Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP77510
DateThu Jan 5 12:30:10 GMT 2012
Unique Job IDb7bb9b09f3c5308c

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2q8fA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
Confidence and coverage
Confidence:100.0% Coverage: 41%
226 residues ( 41% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
455 residues ( 82%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MLQLNENKQFAFFQRLAFPLRIFLLILVFSIFVIAALAQYFTASFEDYLTLHVRDMAMNQ
Secondary structure 
SS confidence 
Disorder  ???????????????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  AKIIASNDSVISAVKTRDYKRLATIANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPM
Secondary structure 
SS confidence 
Disorder 
???
????
???
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  QFTKQGALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKIDSWRAEFL
Secondary structure 
SS confidence 
Disorder 
??
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  LPMAGVFVVLLGILMLLSWFLAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDP
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  HGYITAINRNARKMLGLSSPGRQWLGKPIVEVVRPADFFTEQIDEKRQDVVANFNGLSVI
Secondary structure 
SS confidence 
Disorder 
???????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  ANREAIRSGDDLLGAIISFRSKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNGLL
Secondary structure 
SS confidence 
Disorder 
??
?
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  QMKEYDRVLAMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGLKMIIVPGSQ
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  LSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGV
Secondary structure 
SS confidence 
Disorder 
?????
?
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  PESLRDKIFEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIYIPKV
Secondary structure 
SS confidence 
Disorder 
???????
Disorder confidence 
 
   .........550..
Sequence  KPNDSSINPIDR
Secondary structure 
SS confidence 
Disorder  ????????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2q8f chain A

3D model

Region: 325 - 550
Aligned: 226
Modelled: 226
Confidence: 100.0%
Identity: 15%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2

PDB 3d2r chain B

3D model

Region: 326 - 550
Aligned: 225
Modelled: 225
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2

PDB 2bu8 chain A

3D model

Region: 325 - 550
Aligned: 223
Modelled: 226
Confidence: 100.0%
Identity: 16%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2

PDB 1y8o chain A

3D model

Region: 325 - 550
Aligned: 220
Modelled: 226
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2

PDB 3a0r chain A

3D model

Region: 225 - 543
Aligned: 301
Modelled: 319
Confidence: 100.0%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2

PDB 2c2a chain A

3D model

Region: 320 - 541
Aligned: 214
Modelled: 222
Confidence: 100.0%
Identity: 22%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2

PDB 3d36 chain B

3D model

Region: 333 - 541
Aligned: 199
Modelled: 207
Confidence: 100.0%
Identity: 18%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2

PDB 1gjv chain A

3D model

Region: 347 - 545
Aligned: 191
Modelled: 199
Confidence: 100.0%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2

PDB 1jm6 chain A domain 2

3D model

Region: 393 - 550
Aligned: 157
Modelled: 158
Confidence: 100.0%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 1gkz chain A domain 2

3D model

Region: 393 - 545
Aligned: 150
Modelled: 153
Confidence: 100.0%
Identity: 17%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2

PDB 2c2a chain A domain 2

3D model

Region: 393 - 541
Aligned: 141
Modelled: 149
Confidence: 100.0%
Identity: 26%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1b3q chain A

3D model

Region: 346 - 538
Aligned: 192
Modelled: 193
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2

PDB 3a0t chain A

3D model

Region: 393 - 543
Aligned: 142
Modelled: 151
Confidence: 100.0%
Identity: 23%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2

PDB 1id0 chain A

3D model

Region: 393 - 540
Aligned: 138
Modelled: 148
Confidence: 99.9%
Identity: 22%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 2ch4 chain A

3D model

Region: 393 - 542
Aligned: 149
Modelled: 150
Confidence: 99.9%
Identity: 22%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2

PDB 1bxd chain A

3D model

Region: 390 - 549
Aligned: 152
Modelled: 160
Confidence: 99.9%
Identity: 16%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1i58 chain A

3D model

Region: 393 - 538
Aligned: 145
Modelled: 144
Confidence: 99.9%
Identity: 22%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 1ysr chain A domain 1

3D model

Region: 388 - 541
Aligned: 137
Modelled: 154
Confidence: 99.9%
Identity: 22%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2

PDB 3jz3 chain B

3D model

Region: 363 - 539
Aligned: 141
Modelled: 151
Confidence: 99.8%
Identity: 18%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2

PDB 2hkj chain A domain 3

3D model

Region: 428 - 542
Aligned: 115
Modelled: 115
Confidence: 99.8%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: DNA gyrase/MutL, N-terminal domain

