyre2 PDB 1zym chain A domain 2 Region: 383 - 471 Aligned: 89 Modelled: 89 Confidence: 99.8% Identity: 26% Fold: The "swivelling" beta/beta/alpha domain Superfamily: Phosphohistidine domain Family: N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system Phyre2 PDB 2nzu chain L domain 1 Region: 156 - 241 Aligned: 85 Modelled: 86 Confidence: 99.8% Identity: 31% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1ptf chain A Region: 156 - 238 Aligned: 83 Modelled: 83 Confidence: 99.8% Identity: 30% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1cm3 chain A Region: 156 - 237 Aligned: 81 Modelled: 82 Confidence: 99.8% Identity: 23% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1zvv chain J domain 1 Region: 156 - 238 Aligned: 82 Modelled: 83 Confidence: 99.8% Identity: 29% Fold: HPr-like Superfamily: HPr-like Family: HPr-like Phyre2 PDB 1h6z chain A Region: 389 - 470 Aligned: 80 Modelled: 82 Confidence: 99.7% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:pyruvate phosphate dikinase; PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei Phyre2 PDB 1un8 chain A domain 4 Region: 48 - 172 Aligned: 121 Modelled: 121 Confidence: 96.9% Identity: 18% Fold: DAK1/DegV-like Superfamily: DAK1/DegV-like Family: DAK1 Phyre2 1 c1ezaA_ 2 c2hroA_ 3 c2hwgA_ 4 d3ct6a1 5 d1zyma1 6 d3b48a1 7 d2hpra_ 8 c3gdwA_ 9 d1ka5a_ 10 d1pcha_ 11 c3le1B_ 12 d1qr5a_ 13 d1mo1a_ 14 c3ihsB_ 15 d1zyma2 16 d2nzul1 17 d1ptfa_ 18 d1cm3a_ 19 d1zvvj1 20 c1h6zA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 d1un8a4 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1ezaA_ 100.0 28 PDB header:phosphotransferase Chain: A: PDB Molecule:enzyme i; PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure 2 c2hroA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus 3 c2hwgA_ 100.0 28 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system 4 d3ct6a1 100.0 30 Fold:PTS system fructose IIA component-like Superfamily:PTS system fructose IIA component-like Family:DhaM-like 5 d1zyma1 99.9 30 Fold:SAM domain-like Superfamily:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Family:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 6 d3b48a1 99.9 30 Fold:PTS system fructose IIA component-like Superfamily:PTS system fructose IIA component-like Family:DhaM-like 7 d2hpra_ 99.9 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 8 c3gdwA_ 99.8 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sigma-54 interaction domain protein; PDBTitle: crystal structure of sigma-54 interaction domain protein from2 enterococcus faecalis 9 d1ka5a_ 99.8 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 10 d1pcha_ 99.8 24 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 11 c3le1B_ 99.8 38 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins; PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis 12 d1qr5a_ 99.8 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 13 d1mo1a_ 99.8 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 14 c3ihsB_ 99.8 32 PDB header:transport protein Chain: B: PDB Molecule:phosphocarrier protein hpr; PDBTitle: crystal structure of a phosphocarrier protein hpr from2 bacillus anthracis str. ames 15 d1zyma2 99.8 26 Fold:The "swivelling" beta/beta/alpha domain Superfamily:Phosphohistidine domain Family:N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system 16 d2nzul1 99.8 31 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 17 d1ptfa_ 99.8 30 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 18 d1cm3a_ 99.8 23 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 19 d1zvvj1 99.8 29 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 20 c1h6zA_ 99.7 21 PDB header:transferase Chain: A: PDB Molecule:pyruvate phosphate dikinase; PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei 21 c1kblA_ not modelled 99.7 25 PDB header:transferase Chain: A: PDB Molecule:pyruvate phosphate dikinase; PDBTitle: pyruvate phosphate dikinase 22 d1h6za2 not modelled 99.7 22 Fold:The "swivelling" beta/beta/alpha domain Superfamily:Phosphohistidine domain Family:Pyruvate phosphate dikinase, central domain 23 d1kbla2 not modelled 99.7 28 Fold:The "swivelling" beta/beta/alpha domain Superfamily:Phosphohistidine domain Family:Pyruvate phosphate dikinase, central domain 24 d1vbga2 not modelled 99.7 26 Fold:The "swivelling" beta/beta/alpha domain Superfamily:Phosphohistidine domain Family:Pyruvate phosphate dikinase, central domain 25 c1vbhA_ not modelled 99.5 25 PDB header:transferase Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase; PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize 26 c3gx1A_ not modelled 99.5 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:lin1832 protein; PDBTitle: crystal structure of a domain of lin1832 from listeria innocua 27 c2olsA_ not modelled 99.5 18 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate synthase; PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis 28 c3iprC_ not modelled 99.4 23 PDB header:transferase Chain: C: PDB Molecule:pts system, iia component; PDBTitle: crystal structure of the enterococcus faecalis gluconate2 specific eiia phosphotransferase system component 29 c3t07D_ not modelled 99.2 19 PDB header:transferase/transferase inhibitor Chain: D: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid 30 c2e28A_ not modelled 99.0 19 PDB header:transferase Chain: A: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus 31 d1pdoa_ not modelled 98.5 14 Fold:PTS system fructose IIA component-like Superfamily:PTS system fructose IIA component-like Family:EIIA-man component-like 32 c3mtqA_ not modelled 97.9 16 PDB header:transferase Chain: A: PDB Molecule:putative phosphoenolpyruvate-dependent sugar PDBTitle: crystal structure of a putative phosphoenolpyruvate-dependent sugar2 phosphotransferase system (pts) permease (kpn_04802) from klebsiella3 pneumoniae subsp. pneumoniae mgh 78578 at 1.70 a resolution 33 c3lfhF_ not modelled 97.1 14 PDB header:transferase Chain: F: PDB Molecule:phosphotransferase system, mannose/fructose-specific PDBTitle: crystal structure of manxa from thermoanaerobacter tengcongensis 34 d3beda1 not modelled 97.1 14 Fold:PTS system fructose IIA component-like Superfamily:PTS system fructose IIA component-like Family:EIIA-man component-like 35 d1un8a4 96.9 18 Fold:DAK1/DegV-like Superfamily:DAK1/DegV-like Family:DAK1 36 c3ct4B_ not modelled 96.2 22 PDB header:transferase Chain: B: PDB Molecule:pts-dependent dihydroxyacetone kinase, PDBTitle: structure of dha-kinase subunit dhak from l. lactis 37 c1un9B_ not modelled 96.2 18 PDB header:kinase Chain: B: PDB Molecule:dihydroxyacetone kinase; PDBTitle: crystal structure of the dihydroxyacetone kinase from c.2 freundii in complex with amp-pnp and mg2+ 38 d1oi2a_ not modelled 96.2 23 Fold:DAK1/DegV-like Superfamily:DAK1/DegV-like Family:DAK1 39 c2iu6B_ not modelled 95.7 18 PDB header:transferase Chain: B: PDB Molecule:dihydroxyacetone kinase; PDBTitle: regulation of the dha operon of lactococcus lactis 40 d2hi6a1 not modelled 87.1 18 Fold:The "swivelling" beta/beta/alpha domain Superfamily:LeuD/IlvD-like Family:AF0055-like 41 c3nyiA_ not modelled 84.0 11 PDB header:lipid binding protein Chain: A: PDB Molecule:fat acid-binding protein; PDBTitle: the crystal structure of a fat acid (stearic acid)-binding protein2 from eubacterium ventriosum atcc 27560. 42 d1eepa_ not modelled 78.5 11 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 43 c3navB_ not modelled 76.1 25 PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961 44 c2a7rD_ not modelled 76.0 15 PDB header:oxidoreductase Chain: D: PDB Molecule:gmp reductase 2; PDBTitle: crystal structure of human guanosine monophosphate2 reductase 2 (gmpr2) 45 c2px0D_ not modelled 70.0 13 PDB header:biosynthetic protein Chain: D: PDB Molecule:flagellar biosynthesis protein flhf; PDBTitle: crystal structure of flhf complexed with gmppnp/mg(2+) 46 d1ivsa1 not modelled 69.3 15 