Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	H	L	T	E	M	V	R	Q	H	K	A	G	K	T	N	G	I	Y	A	V	C	S	A	H	P	L	V	L	E	A	A	I	R	Y	A	S	A	N	Q	T	P	L	L	I	E	A	T	S	N	Q	V	D	Q	F	G	G	Y	T
Secondary structure
SS confidence
Disorder		?	?										?																																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	M	T	P	A	D	F	R	G	F	V	C	Q	L	A	D	S	L	N	F	P	Q	D	A	L	I	L	G	G	D	H	L	G	P	N	R	W	Q	N	L	P	A	A	Q	A	M	A	N	A	D	D	L	I	K	S	Y	V	A	A	G
Secondary structure
SS confidence
Disorder																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	K	K	I	H	L	D	C	S	M	S	C	Q	D	D	P	I	P	L	T	D	D	I	V	A	E	R	A	A	R	L	A	K	V	A	E	E	T	C	L	E	H	F	G	E	A	D	L	E	Y	V	I	G	T	E	V	P	V	P	G
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?																					?	?	?	?	?	?		?									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	A	H	E	T	L	S	E	L	A	V	T	T	P	D	A	A	R	A	T	L	E	A	H	R	H	A	F	E	K	Q	G	L	N	A	I	W	P	R	I	I	A	L	V	V	Q	P	G	V	E	F	D	H	T	N	V	I	D	Y	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	A	K	A	S	A	L	S	Q	M	V	E	N	Y	E	T	L	I	F	E	A	H	S	T	D	Y	Q	T	P	Q	S	L	R	Q	L	V	I	D	H	F	A	I	L	K	V	G	P	A	L	T	F	A	L	R	E	A	L	F	S	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	A	I	E	E	E	L	V	P	A	K	A	C	S	G	L	R	Q	V	L	E	D	V	M	L	D	R	P	E	Y	W	Q	S	H	Y	H	G	D	G	N	A	R	R	L	A	R	G	Y	S	Y	S	D	R	V	R	Y	Y	W	P	D
Secondary structure
SS confidence
Disorder																											?										?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	Q	I	D	D	A	F	A	H	L	V	R	N	L	A	D	S	P	I	P	L	P	L	I	S	Q	Y	L	P	L	Q	Y	V	K	V	R	S	G	E	L	Q	P	T	P	R	E	L	I	I	N	H	I	Q	D	I	L	A	Q	Y	H
Secondary structure
SS confidence
Disorder																				?																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		T	A	C	E	G	Q
Secondary structure
SS confidence
Disorder				?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2fiq chain A domain 1 Region: 5 - 424 Aligned: 408 Modelled: 420 Confidence: 100.0% Identity: 53% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: GatZ-like Phyre2 PDB 3q94 chain B Region: 3 - 340 Aligned: 267 Modelled: 293 Confidence: 99.9% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase, class ii; PDBTitle: the crystal structure of fructose 1,6-bisphosphate aldolase from2 bacillus anthracis str. 'ames ancestor' Phyre2 PDB 1rvg chain A Region: 3 - 335 Aligned: 262 Modelled: 287 Confidence: 99.8% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class II FBP aldolase Phyre2 PDB 1dos chain A Region: 1 - 300 Aligned: 261 Modelled: 282 Confidence: 99.8% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class II FBP aldolase Phyre2 PDB 1gvf chain A Region: 3 - 336 Aligned: 259 Modelled: 288 Confidence: 99.8% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class II FBP aldolase Phyre2 PDB 3qm3 chain C Region: 4 - 300 Aligned: 258 Modelled: 266 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: 1.85 angstrom resolution crystal structure of fructose-bisphosphate2 aldolase (fba) from campylobacter jejuni Phyre2 PDB 3c52 chain B Region: 3 - 336 Aligned: 258 Modelled: 279 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor Phyre2 PDB 3pm6 chain B Region: 5 - 341 Aligned: 247 Modelled: 269 Confidence: 99.8% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase; PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr Phyre2 PDB 3elf chain A Region: 6 - 300 Aligned: 246 Modelled: 264 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: structural characterization of tetrameric mycobacterium tuberculosis2 fructose 1,6-bisphosphate aldolase - substrate binding and catalysis3 mechanism of a class iia bacterial aldolase Phyre2 PDB 2isw chain B Region: 3 - 357 Aligned: 266 Modelled: 