Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	E	N	I	S	V	T	D	S	Y	S	T	G	N	A	A	Q	A	M	L	E	K	L	L	Q	I	Y	D	V	K	T	L	V	A	Q	L	N	G	V	G	E	N	H	W	S	A	A	I	L	K	R	A	L	A	N	D	S	A	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?			?	?	?	?	?																		?								?			?	?	?	?	?	?	?	?		?	?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	R	L	S	E	K	E	F	A	H	L	Q	T	L	L	P	K	P	P	A	H	H	P	H	Y	A	F	R	F	I	D	L	F	A	G	I	G	G	I	R	R	G	F	E	S	I	G	G	Q	C	V	F	T	S	E	W	N	K	H	A
Secondary structure
SS confidence
Disorder			?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	R	T	Y	K	A	N	H	Y	C	D	P	A	T	H	H	F	N	E	D	I	R	D	I	T	L	S	H	K	E	G	V	S	D	E	A	A	A	E	H	I	R	Q	H	I	P	E	H	D	V	L	L	A	G	F	P	C	Q	P	F
Secondary structure
SS confidence
Disorder																														?	?	?	?	?		?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	L	A	G	V	S	K	K	N	S	L	G	R	A	H	G	F	A	C	D	T	Q	G	T	L	F	F	D	V	V	R	I	I	D	A	R	R	P	A	M	F	V	L	E	N	V	K	N	L	K	S	H	D	Q	G	K	T	F	R	I
Secondary structure
SS confidence
Disorder						?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	M	Q	T	L	D	E	L	G	Y	D	V	A	D	A	E	D	N	G	P	D	D	P	K	I	I	D	G	K	H	F	L	P	Q	H	R	E	R	I	V	L	V	G	F	R	R	D	L	N	L	K	A	D	F	T	L	R	D	I	S
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	C	F	P	A	Q	R	V	T	L	A	Q	L	L	D	P	M	V	E	A	K	Y	I	L	T	P	V	L	W	K	Y	L	Y	R	Y	A	K	K	H	Q	A	R	G	N	G	F	G	Y	G	M	V	Y	P	N	N	P	Q	S	V	T
Secondary structure
SS confidence
Disorder			?			?	?	?																												?			?	?	?																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	T	L	S	A	R	Y	Y	K	D	G	A	E	I	L	I	D	R	G	W	D	M	A	T	G	E	K	D	F	D	D	P	L	N	Q	Q	H	R	P	R	R	L	T	P	R	E	C	A	R	L	M	G	F	E	A	P	G	E	A	K
Secondary structure
SS confidence
Disorder			?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.
Sequence		F	R	I	P	V	S	D	T	Q	A	Y	R	Q	F	G	N	S	V	V	V	P	V	F	A	A	V	A	K	L	L	E	P	K	I	K	Q	A	V	A	L	R	Q	Q	E	A	Q	H	G	R	R	S	R
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3me5 chain A Region: 15 - 466 Aligned: 414 Modelled: 452 Confidence: 100.0% Identity: 91% PDB header:transferase Chain: A: PDB Molecule:cytosine-specific methyltransferase; PDBTitle: crystal structure of putative dna cytosine methylase from shigella2 flexneri 2a str. 301 Phyre2 PDB 3lx6 chain B Region: 76 - 462 Aligned: 362 Modelled: 373 Confidence: 100.0% Identity: 92% PDB header:transferase Chain: B: PDB Molecule:cytosine-specific methyltransferase; PDBTitle: structure of probable cytosine-specific methyltransferase from2 shigella flexneri Phyre2 PDB 3swr chain A Region: 76 - 456 Aligned: 357 Modelled: 373 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 1; PDBTitle: structure of human dnmt1 (601-1600) in complex with sinefungin Phyre2 PDB 3av6 chain A Region: 80 - 459 Aligned: 356 Modelled: 372 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 1; PDBTitle: crystal structure of mouse dna methyltransferase 1 with adomet Phyre2 PDB 3pt6 chain B Region: 75 - 454 Aligned: 356 Modelled: 380 Confidence: 100.0% Identity: 21% PDB header:transferase/dna Chain: B: PDB Molecule:dna (cytosine-5)-methyltransferase 1; PDBTitle: crystal structure of mouse dnmt1(650-1602) in complex with dna Phyre2 PDB 3pt9 chain A Region: 83 - 454 Aligned: 348 Modelled: 372 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 1; PDBTitle: crystal structure of mouse dnmt1(731-1602) in the free state Phyre2 PDB 1dct chain A Region: 87 - 454 Aligned: 321 