Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	G	L	V	T	A	A	Y	I	V	A	A	I	L	F	I	F	S	L	A	G	L	S	K	H	E	T	S	R	Q	G	N	N	F	G	I	A	G	M	A	I	A	L	I	A	T	I	F	G	P	D	T	G	N	V	G	W	I
Secondary structure
SS confidence
Disorder		?	?	?	?																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	A	M	V	I	G	G	A	I	G	I	R	L	A	K	K	V	E	M	T	E	M	P	E	L	V	A	I	L	H	S	F	V	G	L	A	A	V	L	V	G	F	N	S	Y	L	H	H	D	A	G	M	A	P	I	L	V	N	I
Secondary structure
SS confidence
Disorder																																																					?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	L	T	E	V	F	L	G	I	F	I	G	A	V	T	F	T	G	S	V	V	A	F	G	K	L	C	G	K	I	S	S	K	P	L	M	L	P	N	R	H	K	M	N	L	A	A	L	V	V	S	F	L	L	L	I	V	F	V	R
Secondary structure
SS confidence
Disorder																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	D	S	V	G	L	Q	V	L	A	L	L	I	M	T	A	I	A	L	V	F	G	W	H	L	V	A	S	I	G	G	A	D	M	P	V	V	V	S	M	L	N	S	Y	S	G	W	A	A	A	A	A	G	F	M	L	S	N	D	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	I	V	T	G	A	L	V	G	S	S	G	A	I	L	S	Y	I	M	C	K	A	M	N	R	S	F	I	S	V	I	A	G	G	F	G	T	D	G	S	S	T	G	D	D	Q	E	V	G	E	H	R	E	I	T	A	E	E	T	A
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	L	L	K	N	S	H	S	V	I	I	T	P	G	Y	G	M	A	V	A	Q	A	Q	Y	P	V	A	E	I	T	E	K	L	R	A	R	G	I	N	V	R	F	G	I	H	P	V	A	G	R	L	P	G	H	M	N	V	L	L	A
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		E	A	K	V	P	Y	D	I	V	L	E	M	D	E	I	N	D	D	F	A	D	T	D	T	V	L	V	I	G	A	N	D	T	V	N	P	A	A	Q	D	D	P	K	S	P	I	A	G	M	P	V	L	E	V	W	K	A	Q	N	V
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
Sequence		I	V	F	K	R	S	M	N	T	G	Y	A	G	V	Q	N	P	L	F	F	K	E	N	T	H	M	L	F	G	D	A	K	A	S	V	D	A	I	L	K	A	L
Secondary structure
SS confidence
Disorder								?		?	?		?																													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1pno chain A Region: 284 - 462 Aligned: 179 Modelled: 179 Confidence: 100.0% Identity: 56% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Transhydrogenase domain III (dIII) Phyre2 PDB 1pt9 chain B Region: 288 - 462 Aligned: 175 Modelled: 175 Confidence: 100.0% Identity: 63% PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase, mitochondrial; PDBTitle: crystal structure analysis of the diii component of transhydrogenase2 with a thio-nicotinamide nucleotide analogue Phyre2 PDB 1d4o chain A Region: 289 - 462 Aligned: 174 Modelled: 174 Confidence: 100.0% Identity: 63% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Transhydrogenase domain III (dIII) Phyre2 PDB 2bru chain C Region: 296 - 462 Aligned: 167 Modelled: 167 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: C: PDB Molecule:nad(p) transhydrogenase subunit beta; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase Phyre2 PDB 1q6z chain A domain 1 Region: 295 - 462 Aligned: 134 Modelled: 142 Confidence: 98.1% Identity: 21% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2iht chain A domain 1 Region: 296 - 462 Aligned: 137 Modelled: 154 Confidence: 97.6% Identity: 20% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1ozh chain A domain 1 Region: 289 - 462 Aligned: 142 Modelled: 158 Confidence: 97.4% Identity: 13% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1ybh chain A domain 1 Region: 296 - 462 Aligned: 137 Modelled: 151 Confidence: 97.3% Identity: 18% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ez9 chain A domain 1 Region: 295 - 462 Aligned: 129 Modelled: 141 Confidence: 97.2% Identity: 19% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2ji6 chain B Region: 297 - 462 Aligned: 134 Modelled: 141 Confidence: 97.2% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: x-ray structure of oxalyl-coa decarboxylase in complex with2 