Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	Q	R	R	P	V	R	R	A	L	L	S	V	S	D	K	A	G	I	V	E	F	A	Q	A	L	S	A	R	G	V	E	L	L	S	T	G	G	T	A	R	L	L	A	E	K	G	L	P	V	T	E	V	S	D	Y	T	G	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	E	M	M	D	G	R	V	K	T	L	H	P	K	V	H	G	G	I	L	G	R	R	G	Q	D	D	A	I	M	E	E	H	Q	I	Q	P	I	D	M	V	V	V	N	L	Y	P	F	A	Q	T	V	A	R	E	G	C	S	L	E
Secondary structure
SS confidence
Disorder																						?	?		?	?	?							?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	A	V	E	N	I	D	I	G	G	P	T	M	V	R	S	A	A	K	N	H	K	D	V	A	I	V	V	K	S	S	D	Y	D	A	I	I	K	E	M	D	D	N	E	G	S	L	T	L	A	T	R	F	D	L	A	I	K	A	F
Secondary structure
SS confidence
Disorder																																														?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	H	T	A	A	Y	D	S	M	I	A	N	Y	F	G	S	M	V	P	A	Y	H	G	E	S	K	E	A	A	G	R	F	P	R	T	L	N	L	N	F	I	K	K	L	D	M	R	Y	G	E	N	S	H	Q	Q	A	A	F	Y	I
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?										?			?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	E	N	V	K	E	A	S	V	A	T	A	T	Q	V	Q	G	K	A	L	S	Y	N	N	I	A	D	T	D	A	A	L	E	C	V	K	E	F	A	E	P	A	C	V	I	V	K	H	A	N	P	C	G	V	A	I	G	N	S	I
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	D	A	Y	D	R	A	Y	K	T	D	P	T	S	A	F	G	G	I	I	A	F	N	R	E	L	D	A	E	T	A	Q	A	I	I	S	R	Q	F	V	E	V	I	I	A	P	S	A	S	E	E	A	L	K	I	T	A	A	K	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	V	R	V	L	T	C	G	Q	W	G	E	R	V	P	G	L	D	F	K	R	V	N	G	G	L	L	V	Q	D	R	D	L	G	M	V	G	A	E	E	L	R	V	V	T	K	R	Q	P	S	E	Q	E	L	R	D	A	L	F	C
Secondary structure
SS confidence
Disorder										?	?	?	?																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		W	K	V	A	K	F	V	K	S	N	A	I	V	Y	A	K	N	N	M	T	I	G	I	G	A	G	Q	M	S	R	V	Y	S	A	K	I	A	G	I	K	A	A	D	E	G	L	E	V	K	G	S	S	M	A	S	D	A	F	F	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.
Sequence		F	R	D	G	I	D	A	A	A	A	A	G	V	T	C	V	I	Q	P	G	G	S	I	R	D	D	E	V	I	A	A	A	D	E	H	G	I	A	M	L	F	T	D	M	R	H	F	R	H
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 4a1o chain B Region: 4 - 529 Aligned: 511 Modelled: 526 Confidence: 100.0% Identity: 46% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 1thz chain A Region: 6 - 529 Aligned: 498 Modelled: 505 Confidence: 100.0% Identity: 42% PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Phyre2 PDB 1zcz chain A Region: 7 - 529 Aligned: 452 Modelled: 452 Confidence: 100.0% Identity: 40% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 1g8m chain A domain 2 Region: 220 - 529 Aligned: 304 Modelled: 310 Confidence: 100.0% Identity: 37% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1pkx chain A domain 2 Region: 222 - 529 Aligned: 302 Modelled: 308 Confidence: 100.0% Identity: 42% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1zcz chain A domain 2 Region: 216 - 529 Aligned: 294 Modelled: 310 Confidence: 100.0% Identity: 42% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1pkx chain A domain 1 Region: 6 - 201 Aligned: 195 Modelled: 196 Confidence: 100.0% Identity: 51% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 1g8m chain A domain 1 Region: 6 - 200 Aligned: 194 Modelled: 195 Confidence: 100.0% Identity: 48% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 1zcz chain A domain 1 Region: 7 - 196 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 39% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Inosicase Phyre2 PDB 1a9x chain A domain 2 Region: 3 - 144 Aligned: 122 Modelled: 124 Confidence: 99.4% Identity: 25% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain Phyre2 PDB 2yvq chain A Region: 3 - 161 Aligned: 117 Modelled: 124 Confidence: 99.3% Identity: 22% PDB header:ligase Chain: A: PDB Molecule:carbamoyl-phosphate synthase; PDBTitle: crystal structure of mgs domain of carbamoyl-phosphate2 synthetase from homo sapiens Phyre2 PDB 1wo8 chain A domain 1 Region: 15 - 163 Aligned: 110 Modelled: 125 Confidence: 98.3% Identity: 23% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Methylglyoxal synthase, MgsA Phyre2 PDB 1m6v chain E Region: 9 - 65 Aligned: 57 Modelled: 57 Confidence: 98.0% Identity: 44% PDB header:ligase Chain: E: PDB Molecule:carbamoyl phosphate synthetase large chain; PDBTitle: crystal structure of the g359f (small subunit) point mutant of2 carbamoyl phosphate synthetase Phyre2 PDB 1vmd chain A Region: 1 - 158 Aligned: 117 Modelled: 129 Confidence: 96.9% Identity: 26% Fold: Methylglyoxal synthase-like Superfamily: Methylglyoxal synthase-like Family: Methylglyoxal synthase, MgsA Phyre2 PDB 2pju chain D Region: 12 - 54 Aligned: 43 Modelled: 43 Confidence: 89.7% Identity: 12% PDB header:transcription Chain: D: PDB Molecule:propionate catabolism operon regulatory protein; PDBTitle: crystal structure of propionate catabolism operon2 regulatory protein prpr Phyre2 PDB 3ff4 chain A Region: 482 - 520 Aligned: 37 Modelled: 39 Confidence: 89.1% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein chu_1412 Phyre2 PDB 1iuk chain A Region: 482 - 520 Aligned: 37 Modelled: 39 Confidence: 88.0% Identity: 35% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 2d59 chain A domain 1 Region: 482 - 520 Aligned: 37 Modelled: 39 Confidence: 85.4% Identity: 22% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: CoA-binding domain Phyre2 PDB 2pju chain A domain 1 Region: 12 - 55 Aligned: 44 Modelled: 44 Confidence: 85.1% Identity: 11% Fold: Chelatase-like Superfamily: PrpR receptor domain-like Family: PrpR receptor domain-like Phyre2 PDB 2q5c chain A Region: 12 - 54 Aligned: 43 Modelled: 43 Confidence: 82.6% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:ntrc family transcriptional regulator; PDBTitle: crystal structure of ntrc family transcriptional regulator from2 clostridium acetobutylicum Phyre2 1 c4a1oB_ 2 c1thzA_ 3 c1zczA_ 4 d1g8ma2 5 d1pkxa2 6 d1zcza2 7 d1pkxa1 8 d1g8ma1 9 d1zcza1 10 d1a9xa2 11 c2yvqA_ 12 d1wo8a1 13 c1m6vE_ 14 d1vmda_ 15 c2pjuD_ 16 c3ff4A_ 17 d1iuka_ 18 d2d59a1 19 d2pjua1 20 c2q5cA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156