Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	L	A	Q	E	I	I	R	K	K	R	D	G	H	A	L	S	D	E	E	I	R	F	F	I	N	G	I	R	D	N	T	I	S	E	G	Q	I	A	A	L	A	M	T	I	F	F	H	D	M	T	M	P	E	R	V	S	L	T
Secondary structure
SS confidence
Disorder		?	?	?										?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	A	M	R	D	S	G	T	V	L	D	W	K	S	L	H	L	N	G	P	I	V	D	K	H	S	T	G	G	V	G	D	V	T	S	L	M	L	G	P	M	V	A	A	C	G	G	Y	I	P	M	I	S	G	R	G	L	G	H	T
Secondary structure
SS confidence
Disorder								?			?			?		?	?	?																																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	T	L	D	K	L	E	S	I	P	G	F	D	I	F	P	D	D	N	R	F	R	E	I	I	K	D	V	G	V	A	I	I	G	Q	T	S	S	L	A	P	A	D	K	R	F	Y	A	T	R	D	I	T	A	T	V	D	S	I
Secondary structure
SS confidence
Disorder		?																																																			?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	L	I	T	A	S	I	L	A	K	K	L	A	E	G	L	D	A	L	V	M	D	V	K	V	G	S	G	A	F	M	P	T	Y	E	L	S	E	A	L	A	E	A	I	V	G	V	A	N	G	A	G	V	R	T	T	A	L	L	T
Secondary structure
SS confidence
Disorder									?	?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	M	N	Q	V	L	A	S	S	A	G	N	A	V	E	V	R	E	A	V	Q	F	L	T	G	E	Y	R	N	P	R	L	F	D	V	T	M	A	L	C	V	E	M	L	I	S	G	K	L	A	K	D	D	A	E	A	R	A	K	L
Secondary structure
SS confidence
Disorder									?	?	?	?																	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	A	V	L	D	N	G	K	A	A	E	V	F	G	R	M	V	A	A	Q	K	G	P	T	D	F	V	E	N	Y	A	K	Y	L	P	T	A	M	L	T	K	A	V	Y	A	D	T	E	G	F	V	S	E	M	D	T	R	A	L	G
Secondary structure
SS confidence
Disorder																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		M	A	V	V	A	M	G	G	G	R	R	Q	A	S	D	T	I	D	Y	S	V	G	F	T	D	M	A	R	L	G	D	Q	V	D	G	Q	R	P	L	A	V	I	H	A	K	D	E	N	N	W	Q	E	A	A	K	A	V	K	A	A
Secondary structure
SS confidence
Disorder												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440
Sequence		I	K	L	A	D	K	A	P	E	S	T	P	T	V	Y	R	R	I	S	E
Secondary structure
SS confidence
Disorder				?		?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1otp chain A Region: 1 - 440 Aligned: 440 Modelled: 440 Confidence: 100.0% Identity: 100% PDB header:phosphorylase Chain: A: PDB Molecule:thymidine phosphorylase; PDBTitle: structural and theoretical studies suggest domain movement produces an2 active conformation of thymidine phosphorylase Phyre2 PDB 2j0f chain C Region: 3 - 438 Aligned: 434 Modelled: 436 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: C: PDB Molecule:thymidine phosphorylase; PDBTitle: structural basis for non-competitive product inhibition in2 human thymidine phosphorylase: implication for drug design Phyre2 PDB 1brw chain B Region: 2 - 438 Aligned: 432 Modelled: 437 Confidence: 100.0% Identity: 43% PDB header:transferase Chain: B: PDB Molecule:protein (pyrimidine nucleoside phosphorylase); PDBTitle: the crystal structure of pyrimidine nucleoside2 phosphorylase in a closed conformation Phyre2 PDB 2dsj chain A Region: 2 - 438 Aligned: 423 Modelled: 437 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside (thymidine) phosphorylase; PDBTitle: crystal structure of project id tt0128 from thermus thermophilus hb8 Phyre2 PDB 3h5q chain A Region: 2 - 440 Aligned: 433 Modelled: 436 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside phosphorylase; PDBTitle: crystal structure of a putative pyrimidine-nucleoside phosphorylase2 from staphylococcus aureus Phyre2 PDB 2tpt chain A domain 2 Region: 71 - 335 Aligned: 265 Modelled: 265 Confidence: 100.0% Identity: 100% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 1khd chain D Region: 3 - 318 Aligned: 306 Modelled: 316 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: crystal structure analysis of the anthranilate2 phosphoribosyltransferase from erwinia carotovora at 1.93 resolution (current name, pectobacterium carotovorum) Phyre2 PDB 1v8g chain B Region: 6 - 320 Aligned: 306 Modelled: 315 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: crystal structure of anthranilate phosphoribosyltransferase2 (trpd) from thermus thermophilus hb8 Phyre2 PDB 1vqu chain B Region: 3 - 321 Aligned: 306 Modelled: 318 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase 2; PDBTitle: crystal structure of anthranilate phosphoribosyltransferase 22 (17130499) from nostoc sp. at 1.85 a resolution Phyre2 PDB 1o17 chain A Region: 2 - 326 Aligned: 311 Modelled: 325 Confidence: 100.