3-deaza-thdp and oxalyl-coa Phyre2 PDB 2ji7 chain A domain 1 Region: 297 - 462 Aligned: 128 Modelled: 128 Confidence: 97.2% Identity: 21% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2dji chain A domain 1 Region: 295 - 462 Aligned: 130 Modelled: 140 Confidence: 97.0% Identity: 24% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2dji chain A Region: 297 - 462 Aligned: 127 Modelled: 150 Confidence: 96.5% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: crystal structure of pyruvate oxidase from aerococcus2 viridans containing fad Phyre2 PDB 1t9b chain A domain 1 Region: 297 - 462 Aligned: 148 Modelled: 166 Confidence: 96.5% Identity: 15% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1ozh chain D Region: 268 - 462 Aligned: 160 Modelled: 179 Confidence: 96.5% Identity: 13% PDB header:lyase Chain: D: PDB Molecule:acetolactate synthase, catabolic; PDBTitle: the crystal structure of klebsiella pneumoniae acetolactate2 synthase with enzyme-bound cofactor and with an unusual3 intermediate. Phyre2 PDB 2pgn chain A Region: 297 - 462 Aligned: 130 Modelled: 150 Confidence: 96.5% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:cyclohexane-1,2-dione hydrolase (cdh); PDBTitle: the crystal structure of fad and thdp-dependent cyclohexane-1,2-dione2 hydrolase in complex with cyclohexane-1,2-dione Phyre2 PDB 3cf4 chain G Region: 290 - 462 Aligned: 139 Modelled: 155 Confidence: 96.5% Identity: 22% PDB header:oxidoreductase Chain: G: PDB Molecule:acetyl-coa decarboxylase/synthase epsilon subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex Phyre2 PDB 1upa chain C Region: 297 - 462 Aligned: 144 Modelled: 150 Confidence: 96.4% Identity: 17% PDB header:synthase Chain: C: PDB Molecule:carboxyethylarginine synthase; PDBTitle: carboxyethylarginine synthase from streptomyces2 clavuligerus (semet structure) Phyre2 PDB 2v3w chain C Region: 295 - 462 Aligned: 141 Modelled: 158 Confidence: 96.2% Identity: 17% PDB header:lyase Chain: C: PDB Molecule:benzoylformate decarboxylase; PDBTitle: crystal structure of the benzoylformate decarboxylase2 variant l461a from pseudomonas putida Phyre2 PDB 1pow chain A Region: 297 - 462 Aligned: 135 Modelled: 141 Confidence: 96.1% Identity: 17% PDB header:oxidoreductase(oxygen as acceptor) Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: the refined structures of a stabilized mutant and of wild-type2 pyruvate oxidase from lactobacillus plantarum Phyre2 PDB 2eey chain A Region: 246 - 267 Aligned: 22 Modelled: 22 Confidence: 63.1% Identity: 41% PDB header:biosynthetic protein Chain: A: PDB Molecule:molybdopterin biosynthesis; PDBTitle: structure of gk0241 protein from geobacillus kaustophilus Phyre2 PDB 1ekr chain A Region: 246 - 267 Aligned: 22 Modelled: 22 Confidence: 62.4% Identity: 45% Fold: Ferredoxin-like Superfamily: Molybdenum cofactor biosynthesis protein C, MoaC Family: Molybdenum cofactor biosynthesis protein C, MoaC Phyre2 1 d1pnoa_ 2 c1pt9B_ 3 d1d4oa_ 4 c2bruC_ 5 d1q6za1 6 d2ihta1 7 d1ozha1 8 d1ybha1 9 d2ez9a1 10 c2ji6B_ 11 d2ji7a1 12 d2djia1 13 c2djiA_ 14 d1t9ba1 15 c1ozhD_ 16 c2pgnA_ 17 c3cf4G_ 18 c1upaC_ 19 c2v3wC_ 20 c1powA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 c2eeyA_ 61 62 d1ekra_ 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1pnoa_ 100.0 56 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Transhydrogenase domain III (dIII) 2 c1pt9B_ 100.0 63 PDB header:oxidoreductase Chain: B: PDB Molecule:nad(p) transhydrogenase, mitochondrial; PDBTitle: crystal structure analysis of the diii component of transhydrogenase2 with a thio-nicotinamide