Modelled: 340 Confidence: 100.0% Identity: 27% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: C5 cytosine-specific DNA methylase, DCM Phyre2 PDB 2c7p chain A domain 1 Region: 80 - 457 Aligned: 321 Modelled: 354 Confidence: 100.0% Identity: 35% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: C5 cytosine-specific DNA methylase, DCM Phyre2 PDB 3g7u chain A Region: 86 - 456 Aligned: 327 Modelled: 346 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:cytosine-specific methyltransferase; PDBTitle: crystal structure of putative dna modification methyltransferase2 encoded within prophage cp-933r (e.coli) Phyre2 PDB 2qrv chain A Region: 80 - 453 Aligned: 256 Modelled: 273 Confidence: 100.0% Identity: 23% PDB header:transferase/transferase regulator Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 3a; PDBTitle: structure of dnmt3a-dnmt3l c-terminal domain complex Phyre2 PDB 1g55 chain A Region: 85 - 450 Aligned: 296 Modelled: 321 Confidence: 100.0% Identity: 24% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: C5 cytosine-specific DNA methylase, DCM Phyre2 PDB 2qrv chain C Region: 80 - 287 Aligned: 140 Modelled: 152 Confidence: 100.0% Identity: 19% PDB header:transferase/transferase regulator Chain: C: PDB Molecule:dna (cytosine-5)-methyltransferase 3-like; PDBTitle: structure of dnmt3a-dnmt3l c-terminal domain complex Phyre2 PDB 2pv0 chain A Region: 75 - 297 Aligned: 155 Modelled: 163 Confidence: 100.0% Identity: 17% PDB header:transferase regulator Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 3-like; PDBTitle: dna methyltransferase 3 like protein (dnmt3l) Phyre2 PDB 1wy7 chain A domain 1 Region: 30 - 281 Aligned: 183 Modelled: 198 Confidence: 99.1% Identity: 18% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Ta1320-like Phyre2 PDB 2as0 chain A domain 2 Region: 67 - 255 Aligned: 148 Modelled: 157 Confidence: 98.5% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 1uwv chain A domain 2 Region: 88 - 255 Aligned: 121 Modelled: 143 Confidence: 98.5% Identity: 23% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: (Uracil-5-)-methyltransferase Phyre2 PDB 2b78 chain A Region: 68 - 271 Aligned: 162 Modelled: 173 Confidence: 98.5% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein smu.776; PDBTitle: a putative sam-dependent methyltransferase from2 streptococcus mutans Phyre2 PDB 1uwv chain A Region: 88 - 255 Aligned: 121 Modelled: 143 Confidence: 98.4% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase Phyre2 PDB 3gdh chain C Region: 69 - 186 Aligned: 90 Modelled: 100 Confidence: 98.4% Identity: 16% PDB header:transferase Chain: C: PDB Molecule:trimethylguanosine synthase homolog; PDBTitle: methyltransferase domain of human trimethylguanosine2 synthase 1 (tgs1) bound to m7gtp and adenosyl-homocysteine3 (active form) Phyre2 PDB 2as0 chain A Region: 88 - 255 Aligned: 135 Modelled: 149 Confidence: 98.4% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:hypothetical protein ph1915; PDBTitle: crystal structure of ph1915 (apc 5817): a hypothetical rna2 methyltransferase Phyre2 1 c3me5A_ 2 c3lx6B_ 3 c3swrA_ 4 c3av6A_ 5 c3pt6B_ 6 c3pt9A_ 7 d1dcta_ 8 d2c7pa1 9 c3g7uA_ 10 c2qrvA_ 11 d1g55a_ 12 c2qrvC_ 13 c2pv0A_ 14 d1wy7a1 15 d2as0a2 16 d1uwva2 17 c2b78A_ 18 c1uwvA_ 19 c3gdhC_ 20 c2as0A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322