Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	A	P	V	V	L	I	L	A	A	G	R	G	E	C	F	L	A	S	G	G	N	T	H	K	C	I	G	W	R	Q	S	P	E	V	A	P	Y	R	W	P	F	E	E	N	G	R	T	F	D	L	A	I	E	P	Q	I	T	T
Secondary structure
SS confidence
Disorder		?	?	?	?													?																	?	?	?	?	?						?		?	?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	D	L	R	L	M	L	R	L	A	L	A	G	G	G	I	T	I	A	T	Q	E	T	F	R	P	Y	I	E	S	G	K	L	V	S	L	L	D	D	F	L	P	Q	F	P	G	F	Y	L	Y	F	P	Q	R	R	N	I	A	P	K
Secondary structure
SS confidence
Disorder																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.
Sequence		L	R	A	L	I	D	Y	V	K	E	W	R	Q	Q	L	A
Secondary structure
SS confidence
Disorder															?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3mz1 chain D Region: 5 - 134 Aligned: 130 Modelled: 127 Confidence: 99.7% Identity: 18% PDB header:transcription regulator Chain: D: PDB Molecule:putative transcriptional regulator; PDBTitle: the crystal structure of a possible transcription regulator protein2 from sinorhizobium meliloti 1021 Phyre2 PDB 3hhf chain B Region: 12 - 132 Aligned: 118 Modelled: 121 Confidence: 99.7% Identity: 20% PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: structure of crga regulatory domain, a lysr-type transcriptional2 regulator from neisseria meningitidis. Phyre2 PDB 3t1b chain B Region: 5 - 131 Aligned: 123 Modelled: 127 Confidence: 99.5% Identity: 18% PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: crystal structure of the full-length aphb n100e variant Phyre2 PDB 3hhg chain F Region: 14 - 132 Aligned: 116 Modelled: 119 Confidence: 99.5% Identity: 21% PDB header:transcription regulator Chain: F: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: structure of crga, a lysr-type transcriptional regulator from2 neisseria meningitidis. Phyre2 PDB 3fd3 chain A Region: 9 - 134 Aligned: 119 Modelled: 121 Confidence: 99.5% Identity: 13% PDB header:transcription regulator Chain: A: PDB Molecule:chromosome replication initiation inhibitor protein; PDBTitle: structure of the c-terminal domains of a lysr family protein from2 agrobacterium tumefaciens str. c58. Phyre2 PDB 3kos chain A Region: 14 - 134 Aligned: 117 Modelled: 121 Confidence: 99.5% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional activator ampr; PDBTitle: structure of the ampr effector binding domain from citrobacter2 freundii Phyre2 PDB 2uye chain A Region: 11 - 134 Aligned: 121 Modelled: 124 Confidence: 99.3% Identity: 7% PDB header:transcription Chain: A: PDB Molecule:regulatory protein; PDBTitle: double mutant y110s,f111v dntr from burkholderia sp. strain2 dnt in complex with thiocyanate Phyre2 PDB 1uth chain A Region: 11 - 135 Aligned: 122 Modelled: 125 Confidence: 99.3% Identity: 7% Fold: Periplasmic binding protein-like II Superfamily: Periplasmic binding protein-like II Family: Phosphate binding protein-like Phyre2 PDB 3oxn chain D Region: 11 - 135 Aligned: 121 Modelled: 125 Confidence: 99.3% Identity: 13% PDB header:transcription regulator Chain: D: PDB Molecule:putative transcriptional regulator, lysr family; PDBTitle: the crystal structure of a putative transcriptional regulator from2 vibrio parahaemolyticus Phyre2 PDB 2qsx chain B Region: 12 - 132 Aligned: 114 Modelled: 119 Confidence: 99.3% Identity: 16% PDB header:transcription Chain: B: PDB Molecule:putative transcriptional regulator, lysr family; PDBTitle: crystal structure of putative transcriptional regulator lysr from2 vibrio parahaemolyticus Phyre2 PDB 3isp chain A Region: 9 - 135 Aligned: 119 Modelled: 123 Confidence: 99.2% Identity: 15% PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional regulator PDBTitle: crystal structure of argp from mycobacterium tuberculosis Phyre2 PDB 2hxr chain A Region: 12 - 132 Aligned: 115 Modelled: 121 Confidence: 99.2% Identity: 11% PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional regulator cynr; PDBTitle: structure of the ligand binding domain of e. coli cynr, a2 transcriptional regulator controlling cyanate metabolism Phyre2 PDB 1al3 chain A Region: 12 - 134 Aligned: 119 Modelled: 123 Confidence: 99.2% Identity: 9% PDB header:transcription regulation Chain: A: PDB Molecule:cys regulon transcriptional activator cysb; PDBTitle: cofactor binding fragment of cysb from klebsiella aerogenes Phyre2 PDB 1al3 chain A Region: 12 - 134 Aligned: 119 Modelled: 123 Confidence: 99.2% Identity: 9% Fold: Periplasmic binding protein-like II Superfamily: Periplasmic binding protein-like II Family: Phosphate binding protein-like Phyre2 PDB 3fzv chain C Region: 12 - 132 Aligned: 117 Modelled: 121 Confidence: 99.2% Identity: 16% PDB header:transcription regulator Chain: C: PDB Molecule:probable transcriptional regulator; PDBTitle: crystal structure of pa01 protein, putative lysr family2 transcriptional regulator from pseudomonas aeruginosa Phyre2 PDB 2ql3 chain G Region: 10 - 129 Aligned: 116 Modelled: 116 Confidence: 99.1% Identity: 17% PDB header:transcription Chain: G: PDB Molecule:probable transcriptional regulator, lysr family protein; PDBTitle: crystal structure of the c-terminal domain of a probable lysr family2 transcriptional regulator from rhodococcus sp. rha1 Phyre2 PDB 3fzj chain C Region: 53 - 131 Aligned: 79 Modelled: 79 Confidence: 99.1% Identity: 10% PDB header:transcription regulator Chain: C: PDB Molecule:lysr type regulator of tsambcd; PDBTitle: tsar low resolution crystal structure, tetragonal form Phyre2 PDB 1i6a chain A Region: 12 - 134 Aligned: 120 Modelled: 123 Confidence: 99.1% Identity: 12% Fold: Periplasmic binding protein-like II Superfamily: Periplasmic binding protein-like II Family: Phosphate binding protein-like Phyre2 PDB 2fyi chain A domain 1 Region: 10 - 134 Aligned: 121 Modelled: 125 Confidence: 99.1% Identity: 10% Fold: Periplasmic binding protein-like II Superfamily: Periplasmic binding protein-like II Family: Phosphate binding protein-like Phyre2 PDB 2h9q chain C Region: 9 - 134 Aligned: 122 Modelled: 126 Confidence: 99.1% Identity: 14% PDB header:transcription Chain: C: PDB Molecule:hth-type transcriptional regulator catm; PDBTitle: crystal structure of the effector binding domain of a catm2 variant (r156h) Phyre2 1 c3mz1D_ 2 c3hhfB_ 3 c3t1bB_ 4 c3hhgF_ 5 c3fd3A_ 6 c3kosA_ 7 c2uyeA_ 8 d1utha_ 9 c3oxnD_ 10 c2qsxB_ 11 c3ispA_ 12 c2hxrA_ 13 c1al3A_ 14 d1al3a_ 15 c3fzvC_ 16 c2ql3G_ 17 c3fzjC_ 18 d1i6aa_ 19 d2fyia1 20 c2h9qC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3mz1D_ 99.7 18 PDB header:transcription regulator Chain: D: PDB Molecule:putative transcriptional regulator; PDBTitle: the crystal structure of a possible transcription regulator protein2 from sinorhizobium meliloti 1021 2 c3hhfB_ 99.7 20 PDB header:transcription regulator Chain: B: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: structure of crga regulatory domain, a lysr-type transcriptional2 regulator from neisseria meningitidis. 3 c3t1bB_ 99.5 18 PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: crystal structure of the full-length aphb n100e variant 4 c3hhgF_ 99.5 21 PDB header:transcription regulator Chain: F: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: structure of crga, a lysr-type transcriptional regulator from2 neisseria meningitidis. 5 c3fd3A_ 99.5 13 PDB header:transcription regulator Chain: A: PDB Molecule:chromosome replication initiation inhibitor protein; PDBTitle: structure of the c-terminal domains of a lysr family protein from2 agrobacterium tumefaciens str. c58. 6 c3kosA_ 99.5 14 PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional activator ampr; PDBTitle: structure of the ampr effector binding domain from citrobacter2 freundii 7 c2uyeA_ 99.3 7 PDB header:transcription Chain: A: PDB Molecule:regulatory protein; PDBTitle: double mutant y110s,f111v dntr from burkholderia sp. strain2 dnt in complex with thiocyanate 8 d1utha_ 99.3 7 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 9 c3oxnD_ 99.3 13 PDB header:transcription regulator Chain: D: PDB Molecule:putative transcriptional regulator, lysr family; PDBTitle: the crystal structure of a putative transcriptional regulator from2 vibrio parahaemolyticus 10 c2qsxB_ 99.3 16 PDB header:transcription Chain: B: PDB Molecule:putative transcriptional regulator, lysr family; PDBTitle: crystal structure of putative transcriptional regulator lysr from2 vibrio parahaemolyticus 11 c3ispA_ 99.2 15 PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional regulator PDBTitle: crystal structure of argp from mycobacterium tuberculosis 12 c2hxrA_ 99.2 11 PDB header:transcription Chain: A: PDB Molecule:hth-type transcriptional regulator cynr; PDBTitle: structure of the ligand binding domain of e. coli cynr, a2 transcriptional regulator controlling cyanate metabolism 13 c1al3A_ 99.2 9 PDB header:transcription regulation Chain: A: PDB Molecule:cys regulon transcriptional activator