Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP76104
DateThu Jan 5 12:18:59 GMT 2012
Unique Job ID5a7e5330791bc35c

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3qjaA_
Top template information
PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form
Confidence and coverage
Confidence: 98.1% Coverage: 16%
107 residues ( 16% of your sequence) have been modelled with 98.1% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
203 residues ( 31%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MTVSSHRLELLSPARDAAIAREAILHGADAVYIGGPGFGARHNASNSLKDIAELVPFAHR
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Disorder  ???????

































?

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   .........70.........80.........90.........100.........110.........120
Sequence  YGAKIFVTLNTILHDDELEPAQRLITDLYQTGVDALIVQDMGILELDIPPIELHASTQCD
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   .........130.........140.........150.........160.........170.........180
Sequence  IRTVEKAKFLSDVGFTQIVLARELNLDQIRAIHQATDATIEFFIHGALCVAYSGQCYISH
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   .........190.........200.........210.........220.........230.........240
Sequence  AQTGRSANRGDCSQACRLPYTLKDDQGRVVSYEKHLLSMKDNDQTANLGALIDAGVRSFK
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??????
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?


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   .........250.........260.........270.........280.........290.........300
Sequence  IEGRYKDMSYVKNITAHYRQMLDAIIEERGDLARASSGRTEHFFVPSTEKTFHRGSTDYF
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?????????

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   .........310.........320.........330.........340.........350.........360
Sequence  VNARKGDIGAFDSPKFIGLPVGEVVKVAKDHLDVAVTEPLANGDGLNVLIKREVVGFRAN
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Disorder 



??????????













































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   .........370.........380.........390.........400.........410.........420
Sequence  TVEKTGENQYRVWPNEMPADLHKIRPHHPLNRNLDHNWQQALTKTSSERRVAVDIELGGW
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Disorder 


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?
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   .........430.........440.........450.........460.........470.........480
Sequence  QEQLILTLTSEEGVSITHTLDGQFDEANNAEKAMNNLKDGLAKLGQTLYYARDVQINLPG
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???
??????????


























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   .........490.........500.........510.........520.........530.........540
Sequence  ALFVPNSLLNQFRREAADMLDAARLASYQRGSRKPVADPAPVYPQTHLSFLANVYNQKAR
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   .........550.........560.........570.........580.........590.........600
Sequence  EFYHRYGVQLIDAAYEAHEEKGEVPVMITKHCLRFAFNLCPKQAKGNIKSWKATPMQLVN
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   .........610.........620.........630.........640.........650...
Sequence  GDEVLTLKFDCRPCEMHVIGKIKNHILKMPLPGSVVASVSPDELLKTLPKRKG
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????








???????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3qja chain A

3D model

Region: 16 - 142
Aligned: 107
Modelled: 127
Confidence: 98.1%
Identity: 14%
PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form

Phyre2

PDB 3iwp chain K

3D model

Region: 14 - 166
Aligned: 148
Modelled: 153
Confidence: 98.0%
Identity: 18%
PDB header:metal binding protein
Chain: K: PDB Molecule:copper homeostasis protein cutc homolog;
PDBTitle: crystal structure of human copper homeostasis protein cutc

Phyre2

PDB 2bdq chain A

3D model

Region: 7 - 168
Aligned: 158
Modelled: 159
Confidence: 97.9%
Identity: 21%
PDB header:metal transport
Chain: A: PDB Molecule:copper homeostasis protein cutc;
PDBTitle: crystal structure of the putative copper homeostasis2 protein cutc from streptococcus agalactiae, northeast3 strucural genomics target sar15.

