Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP77439
DateThu Jan 5 12:29:20 GMT 2012
Unique Job ID4f175ca91a4ecfc8

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2hwgA_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
Confidence and coverage
Confidence:100.0% Coverage: 68%
564 residues ( 68% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
795 residues ( 96%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MLTIQFLCPLPNGLHARPAWELKEQCSQWQSEITFINHRQNAKADAKSSLALIGTGTLFN
Secondary structure 
SS confidence 
Disorder  ?
??????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  DSCSLNISGSDEEQARRVLEEYIQVRFIDSDSVQPTQAELTAHPLPRSLSRLNPDLLYGN
Secondary structure 
SS confidence 
Disorder 
??????????????????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  VLASGVGVGTLTLLQSDSLDSYRAIPASAQDSTRLEHSLATLAEQLNQQLRERDGESKTI
Secondary structure 
SS confidence 
Disorder 
??????????
????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  LSAHLSLIQDDEFAGNIRRLMTEQHQGLGAAIISNMEQVCAKLSASASDYLRERVSDIRD
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  ISEQLLHITWPELKPRNKLVLEKPTILVAEDLTPSQFLSLDLKNLAGMILEKTGRTSHTL
Secondary structure 
SS confidence 
Disorder 
????????????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  ILARASAIPVLSGLPLDAIARYAGQPAVLDAQCGVLAINPNDAVSGYYQVAQTLADKRQK
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  QQAQAAAQLAYSRDNKRIDIAANIGTALEAPGAFANGAEGVGLFRTEMLYMDRDSAPDEQ
Secondary structure 
SS confidence 
Disorder 
?
????
?
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  EQFEAYQQVLLAAGDKPIIFRTMDIGGDKSIPYLNIPQEENPFLGYRAVRIYPEFAGLFR
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  TQLRAILRAASFGNAQLMIPMVHSLDQILWVKGEIQKAIVELKRDGLRHAETITLGIMVE
Secondary structure 
SS confidence 
Disorder 
?????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  VPSVCYIIDHFCDEVDFFSIGSNDMTQYLYAVDRNNPRVSPLYNPITPSFLRMLQQIVTT
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  AHQRGKWVGICGELGGESRYLPLLLGLGLDELSMSSPRIPAVKSQLRQLDSEACRELARQ
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........670.........680.........690.........700.........710.........720
Sequence  ACECRSAQEIEALLTAFTPEEDVRPLLALENIFVDQDFSNKEQAIQFLCGNLGVNGRTEH
Secondary structure 
SS confidence 
Disorder 
?
?
Disorder confidence 
 
   .........730.........740.........750.........760.........770.........780
Sequence  PFELEEDVWQREEIVTTGVGFGVAIPHTKSQWIRHSSISIARLAKPIGWQSEMGEVELVI
Secondary structure 
SS confidence 
Disorder 
?
?
???
Disorder confidence 
 
   .........790.........800.........810.........820.........830.
Sequence  MLTLGANEGMNHVKVFSQLARKLVNKNFRQSLFAAQDAQSILTLLETELTF
Secondary structure 
SS confidence 
Disorder 
?
????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2hwg chain A

3D model

Region: 117 - 682
Aligned: 564
Modelled: 552
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system

Phyre2

PDB 2hro chain A

3D model

Region: 117 - 679
Aligned: 545
Modelled: 560
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus

Phyre2

PDB 1h6z chain A

3D model

Region: 257 - 656
Aligned: 384
Modelled: 387
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei

Phyre2

PDB 2bg5 chain C

3D model

Region: 360 - 680
Aligned: 321
Modelled: 321
Confidence: 100.0%
Identity: 45%
PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)

Phyre2

PDB 1kbl chain A

3D model

Region: 262 - 648
Aligned: 371
Modelled: 374
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase

Phyre2

PDB 1vbh chain A

3D model

Region: 260 - 649
Aligned: 371
Modelled: 377
Confidence: 100.0%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize

Phyre2

PDB 2ols chain A

3D model

Region: 250 - 648
Aligned: 356
Modelled: 358
Confidence: 100.0%
Identity: 25%
PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis

Phyre2

PDB 1vbg chain A domain 1

3D model

Region: 374 - 650
Aligned: 276
Modelled: 277
Confidence: 100.0%
Identity: 29%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1h6z chain A domain 1

3D model

Region: 376 - 656
Aligned: 280
Modelled: 281
Confidence: 100.0%
Identity: 29%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1kbl chain A domain 1

3D model

Region: 376 - 648
Aligned: 272
Modelled: 273
Confidence: 100.0%
Identity: 28%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: Pyruvate phosphate dikinase, C-terminal domain

Phyre2

PDB 1eza chain A

3D model

Region: 116 - 368
Aligned: 252
Modelled: 253
Confidence: 100.0%
Identity: 27%
PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure

Phyre2

PDB 1zym chain A domain 2

3D model

Region: 252 - 358
Aligned: 107
Modelled: 107
Confidence: 99.9%
Identity: 31%
Fold: The "swivelling" beta/beta/alpha domain
Superfamily: Phosphohistidine domain
Family: N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system

Phyre2

PDB 1zym chain A domain 1

3D model

Region: 139 - 251
Aligned: 113
Modelled: 113
Confidence: 99.9%
Identity: 25%
Fold: SAM domain-like
Superfamily: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family: Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain

Phyre2

PDB 3qz6 chain A

3D model

Region: 384 - 658
Aligned: 209
Modelled: 239
Confidence: 99.9%
Identity: 16%
PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2

Phyre2

PDB 1dxe chain A

3D model

Region: 373 - 649
Aligned: 211
Modelled: 244
Confidence: 99.9%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Phosphoenolpyruvate/pyruvate domain
Family: HpcH/HpaI aldolase

Phyre2

PDB 2a0j chain A

3D model

Region: 686 - 826
Aligned: 140
Modelled: 141
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein;
PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis

Phyre2

PDB 3urr chain B

3D model

Region: 686 - 827
Aligned: 139
Modelled: 142
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn;
PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn)

Phyre2

PDB 3le1 chain B

3D model

Region: 1 - 87
Aligned: 85
Modelled: 85
Confidence: 99.8%
Identity: 31%
PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins;
PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis

Phyre2

PDB 1ka5 chain A

3D model

Region: 1 - 89
Aligned: 87
Modelled: 89
Confidence: 99.8%
Identity: 23%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1mo1 chain A

3D model

Region: 1 - 87
Aligned: 85
Modelled: 85
Confidence: 99.8%
Identity: 26%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1qr5 chain A

3D model

Region: 1 - 89
Aligned: 87
Modelled: 87
Confidence: 99.8%
Identity: 23%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 1a6j chain A

3D model

Region: 686 - 827
Aligned: 141
Modelled: 141
Confidence: 99.8%
Identity: 23%
Fold: Phoshotransferase/anion transport protein
Superfamily: Phoshotransferase/anion transport protein
Family: IIA domain of mannitol-specific and ntr phosphotransferase EII

Phyre2

PDB 2hpr chain A

3D model

Region: 5 - 89
Aligned: 83
Modelled: 83
Confidence: 99.8%
Identity: 24%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 3oxp chain B

3D model

Region: 686 - 827
Aligned: 138
Modelled: 137
Confidence: 99.8%
Identity: 26%
PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution

Phyre2

PDB 3oxp chain A

3D model

Region: 686 - 827
Aligned: 138
Modelled: 137
Confidence: 99.8%
Identity: 26%
PDB header:transferase
Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution

Phyre2

PDB 1ptf chain A

3D model

Region: 1 - 86
Aligned: 84
Modelled: 84
Confidence: 99.8%
Identity: 24%
Fold: HPr-like
Superfamily: HPr-like
Family: HPr-like

Phyre2

PDB 2oqt chain D

3D model

Region: 686 - 828
Aligned: 139
Modelled: 131
Confidence: 99.8%
Identity: 17%
PDB header:transferase
Chain: D: PDB Molecule:hypothetical protein spy0176;
PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas

Phyre2
1
c2hwgA_
2
c2hroA_
3
c1h6zA_
4
c2bg5C_
5
c1kblA_
6
c1vbhA_
7
c2olsA_
8
d1vbga1
9
d1h6za1
10
d1kbla1
11
c1ezaA_
12
d1zyma2
13
d1zyma1
14
c3qz6A_
15
d1dxea_
16
c2a0jA_
17
c3urrB_
18
c3le1B_
19
d1ka5a_
20
d1mo1a_
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d1qr5a_
22
d1a6ja_
23
d2hpra_
24
c3oxpB_
25
c3oxpA_
26
d1ptfa_
27
28
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c2oqtD_
33
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2hwgA_
100.0 37 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of phosphorylated enzyme i of the2 phosphoenolpyruvate:sugar phosphotransferase system
2c2hroA_
100.0 37 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase;
PDBTitle: structure of the full-lenght enzyme i of the pts system from2 staphylococcus carnosus
3c1h6zA_
100.0 26 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: 3.0 a resolution crystal structure of glycosomal pyruvate2 phosphate dikinase from trypanosoma brucei
4c2bg5C_
100.0 45 PDB header:transferase
Chain: C: PDB Molecule:phosphoenolpyruvate-protein kinase;
PDBTitle: crystal structure of the phosphoenolpyruvate-binding enzyme2 i-domain from the thermoanaerobacter tengcongensis pep:3 sugar phosphotransferase system (pts)
5c1kblA_
100.0 25 PDB header:transferase
Chain: A: PDB Molecule:pyruvate phosphate dikinase;
PDBTitle: pyruvate phosphate dikinase
6c1vbhA_
100.0 26 PDB header:transferase
Chain: A: PDB Molecule:pyruvate,orthophosphate dikinase;
PDBTitle: pyruvate phosphate dikinase with bound mg-pep from maize
7c2olsA_
100.0 25 PDB header:transferase
Chain: A: PDB Molecule:phosphoenolpyruvate synthase;
PDBTitle: the crystal structure of the phosphoenolpyruvate synthase from2 neisseria meningitidis
8d1vbga1
100.0 29 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
9d1h6za1
100.0 29 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
10d1kbla1
100.0 28 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate phosphate dikinase, C-terminal domain
11c1ezaA_
100.0 27 PDB header:phosphotransferase
Chain: A: PDB Molecule:enzyme i;
PDBTitle: amino terminal domain of enzyme i from escherichia coli nmr,2 restrained regularized mean structure
12d1zyma2
99.9 31 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:N-terminal domain of enzyme I of the PEP:sugar phosphotransferase system
13d1zyma1
99.9 25 Fold:SAM domain-like
Superfamily:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
Family:Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
14c3qz6A_
99.9 16 PDB header:lyase
Chain: A: PDB Molecule:hpch/hpai aldolase;
PDBTitle: the crystal structure of hpch/hpai aldolase from desulfitobacterium2 hafniense dcb-2
15d1dxea_
99.9 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
16c2a0jA_
99.9 27 PDB header:transferase
Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein;
PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis
17c3urrB_
99.9 27 PDB header:transferase
Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn;
PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn)
18c3le1B_
99.8 31 PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins;
PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis
19d1ka5a_
99.8 23 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
20d1mo1a_
99.8 26 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
21d1qr5a_
99.8 23 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
22d1a6ja_
99.8 23 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
23d2hpra_
99.8 24 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
24c3oxpB_
99.8 26 PDB header:transferase
Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution
25c3oxpA_
99.8 26 PDB header:transferase
Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component;
PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution
26d1ptfa_
99.8 24 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
27d1pcha_
not modelled 99.8 25 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
28c3ihsB_
not modelled 99.8 24 PDB header:transport protein
Chain: B: PDB Molecule:phosphocarrier protein hpr;
PDBTitle: crystal structure of a phosphocarrier protein hpr from2 bacillus anthracis str. ames
29d1izca_
not modelled 99.8 17 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
30c1izcA_
not modelled 99.8 17 PDB header:lyase
Chain: A: PDB Molecule:macrophomate synthase intermolecular diels-alderase;