nucleotide analogue 3 d1d4oa_ 100.0 63 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Transhydrogenase domain III (dIII) 4 c2bruC_ 100.0 100 PDB header:oxidoreductase Chain: C: PDB Molecule:nad(p) transhydrogenase subunit beta; PDBTitle: complex of the domain i and domain iii of escherichia coli2 transhydrogenase 5 d1q6za1 98.1 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 6 d2ihta1 97.6 20 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 7 d1ozha1 97.4 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 8 d1ybha1 97.3 18 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 9 d2ez9a1 97.2 19 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 10 c2ji6B_ 97.2 20 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: x-ray structure of oxalyl-coa decarboxylase in complex with2 3-deaza-thdp and oxalyl-coa 11 d2ji7a1 97.2 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 12 d2djia1 97.0 24 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 13 c2djiA_ 96.5 22 PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: crystal structure of pyruvate oxidase from aerococcus2 viridans containing fad 14 d1t9ba1 96.5 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 15 c1ozhD_ 96.5 13 PDB header:lyase Chain: D: PDB Molecule:acetolactate synthase, catabolic; PDBTitle: the crystal structure of klebsiella pneumoniae acetolactate2 synthase with enzyme-bound cofactor and with an unusual3 intermediate. 16 c2pgnA_ 96.5 23 PDB header:hydrolase Chain: A: PDB Molecule:cyclohexane-1,2-dione hydrolase (cdh); PDBTitle: the crystal structure of fad and thdp-dependent cyclohexane-1,2-dione2 hydrolase in complex with cyclohexane-1,2-dione 17 c3cf4G_ 96.5 22 PDB header:oxidoreductase Chain: G: PDB Molecule:acetyl-coa decarboxylase/synthase epsilon subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex 18 c1upaC_ 96.4 17 PDB header:synthase Chain: C: PDB Molecule:carboxyethylarginine synthase; PDBTitle: carboxyethylarginine synthase from streptomyces2 clavuligerus (semet structure) 19 c2v3wC_ 96.2 17 PDB header:lyase Chain: C: PDB Molecule:benzoylformate decarboxylase; PDBTitle: crystal structure of the benzoylformate decarboxylase2 variant l461a from pseudomonas putida 20 c1powA_ 96.1 17 PDB header:oxidoreductase(oxygen as acceptor) Chain: A: PDB Molecule:pyruvate oxidase; PDBTitle: the refined structures of a stabilized mutant and of wild-type2 pyruvate oxidase from lactobacillus plantarum 21 c2ag1A_ not modelled 95.9 16 PDB header:lyase Chain: A: PDB Molecule:benzaldehyde lyase; PDBTitle: crystal structure of benzaldehyde lyase (bal)- semet 22 c2q27B_ not modelled 95.8 20 PDB header:lyase Chain: B: PDB Molecule:oxalyl-coa decarboxylase; PDBTitle: crystal structure of oxalyl-coa decarboxylase from escherichia coli 23 d1ovma1 not modelled 95.7 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 24 c2vbgB_ not modelled 95.0 15 PDB header:lyase Chain: B: PDB Molecule:branched-chain alpha-ketoacid decarboxylase; PDBTitle: the complex structure of the branched-chain keto acid2 decarboxylase (kdca) from lactococcus lactis with 2r-1-3 hydroxyethyl-deazathdp 25 c3eyaE_ not modelled 94.9 23 PDB header:oxidoreductase Chain: E: PDB Molecule:pyruvate dehydrogenase [cytochrome]; PDBTitle: structural basis for membrane binding and catalytic2 activation of the peripheral membrane enzyme pyruvate3 oxidase from escherichia coli 26 c1t9dB_ not modelled 94.6 14 PDB header:transferase Chain: B: PDB Molecule:acetolactate synthase, mitochondrial; PDBTitle: crystal structure of yeast acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, metsulfuron