Phyre2

PDB 1a53 chain A

3D model

Region: 16 - 141
Aligned: 106
Modelled: 116
Confidence: 97.9%
Identity: 16%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Tryptophan biosynthesis enzymes

Phyre2

PDB 2c3z chain A

3D model

Region: 16 - 142
Aligned: 107
Modelled: 127
Confidence: 97.8%
Identity: 16%
PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus

Phyre2

PDB 1twd chain A

3D model

Region: 14 - 166
Aligned: 147
Modelled: 149
Confidence: 97.7%
Identity: 16%
Fold: TIM beta/alpha-barrel
Superfamily: CutC-like
Family: CutC-like

Phyre2

PDB 3igs chain B

3D model

Region: 15 - 140
Aligned: 107
Modelled: 124
Confidence: 97.5%
Identity: 10%
PDB header:isomerase
Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2;
PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase

Phyre2

PDB 2ze3 chain A

3D model

Region: 5 - 169
Aligned: 164
Modelled: 165
Confidence: 97.4%
Identity: 21%
PDB header:isomerase
Chain: A: PDB Molecule:dfa0005;
PDBTitle: crystal structure of dfa0005 complexed with alpha-ketoglutarate: a2 novel member of the icl/pepm superfamily from alkali-tolerant3 deinococcus ficus

Phyre2

PDB 1vli chain A domain 2

3D model

Region: 4 - 157
Aligned: 144
Modelled: 154
Confidence: 97.4%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Family: NeuB-like

Phyre2

PDB 2zdr chain A domain 2

3D model

Region: 17 - 185
Aligned: 150
Modelled: 169
Confidence: 97.4%
Identity: 15%
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Family: NeuB-like

Phyre2

PDB 1vli chain A

3D model

Region: 17 - 175
Aligned: 140
Modelled: 153
Confidence: 97.4%
Identity: 20%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:spore coat polysaccharide biosynthesis protein spse;
PDBTitle: crystal structure of spore coat polysaccharide biosynthesis protein2 spse (bsu37870) from bacillus subtilis at 2.38 a resolution

Phyre2

PDB 1xi3 chain A

3D model

Region: 17 - 160
Aligned: 122
Modelled: 130
Confidence: 97.4%
Identity: 21%
Fold: TIM beta/alpha-barrel
Superfamily: Thiamin phosphate synthase
Family: Thiamin phosphate synthase

Phyre2

PDB 1pii chain A domain 2

3D model

Region: 16 - 141
Aligned: 105
Modelled: 116
Confidence: 97.3%
Identity: 12%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Tryptophan biosynthesis enzymes

Phyre2

PDB 1j5t chain A

3D model

Region: 16 - 141
Aligned: 106
Modelled: 126
Confidence: 97.3%
Identity: 18%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Tryptophan biosynthesis enzymes

Phyre2

PDB 1xuz chain A

3D model

Region: 17 - 185
Aligned: 150
Modelled: 169
Confidence: 97.2%
Identity: 15%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:polysialic acid capsule biosynthesis protein siac;
PDBTitle: crystal structure analysis of sialic acid synthase (neub)from2 neisseria meningitidis, bound to mn2+, phosphoenolpyruvate, and n-3 acetyl mannosaminitol

Phyre2

PDB 1i4n chain A

3D model

Region: 16 - 141
Aligned: 106
Modelled: 120
Confidence: 97.2%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Tryptophan biosynthesis enzymes

Phyre2

PDB 3q58 chain A

3D model

Region: 15 - 140
Aligned: 107
Modelled: 122
Confidence: 97.2%
Identity: 17%
PDB header:isomerase
Chain: A: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase;
PDBTitle: structure of n-acetylmannosamine-6-phosphate epimerase from salmonella2 enterica

Phyre2

PDB 1h5y chain A

3D model

Region: 7 - 161
Aligned: 145
Modelled: 153
Confidence: 97.2%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Histidine biosynthesis enzymes

Phyre2

PDB 1n7k chain A

3D model

Region: 17 - 141
Aligned: 118
Modelled: 125
Confidence: 97.1%
Identity: 22%
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Family: Class I aldolase

Phyre2

PDB 1vc4 chain A

3D model

Region: 16 - 141
Aligned: 104
Modelled: 126
Confidence: 97.1%
Identity: 20%
Fold: TIM beta/alpha-barrel
Superfamily: Ribulose-phoshate binding barrel
Family: Tryptophan biosynthesis enzymes

Phyre2

PDB 3inp chain A

3D model

Region: 18 - 263
Aligned: 182
Modelled: 182
Confidence: 94.2%
Identity: 15%
PDB header:isomerase
Chain: A: PDB Molecule:d-ribulose-phosphate 3-epimerase;
PDBTitle: 2.05 angstrom resolution crystal structure of d-ribulose-phosphate 3-2 epimerase from francisella tularensis.