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: anthranilate phosphoribosyl-transferase (trpd) Phyre2 PDB 1brw chain A domain 2 Region: 76 - 335 Aligned: 258 Modelled: 260 Confidence: 100.0% Identity: 47% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 1uou chain A domain 2 Region: 69 - 344 Aligned: 270 Modelled: 274 Confidence: 100.0% Identity: 47% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 2bpq chain B Region: 3 - 320 Aligned: 305 Modelled: 318 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: anthranilate phosphoribosyltransferase (trpd) from2 mycobacterium tuberculosis (apo structure) Phyre2 PDB 2elc chain A domain 2 Region: 78 - 319 Aligned: 237 Modelled: 242 Confidence: 100.0% Identity: 22% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 1o17 chain A domain 2 Region: 81 - 322 Aligned: 235 Modelled: 242 Confidence: 100.0% Identity: 12% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 1khd chain A domain 2 Region: 76 - 318 Aligned: 230 Modelled: 243 Confidence: 100.0% Identity: 17% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 2tpt chain A domain 3 Region: 336 - 440 Aligned: 105 Modelled: 105 Confidence: 100.0% Identity: 100% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 1brw chain A domain 3 Region: 336 - 438 Aligned: 102 Modelled: 103 Confidence: 100.0% Identity: 31% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 1uou chain A domain 3 Region: 336 - 438 Aligned: 95 Modelled: 103 Confidence: 99.9% Identity: 21% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 2tpt chain A domain 1 Region: 1 - 70 Aligned: 70 Modelled: 70 Confidence: 99.8% Identity: 99% Fold: Methionine synthase domain-like Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family: Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Phyre2 1 c1otpA_ 2 c2j0fC_ 3 c1brwB_ 4 c2dsjA_ 5 c3h5qA_ 6 d2tpta2 7 c1khdD_ 8 c1v8gB_ 9 c1vquB_ 10 c1o17A_ 11 d1brwa2 12 d1uoua2 13 c2bpqB_ 14 d2elca2 15 d1o17a2 16 d1khda2 17 d2tpta3 18 d1brwa3 19 d1uoua3 20 d2tpta1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1otpA_ 100.0 100 PDB header:phosphorylase Chain: A: PDB Molecule:thymidine phosphorylase; PDBTitle: structural and theoretical studies suggest domain movement produces an2 active conformation of thymidine phosphorylase 2 c2j0fC_ 100.0 40 PDB header:transferase Chain: C: PDB Molecule:thymidine phosphorylase; PDBTitle: structural basis for non-competitive product inhibition in2 human thymidine phosphorylase: implication for drug design 3 c1brwB_ 100.0 43 PDB header:transferase Chain: B: PDB Molecule:protein (pyrimidine nucleoside phosphorylase); PDBTitle: the crystal structure of pyrimidine nucleoside2 phosphorylase in a closed conformation 4 c2dsjA_ 100.0 40 PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside (thymidine) phosphorylase; PDBTitle: crystal structure of project id tt0128 from thermus thermophilus hb8 5 c3h5qA_ 100.0 41 PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside phosphorylase; PDBTitle: crystal structure of a putative pyrimidine-nucleoside phosphorylase2 from staphylococcus aureus 6 d2tpta2 100.0 100 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 