cysb; PDBTitle: cofactor binding fragment of cysb from klebsiella aerogenes 14 d1al3a_ 99.2 9 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 15 c3fzvC_ 99.2 16 PDB header:transcription regulator Chain: C: PDB Molecule:probable transcriptional regulator; PDBTitle: crystal structure of pa01 protein, putative lysr family2 transcriptional regulator from pseudomonas aeruginosa 16 c2ql3G_ 99.1 17 PDB header:transcription Chain: G: PDB Molecule:probable transcriptional regulator, lysr family protein; PDBTitle: crystal structure of the c-terminal domain of a probable lysr family2 transcriptional regulator from rhodococcus sp. rha1 17 c3fzjC_ 99.1 10 PDB header:transcription regulator Chain: C: PDB Molecule:lysr type regulator of tsambcd; PDBTitle: tsar low resolution crystal structure, tetragonal form 18 d1i6aa_ 99.1 12 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 19 d2fyia1 99.1 10 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 20 c2h9qC_ 99.1 14 PDB header:transcription Chain: C: PDB Molecule:hth-type transcriptional regulator catm; PDBTitle: crystal structure of the effector binding domain of a catm2 variant (r156h) 21 c1iz1B_ not modelled 99.0 10 PDB header:dna binding protein Chain: B: PDB Molecule:lysr-type regulatory protein; PDBTitle: crystal structure of cbnr, a lysr family transcriptional2 regulator 22 d2esna2 not modelled 99.0 14 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 23 c2esnC_ not modelled 99.0 12 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:probable transcriptional regulator; PDBTitle: the crystal structure of probable transcriptional regulator pa04772 from pseudomonas aeruginosa 24 c3n6uA_ not modelled 99.0 9 PDB header:transcription regulator Chain: A: PDB Molecule:lysr type regulator of tsambcd; PDBTitle: effector binding domain of tsar in complex with its inducer p-2 toluenesulfonate 25 c3jv9B_ not modelled 99.0 7 PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator, lysr family; PDBTitle: the structure of a reduced form of oxyr from n. meningitidis 26 d1ixca2 not modelled 98.9 9 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 27 c3ho7A_ not modelled 98.9 13 PDB header:transcription Chain: A: PDB Molecule:oxyr; PDBTitle: crystal structure of oxyr from porphyromonas gingivalis 28 c2f7cA_ not modelled 98.8 13 PDB header:gene regulation Chain: A: PDB Molecule:hth-type transcriptional regulator catm; PDBTitle: catm effector binding domain with its effector cis,cis-muconate 29 c2h9bB_ not modelled 98.8 15 PDB header:transcription Chain: B: PDB Molecule:hth-type transcriptional regulator benm; PDBTitle: crystal structure of the effector binding domain of a benm variant2 (benm r156h/t157s) 30 c2f78A_ not modelled 98.6 15 PDB header:gene regulation Chain: A: PDB Molecule:hth-type transcriptional regulator benm; PDBTitle: benm effector binding domain with its effector benzoate 31 c3onmB_ not modelled 97.8 15 PDB header:transcription Chain: B: PDB Molecule:transcriptional regulator lrha; PDBTitle: effector binding domain of lysr-type transcription factor rovm from y.2 pseudotuberculosis 32 d1twya_ not modelled 59.1 6 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 33 c1twyG_ not modelled 49.8 8 PDB header:structural genomics, unknown function Chain: G: PDB Molecule:abc transporter, periplasmic substrate-binding protein; PDBTitle: crystal structure of an abc-type phosphate transport receptor from2 vibrio cholerae 34 c3c5tB_ not modelled 36.4 27 PDB header:signaling protein/signaling protein Chain: B: PDB Molecule:exendin-4; PDBTitle: crystal structure of the ligand-bound glucagon-like peptide-1 receptor2 extracellular domain 35 c3lr1A_ not modelled 34.1 17 PDB header:transport protein Chain: A: PDB Molecule:tungstate abc transporter, periplasmic tungstate- PDBTitle: the crystal structure of the tungstate abc transporter from2 geobacter sulfurreducens 36 c1vi7A_ not modelled 33.4 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yigz; PDBTitle: crystal structure of an hypothetical protein 37 d1vi7a1 not modelled 33.3 19 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:YigZ N-terminal domain-like 38 c3muqB_ not modelled 31.6 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved functionally unknown protein from2 vibrio parahaemolyticus rimd 2210633 39 d1wj9a2 not modelled 30.7 16 Fold:Ferredoxin-like Superfamily:CRISPR-associated protein Family:CRISPR-associated