295 Confidence: 99.8% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:putative fructose-1,6-bisphosphate aldolase; PDBTitle: structure of giardia fructose-1,6-biphosphate aldolase in2 complex with phosphoglycolohydroxamate Phyre2 PDB 1f6y chain A Region: 1 - 136 Aligned: 111 Modelled: 136 Confidence: 95.8% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Methyltetrahydrofolate-utiluzing methyltransferases Phyre2 PDB 3bol chain B Region: 4 - 153 Aligned: 124 Modelled: 150 Confidence: 94.8% Identity: 10% PDB header:transferase Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+ Phyre2 PDB 3bof chain A domain 1 Region: 1 - 136 Aligned: 110 Modelled: 123 Confidence: 93.6% Identity: 12% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Methyltetrahydrofolate-utiluzing methyltransferases Phyre2 PDB 1rr2 chain A Region: 1 - 221 Aligned: 176 Modelled: 188 Confidence: 93.2% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid Phyre2 PDB 3k13 chain A Region: 20 - 128 Aligned: 90 Modelled: 107 Confidence: 92.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase; PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron Phyre2 PDB 2yci chain X Region: 1 - 136 Aligned: 111 Modelled: 123 Confidence: 91.6% Identity: 14% PDB header:transferase Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein PDBTitle: methyltransferase native Phyre2 PDB 2h9a chain A Region: 20 - 129 Aligned: 76 Modelled: 93 Confidence: 91.6% Identity: 33% PDB header:oxidoreductase Chain: A: PDB Molecule:carbon monoxide dehydrogenase corrinoid/iron- PDBTitle: corrinoid iron-sulfur protein Phyre2 PDB 2nx9 chain B Region: 1 - 220 Aligned: 176 Modelled: 187 Confidence: 91.3% Identity: 13% PDB header:lyase Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha; PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae Phyre2 PDB 3cqk chain B Region: 16 - 174 Aligned: 157 Modelled: 159 Confidence: 87.7% Identity: 11% PDB header:isomerase Chain: B: PDB Molecule:l-ribulose-5-phosphate 3-epimerase ulae; PDBTitle: crystal structure of l-xylulose-5-phosphate 3-epimerase ulae (form b)2 complex with zn2+ and sulfate Phyre2 PDB 3k2g chain A Region: 13 - 153 Aligned: 115 Modelled: 128 Confidence: 86.7% Identity: 21% PDB header:resiniferatoxin binding protein Chain: A: PDB Molecule:resiniferatoxin-binding, phosphotriesterase- PDBTitle: crystal structure of a resiniferatoxin-binding protein from2 rhodobacter sphaeroides Phyre2 1 d2fiqa1 2 c3q94B_ 3 d1rvga_ 4 d1dosa_ 5 d1gvfa_ 6 c3qm3C_ 7 c3c52B_ 8 c3pm6B_ 9 c3elfA_ 10 c2iswB_ 11 d1f6ya_ 12 c3bolB_ 13 d3bofa1 14 c1rr2A_ 15 c3k13A_ 16 c2yciX_ 17 c2h9aA_ 18 c2nx9B_ 19 c3cqkB_ 20 c3k2gA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2fiqa1 100.0 53 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:GatZ-like 2 c3q94B_ 99.9 15 PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase, class ii; PDBTitle: the crystal structure of fructose 1,6-bisphosphate aldolase from2 bacillus anthracis str. 'ames ancestor' 3 d1rvga_ 99.8 21 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 4 d1dosa_ 99.8 15 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 5 d1gvfa_ 99.8 17 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 6 c3qm3C_ 99.8 18 PDB header:lyase Chain: C: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: 1.85 angstrom resolution crystal structure of fructose-bisphosphate2 aldolase (fba) from campylobacter jejuni 7 c3c52B_ 99.8 18 PDB header:lyase Chain: B: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: class ii fructose-1,6-bisphosphate aldolase from2 helicobacter pylori in complex with3 phosphoglycolohydroxamic