7 c1khdD_ 100.0 16 PDB header:transferase Chain: D: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: crystal structure analysis of the anthranilate2 phosphoribosyltransferase from erwinia carotovora at 1.93 resolution (current name, pectobacterium carotovorum) 8 c1v8gB_ 100.0 21 PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: crystal structure of anthranilate phosphoribosyltransferase2 (trpd) from thermus thermophilus hb8 9 c1vquB_ 100.0 15 PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase 2; PDBTitle: crystal structure of anthranilate phosphoribosyltransferase 22 (17130499) from nostoc sp. at 1.85 a resolution 10 c1o17A_ 100.0 14 PDB header:transferase Chain: A: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: anthranilate phosphoribosyl-transferase (trpd) 11 d1brwa2 100.0 47 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 12 d1uoua2 100.0 47 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 13 c2bpqB_ 100.0 22 PDB header:transferase Chain: B: PDB Molecule:anthranilate phosphoribosyltransferase; PDBTitle: anthranilate phosphoribosyltransferase (trpd) from2 mycobacterium tuberculosis (apo structure) 14 d2elca2 100.0 22 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 15 d1o17a2 100.0 12 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 16 d1khda2 100.0 17 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 17 d2tpta3 100.0 100 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 18 d1brwa3 100.0 31 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 19 d1uoua3 99.9 21 Fold:alpha/beta-Hammerhead Superfamily:Pyrimidine nucleoside phosphorylase C-terminal domain Family:Pyrimidine nucleoside phosphorylase C-terminal domain 20 d2tpta1 99.8 99 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 21 d1brwa1 not modelled 99.8 46 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 22 d1uoua1 not modelled 99.7 36 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 23 d1o17a1 not modelled 99.7 20 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 24 d1khda1 not modelled 99.7 16 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 25 d1v8ga1 not modelled 99.7 19 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 26 d2elca1 not modelled 99.4 18 Fold:Methionine synthase domain-like Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Family:Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain 27 d1vf7a_ not modelled 93.3 19 Fold:HlyD-like secretion proteins Superfamily:HlyD-like secretion proteins Family:HlyD-like secretion proteins 28 d1vkma_ not modelled 93.1 18 Fold:Indigoidine synthase A-like Superfamily:Indigoidine synthase A-like Family:Indigoidine synthase A-like 29 c3lnnB_ not modelled 93.1 27 PDB header:metal transport Chain: B: PDB Molecule:membrane fusion protein (mfp) heavy metal cation efflux PDBTitle: crystal structure of zneb from cupriavidus metallidurans 30 d1qpoa2 not modelled 92.4 15 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 31 c2gu1A_ not modelled 91.9 18 PDB header:hydrolase Chain: A: PDB Molecule:zinc peptidase; PDBTitle: crystal structure of a zinc containing peptidase from2 vibrio cholerae 32 c2f1mA_ not modelled 91.8 17 PDB header:transport protein Chain: A: PDB Molecule:acriflavine resistance protein a; PDBTitle: conformational flexibility in the multidrug efflux system protein acra 33 c3h9iB_ not modelled 90.6 21 PDB header:transport protein Chain: B: PDB Molecule:cation efflux system protein cusb; PDBTitle: crystal structure of the membrane fusion protein cusb from escherichia2 coli 34 c1t5eB_ not modelled 89.9 17 PDB header:transport protein Chain: B: PDB Molecule:multidrug resistance protein mexa; PDBTitle: the structure of mexa 35 d1dcza_ not modelled 89.7 20 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 36 c2b8gA_ not modelled 88.3 18 PDB header:biosynthetic protein Chain: A: PDB Molecule:biotin/lipoyl attachment protein; PDBTitle: solution structure of bacillus subtilis blap biotinylated-2 form (energy minimized mean structure) 37 d1o4ua2 not modelled 88.0 13 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 38 c2hsiB_ not modelled 87.8 26 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative peptidase m23; PDBTitle: crystal structure of putative peptidase m23 from2 pseudomonas aeruginosa, new york structural genomics3 consortium 39 c3pajA_ not modelled 87.3 13 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase, carboxylating; PDBTitle: 2.00 angstrom resolution crystal structure of a quinolinate2 phosphoribosyltransferase from vibrio cholerae o1 biovar eltor str.3 n16961 40 c3tqvA_ not modelled 87.2 10 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: structure of the nicotinate-nucleotide pyrophosphorylase from2 francisella tularensis. 41 d2pnrc1 not modelled 86.7 18 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 42 c2q8iB_ not modelled 85.2 17 PDB header:transferase Chain: B: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase component of PDBTitle: pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug2 radicicol 43 d1o78a_ not modelled 85.0 19 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 44 d2gpra_ not modelled 84.9 17 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 45 d1gjxa_ not modelled 84.9 13 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 46 d1glaf_ not modelled 84.3 21 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 47 d1gpra_ not modelled 84.2 29 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 48 d1y8ob1 not modelled 84.0 17 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 49 c2dneA_ not modelled 83.9 13 PDB header:transferase Chain: A: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase PDBTitle: solution structure of rsgi ruh-058, a lipoyl domain of2 human 2-oxoacid dehydrogenase 50 c2dncA_ not modelled 83.8 17 PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase protein x component; PDBTitle: solution structure of rsgi ruh-054, a lipoyl domain from2 human 2-oxoacid dehydrogenase 51 c2ejmA_ not modelled 83.8 25 PDB header:ligase Chain: A: PDB Molecule:methylcrotonoyl-coa carboxylase subunit alpha; PDBTitle: solution structure of ruh-072, an apo-biotnyl domain form2 human acetyl coenzyme a carboxylase 52 d1iyua_ not modelled 83.7 17 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 53 d1qapa2 not modelled 83.0 14 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:NadC N-terminal domain-like 54 d2pa2a1 not modelled 82.5 21 Fold:alpha/beta-Hammerhead Superfamily:Ribosomal protein L16p/L10e Family:Ribosomal protein L10e 55 c2ejgD_ not modelled 82.5 30 PDB header:ligase Chain: D: PDB Molecule:149aa long hypothetical methylmalonyl-coa decarboxylase PDBTitle: crystal structure of the biotin protein ligase (mutation r48a) and2 biotin carboxyl carrier protein complex from pyrococcus horikoshii3 ot3 56 d2f3ga_ not modelled 82.4 21 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 57 c2k33A_ not modelled 82.2 22 PDB header:membrane protein, transport protein Chain: A: PDB Molecule:acra; PDBTitle: solution structure of an n-glycosylated protein using in2 vitro glycosylation 58 c3n6rK_ not modelled 82.0 28 PDB header:ligase Chain: K: PDB Molecule:propionyl-coa carboxylase, alpha subunit; PDBTitle: crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) 59 c3fppB_ not modelled 81.8 37 PDB header:membrane protein Chain: B: PDB