methyl 27 d1zpda1 not modelled 94.4 15 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 28 c1jscA_ not modelled 93.8 16 PDB header:lyase Chain: A: PDB Molecule:acetohydroxy-acid synthase; PDBTitle: crystal structure of the catalytic subunit of yeast2 acetohydroxyacid synthase: a target for herbicidal3 inhibitors 29 d1s5pa_ not modelled 93.5 26 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 30 c1yi1A_ not modelled 93.5 14 PDB header:transferase Chain: A: PDB Molecule:acetolactate synthase; PDBTitle: crystal structure of arabidopsis thaliana acetohydroxyacid synthase in2 complex with a sulfonylurea herbicide, tribenuron methyl 31 c3pkiF_ not modelled 93.4 10 PDB header:hydrolase Chain: F: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: human sirt6 crystal structure in complex with adp ribose 32 c2w93A_ not modelled 93.3 12 PDB header:lyase Chain: A: PDB Molecule:pyruvate decarboxylase isozyme 1; PDBTitle: crystal structure of the saccharomyces cerevisiae pyruvate2 decarboxylase variant e477q in complex with the surrogate3 pyruvamide 33 c3glsC_ not modelled 93.2 19 PDB header:hydrolase Chain: C: PDB Molecule:nad-dependent deacetylase sirtuin-3, PDBTitle: crystal structure of human sirt3 34 d1pvda1 not modelled 93.1 16 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Pyruvate oxidase and decarboxylase, middle domain 35 d1yc5a1 not modelled 93.0 18 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 36 c2x7jA_ not modelled 92.9 18 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: structure of the menaquinone biosynthesis protein mend from2 bacillus subtilis 37 c3k35D_ not modelled 92.7 12 PDB header:hydrolase Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6 38 d2b4ya1 not modelled 92.7 23 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 39 c1ovmC_ not modelled 92.7 14 PDB header:lyase Chain: C: PDB Molecule:indole-3-pyruvate decarboxylase; PDBTitle: crystal structure of indolepyruvate decarboxylase from2 enterobacter cloacae 40 c2panF_ not modelled 92.6 18 PDB header:lyase Chain: F: PDB Molecule:glyoxylate carboligase; PDBTitle: crystal structure of e. coli glyoxylate carboligase 41 c2nxwB_ not modelled 92.3 23 PDB header:lyase Chain: B: PDB Molecule:phenyl-3-pyruvate decarboxylase; PDBTitle: crystal structure of phenylpyruvate decarboxylase of azospirillum2 brasilense 42 d1m2ka_ not modelled 91.7 20 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 43 d1ma3a_ not modelled 91.4 21 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 44 c1zpdA_ not modelled 91.1 12 PDB header:alcohol fermentation Chain: A: PDB Molecule:pyruvate decarboxylase; PDBTitle: pyruvate decarboxylase from zymomonas mobilis 45 c2vbiF_ not modelled 88.9 16 PDB header:lyase Chain: F: PDB Molecule:pyruvate decarboxylase; PDBTitle: holostructure of pyruvate decarboxylase from acetobacter2 pasteurianus 46 d1q1aa_ not modelled 88.1 11 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 47 c3jwpA_ not modelled 87.0 21 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulatory protein sir2 homologue; PDBTitle: crystal structure of plasmodium falciparum sir2a (pf13_0152) in2 complex with amp 48 c3lq1A_ not modelled 86.7 16 PDB header:transferase Chain: A: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene- PDBTitle: crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene2 1-carboxylic acid synthase/2-oxoglutarate decarboxylase3 from listeria monocytogenes str. 4b f2365 49 c2jlaD_ not modelled 84.1 14 PDB header:transferase Chain: D: PDB