Phyre2
1

c3qjaA_
2

c3iwpK_
3

c2bdqA_
4

d1a53a_
5

c2c3zA_
6

d1twda_
7

c3igsB_
8

c2ze3A_
9

d1vlia2
10

d2zdra2
11

c1vliA_
12

d1xi3a_
13

d1piia2
14

d1j5ta_
15

c1xuzA_
16

d1i4na_
17

c3q58A_
18

d1h5ya_
19

d1n7ka_
20

d1vc4a_
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c3inpA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3qjaA_



98.1 14 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form
2c3iwpK_



98.0 18 PDB header:metal binding protein
Chain: K: PDB Molecule:copper homeostasis protein cutc homolog;
PDBTitle: crystal structure of human copper homeostasis protein cutc
3c2bdqA_



97.9 21 PDB header:metal transport
Chain: A: PDB Molecule:copper homeostasis protein cutc;
PDBTitle: crystal structure of the putative copper homeostasis2 protein cutc from streptococcus agalactiae, northeast3 strucural genomics target sar15.
4d1a53a_



97.9 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
5c2c3zA_



97.8 16 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus
6d1twda_



97.7 16 Fold:TIM beta/alpha-barrel
Superfamily:CutC-like
Family:CutC-like
7c3igsB_



97.5 10 PDB header:isomerase
Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2;
PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase
8c2ze3A_



97.4 21 PDB header:isomerase
Chain: A: PDB Molecule:dfa0005;
PDBTitle: crystal structure of dfa0005 complexed with alpha-ketoglutarate: a2 novel member of the icl/pepm superfamily from alkali-tolerant3 deinococcus ficus
9d1vlia2



97.4 19 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:NeuB-like
10d2zdra2



97.4 15 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:NeuB-like
11c1vliA_



97.4 20 PDB header:biosynthetic protein
Chain: A: PDB Molecule:spore coat polysaccharide biosynthesis protein spse;
PDBTitle: crystal structure of spore coat polysaccharide biosynthesis protein2 spse (bsu37870) from bacillus subtilis at 2.38 a resolution
12d1xi3a_



97.4 21 Fold:TIM beta/alpha-barrel
Superfamily:Thiamin phosphate synthase
Family:Thiamin phosphate synthase
13d1piia2



97.3 12 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
14d1j5ta_



97.3 18 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
15c1xuzA_



97.2 15 PDB header:biosynthetic protein
Chain: A: PDB Molecule:polysialic acid capsule biosynthesis protein siac;
PDBTitle: crystal structure analysis of sialic acid synthase (neub)from2 neisseria meningitidis, bound to mn2+, phosphoenolpyruvate, and n-3 acetyl mannosaminitol
16d1i4na_



97.2 19 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
17c3q58A_



97.2 17 PDB header:isomerase
Chain: A: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase;
PDBTitle: structure of n-acetylmannosamine-6-phosphate epimerase from salmonella2 enterica
18d1h5ya_



97.2 19 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
19d1n7ka_



97.1 22 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
20d1vc4a_



97.1 20 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
21c3lyeA_



not modelled 97.0 12 PDB header:hydrolase
Chain: A: PDB Molecule:oxaloacetate acetyl hydrolase;
PDBTitle: crystal structure of oxaloacetate acetylhydrolase
22d1jvna1



not modelled 97.0 20 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
23c2ftpA_



not modelled 96.9 13 PDB header:lyase
Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase;
PDBTitle: crystal structure of hydroxymethylglutaryl-coa lyase from pseudomonas2 aeruginosa
24c1zlpA_