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Valyl-tRNA synthetase (ValRS) C-terminal domain 47 c3jr7A_ not modelled 62.9 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized egv family protein cog1307; PDBTitle: the crystal structure of the protein of degv family cog1307 with2 unknown function from ruminococcus gnavus atcc 29149 48 c1mgpA_ not modelled 62.0 21 PDB header:lipid binding protein Chain: A: PDB Molecule:hypothetical protein tm841; PDBTitle: hypothetical protein tm841 from thermotoga maritima reveals2 fatty acid binding function 49 d1mgpa_ not modelled 62.0 21 Fold:DAK1/DegV-like Superfamily:DAK1/DegV-like Family:DegV-like 50 d2auna1 not modelled 61.3 18 Fold:The "swivelling" beta/beta/alpha domain Superfamily:LD-carboxypeptidase A C-terminal domain-like Family:LD-carboxypeptidase A C-terminal domain-like 51 c3thaB_ not modelled 59.8 17 PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: tryptophan synthase subunit alpha from campylobacter jejuni. 52 d1vrda1 not modelled 57.4 11 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 53 d2gp4a1 not modelled 57.0 11 Fold:The "swivelling" beta/beta/alpha domain Superfamily:LeuD/IlvD-like Family:IlvD/EDD C-terminal domain-like 54 c1nw3A_ not modelled 56.7 28 PDB header:transferase Chain: A: PDB Molecule:histone methyltransferase dot1l; PDBTitle: structure of the catalytic domain of human dot1l, a non-set2 domain nucleosomal histone methyltransferase 55 d1nw3a_ not modelled 56.7 28 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Catalytic, N-terminal domain of histone methyltransferase Dot1l 56 d1jr1a1 not modelled 56.3 9 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 57 c2g7zB_ not modelled 56.0 13 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:conserved hypothetical protein spy1493; PDBTitle: conserved degv-like protein of unknown function from streptococcus2 pyogenes m1 gas binds long-chain fatty acids 58 d1oi7a2 not modelled 54.9 18 Fold:Flavodoxin-like Superfamily:Succinyl-CoA synthetase domains Family:Succinyl-CoA synthetase domains 59 c1u2zC_ not modelled 54.9 18 PDB header:transferase Chain: C: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-79 PDBTitle: crystal structure of histone k79 methyltransferase dot1p2 from yeast 60 c2dt8A_ not modelled 54.2 21 PDB header:lipid binding protein Chain: A: PDB Molecule:degv family protein; PDBTitle: fatty acid binding of a degv family protein from thermus thermophilus 61 c2jgqB_ not modelled 53.9 18 PDB header:isomerase Chain: B: PDB Molecule:triosephosphate isomerase; PDBTitle: kinetics and structural properties of triosephosphate2 isomerase from helicobacter pylori 62 c3iz5H_ not modelled 52.6 24 PDB header:ribosome Chain: H: PDB Molecule:60s ribosomal protein l7a (l7ae); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome 63 c1vrdA_ not modelled 52.0 11 PDB header:oxidoreductase Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase; PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase (tm1347)2 from thermotoga maritima at 2.18 a resolution 64 c1w2wJ_ not modelled 50.6 19 PDB header:isomerase Chain: J: PDB Molecule:5-methylthioribose-1-phosphate isomerase; PDBTitle: crystal structure of yeast ypr118w, a methylthioribose-1-2 phosphate isomerase related to regulatory eif2b subunits 65 c4a1eF_ not modelled 48.0 24 PDB header:ribosome Chain: F: PDB Molecule:rpl7a; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna, 5.8s rrna3 and proteins of molecule 1 66 d1u2za_ not modelled 47.8 18 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Catalytic, N-terminal domain of histone methyltransferase Dot1l 67 d1zfja1 not modelled 47.7 13 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 68 d2fzva1 not modelled 47.6 15 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:NADPH-dependent FMN reductase 69 c3pl5A_ not modelled 46.5 14 PDB header:lipid binding protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: fatty acid binding protein 70 d2nu7a2 not modelled 45.7 