acid, a competitive inhibitor 8 c3pm6B_ 99.8 20 PDB header:lyase Chain: B: PDB Molecule:putative fructose-bisphosphate aldolase; PDBTitle: crystal structure of a putative fructose-1,6-biphosphate aldolase from2 coccidioides immitis solved by combined sad mr 9 c3elfA_ 99.8 18 PDB header:lyase Chain: A: PDB Molecule:fructose-bisphosphate aldolase; PDBTitle: structural characterization of tetrameric mycobacterium tuberculosis2 fructose 1,6-bisphosphate aldolase - substrate binding and catalysis3 mechanism of a class iia bacterial aldolase 10 c2iswB_ 99.8 17 PDB header:lyase Chain: B: PDB Molecule:putative fructose-1,6-bisphosphate aldolase; PDBTitle: structure of giardia fructose-1,6-biphosphate aldolase in2 complex with phosphoglycolohydroxamate 11 d1f6ya_ 95.8 15 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Methyltetrahydrofolate-utiluzing methyltransferases 12 c3bolB_ 94.8 10 PDB header:transferase Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+ 13 d3bofa1 93.6 12 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Methyltetrahydrofolate-utiluzing methyltransferases 14 c1rr2A_ 93.2 10 PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid 15 c3k13A_ 92.0 19 PDB header:transferase Chain: A: PDB Molecule:5-methyltetrahydrofolate-homocysteine methyltransferase; PDBTitle: structure of the pterin-binding domain metr of 5-2 methyltetrahydrofolate-homocysteine methyltransferase from3 bacteroides thetaiotaomicron 16 c2yciX_ 91.6 14 PDB header:transferase Chain: X: PDB Molecule:5-methyltetrahydrofolate corrinoid/iron sulfur protein PDBTitle: methyltransferase native 17 c2h9aA_ 91.6 33 PDB header:oxidoreductase Chain: A: PDB Molecule:carbon monoxide dehydrogenase corrinoid/iron- PDBTitle: corrinoid iron-sulfur protein 18 c2nx9B_ 91.3 13 PDB header:lyase Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha; PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae 19 c3cqkB_ 87.7 11 PDB header:isomerase Chain: B: PDB Molecule:l-ribulose-5-phosphate 3-epimerase ulae; PDBTitle: crystal structure of l-xylulose-5-phosphate 3-epimerase ulae (form b)2 complex with zn2+ and sulfate 20 c3k2gA_ 86.7 21 PDB header:resiniferatoxin binding protein Chain: A: PDB Molecule:resiniferatoxin-binding, phosphotriesterase- PDBTitle: crystal structure of a resiniferatoxin-binding protein from2 rhodobacter sphaeroides 21 c2vp8A_ not modelled 86.5 17 PDB header:transferase Chain: A: PDB Molecule:dihydropteroate synthase 2; PDBTitle: structure of mycobacterium tuberculosis rv1207 22 c2dzaA_ not modelled 85.8 18 PDB header:transferase Chain: A: PDB Molecule:dihydropteroate synthase; PDBTitle: crystal structure of dihydropteroate synthase from thermus2 thermophilus hb8 in complex with 4-aminobenzoate 23 c3lhlA_ not modelled 85.1 14 PDB header:hydrolase Chain: A: PDB Molecule:putative agmatinase; PDBTitle: crystal structure of a putative agmatinase from clostridium difficile 24 c2ze3A_ not modelled 83.6 15 PDB header:isomerase Chain: A: PDB Molecule:dfa0005; PDBTitle: crystal structure of dfa0005 complexed with alpha-ketoglutarate: a2 novel member of the icl/pepm superfamily from alkali-tolerant3 deinococcus ficus 25 d1eyea_ not modelled 82.4 17 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Dihydropteroate synthetase 26 d1muma_ not modelled 81.4 15 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 27 d1ad1a_ not modelled 81.3 18 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Dihydropteroate synthetase 28 c2uvaI_ not modelled 79.4 25 PDB header:transferase Chain: I: PDB Molecule:fatty acid synthase beta subunits; PDBTitle: crystal