Molecule:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene PDBTitle: crystal structure of e.coli mend, 2-succinyl-5-enolpyruvyl-2 6-hydroxy-3-cyclohexadiene-1-carboxylate synthase - semet3 protein 50 d1j8fa_ not modelled 83.6 18 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators 51 c2hjhB_ not modelled 83.0 18 PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase 52 c1q14A_ not modelled 74.9 12 PDB header:hydrolase Chain: A: PDB Molecule:hst2 protein; PDBTitle: structure and autoregulation of the yeast hst2 homolog of sir2 53 d1sqsa_ not modelled 74.3 11 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Hypothetical protein SP1951 54 c8jdwA_ not modelled 73.9 25 PDB header:transferase Chain: A: PDB Molecule:protein (l-arginine:glycine amidinotransferase); PDBTitle: crystal structure of human l-arginine:glycine2 amidinotransferase in complex with l-alanine 55 d1u0ta_ not modelled 73.7 29 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:NAD kinase-like 56 d1jdwa_ not modelled 72.2 25 Fold:Pentein, beta/alpha-propeller Superfamily:Pentein Family:Amidinotransferase 57 c1jdwA_ not modelled 72.2 25 PDB header:transferase Chain: A: PDB Molecule:l-arginine\:glycine amidinotransferase; PDBTitle: crystal structure and mechanism of l-arginine: glycine2 amidinotransferase: a mitochondrial enzyme involved in3 creatine biosynthesis 58 d1z0sa1 not modelled 71.1 30 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:NAD kinase-like 59 c1z0zC_ not modelled 71.0 30 PDB header:transferase Chain: C: PDB Molecule:probable inorganic polyphosphate/atp-nad kinase; PDBTitle: crystal structure of a nad kinase from archaeoglobus2 fulgidus in complex with nad 60 c2eeyA_ 63.1 41 PDB header:biosynthetic protein Chain: A: PDB Molecule:molybdopterin biosynthesis; PDBTitle: structure of gk0241 protein from geobacillus kaustophilus 61 c2an1D_ not modelled 62.7 21 PDB header:transferase Chain: D: PDB Molecule:putative kinase; PDBTitle: structural genomics, the crystal structure of a putative kinase from2 salmonella typhimurim lt2 62 d1ekra_ 62.4 45 Fold:Ferredoxin-like Superfamily:Molybdenum cofactor biosynthesis protein C, MoaC Family:Molybdenum cofactor biosynthesis protein C, MoaC 63 c2ideE_ not modelled 61.7 32 PDB header:biosynthetic protein Chain: E: PDB Molecule:molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of the molybdenum cofactor biosynthesis protein c2 (ttha1789) from thermus theromophilus hb8 64 d1a9xa4 not modelled 59.4 26 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 65 d1jaka1 not modelled 58.6 33 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 66 c2x3yA_ not modelled 58.2 21 PDB header:isomerase Chain: A: PDB Molecule:phosphoheptose isomerase; PDBTitle: crystal structure of gmha from burkholderia pseudomallei 67 c3vh3A_ not modelled 57.7 10 PDB header:metal binding protein/protein transport Chain: A: PDB Molecule:ubiquitin-like modifier-activating enzyme atg7; PDBTitle: crystal structure of atg7ctd-atg8 complex 68 d1bwda_ not modelled 56.8 17 Fold:Pentein, beta/alpha-propeller Superfamily:Pentein Family:Amidinotransferase 69 d2choa2 not modelled 55.4 15 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 70 d1yhta1 not modelled 55.3 26 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 71 d1nowa1 not modelled 54.5 30 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 72 d1uxoa_ not modelled 52.6 22 Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:YdeN-like 73 c3rpmA_ not modelled 52.6 20 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetyl-hexosaminidase; PDBTitle: crystal structure