Phyre2

PDB 3by8 chain A domain 1

3D model

Region: 47 - 177
Aligned: 131
Modelled: 131
Confidence: 99.1%
Identity: 25%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2

PDB 1p0z chain A

3D model

Region: 49 - 172
Aligned: 124
Modelled: 124
Confidence: 99.1%
Identity: 37%
Fold: Profilin-like
Superfamily: Sensory domain-like
Family: Sensory domain of two-component sensor kinase

Phyre2
1
c2q8fA_
2
c3d2rB_
3
c2bu8A_
4
c1y8oA_
5
c3a0rA_
6
c2c2aA_
7
c3d36B_
8
c1gjvA_
9
d1jm6a2
10
d1gkza2
11
d2c2aa2
12
c1b3qA_
13
c3a0tA_
14
d1id0a_
15
c2ch4A_
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d1bxda_
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d1i58a_
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d1ysra1
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c3jz3B_
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d2hkja3
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d3by8a1
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d1p0za_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2q8fA_
100.0 15 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
2c3d2rB_
100.0 16 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
3c2bu8A_
100.0 16 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
4c1y8oA_
100.0 17 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
5c3a0rA_
100.0 17 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
6c2c2aA_
100.0 22 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
7c3d36B_
100.0 18 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
8c1gjvA_
100.0 18 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
9d1jm6a2
100.0 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
10d1gkza2
100.0 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
11d2c2aa2
100.0 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
12c1b3qA_
100.0 21 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
13c3a0tA_
100.0 23 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
14d1id0a_
99.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
15c2ch4A_
99.9 22 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
16d1bxda_
99.9 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
17d1i58a_
99.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
18d1ysra1
99.9 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
19c3jz3B_
99.8 18 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
20d2hkja3
99.8 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
21d1r62a_
not modelled 99.8 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
22c3ehgA_
not modelled 99.7 19 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
23c3gieA_
not modelled 99.7 17 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
24c3zxqA_
not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
25c1mx0D_
not modelled 99.7 19 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
26c2zbkB_
not modelled 99.7 20 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
27c2q2eB_
not modelled 99.6 19 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
28c3zxoB_
not modelled 99.6 26 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
29d1ixma_
not modelled 99.6 17 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
30d1th8a_
not modelled 99.5 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
31d1h7sa2
not modelled 99.5 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
32d1b63a2
not modelled 99.4 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
33d1bkna2
not modelled 99.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
34d1y8oa2
not modelled 99.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
35c3na3A_
not modelled 99.1 21 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
36d3by8a1
99.1 25 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:Sensory domain of two-component sensor kinase
37d1p0za_
99.1 37 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:Sensory domain of two-component sensor kinase
38c3h4lB_
not modelled 98.8 19 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
39d1kija2
not modelled 98.5 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
40d1pvga2
not modelled 98.4 29 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
41d1ei1a2
not modelled 98.4 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
42c1kijB_
not modelled 98.3 21 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
43d1s16a2
not modelled 98.3 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
44c1bknA_
not modelled 98.3 20 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
45c1y4sA_
not modelled 98.3 22 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
46c1ei1B_
not modelled 98.2 21 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
47c2cg9A_
not modelled 98.1 22 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
48d2iwxa1
not modelled 98.1 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
49c3ke6A_
not modelled 98.1 23 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
50c1s16B_
not modelled 98.1 23 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
51c1zwhA_
not modelled 98.1 21 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
52c1ea6A_
not modelled 98.1 32 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
53d1uyla_