structure of fatty acid synthase from thermomyces2 lanuginosus at 3.1 angstrom resolution. this file contains3 the beta subunits of the fatty acid synthase. the entire4 crystal structure consists of one heterododecameric fatty5 acid synthase and is described in remark 400 29 d2a0ma1 not modelled 79.0 20 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 30 d1xfka_ not modelled 77.8 20 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 31 c3o1lB_ not modelled 77.3 14 PDB header:hydrolase Chain: B: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pspto_4314)2 from pseudomonas syringae pv. tomato str. dc3000 at 2.20 a resolution 32 d2ceva_ not modelled 77.1 24 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 33 c2vkzH_ not modelled 76.9 20 PDB header:transferase Chain: H: PDB Molecule:fatty acid synthase subunit beta; PDBTitle: structure of the cerulenin-inhibited fungal fatty acid2 synthase type i multienzyme complex 34 d1gq6a_ not modelled 76.4 18 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 35 c3nioF_ not modelled 76.3 20 PDB header:hydrolase Chain: F: PDB Molecule:guanidinobutyrase; PDBTitle: crystal structure of pseudomonas aeruginosa guanidinobutyrase 36 c3nrbD_ not modelled 76.0 16 PDB header:hydrolase Chain: D: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (puru,2 pp_1943) from pseudomonas putida kt2440 at 2.05 a resolution 37 d1vhna_ not modelled 75.8 21 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 38 d1t4ba1 not modelled 74.2 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 39 d1pq3a_ not modelled 73.0 17 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 40 c2y5sA_ not modelled 70.3 17 PDB header:transferase Chain: A: PDB Molecule:dihydropteroate synthase; PDBTitle: crystal structure of burkholderia cenocepacia dihydropteroate2 synthase complexed with 7,8-dihydropteroate. 41 d1ajza_ not modelled 69.8 19 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Dihydropteroate synthetase 42 d1tx2a_ not modelled 67.6 19 Fold:TIM beta/alpha-barrel Superfamily:Dihydropteroate synthetase-like Family:Dihydropteroate synthetase 43 c1tx2A_ not modelled 67.6 19 PDB header:transferase Chain: A: PDB Molecule:dhps, dihydropteroate synthase; PDBTitle: dihydropteroate synthetase, with bound inhibitor manic, from bacillus2 anthracis 44 c2hjpA_ not modelled 66.9 16 PDB header:hydrolase Chain: A: PDB Molecule:phosphonopyruvate hydrolase; PDBTitle: crystal structure of phosphonopyruvate hydrolase complex with2 phosphonopyruvate and mg++ 45 c3obiC_ not modelled 66.0 18 PDB header:hydrolase Chain: C: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (np_949368)2 from rhodopseudomonas palustris cga009 at 1.95 a resolution 46 c2qiwA_ not modelled 66.0 17 PDB header:transferase Chain: A: PDB Molecule:pep phosphonomutase; PDBTitle: crystal structure of a putative phosphoenolpyruvate phosphonomutase2 (ncgl1015, cgl1060) from corynebacterium glutamicum atcc 13032 at3 1.80 a resolution 47 c3nipB_ not modelled 65.5 18 PDB header:hydrolase Chain: B: PDB Molecule:3-guanidinopropionase; PDBTitle: crystal structure of pseudomonas aeruginosa guanidinopropionase2 complexed with 1,6-diaminohexane 48 d1woha_ not modelled 64.6 20 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 49 c3mmrA_ not modelled 62.8 23 PDB header:hydrolase Chain: A: PDB Molecule:arginase; PDBTitle: structure of plasmodium falciparum arginase in complex with abh 50 c3louB_ not modelled 62.4 19 PDB header:hydrolase Chain: B: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of formyltetrahydrofolate deformylase (yp_105254.1)2 from burkholderia