of the first gh20 domain of a novel beta-n-acetyl-2 hexosaminidase strh from streptococcus pneumoniae r6 74 c2ylaA_ not modelled 52.2 26 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: inhibition of the pneumococcal virulence factor strh and2 molecular insights into n-glycan recognition and3 hydrolysis 75 d2cbia2 not modelled 52.1 23 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 76 d1dxqa_ not modelled 51.5 21 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Quinone reductase 77 c2axqA_ not modelled 50.6 20 PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine dehydrogenase; PDBTitle: apo histidine-tagged saccharopine dehydrogenase (l-glu2 forming) from saccharomyces cerevisiae 78 c2xsbA_ not modelled 50.2 22 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: ogoga pugnac complex 79 c3pfnB_ not modelled 49.9 15 PDB header:transferase Chain: B: PDB Molecule:nad kinase; PDBTitle: crystal structure of human nad kinase 80 c3i4aA_ not modelled 48.0 18 PDB header:hydrolase Chain: A: PDB Molecule:n(g),n(g)-dimethylarginine dimethylaminohydrolase PDBTitle: crystal structure of dimethylarginine2 dimethylaminohydrolase-1 (ddah-1) in complex with n5-(1-3 iminopropyl)-l-ornithine 81 c1mv8A_ not modelled 48.0 16 PDB header:oxidoreductase Chain: A: PDB Molecule:gdp-mannose 6-dehydrogenase; PDBTitle: 1.55 a crystal structure of a ternary complex of gdp-mannose2 dehydrogenase from psuedomonas aeruginosa 82 d1e5qa1 not modelled 47.4 22 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 83 c2eknC_ not modelled 46.4 47 PDB header:biosynthetic protein Chain: C: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: structure of ph1811 protein from pyrococcus horikoshii 84 d1ka9f_ not modelled 45.8 16 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 85 d2hc5a1 not modelled 44.8 16 Fold:FlaG-like Superfamily:FlaG-like Family:FlaG-like 86 d1thfd_ not modelled 44.8 23 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 87 c3l3bA_ not modelled 43.7 18 PDB header:biosynthetic protein Chain: A: PDB Molecule:es1 family protein; PDBTitle: crystal structure of isoprenoid biosynthesis protein with2 amidotransferase-like domain from ehrlichia chaffeensis at 1.90a3 resolution 88 c2iyaB_ not modelled 43.6 31 PDB header:transferase Chain: B: PDB Molecule:oleandomycin glycosyltransferase; PDBTitle: the crystal structure of macrolide glycosyltransferases: a2 blueprint for antibiotic engineering 89 c2yl8A_ not modelled 43.2 21 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: inhibition of the pneumococcal virulence factor strh and2 molecular insights into n-glycan recognition and3 hydrolysis 90 c3gh7A_ not modelled 42.9 36 PDB header:hydrolase Chain: A: PDB Molecule:beta-hexosaminidase; PDBTitle: crystal structure of beta-hexosaminidase from paenibacillus2 sp. ts12 in complex with galnac 91 c3afoB_ not modelled 42.7 14 PDB header:transferase Chain: B: PDB Molecule:nadh kinase pos5; PDBTitle: crystal structure of yeast nadh kinase complexed with nadh 92 c2yzkC_ not modelled 41.6 30 PDB header:transferase Chain: C: PDB Molecule:orotate phosphoribosyltransferase; PDBTitle: crystal structure of orotate phosphoribosyltransferase from2 aeropyrum pernix 93 c1m04A_ not modelled 41.5 33 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: mutant streptomyces plicatus beta-hexosaminidase (d313n) in complex2 with product (glcnac) 94 d1j6ua2 not modelled 41.1 24 Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain 95 c2g1uA_ not modelled 39.9 19 PDB header:transport protein Chain: A: PDB Molecule:hypothetical