PDBTitle: crystal structure analysis of macrophomate synthase
31d1cm3a_
not modelled 99.8 28 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
32c2oqtD_
99.8 17 PDB header:transferase
Chain: D: PDB Molecule:hypothetical protein spy0176;
PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas
33d2nzul1
not modelled 99.8 24 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
34d1h6za2
not modelled 99.8 32 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
35c2oq3A_
not modelled 99.8 17 PDB header:transferase
Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase
PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli
36d1zvvj1
not modelled 99.8 27 Fold:HPr-like
Superfamily:HPr-like
Family:HPr-like
37d1xiza_
not modelled 99.8 24 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
38c2v5jB_
not modelled 99.8 19 PDB header:lyase
Chain: B: PDB Molecule:2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase;
PDBTitle: apo class ii aldolase hpch
39c3bjvA_
not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:rmpa;
PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans
40d1a3aa_
not modelled 99.7 22 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:IIA domain of mannitol-specific and ntr phosphotransferase EII
41c2vwtA_
not modelled 99.7 20 PDB header:lyase
Chain: A: PDB Molecule:yfau, 2-keto-3-deoxy sugar aldolase;
PDBTitle: crystal structure of yfau, a metal ion dependent class ii2 aldolase from escherichia coli k12 - mg-pyruvate product3 complex
42d1vbga2
not modelled 99.7 24 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
43d1kbla2
not modelled 99.7 23 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:Phosphohistidine domain
Family:Pyruvate phosphate dikinase, central domain
44c3qqwC_
not modelled 99.3 13 PDB header:lyase
Chain: C: PDB Molecule:putative citrate lyase;
PDBTitle: crystal structure of a hypothetical lyase (reut_b4148) from ralstonia2 eutropha jmp134 at 2.44 a resolution
45c3t07D_
not modelled 99.3 19 PDB header:transferase/transferase inhibitor
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of s. aureus pyruvate kinase in complex with a2 naturally occurring bis-indole alkaloid
46c1sgjB_
not modelled 99.1 14 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase, beta subunit;
PDBTitle: crystal structure of citrate lyase beta subunit
47c2e28A_
not modelled 99.1 23 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure analysis of pyruvate kinase from bacillus2 stearothermophilus
48d1sgja_
not modelled 99.1 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
49d1e0ta2
not modelled 99.0 13 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
50c3r4iB_
not modelled 99.0 21 PDB header:lyase
Chain: B: PDB Molecule:citrate lyase;
PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution
51d2g50a2
not modelled 99.0 13 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
52d1a3xa2
not modelled 98.9 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
53d1pkla2
not modelled 98.8 19 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
54d1u5ha_
not modelled 98.8 15 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:HpcH/HpaI aldolase
55c1u5vA_
not modelled 98.8 15 PDB header:lyase
Chain: A: PDB Molecule:cite;
PDBTitle: structure of cite complexed with triphosphate group of atp2 form mycobacterium tuberculosis
56c3cuzA_
not modelled 98.7 16 PDB header:transferase
Chain: A: PDB Molecule:malate synthase a;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
57d1liua2
not modelled 98.7 14 Fold:TIM beta/alpha-barrel
Superfamily:Phosphoenolpyruvate/pyruvate domain
Family:Pyruvate kinase
58c3cuxA_
not modelled 98.3 16 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design
59c3pugA_
not modelled 97.6 16 PDB header:transferase
Chain: A: PDB Molecule:malate synthase;
PDBTitle: haloferax volcanii malate synthase native at 3mm glyoxylate
60d1d8ca_
not modelled 97.6 13 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
61c3e0vB_
not modelled 96.7 15 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions
62c1aqfB_
not modelled 96.6 9 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from rabbit muscle with mg, k, and l-2 phospholactate
63c1t5aB_
not modelled 96.6 9 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase, m2 isozyme;
PDBTitle: human pyruvate kinase m2
64c2vgbB_