Molecule:macrolide-specific efflux protein maca; PDBTitle: crystal structure of e.coli maca 60 d1k8ma_ not modelled 81.6 12 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 61 d1qjoa_ not modelled 81.2 21 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 62 d1laba_ not modelled 80.3 17 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 63 c2jbmA_ not modelled 79.6 7 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: qprtase structure from human 64 c2dn8A_ not modelled 79.1 13 PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: solution structure of rsgi ruh-053, an apo-biotin carboxy2 carrier protein from human transcarboxylase 65 d1ghja_ not modelled 79.0 17 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 66 c2l5tA_ not modelled 76.3 12 PDB header:transferase Chain: A: PDB Molecule:lipoamide acyltransferase; PDBTitle: solution nmr structure of e2 lipoyl domain from thermoplasma2 acidophilum 67 c3l0gD_ not modelled 76.1 15 PDB header:transferase Chain: D: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide pyrophosphorylase from2 ehrlichia chaffeensis at 2.05a resolution 68 c2kccA_ not modelled 75.9 13 PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: solution structure of biotinoyl domain from human acetyl-2 coa carboxylase 2 69 c1x1oC_ not modelled 75.6 10 PDB header:transferase Chain: C: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of project id tt0268 from thermus thermophilus hb8 70 c3gnnA_ not modelled 74.5 13 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide2 pyrophosphorylase from burkholderi pseudomallei 71 c3c2vA_ not modelled 72.9 12 PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of the quinolinate phosphoribosyl2 transferase (bna6) from saccharomyces cerevisiae complexed3 with prpp and the inhibitor phthalate 72 c2yvqA_ not modelled 71.3 18 PDB header:ligase Chain: A: PDB Molecule:carbamoyl-phosphate synthase; PDBTitle: crystal structure of mgs domain of carbamoyl-phosphate2 synthetase from homo sapiens 73 c2qj8B_ not modelled 69.9 24 PDB header:hydrolase Chain: B: PDB Molecule:mlr6093 protein; PDBTitle: crystal structure of an aspartoacylase family protein (mlr6093) from2 mesorhizobium loti maff303099 at 2.00 a resolution 74 c2kvcA_ not modelled 69.1 16 PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution structure of the mycobacterium tuberculosis protein rv0543c,2 a member of the duf3349 superfamily. seattle structural genomics3 center for infectious disease target mytud.17112.a 75 c2b7pA_ not modelled 69.0 17 PDB header:transferase Chain: A: PDB Molecule:probable nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of quinolinic acid phosphoribosyltransferase from2 helicobacter pylori 76 c3nyyA_ not modelled 68.8 29 PDB header:hydrolase Chain: A: PDB Molecule:putative glycyl-glycine endopeptidase lytm; PDBTitle: crystal structure of a putative glycyl-glycine endopeptidase lytm2 (rumgna_02482) from ruminococcus gnavus atcc 29149 at 1.60 a3 resolution 77 d1bdoa_ not modelled 68.6 18 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 78 c1qpoA_ not modelled 68.4 17 PDB header:transferase Chain: A: PDB Molecule:quinolinate acid phosphoribosyl transferase; PDBTitle: quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme from2 mycobacterium tuberculosis 79 d1e2wa2 not modelled 68.2 26 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 80 d1ci3m2 not modelled 68.1 21 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 81 c2qguA_ not modelled 66.3 6 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:probable signal peptide protein; PDBTitle: three-dimensional structure of the phospholipid-binding protein from2 ralstonia solanacearum q8xv73_ralsq