protein 40 d1amfa_ not modelled 28.8 14 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 41 c1wj9A_ not modelled 25.6 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:crispr-associated protein; PDBTitle: crystal structure of a crispr-associated protein from2 thermus thermophilus 42 c3qrqA_ not modelled 25.6 18 PDB header:rna binding protein/rna Chain: A: PDB Molecule:putative uncharacterized protein tthb192; PDBTitle: structure of thermus thermophilus cse3 bound to an rna representing a2 pre-cleavage complex 43 d1atga_ not modelled 19.4 4 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 44 c2h5yC_ not modelled 17.0 11 PDB header:metal transport Chain: C: PDB Molecule:molybdate-binding periplasmic protein; PDBTitle: crystallographic structure of the molybdate-binding protein of2 xanthomonas citri at 1.7 ang resolution bound to molybdate 45 d2gk3a1 not modelled 14.9 16 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:STM3548-like 46 c3rhtB_ not modelled 14.2 16 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:(gatase1)-like protein; PDBTitle: crystal structure of type 1 glutamine amidotransferase (gatase1)-like2 protein from planctomyces limnophilus 47 d2ezwa1 not modelled 12.3 18 Fold:Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit Superfamily:Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit Family:Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit 48 c2pksC_ not modelled 11.6 13 PDB header:hydrolase/hydrolase inhibitor Chain: C: PDB Molecule:thrombin heavy chain fragment; PDBTitle: thrombin in complex with inhibitor 49 d1sbpa_ not modelled 10.1 7 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 50 d1ezxc_ not modelled 9.8 13 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 51 d1ixha_ not modelled 8.4 10 Fold:Periplasmic binding protein-like II Superfamily:Periplasmic binding protein-like II Family:Phosphate binding protein-like 52 c1jrjA_ not modelled 7.3 27 PDB header:hormone/growth factor Chain: A: PDB Molecule:exendin-4; PDBTitle: solution structure of exendin-4 in 30-vol% trifluoroethanol 53 c3fj7A_ not modelled 6.7 8 PDB header:protein binding Chain: A: PDB Molecule:major antigenic peptide peb3; PDBTitle: crystal structure of l-phospholactate bound peb3 54 c1nauA_ not modelled 6.6 0 PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon; PDBTitle: nmr solution structure of the glucagon antagonist [deshis1,2 desphe6, glu9]glucagon amide in the presence of3 perdeuterated dodecylphosphocholine micelles 55 d1rgig3 not modelled 6.4 10 Fold:Gelsolin-like Superfamily:Actin depolymerizing proteins Family:Gelsolin-like 56 d1iaua_ not modelled 6.2 13 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Eukaryotic proteases 57 c1d0rA_ not modelled 6.1 9 PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon-like peptide-1-(7-36)-amide; PDBTitle: solution structure of glucagon-like peptide-1-(7-36)-amide2 in trifluoroethanol/water 58 d1j72a3 not modelled 6.1 14 Fold:Gelsolin-like Superfamily:Actin depolymerizing proteins Family:Gelsolin-like 59 c1aksB_ not modelled 6.0 7 PDB header:serine protease Chain: B: PDB Molecule:alpha trypsin; PDBTitle: crystal structure of the first active autolysate form of2 the porcine alpha trypsin 60 d1os8a_ not modelled 5.9 6 Fold:Trypsin-like serine proteases Superfamily:Trypsin-like serine proteases Family:Prokaryotic proteases 61 c1ca0C_ not modelled 5.8 21 PDB header:complex (serine protease/inhibitor) Chain: C: PDB Molecule:bovine chymotrypsin; PDBTitle: bovine chymotrypsin complexed to appi 62 c2cveA_ not modelled 5.7 19 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ttha1053; PDBTitle: crystal structure of a conserved hypothetical protein tt1547 from2 thermus thermophilus hb8 63 d2qqra1 not modelled 5.5 10 Fold:SH3-like barrel Superfamily:Tudor/PWWP/MBT Family:Tudor domain 64 c1lypA_ not modelled 5.2 24 PDB header:lipopolysaccharide-binding protein Chain: A: PDB Molecule:cap18; PDBTitle: the solution structure of the active domain of cap18: a2 lipopolysaccharide binding protein from rabbit leukocytes 65 c2mltB_ not modelled 5.0 58 PDB header:toxin (hemolytic polypeptide) Chain: B: PDB Molecule:melittin; PDBTitle: melittin 66 c1bh1A_ not modelled 5.0 58 PDB header:toxin Chain: A: PDB Molecule:melittin; PDBTitle: structural studies of d-pro melittin, nmr, 20 structures

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0