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 Protein Homology/analogY Recognition Engine V 2.0



The Phyre2 webserver was designed and written by Dr. Lawrence Kelley

Phyre2 is the successor to the two web servers I previously developed, 3D-pssm and Phyre. Phyre2 has been ranked amongst the best systems of its kind for the last four years as judged by the biannual Critical Assessment of Structure Prediction (CASP) meetings.

The work on developing the Phyre2 web server is supported by a BBSRC tools and resources grant

Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0
Re-orienting structures for easy viewing: OVOP

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg 
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Phyre2 is part of Genome3D