not modelled 96.6 12 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase isozymes r/l;
PDBTitle: human erythrocyte pyruvate kinase
65c1pklB_
not modelled 96.5 12 PDB header:transferase
Chain: B: PDB Molecule:protein (pyruvate kinase);
PDBTitle: the structure of leishmania pyruvate kinase
66c3ma8A_
not modelled 96.5 12 PDB header:transferase
Chain: A: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of cgd1_2040, a pyruvate kinase from cryptosporidium2 parvum
67c3eoeC_
not modelled 96.4 15 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pyruvate kinase from toxoplasma gondii, 55.m00007
68c1e0tD_
not modelled 96.1 10 PDB header:phosphotransferase
Chain: D: PDB Molecule:pyruvate kinase;
PDBTitle: r292d mutant of e. coli pyruvate kinase
69c1a3wB_
not modelled 95.7 13 PDB header:transferase
Chain: B: PDB Molecule:pyruvate kinase;
PDBTitle: pyruvate kinase from saccharomyces cerevisiae complexed with fbp, pg,2 mn2+ and k+
70c3khdC_
not modelled 94.6 16 PDB header:transferase
Chain: C: PDB Molecule:pyruvate kinase;
PDBTitle: crystal structure of pff1300w.
71d1eepa_
not modelled 94.6 17 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
72c2a7rD_
not modelled 93.6 22 PDB header:oxidoreductase
Chain: D: PDB Molecule:gmp reductase 2;
PDBTitle: crystal structure of human guanosine monophosphate2 reductase 2 (gmpr2)
73c2zbtB_
not modelled 93.4 18 PDB header:lyase
Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: crystal structure of pyridoxine biosynthesis protein from thermus2 thermophilus hb8
74c3femB_
not modelled 92.9 16 PDB header:biosynthetic protein, transferase
Chain: B: PDB Molecule:pyridoxine biosynthesis protein snz1;
PDBTitle: structure of the synthase subunit pdx1.1 (snz1) of plp synthase from2 saccharomyces cerevisiae
75c2nv2U_
not modelled 92.9 17 PDB header:lyase/transferase
Chain: U: PDB Molecule:pyridoxal biosynthesis lyase pdxs;
PDBTitle: structure of the plp synthase complex pdx1/2 (yaad/e) from bacillus2 subtilis
76d1vrda1
not modelled 92.4 20 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
77d1jr1a1
not modelled 91.9 18 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
78c1jcnA_
not modelled 91.8 21 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine monophosphate dehydrogenase i;
PDBTitle: binary complex of human type-i inosine monophosphate dehydrogenase2 with 6-cl-imp
79d1n8ia_
not modelled 91.4 12 Fold:TIM beta/alpha-barrel
Superfamily:Malate synthase G
Family:Malate synthase G
80c1vrdA_
not modelled 91.2 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine-5'-monophosphate dehydrogenase (tm1347)2 from thermotoga maritima at 2.18 a resolution
81c3r2gA_
not modelled 90.1 22 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine 5'-monophosphate dehydrogenase;
PDBTitle: crystal structure of inosine 5' monophosphate dehydrogenase from2 legionella pneumophila
82d2hi6a1
not modelled 89.1 25 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:AF0055-like
83d1tb3a1
not modelled 88.8 23 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
84d1pvna1
not modelled 88.7 16 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
85d1hl2a_
not modelled 88.7 19 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
86d1jcna1
not modelled 88.5 20 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
87c3dz1A_
not modelled 88.3 15 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 1.87a resolution
88c3khjE_
not modelled 88.2 21 PDB header:oxidoreductase
Chain: E: PDB Molecule:inosine-5-monophosphate dehydrogenase;
PDBTitle: c. parvum inosine monophosphate dehydrogenase bound by inhibitor c64
89d1zfja1
not modelled 87.9 17 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
90c3lciA_
not modelled 87.5 16 PDB header:lyase
Chain: A: PDB Molecule:n-acetylneuraminate lyase;
PDBTitle: the d-sialic acid aldolase mutant v251w
91c2v9dB_
not modelled 87.2 15 PDB header:lyase
Chain: B: PDB Molecule:yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to2 the dihydrodipicolinic acid synthase family from e. coli3 k12
92c3cprB_
not modelled 86.4 20 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthetase;
PDBTitle: the crystal structure of corynebacterium glutamicum2 dihydrodipicolinate synthase to 2.2 a resolution
93c2vc6A_
not modelled 86.2 21 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: structure of mosa from s. meliloti with pyruvate bound