not modelled 96.9 16 PDB header:lyase
Chain: A: PDB Molecule:petal death protein;
PDBTitle: petal death protein psr132 with cysteine-linked glutaraldehyde forming2 a thiohemiacetal adduct
25d1qo2a_



not modelled 96.8 15 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
26c3q94B_



not modelled 96.8 21 PDB header:lyase
Chain: B: PDB Molecule:fructose-bisphosphate aldolase, class ii;
PDBTitle: the crystal structure of fructose 1,6-bisphosphate aldolase from2 bacillus anthracis str. 'ames ancestor'
27d1wa3a1



not modelled 96.8 16 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
28d1yxya1



not modelled 96.7 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:NanE-like
29d1thfd_



not modelled 96.7 16 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
30c3ivuB_



not modelled 96.7 18 PDB header:transferase
Chain: B: PDB Molecule:homocitrate synthase, mitochondrial;
PDBTitle: homocitrate synthase lys4 bound to 2-og
31c2iswB_



not modelled 96.7 22 PDB header:lyase
Chain: B: PDB Molecule:putative fructose-1,6-bisphosphate aldolase;
PDBTitle: structure of giardia fructose-1,6-biphosphate aldolase in2 complex with phosphoglycolohydroxamate
32d1vzwa1



not modelled 96.6 17 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
33d1gvfa_



not modelled 96.6 23 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class II FBP aldolase
34c3ktsA_



not modelled 96.5 16 PDB header:transcriptional regulator
Chain: A: PDB Molecule:glycerol uptake operon antiterminator regulatory protein;
PDBTitle: crystal structure of glycerol uptake operon antiterminator regulatory2 protein from listeria monocytogenes str. 4b f2365
35c3bleA_



not modelled 96.5 18 PDB header:transferase
Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans;
PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate
36d1o0ya_



not modelled 96.5 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
37c3fa4D_



not modelled 96.3 16 PDB header:lyase
Chain: D: PDB Molecule:2,3-dimethylmalate lyase;
PDBTitle: crystal structure of 2,3-dimethylmalate lyase, a pep mutase/isocitrate2 lyase superfamily member, triclinic crystal form
38c3oa3A_



not modelled 96.3 18 PDB header:lyase
Chain: A: PDB Molecule:aldolase;
PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 coccidioides immitis
39c2z6jB_



not modelled 96.2 19 PDB header:oxidoreductase
Chain: B: PDB Molecule:trans-2-enoyl-acp reductase ii;
PDBTitle: crystal structure of s. pneumoniae enoyl-acyl carrier2 protein reductase (fabk) in complex with an inhibitor
40c2ekcA_



not modelled 96.2 22 PDB header:lyase
Chain: A: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5
41d1ub3a_



not modelled 96.2 17 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
42c2y85D_



not modelled 96.1 20 PDB header:isomerase
Chain: D: PDB Molecule:phosphoribosyl isomerase a;
PDBTitle: crystal structure of mycobacterium tuberculosis phosphoribosyl2 isomerase with bound rcdrp
43c3eooL_



not modelled 96.1 19 PDB header:lyase
Chain: L: PDB Molecule:methylisocitrate lyase;
PDBTitle: 2.9a crystal structure of methyl-isocitrate lyase from2 burkholderia pseudomallei
44d1muma_



not modelled 96.1 18 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like
45c1ydnA_



not modelled 96.1 13 PDB header:lyase
Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase;
PDBTitle: crystal structure of the hmg-coa lyase from brucella melitensis,2 northeast structural genomics target lr35.
46d1ka9f_



not modelled 96.0 15 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Histidine biosynthesis enzymes
47d1tqxa_



not modelled 96.0 10 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
48c3ih1A_



not modelled 96.0 17 PDB header:lyase
Chain: A: PDB Molecule:methylisocitrate lyase;
PDBTitle: crystal structure of carboxyvinyl-carboxyphosphonate phosphorylmutase2 from bacillus anthracis
49c3gr7A_



not modelled 95.9 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:nadph dehydrogenase;
PDBTitle: structure of oye from geobacillus kaustophilus, hexagonal2 crystal form
50d1ujqa_