in complex with a phospholipid at3 the resolution 1.53 a. northeast structural genomics consortium4 target rsr89 82 c3fmcC_ not modelled 65.5 14 PDB header:hydrolase Chain: C: PDB Molecule:putative succinylglutamate desuccinylase / aspartoacylase; PDBTitle: crystal structure of a putative succinylglutamate desuccinylase /2 aspartoacylase family protein (sama_0604) from shewanella amazonensis3 sb2b at 1.80 a resolution 83 d1pmra_ not modelled 63.7 18 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 84 d1a0pa2 not modelled 63.5 16 Fold:DNA breaking-rejoining enzymes Superfamily:DNA breaking-rejoining enzymes Family:Lambda integrase-like, catalytic core 85 c2lkyA_ not modelled 61.3 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of msmeg_1053, the second duf3349 annotated protein2 in the genome of mycobacterium smegmatis, seattle structural genomics3 center for infectious disease target mysma.17112.b 86 c2jkuA_ not modelled 59.7 27 PDB header:ligase Chain: A: PDB Molecule:propionyl-coa carboxylase alpha chain, PDBTitle: crystal structure of the n-terminal region of the biotin2 acceptor domain of human propionyl-coa carboxylase 87 c3na6A_ not modelled 54.7 24 PDB header:hydrolase Chain: A: PDB Molecule:succinylglutamate desuccinylase/aspartoacylase; PDBTitle: crystal structure of a succinylglutamate desuccinylase (tm1040_2694)2 from silicibacter sp. tm1040 at 2.00 a resolution 88 d1vqoh1 not modelled 54.2 18 Fold:alpha/beta-Hammerhead Superfamily:Ribosomal protein L16p/L10e Family:Ribosomal protein L10e 89 c1ctmA_ not modelled 53.7 21 PDB header:electron transport(cytochrome) Chain: A: PDB Molecule:cytochrome f; PDBTitle: crystal structure of chloroplast cytochrome f reveals a2 novel cytochrome fold and unexpected heme ligation 90 c4a1aH_ not modelled 52.6 25 PDB header:ribosome Chain: H: PDB Molecule:60s ribosomal protein l10; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 3. 91 c1qapA_ not modelled 49.2 12 PDB header:glycosyltransferase Chain: A: PDB Molecule:quinolinic acid phosphoribosyltransferase; PDBTitle: quinolinic acid phosphoribosyltransferase with bound2 quinolinic acid 92 c2jxmB_ not modelled 48.4 26 PDB header:electron transport Chain: B: PDB Molecule:cytochrome f; PDBTitle: ensemble of twenty structures of the prochlorothrix2 hollandica plastocyanin- cytochrome f complex 93 c1e2vB_ not modelled 48.3 26 PDB header:electron transport proteins Chain: B: PDB Molecule:cytochrome f; PDBTitle: n153q mutant of cytochrome f from chlamydomonas reinhardtii 94 c2iy3A_ not modelled 46.6 12 PDB header:rna-binding Chain: A: PDB Molecule:signal recognition particle protein ffh; PDBTitle: structure of the e. coli signal recognition particle2 bound to a translating ribosome 95 c1tu2B_ not modelled 45.7 19 PDB header:electron transport Chain: B: PDB Molecule:apocytochrome f; PDBTitle: the complex of nostoc cytochrome f and plastocyanin determin with2 paramagnetic nmr. based on the structures of cytochrome f and3 plastocyanin, 10 structures 96 d1qwya_ not modelled 45.0 21 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Peptidoglycan hydrolase LytM 97 d1hpca_ not modelled 44.0 10 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 98 c2aukA_ not modelled 43.8 23 PDB header:transferase Chain: A: PDB Molecule:dna-directed rna polymerase beta' chain; PDBTitle: structure of e. coli rna polymerase beta' g/g' insert 99 c3cdxB_ not modelled 43.6 24 PDB header:hydrolase Chain: B: PDB Molecule:succinylglutamatedesuccinylase/aspartoacylase; PDBTitle: crystal structure of2 succinylglutamatedesuccinylase/aspartoacylase from3 rhodobacter sphaeroides 100 d1mula_ not modelled 43.5 10 Fold:IHF-like DNA-binding proteins