94c3lerA_
not modelled 85.6 20 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168
95d1o5ka_
not modelled 85.4 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
96c2zrvC_
not modelled 84.8 24 PDB header:isomerase
Chain: C: PDB Molecule:isopentenyl-diphosphate delta-isomerase;
PDBTitle: crystal structure of sulfolobus shibatae isopentenyl2 diphosphate isomerase in complex with reduced fmn.
97c3pueA_
not modelled 83.0 29 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of the complex of dhydrodipicolinate synthase from2 acinetobacter baumannii with lysine at 2.6a resolution
98d2cu0a1
not modelled 82.0 21 Fold:TIM beta/alpha-barrel
Superfamily:Inosine monophosphate dehydrogenase (IMPDH)
Family:Inosine monophosphate dehydrogenase (IMPDH)
99c2ehhE_
not modelled 80.6 22 PDB header:lyase
Chain: E: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from2 aquifex aeolicus
100c3s5oA_
not modelled 78.8 20 PDB header:lyase
Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase, mitochondrial;
PDBTitle: crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to2 pyruvate
101c2rduA_
not modelled 78.6 24 PDB header:oxidoreductase
Chain: A: PDB Molecule:hydroxyacid oxidase 1;
PDBTitle: crystal structure of human glycolate oxidase in complex with2 glyoxylate
102c3na8A_
not modelled 78.3 19 PDB header:lyase
Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase;
PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa
103c3daqB_
not modelled 77.9 15 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus
104c2e77B_
not modelled 77.6 27 PDB header:oxidoreductase
Chain: B: PDB Molecule:lactate oxidase;
PDBTitle: crystal structure of l-lactate oxidase with pyruvate complex
105d1xxxa1
not modelled 77.5 20 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
106c1me9A_
not modelled 76.3 18 PDB header:oxidoreductase
Chain: A: PDB Molecule:inosine-5'-monophosphate dehydrogenase;
PDBTitle: inosine monophosphate dehydrogenase (impdh) from2 tritrichomonas foetus with imp bound
107c3qjaA_
not modelled 76.1 12 PDB header:lyase
Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form
108c3noeA_
not modelled 75.9 19 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from pseudomonas2 aeruginosa
109d1goxa_
not modelled 75.8 29 Fold:TIM beta/alpha-barrel
Superfamily:FMN-linked oxidoreductases
Family:FMN-linked oxidoreductases
110c3pm6B_
not modelled 73.9 20 PDB header:lyase
Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase;
PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr
111d1f74a_
not modelled 73.5 14 Fold:TIM beta/alpha-barrel
Superfamily:Aldolase
Family:Class I aldolase
112c3n2xB_
not modelled 73.5 17 PDB header:lyase
Chain: B: PDB Molecule:uncharacterized protein yage;
PDBTitle: crystal structure of yage, a prophage protein belonging to the2 dihydrodipicolinic acid synthase family from e. coli k12 in complex3 with pyruvate
113c1hynQ_
not modelled 71.8 15 PDB header:membrane protein
Chain: Q: PDB Molecule:band 3 anion transport protein;
PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein
114d2gp4a1
not modelled 71.8 16 Fold:The "swivelling" beta/beta/alpha domain
Superfamily:LeuD/IlvD-like
Family:IlvD/EDD C-terminal domain-like
115c3b4uB_
not modelled 71.6 20 PDB header:lyase
Chain: B: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from agrobacterium2 tumefaciens str. c58
116c3bi8A_
not modelled 71.5 22 PDB header:lyase
Chain: A: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: structure of dihydrodipicolinate synthase from clostridium2 botulinum
117d1hynp_
not modelled 71.2 15 Fold:Phoshotransferase/anion transport protein
Superfamily:Phoshotransferase/anion transport protein
Family:Anion transport protein, cytoplasmic domain
118c3fluD_
not modelled 71.1 17 PDB header:lyase
Chain: D: PDB Molecule:dihydrodipicolinate synthase;
PDBTitle: crystal structure of dihydrodipicolinate synthase from the pathogen2 neisseria meningitidis
119c3fkkA_
not modelled 71.0 18 PDB header:lyase
Chain: A: PDB Molecule:l-2-keto-3-deoxyarabonate dehydratase;
PDBTitle: structure of l-2-keto-3-deoxyarabonate dehydratase
120c1ypfB_
not modelled 70.4 17 PDB header:oxidoreductase
Chain: B: PDB Molecule:gmp reductase;
PDBTitle: crystal structure of guac (ba5705) from bacillus anthracis at 1.8 a2 resolution

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0