mallei atcc 23344 at 1.90 a resolution 51 c3n0vD_ not modelled 62.2 21 PDB header:hydrolase Chain: D: PDB Molecule:formyltetrahydrofolate deformylase; PDBTitle: crystal structure of a formyltetrahydrofolate deformylase (pp_0327)2 from pseudomonas putida kt2440 at 2.25 a resolution 52 d1aw1a_ not modelled 61.2 14 Fold:TIM beta/alpha-barrel Superfamily:Triosephosphate isomerase (TIM) Family:Triosephosphate isomerase (TIM) 53 c1vraB_ not modelled 58.4 16 PDB header:transferase Chain: B: PDB Molecule:arginine biosynthesis bifunctional protein argj; PDBTitle: crystal structure of arginine biosynthesis bifunctional protein argj2 (10175521) from bacillus halodurans at 2.00 a resolution 54 c1ydnA_ not modelled 58.3 12 PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of the hmg-coa lyase from brucella melitensis,2 northeast structural genomics target lr35. 55 c3it4B_ not modelled 58.1 22 PDB header:transferase Chain: B: PDB Molecule:arginine biosynthesis bifunctional protein argj PDBTitle: the crystal structure of ornithine acetyltransferase from2 mycobacterium tuberculosis (rv1653) at 1.7 a 56 d2ihta3 not modelled 56.6 31 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:Pyruvate oxidase and decarboxylase PP module 57 c3r4iB_ not modelled 56.3 4 PDB header:lyase Chain: B: PDB Molecule:citrate lyase; PDBTitle: crystal structure of a citrate lyase (bxe_b2899) from burkholderia2 xenovorans lb400 at 2.24 a resolution 58 c3lerA_ not modelled 55.1 17 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 campylobacter jejuni subsp. jejuni nctc 11168 59 c1cqxB_ not modelled 55.0 19 PDB header:lipid binding protein Chain: B: PDB Molecule:flavohemoprotein; PDBTitle: crystal structure of the flavohemoglobin from alcaligenes eutrophus at2 1.75 a resolution 60 d1pqua1 not modelled 54.7 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 61 d2aeba1 not modelled 52.4 22 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 62 c3pzlA_ not modelled 51.9 13 PDB header:hydrolase Chain: A: PDB Molecule:agmatine ureohydrolase; PDBTitle: the crystal structure of agmatine ureohydrolase of thermoplasma2 volcanium 63 c3d0kA_ not modelled 50.9 18 PDB header:hydrolase Chain: A: PDB Molecule:putative poly(3-hydroxybutyrate) depolymerase lpqc; PDBTitle: crystal structure of the lpqc, poly(3-hydroxybutyrate) depolymerase2 from bordetella parapertussis 64 d1mb4a1 not modelled 49.7 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 65 c3dxiB_ not modelled 48.8 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative aldolase; PDBTitle: crystal structure of the n-terminal domain of a putative2 aldolase (bvu_2661) from bacteroides vulgatus 66 d1yl7a1 not modelled 48.5 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 67 c3m1rF_ not modelled 48.3 23 PDB header:hydrolase Chain: F: PDB Molecule:formimidoylglutamase; PDBTitle: the crystal structure of formimidoylglutamase from bacillus2 subtilis subsp. subtilis str. 168 68 d1ujqa_ not modelled 48.2 15 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 69 d1d3va_ not modelled 48.1 20 Fold:Arginase/deacetylase Superfamily:Arginase/deacetylase Family:Arginase-like amidino hydrolases 70 c3fdgA_ not modelled 45.6 14 PDB header:hydrolase Chain: A: PDB Molecule:dipeptidase ac. metallo peptidase. merops family m19; PDBTitle: the crystal structure of the dipeptidase ac, metallo peptidase. merops2 family m19 71 c3ez4B_ not modelled 44.6 16 PDB header:transferase Chain: B: PDB Molecule:3-methyl-2-oxobutanoate hydroxymethyltransferase; PDBTitle: crystal structure of 3-methyl-2-oxobutanoate2 hydroxymethyltransferase