not modelled 95.8 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like
51c1jvnB_



not modelled 95.8 21 PDB header:transferase
Chain: B: PDB Molecule:bifunctional histidine biosynthesis protein hishf;
PDBTitle: crystal structure of imidazole glycerol phosphate synthase: a tunnel2 through a (beta/alpha)8 barrel joins two active sites
52d2tpsa_



not modelled 95.8 16 Fold:TIM beta/alpha-barrel
Superfamily:Thiamin phosphate synthase
Family:Thiamin phosphate synthase
53c3b8iF_



not modelled 95.8 20 PDB header:lyase
Chain: F: PDB Molecule:pa4872 oxaloacetate decarboxylase;
PDBTitle: crystal structure of oxaloacetate decarboxylase from pseudomonas2 aeruginosa (pa4872) in complex with oxalate and mg2+.
54c3t7vA_



not modelled 95.8 16 PDB header:transferase
Chain: A: PDB Molecule:methylornithine synthase pylb;
PDBTitle: crystal structure of methylornithine synthase (pylb)
55d1mxsa_



not modelled 95.8 14 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
56c1yadD_



not modelled 95.7 12 PDB header:transcription
Chain: D: PDB Molecule:regulatory protein teni;
PDBTitle: structure of teni from bacillus subtilis
57c3pm6B_



not modelled 95.7 21 PDB header:lyase
Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase;
PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr
58c3cixA_



not modelled 95.7 13 PDB header:adomet binding protein
Chain: A: PDB Molecule:fefe-hydrogenase maturase;
PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate
59c2w6rA_



not modelled 95.7 15 PDB header:lyase
Chain: A: PDB Molecule:imidazole glycerol phosphate synthase subunit
PDBTitle: crystal structure of an artificial (ba)8-barrel protein2 designed from identical half barrels
60c3elfA_



not modelled 95.6 13 PDB header:lyase
Chain: A: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: structural characterization of tetrameric mycobacterium tuberculosis2 fructose 1,6-bisphosphate aldolase - substrate binding and catalysis3 mechanism of a class iia bacterial aldolase
61c2hjpA_



not modelled 95.6 15 PDB header:hydrolase
Chain: A: PDB Molecule:phosphonopyruvate hydrolase;
PDBTitle: crystal structure of phosphonopyruvate hydrolase complex with2 phosphonopyruvate and mg++
62d1mzha_



not modelled 95.5 19 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
63d1rvga_



not modelled 95.5 23 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class II FBP aldolase
64d1rpxa_



not modelled 95.5 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
65d1u5ha_



not modelled 95.5 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
66c3ng3A_



not modelled 95.5 22 PDB header:lyase
Chain: A: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of deoxyribose phosphate aldolase from mycobacterium2 avium 104 in a schiff base with an unknown aldehyde
67c2gjlA_



not modelled 95.4 22 PDB header:oxidoreductase
Chain: A: PDB Molecule:hypothetical protein pa1024;
PDBTitle: crystal structure of 2-nitropropane dioxygenase
68d1e0ta2



not modelled 95.4 18 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
69c3thaB_



not modelled 95.4 16 PDB header:lyase
Chain: B: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: tryptophan synthase subunit alpha from campylobacter jejuni.
70c3ngjC_



not modelled 95.4 17 PDB header:lyase
Chain: C: PDB Molecule:deoxyribose-phosphate aldolase;
PDBTitle: crystal structure of a putative deoxyribose-phosphate aldolase from2 entamoeba histolytica
71c3bo9B_



not modelled 95.2 17 PDB header:oxidoreductase
Chain: B: PDB Molecule:putative nitroalkan dioxygenase;
PDBTitle: crystal structure of putative nitroalkan dioxygenase (tm0800) from2 thermotoga maritima at 2.71 a resolution
72c1u5vA_



not modelled 95.1 16 PDB header:lyase
Chain: A: PDB Molecule:cite;
PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis
73c1r30A_



not modelled 95.1 11 PDB header:transferase
Chain: A: PDB Molecule:biotin synthase;
PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme
74d1r30a_