protein tm1088a; PDBTitle: crystal structure of a putative transport protein (tm1088a) from2 thermotoga maritima at 1.50 a resolution 96 d2gjxa1 not modelled 39.8 33 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 97 c1e5lA_ not modelled 39.6 24 PDB header:oxidoreductase Chain: A: PDB Molecule:saccharopine reductase; PDBTitle: apo saccharopine reductase from magnaporthe grisea 98 c2cbjA_ not modelled 39.6 23 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronidase; PDBTitle: structure of the clostridium perfringens nagj family 842 glycoside hydrolase, a homologue of human o-glcnacase in3 complex with pugnac 99 d1iira_ not modelled 39.4 22 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Gtf glycosyltransferase 100 d1bxca_ not modelled 38.9 22 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 101 d1g5ha1 not modelled 38.4 17 Fold:Anticodon-binding domain-like Superfamily:Class II aaRS ABD-related Family:Anticodon-binding domain of Class II aaRS 102 c2qc8J_ not modelled 37.7 17 PDB header:ligase Chain: J: PDB Molecule:glutamine synthetase; PDBTitle: crystal structure of human glutamine synthetase in complex with adp2 and methionine sulfoximine phosphate 103 c2ohdB_ not modelled 37.6 33 PDB header:biosynthetic protein Chain: B: PDB Molecule:probable molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of hypothetical molybdenum cofactor biosynthesis2 protein c from sulfolobus tokodaii 104 d1sy7a1 not modelled 37.4 13 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:Catalase, C-terminal domain 105 c3rcnA_ not modelled 37.1 33 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: crystal structure of beta-n-acetylhexosaminidase from arthrobacter2 aurescens 106 c2jp3A_ not modelled 37.0 19 PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles 107 d2ahua2 not modelled 37.0 16 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase alpha subunit-like 108 c1nouA_ not modelled 36.9 30 PDB header:hydrolase Chain: A: PDB Molecule:beta-hexosaminidase beta chain; PDBTitle: native human lysosomal beta-hexosaminidase isoform b 109 c2ahvC_ not modelled 36.8 14 PDB header:transferase Chain: C: PDB Molecule:putative enzyme ydif; PDBTitle: crystal structure of acyl-coa transferase from e. coli o157:h7 (ydif)-2 thioester complex with coa- 1 110 d1ycga1 not modelled 36.3 22 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Flavodoxin-related 111 c2jo1A_ not modelled 35.6 22 PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles 112 d1h5ya_ not modelled 34.8 21 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 113 d1vima_ not modelled 34.6 22 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 114 c3canA_ not modelled 34.6 17 PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 115 d1s9ra_ not modelled 34.5 25 Fold:Pentein, beta/alpha-propeller Superfamily:Pentein Family:Arginine deiminase 116 d1ltqa1 not modelled 33.8 22 Fold:HAD-like Superfamily:HAD-like Family:phosphatase domain of polynucleotide kinase 117 d2g39a1 not modelled 33.4 18 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase alpha subunit-like 118 c2choA_ not modelled 33.1 15 PDB header:hydrolase Chain: A: PDB Molecule:glucosaminidase; PDBTitle: bacteroides thetaiotaomicron hexosaminidase with o-2 glcnacase activity 119 c3othB_ not modelled 33.0 19 PDB header:transferase/antibiotic Chain: B: PDB Molecule:calg1; PDBTitle: crystal structure of calg1, calicheamicin glycostyltransferase, tdp2 and calicheamicin alpha3i bound form 120 d1qt1a_ not modelled 32.1 22 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0