not modelled 98.0 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
54c3iedA_
not modelled 98.0 21 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
55c2iopD_
not modelled 98.0 22 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
56c2fwyA_
not modelled 97.9 18 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
57c1zxnB_
not modelled 97.9 26 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
58c3g7bB_
not modelled 97.9 19 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
59c2iorA_
not modelled 97.9 22 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
60c1qzrA_
not modelled 97.9 29 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
61c2o1wB_
not modelled 97.8 19 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
62c3pehB_
not modelled 97.8 22 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
63d1uyma_
not modelled 97.7 13 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
64c2akpA_
not modelled 97.7 22 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
65d2gqpa1
not modelled 97.6 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
66d1s14a_
not modelled 97.5 26 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
67d1qy5a_
not modelled 97.4 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
68c2o1uA_
not modelled 97.3 24 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
69c3lnuA_
not modelled 97.1 30 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
70c2w0nA_
not modelled 96.9 25 PDB header:transferase
Chain: A: PDB Molecule:sensor protein dcus;
PDBTitle: plasticity of pas domain and potential role for signal2 transduction in the histidine-kinase dcus
71c2jheB_
not modelled 96.3 14 PDB header:transcription
Chain: B: PDB Molecule:transcription regulator tyrr;
PDBTitle: n-terminal domain of tyrr transcription factor (residues 1 -2 190)
72c2qkpD_
not modelled 96.2 15 PDB header:structural genomics, unknown function
Chain: D: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of c-terminal domain of smu_1151c from streptococcus2 mutans
73c3lyxA_
not modelled 96.0 15 PDB header:transcription
Chain: A: PDB Molecule:sensory box/ggdef domain protein;
PDBTitle: crystal structure of the pas domain of the protein cps_12912 from colwellia psychrerythraea. northeast structural3 genomics consortium target id csr222b
74c3caxA_
not modelled 95.7 10 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein pf0695;
PDBTitle: crystal structure of uncharacterized protein pf0695
75c3mqoB_
not modelled 95.5 14 PDB header:transcription regulator
Chain: B: PDB Molecule:transcriptional regulator, luxr family;
PDBTitle: the crystal structure of the pas domain in complex with isopropanol of2 a transcriptional regulator in the luxr family from burkholderia3 thailandensis to 1.7a
76c3mxqC_
not modelled 95.5 14 PDB header:transferase
Chain: C: PDB Molecule:sensor protein;
PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae
77c3cwvB_
not modelled 95.1 23 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
78c3mfxA_
not modelled 95.1 11 PDB header:transcription
Chain: A: PDB Molecule:sensory box/ggdef family protein;
PDBTitle: crystal structure of the sensory box domain of the sensory-2 box/ggdef protein so_1695 from shewanella oneidensis,3 northeast structural genomics consortium target sor288b
79c3b33A_
not modelled 95.0 14 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the pas domain of nitrogen regulation protein2 nr(ii) from vibrio parahaemolyticus
80d1nwza_
not modelled 95.0 18 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:PYP-like
81d1mzua_
not modelled 94.5 19 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:PYP-like
82c2gj3A_
not modelled 94.3 13 PDB header:transferase
Chain: A: PDB Molecule:nitrogen fixation regulatory protein;
PDBTitle: crystal structure of the fad-containing pas domain of the2 protein nifl from azotobacter vinelandii.
83c1v9yA_
not modelled 93.9 9 PDB header:signaling protein
Chain: A: PDB Molecule:heme pas sensor protein;
PDBTitle: crystal structure of the heme pas sensor domain of ec dos (ferric2 form)
84d1v9ya_
not modelled 93.9 9 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:Heme-binding PAS domain
85d1otda_
not modelled 93.7 17 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:PYP-like
86c2pr6A_
not modelled 93.7 13 PDB header:flavoprotein, signaling protein
Chain: A: PDB Molecule:blue-light photoreceptor;
PDBTitle: structural basis for light-dependent signaling in the dimeric lov2 photosensor ytva (light structure)
87c3fg8B_
not modelled 93.7 20 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein rha05790;
PDBTitle: crystal structure of pas domain of rha05790
88c3oloB_
not modelled 93.6 12 PDB header:transferase
Chain: B: PDB Molecule:two-component sensor histidine kinase;
PDBTitle: crystal structure of a pas domain from two-component sensor histidine2 kinase
89c3b42B_
not modelled 93.4 10 PDB header:signaling protein
Chain: B: PDB Molecule:methyl-accepting chemotaxis protein, putative;
PDBTitle: periplasmic sensor domain of chemotaxis protein gsu0935
90c2v1bA_
not modelled 93.2 13 PDB header:transferase
Chain: A: PDB Molecule:nph1-1;
PDBTitle: n- and c-terminal helices of oat lov2 (404-546) are2 involved in light-induced signal transduction (room3 temperature (293k) light structure of lov2 (404-546))