21 Fold:Flavodoxin-like Superfamily:Succinyl-CoA synthetase domains Family:Succinyl-CoA synthetase domains 71 c2fzvC_ not modelled 44.6 16 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:putative arsenical resistance protein; PDBTitle: crystal structure of an apo form of a flavin-binding protein from2 shigella flexneri 72 d1qopa_ not modelled 44.4 19 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 73 c2zkrf_ not modelled 43.8 28 PDB header:ribosomal protein/rna Chain: F: PDB Molecule:rna expansion segment es7 part iii; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 74 c3khjE_ not modelled 43.8 13 PDB header:oxidoreductase Chain: E: PDB Molecule:inosine-5-monophosphate dehydrogenase; PDBTitle: c. parvum inosine monophosphate dehydrogenase bound by inhibitor c64 75 c2yvkA_ not modelled 43.4 15 PDB header:isomerase Chain: A: PDB Molecule:methylthioribose-1-phosphate isomerase; PDBTitle: crystal structure of 5-methylthioribose 1-phosphate2 isomerase product complex from bacillus subtilis 76 c2ekcA_ not modelled 43.3 24 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 77 c3izcH_ not modelled 43.2 26 PDB header:ribosome Chain: H: PDB Molecule:60s ribosomal protein rpl8 (l7ae); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 78 c2gp4A_ not modelled 41.5 11 PDB header:lyase Chain: A: PDB Molecule:6-phosphogluconate dehydratase; PDBTitle: structure of [fes]cluster-free apo form of 6-phosphogluconate2 dehydratase from shewanella oneidensis 79 d1cf7b_ not modelled 39.8 17 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Cell cycle transcription factor e2f-dp 80 c3r2gA_ not modelled 38.9 13 PDB header:oxidoreductase Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase; PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila 81 d1pzxa_ not modelled 38.1 10 Fold:DAK1/DegV-like Superfamily:DAK1/DegV-like Family:DegV-like 82 d1vzwa1 not modelled 36.6 23 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 83 c2jpiA_ not modelled 34.5 13 PDB header:structural genomics Chain: A: PDB Molecule:hypothetical protein; PDBTitle: chemical shift assignments of pa4090 from pseudomonas2 aeruginosa 84 d1y0ea_ not modelled 34.1 12 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:NanE-like 85 d1g0da4 not modelled 33.2 29 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Transglutaminase core 86 d1tuba1 not modelled 33.2 13 Fold:Tubulin nucleotide-binding domain-like Superfamily:Tubulin nucleotide-binding domain-like Family:Tubulin, GTPase domain 87 d1piia2 not modelled 33.1 29 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 88 d1j5ta_ not modelled 32.1 28 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 89 c1jcnA_ not modelled 32.0 10 PDB header:oxidoreductase Chain: A: PDB Molecule:inosine monophosphate dehydrogenase i; PDBTitle: binary complex of human type-i inosine monophosphate dehydrogenase2 with 6-cl-imp 90 d1hg3a_ not modelled 31.7 27 Fold:TIM beta/alpha-barrel Superfamily:Triosephosphate isomerase (TIM) Family:Triosephosphate isomerase (TIM) 91 d2csua2 not modelled 31.7 19 Fold:Flavodoxin-like Superfamily:Succinyl-CoA synthetase domains Family:Succinyl-CoA synthetase domains 92 c3dmaA_ not modelled 31.5 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:exopolyphosphatase-related protein; PDBTitle: crystal structure of an exopolyphosphatase-related protein2 from bacteroides fragilis. northeast structural genomics3 target bfr192 93 d1tb3a1 not modelled 31.3 18 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 94 c1oi7A_ not modelled 30.1 18 PDB header:synthetase Chain: A: PDB Molecule:succinyl-coa synthetase alpha chain; PDBTitle: the crystal structure of succinyl-coa synthetase alpha2 subunit from thermus thermophilus 95 d2btma_ not modelled 30.0 19 Fold:TIM beta/alpha-barrel Superfamily:Triosephosphate isomerase (TIM) Family:Triosephosphate isomerase (TIM) 96 c2fpgA_ not modelled 29.1 21 PDB header:ligase Chain: A: PDB Molecule:succinyl-coa ligase [gdp-forming] alpha-chain, PDBTitle: crystal structure of pig gtp-specific succinyl-coa2 synthetase in complex with gdp 97 d1pvna1 not modelled 27.5 11 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 98 c3lupA_ not modelled 27.1 10 PDB header:structure genomics, unknown function Chain: A: PDB Molecule:degv family protein; PDBTitle: crystal structure of fatty acid binding degv family protein sag13422 from streptococcus agalactiae 99 d1wv2a_ not modelled 26.5 29 Fold:TIM beta/alpha-barrel Superfamily:ThiG-like Family:ThiG-like 100 d1o8bb1 not modelled 25.7 29 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:D-ribose-5-phosphate isomerase (RpiA), catalytic domain 101 d1v7la_ not modelled 25.6 21 Fold:The "swivelling" beta/beta/alpha domain Superfamily:LeuD/IlvD-like Family:LeuD-like 102 d1aopa2 not modelled 25.4 18 Fold:Ferredoxin-like Superfamily:Nitrite/Sulfite reductase N-terminal domain-like Family:Duplicated SiR/NiR-like domains 1 and 3 103 c2rkbE_ not modelled 25.1 25 PDB header:lyase Chain: E: PDB Molecule:serine dehydratase-like; PDBTitle: serine dehydratase like-1 from human cancer cells 104 d1a53a_ not modelled 24.8 18 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 105 d1i4na_ not modelled 24.8 26 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 106 d2cu0a1 not modelled 24.6 14 Fold:TIM beta/alpha-barrel Superfamily:Inosine monophosphate dehydrogenase (IMPDH) Family:Inosine monophosphate dehydrogenase (IMPDH) 107 c2k8hA_ not modelled 24.3 16 PDB header:signaling protein Chain: A: PDB Molecule:small ubiquitin protein; PDBTitle: solution structure of sumo from trypanosoma brucei 108 c2nu8D_ not modelled 23.9 20 PDB header:ligase Chain: D: PDB Molecule:succinyl-coa ligase [adp-forming] subunit alpha; PDBTitle: c123at mutant of e. coli succinyl-coa synthetase 109 c1ypfB_ not modelled 23.7 14 PDB header:oxidoreductase Chain: B: PDB Molecule:gmp reductase; PDBTitle: crystal structure of guac (ba5705) from bacillus anthracis at 1.8 a2 resolution 110 c3fdjA_ not modelled 23.6 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:degv family protein; PDBTitle: the structure of a degv family protein from eubacterium eligens. 111 c2ekeC_ not modelled 23.6 8 PDB header:ligase/protein binding Chain: C: PDB Molecule:ubiquitin-like protein smt3; PDBTitle: structure of a sumo-binding-motif mimic bound to smt3p-2 ubc9p: conservation of a noncovalent ubiquitin-like3 protein-e2 complex as a platform for selective4 interactions within a sumo pathway 112 d1geqa_ not modelled 23.5 28 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 113 c3no4A_ not modelled 23.1 25 PDB header:hydrolase Chain: A: PDB Molecule:creatinine amidohydrolase; PDBTitle: crystal structure of a creatinine amidohydrolase (npun_f1913) from2 nostoc punctiforme pcc 73102 at 2.00 a resolution 114 c2dy0A_ not modelled 23.0 20 PDB header:transferase Chain: A: PDB Molecule:adenine phosphoribosyltransferase; PDBTitle: crystal structure of project jw0458 from escherichia coli 115 c2rbfB_ not modelled 22.8 13 PDB header:oxidoreductase/dna Chain: B: PDB Molecule:bifunctional protein puta; PDBTitle: structure of the ribbon-helix-helix domain of escherichia coli puta2 (puta52) complexed with operator dna (o2) 116 d1ka9f_ not modelled 22.6 24 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 117 d2pw9a1 not modelled 22.4 13 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:FdhD/NarQ 118 c3m3hA_ not modelled 22.2 10 PDB header:transferase Chain: A: PDB Molecule:orotate phosphoribosyltransferase; PDBTitle: 1.75 angstrom resolution crystal structure of an orotate2 phosphoribosyltransferase from bacillus anthracis str. 'ames3 ancestor' 119 d1h41a1 not modelled 22.1 18 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 120 c3edlA_ not modelled 21.8 15 PDB header:structural protein Chain: A: PDB Molecule:alpha-tubulin; PDBTitle: kinesin13-microtubule ring complex

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0