Superfamily:IHF-like DNA-binding proteins Family:Prokaryotic DNA-bending protein 101 d1onla_ not modelled 43.1 19 Fold:Barrel-sandwich hybrid Superfamily:Single hybrid motif Family:Biotinyl/lipoyl-carrier proteins and domains 102 c1qzwC_ not modelled 43.0 13 PDB header:signaling protein/rna Chain: C: PDB Molecule:signal recognition 54 kda protein; PDBTitle: crystal structure of the complete core of archaeal srp and2 implications for inter-domain communication 103 c2zkrh_ not modelled 42.5 21 PDB header:ribosomal protein/rna Chain: H: PDB Molecule:rna expansion segment es12; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 104 c2edgA_ not modelled 41.7 10 PDB header:biosynthetic protein Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: solution structure of the gcv_h domain from mouse glycine 105 c2b44A_ not modelled 41.4 22 PDB header:hydrolase Chain: A: PDB Molecule:glycyl-glycine endopeptidase lytm; PDBTitle: truncated s. aureus lytm, p 32 2 1 crystal form 106 c3iftA_ not modelled 41.2 10 PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from2 mycobacterium tuberculosis, using x-rays from the compact light3 source. 107 c1q90A_ not modelled 41.2 26 PDB header:photosynthesis Chain: A: PDB Molecule:apocytochrome f; PDBTitle: structure of the cytochrome b6f (plastohydroquinone : plastocyanin2 oxidoreductase) from chlamydomonas reinhardtii 108 c2xhaB_ not modelled 39.3 17 PDB header:transcription Chain: B: PDB Molecule:transcription antitermination protein nusg; PDBTitle: crystal structure of domain 2 of thermotoga maritima n-utilization2 substance g (nusg) 109 c2j37W_ not modelled 39.3 10 PDB header:ribosome Chain: W: PDB Molecule:signal recognition particle 54 kda protein PDBTitle: model of mammalian srp bound to 80s rncs 110 d1b8za_ not modelled 38.6 10 Fold:IHF-like DNA-binding proteins Superfamily:IHF-like DNA-binding proteins Family:Prokaryotic DNA-bending protein 111 c2e75C_ not modelled 38.3 21 PDB header:photosynthesis Chain: C: PDB Molecule:apocytochrome f; PDBTitle: crystal structure of the cytochrome b6f complex with 2-nonyl-4-2 hydroxyquinoline n-oxide (nqno) from m.laminosus 112 c3mxuA_ not modelled 38.3 14 PDB header:oxidoreductase Chain: A: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of glycine cleavage system protein h from bartonella2 henselae 113 d1p88a_ not modelled 38.0 15 Fold:IF3-like Superfamily:EPT/RTPC-like Family:Enolpyruvate transferase, EPT 114 c2aujD_ not modelled 37.3 31 PDB header:transferase Chain: D: PDB Molecule:dna-directed rna polymerase beta' chain; PDBTitle: structure of thermus aquaticus rna polymerase beta'-subunit2 insert 115 c3ol4B_ not modelled 34.4 16 PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium smegmatis, an ortholog of rv0543c 116 d1xpja_ not modelled 33.4 16 Fold:HAD-like Superfamily:HAD-like Family:Hypothetical protein VC0232 117 c3a8jF_ not modelled 33.3 19 PDB header:transferase/transport protein Chain: F: PDB Molecule:glycine cleavage system h protein; PDBTitle: crystal structure of et-ehred complex 118 c3d4rE_ not modelled 32.9 21 PDB header:unknown function Chain: E: PDB Molecule:domain of unknown function from the pfam-b_34464 family; PDBTitle: crystal structure of a duf2118 family protein (mmp0046) from2 methanococcus maripaludis at 2.20 a resolution 119 d1r71a_ not modelled 32.7 14 Fold:DNA/RNA-binding 3-helical bundle Superfamily:KorB DNA-binding domain-like Family:KorB DNA-binding domain-like 120 c2j7pA_ not modelled 32.3 13 PDB header:signal recognition Chain: A: PDB Molecule:signal recognition particle protein; PDBTitle: gmppnp-stabilized ng domain complex of the srp gtpases ffh2 and ftsy

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0