not modelled 95.1 11 Fold:TIM beta/alpha-barrel
Superfamily:Radical SAM enzymes
Family:Biotin synthase
75c3navB_



not modelled 95.1 20 PDB header:lyase
Chain: B: PDB Molecule:tryptophan synthase alpha chain;
PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961
76c3c52B_



not modelled 95.1 20 PDB header:lyase
Chain: B: PDB Molecule:fructose-bisphosphate aldolase;
PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor
77c3hf3A_



not modelled 95.1 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:chromate reductase;
PDBTitle: old yellow enzyme from thermus scotoductus sa-01
78c3pg8B_



not modelled 95.1 17 PDB header:transferase
Chain: B: PDB Molecule:phospho-2-dehydro-3-deoxyheptonate aldolase;
PDBTitle: truncated form of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase2 from thermotoga maritima
79d1wbha1



not modelled 95.0 12 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
80d1y0ea_



not modelled 94.9 18 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:NanE-like
81c2dh3A_



not modelled 94.9 21 PDB header:transport protein, signaling protein
Chain: A: PDB Molecule:4f2 cell-surface antigen heavy chain;
PDBTitle: crystal structure of human ed-4f2hc
82d1geqa_



not modelled 94.9 20 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
83d1vhca_



not modelled 94.8 21 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
84d1nvma2



not modelled 94.8 16 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:HMGL-like
85d2flia1



not modelled 94.8 22 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:D-ribulose-5-phosphate 3-epimerase
86c3r2gA_



not modelled 94.7 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila
87c2pz0B_



not modelled 94.7 24 PDB header:hydrolase
Chain: B: PDB Molecule:glycerophosphoryl diester phosphodiesterase;
PDBTitle: crystal structure of glycerophosphodiester phosphodiesterase (gdpd)2 from t. tengcongensis
88c3ewbX_



not modelled 94.7 9 PDB header:transferase
Chain: X: PDB Molecule:2-isopropylmalate synthase;
PDBTitle: crystal structure of n-terminal domain of putative 2-2 isopropylmalate synthase from listeria monocytogenes
89c2v82A_



not modelled 94.6 18 PDB header:lyase
Chain: A: PDB Molecule:2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
PDBTitle: kdpgal complexed to kdpgal
90c3gndC_



not modelled 94.5 14 PDB header:lyase
Chain: C: PDB Molecule:aldolase lsrf;
PDBTitle: crystal structure of e. coli lsrf in complex with ribulose-5-phosphate
91c3l12A_



not modelled 94.4 25 PDB header:hydrolase
Chain: A: PDB Molecule:putative glycerophosphoryl diester phosphodiesterase;
PDBTitle: crystal structure of putative glycerophosphoryl diester2 phosphodiesterase (yp_165505.1) from silicibacter pomeroyi dss-3 at3 1.60 a resolution
92c1nvmG_



not modelled 94.3 15 PDB header:lyase/oxidoreductase
Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase;
PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate
93d1qopa_



not modelled 94.3 21 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
94c2cw6B_



not modelled 94.3 13 PDB header:lyase
Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial;
PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria
95c3inpA_



94.2 15 PDB header:isomerase
Chain: A: PDB Molecule:d-ribulose-phosphate 3-epimerase;
PDBTitle: 2.05 angstrom resolution crystal structure of d-ribulose-phosphate 3-2 epimerase from francisella tularensis.
96d1o60a_



not modelled 94.2 12 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
97c3g8rA_



not modelled 94.2 20 PDB header:biosynthetic protein
Chain: A: PDB Molecule:probable spore coat polysaccharide biosynthesis protein e;
PDBTitle: crystal structure of putative spore coat polysaccharide biosynthesis2 protein e from chromobacterium violaceum atcc 12472
98d1ojxa_



not modelled 94.2 17 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
99c3sz8D_



not modelled 94.1 8 PDB header:transferase
Chain: D: PDB Molecule:2-dehydro-3-deoxyphosphooctonate aldolase 2;
PDBTitle: crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from2 burkholderia pseudomallei
100c3rlgA_