91c3fc7B_
not modelled 93.1 12 PDB header:transferase
Chain: B: PDB Molecule:htr-like protein;
PDBTitle: the crystal structure of a domain of htr-like protein from haloarcula2 marismortui atcc 43049
92c3luqC_
not modelled 91.9 12 PDB header:transferase
Chain: C: PDB Molecule:sensor protein;
PDBTitle: the crystal structure of a pas domain from a sensory box2 histidine kinase regulator from geobacter sulfurreducens to3 2.5a
93d1y28a_
not modelled 91.8 19 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:Heme-binding PAS domain
94c2r78D_
not modelled 91.1 18 PDB header:transferase
Chain: D: PDB Molecule:sensor protein;
PDBTitle: crystal structure of a domain of the sensory box sensor2 histidine kinase/response regulator from geobacter3 sulfurreducens
95c3mr0B_
not modelled 90.5 8 PDB header:transcription regulator
Chain: B: PDB Molecule:sensory box histidine kinase/response regulator;
PDBTitle: crystal structure of sensory box histidine kinase/response regulator2 from burkholderia thailandensis e264
96d1xfna1
not modelled 90.4 20 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:PYP-like
97c3a0vA_
not modelled 90.1 16 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: pas domain of histidine kinase thka (tm1359) (semet,2 f486m/f489m)
98c3lmmA_
not modelled 90.0 13 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
99c3e4pB_
not modelled 89.5 14 PDB header:transferase
Chain: B: PDB Molecule:c4-dicarboxylate transport sensor protein dctb;
PDBTitle: crystal structure of malonate occupied dctb
100c3mjqB_
not modelled 89.0 7 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the pas domain of q24qt8_deshy protein from2 desulfitobacterium hafniense. northeast structural genomics3 consortium target dhr85c.
101c3by9A_
not modelled 88.6 8 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of the v. cholerae histidine kinase dctb2 sensor domain
102c3k3dA_
not modelled 87.6 13 PDB header:signaling protein
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the n-terminal pas domain crystal structure of rv1364c from2 mycobacterium tuberculosis at 2.3 angstrom
103c3fosA_
not modelled 87.2 9 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of two-component sensor histidine kinase domain from2 bacillus subtilis subsp. subtilis str. 168
104d1ew0a_
not modelled 84.1 14 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:Heme-binding PAS domain
105d1ll8a_
not modelled 84.0 24 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:N-terminal PAS domain of Pas kinase
106c2vlgD_
not modelled 82.3 18 PDB header:transferase
Chain: D: PDB Molecule:sporulation kinase a;
PDBTitle: kina pas-a domain, homodimer
107c3kx0X_
not modelled 76.3 12 PDB header:signaling protein
Chain: X: PDB Molecule:uncharacterized protein rv1364c/mt1410;
PDBTitle: crystal structure of the pas domain of rv1364c
108c3bwlA_
not modelled 75.8 21 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of pas domain of htr-like protein from haloarcula2 marismortui
109d2p7ja2
not modelled 74.7 8 Fold:Profilin-like
Superfamily:Sensory domain-like
Family:YkuI C-terminal domain-like
110d1xj3a1
not modelled 71.4 22 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:Heme-binding PAS domain
111d1wmaa1
not modelled 70.3 27 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Tyrosine-dependent oxidoreductases
112d1n9la_
not modelled 69.4 8 Fold:Profilin-like
Superfamily:PYP-like sensor domain (PAS domain)
Family:Flavin-binding PAS domain
113c2l4rA_
not modelled 66.9 11 PDB header:transport protein
Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h member 2;
PDBTitle: nmr solution structure of the n-terminal pas domain of herg
114c2wkqA_
not modelled 65.8 13 PDB header:transferase, cell adhesion
Chain: A: PDB Molecule:nph1-1, ras-related c3 botulinum toxin substrate
PDBTitle: structure of a photoactivatable rac1 containing the lov22 c450a mutant
115c3c38A_
not modelled 61.2 15 PDB header:signaling protein, transferase
Chain: A: PDB Molecule:autoinducer 2 sensor kinase/phosphatase luxq;
PDBTitle: crystal structure of the periplasmic domain of vibrio2 cholerae luxq
116c3p7nB_
not modelled 59.2 13 PDB header:dna binding protein
Chain: B: PDB Molecule:sensor histidine kinase;
PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis
117d2c2aa1
not modelled 57.7 13 Fold:ROP-like
Superfamily:Homodimeric domain of signal transducing histidine kinase
Family:Homodimeric domain of signal transducing histidine kinase
118c3eehA_
not modelled 55.8 13 PDB header:transferase
Chain: A: PDB Molecule:putative light and redox sensing histidine kinase;
PDBTitle: the crystal structure of the domain of the putative light and redox2 sensing histidine kinase from haloarcula marismortui
119c3rtyA_
not modelled 50.2 19 PDB header:circadian clock protein
Chain: A: PDB Molecule:period circadian protein;
PDBTitle: structure of an enclosed dimer formed by the drosophila period protein
120c3ewkA_
not modelled 48.6 15 PDB header:flavoprotein
Chain: A: PDB Molecule:sensor protein;
PDBTitle: structure of the redox sensor domain of methylococcus capsulatus2 (bath) mmos

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0