not modelled 94.1 10 PDB header:hydrolase
Chain: A: PDB Molecule:sphingomyelin phosphodiesterase d lisictox-alphaia1a;
PDBTitle: crystal structure of loxosceles intermedia phospholipase d isoform 12 h12a mutant
101d1xcfa_



not modelled 94.0 15 Fold:TIM beta/alpha-barrel
Superfamily:Ribulose-phoshate binding barrel
Family:Tryptophan biosynthesis enzymes
102c3ffsC_



not modelled 94.0 20 PDB header:oxidoreductase
Chain: C: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: the crystal structure of cryptosporidium parvum inosine-5'-2 monophosphate dehydrogenase
103d1w3ia_



not modelled 93.9 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
104c2nx9B_



not modelled 93.9 19 PDB header:lyase
Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha;
PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae
105c3ez4B_



not modelled 93.8 17 PDB header:transferase
Chain: B: PDB Molecule:3-methyl-2-oxobutanoate hydroxymethyltransferase;
PDBTitle: crystal structure of 3-methyl-2-oxobutanoate2 hydroxymethyltransferase from burkholderia pseudomallei
106c3bg3B_



not modelled 93.7 20 PDB header:ligase
Chain: B: PDB Molecule:pyruvate carboxylase, mitochondrial;
PDBTitle: crystal structure of human pyruvate carboxylase (missing2 the biotin carboxylase domain at the n-terminus)
107c1rr2A_



not modelled 93.7 16 PDB header:transferase
Chain: A: PDB Molecule:transcarboxylase 5s subunit;
PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid
108c1piiA_



not modelled 93.6 20 PDB header:bifunctional(isomerase and synthase)
Chain: A: PDB Molecule:n-(5'phosphoribosyl)anthranilate isomerase;
PDBTitle: three-dimensional structure of the bifunctional enzyme2 phosphoribosylanthranilate isomerase:3 indoleglycerolphosphate synthase from escherichia coli4 refined at 2.0 angstroms resolution
109d1ps9a1



not modelled 93.6 17 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
110c1qpoA_



not modelled 93.6 11 PDB header:transferase
Chain: A: PDB Molecule:quinolinate acid phosphoribosyl transferase;
PDBTitle: quinolinate phosphoribosyl transferase (qaprtase) apo-enzyme from2 mycobacterium tuberculosis
111d1dxea_



not modelled 93.5 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
112d1d9ea_



not modelled 93.5 9 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I DAHP synthetase
113c3eegB_



not modelled 93.4 16 PDB header:transferase
Chain: B: PDB Molecule:2-isopropylmalate synthase;
PDBTitle: crystal structure of a 2-isopropylmalate synthase from2 cytophaga hutchinsonii
114c2z1kA_



not modelled 93.4 20 PDB header:hydrolase
Chain: A: PDB Molecule:(neo)pullulanase;
PDBTitle: crystal structure of ttha1563 from thermus thermophilus hb8
115d1o4ua1



not modelled 93.4 15 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
116d1qpoa1



not modelled 93.3 11 Fold:TIM beta/alpha-barrel
Superfamily:Nicotinate/Quinolinate PRTase C-terminal domain-like
Family:NadC C-terminal domain-like
117d1p1xa_



not modelled 93.2 17 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
118d1m3ua_



not modelled 93.1 16 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Ketopantoate hydroxymethyltransferase PanB
119c2r94B_



not modelled 93.1 19 PDB header:lyase
Chain: B: PDB Molecule:2-keto-3-deoxy-(6-phospho-)gluconate aldolase;
PDBTitle: crystal structure of kd(p)ga from t.tenax
120c3bmwA_



not modelled 93.0 26 PDB header:transferase
Chain: A: PDB Molecule:cyclomaltodextrin glucanotransferase;
PDBTitle: cyclodextrin glycosyl transferase from thermoanerobacterium2 thermosulfurigenes em1 mutant s77p complexed with a maltoheptaose3 inhibitor

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0