from burkholderia pseudomallei 72 d1f16a_ not modelled 43.7 15 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 73 d1m6ja_ not modelled 43.0 19 Fold:TIM beta/alpha-barrel Superfamily:Triosephosphate isomerase (TIM) Family:Triosephosphate isomerase (TIM) 74 c3ai9X_ not modelled 40.7 17 PDB header:transferase Chain: X: PDB Molecule:upf0217 protein mj1640; PDBTitle: crystal structure of duf358 protein reveals a putative spout-class2 rrna methyltransferase 75 c3gvgA_ not modelled 40.3 14 PDB header:isomerase Chain: A: PDB Molecule:triosephosphate isomerase; PDBTitle: crystal structure of triosephosphate isomerase from mycobacterium2 tuberculosis 76 c2vzkD_ not modelled 40.1 18 PDB header:transferase Chain: D: PDB Molecule:glutamate n-acetyltransferase 2 beta chain; PDBTitle: structure of the acyl-enzyme complex of an n-terminal2 nucleophile (ntn) hydrolase, oat2 77 c3b8iF_ not modelled 39.9 18 PDB header:lyase Chain: F: PDB Molecule:pa4872 oxaloacetate decarboxylase; PDBTitle: crystal structure of oxaloacetate decarboxylase from pseudomonas2 aeruginosa (pa4872) in complex with oxalate and mg2+. 78 c3bleA_ not modelled 39.5 15 PDB header:transferase Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans; PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate 79 c2h31A_ not modelled 38.5 17 PDB header:ligase, lyase Chain: A: PDB Molecule:multifunctional protein ade2; PDBTitle: crystal structure of human paics, a bifunctional carboxylase and2 synthetase in purine biosynthesis 80 d2p02a1 not modelled 38.5 16 Fold:S-adenosylmethionine synthetase Superfamily:S-adenosylmethionine synthetase Family:S-adenosylmethionine synthetase 81 d1trea_ not modelled 37.7 15 Fold:TIM beta/alpha-barrel Superfamily:Triosephosphate isomerase (TIM) Family:Triosephosphate isomerase (TIM) 82 c3tr9A_ not modelled 37.6 12 PDB header:transferase Chain: A: PDB Molecule:dihydropteroate synthase; PDBTitle: structure of a dihydropteroate synthase (folp) in complex with pteroic2 acid from coxiella burnetii 83 c1zorB_ not modelled 36.6 10 PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase; PDBTitle: isocitrate dehydrogenase from the hyperthermophile thermotoga maritima 84 c2gq0B_ not modelled 36.3 16 PDB header:chaperone, hydrolase Chain: B: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the middle domain of htpg, the e. coli2 hsp90 85 c3gndC_ not modelled 36.0 15 PDB header:lyase Chain: C: PDB Molecule:aldolase lsrf; PDBTitle: crystal structure of e. coli lsrf in complex with ribulose-5-phosphate 86 c1k87A_ not modelled 35.5 19 PDB header:oxidoreductase Chain: A: PDB Molecule:proline dehydrogenase; PDBTitle: crystal structure of e.coli puta (residues 1-669) 87 c1y6zA_ not modelled 35.2 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:heat shock protein, putative; PDBTitle: middle domain of plasmodium falciparum putative heat shock protein2 pf14_0417 88 c2h9aB_ not modelled 33.8 12 PDB header:oxidoreductase Chain: B: PDB Molecule:co dehydrogenase/acetyl-coa synthase, iron- PDBTitle: corrinoid iron-sulfur protein 89 c2o1tB_ not modelled 33.5 16 PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of middle plus c-terminal domains (m+c) of grp94 90 d1mxaa1 not modelled 33.1 14 Fold:S-adenosylmethionine synthetase Superfamily:S-adenosylmethionine synthetase Family:S-adenosylmethionine synthetase 91 c2v1dA_ not modelled 32.0 15 PDB header:oxidoreductase/repressor Chain: A: PDB Molecule:lysine-specific histone demethylase 1; PDBTitle: structural basis of lsd1-corest selectivity in histone h32 recognition 92 c3h7uA_ not modelled 31.8 27 PDB header:oxidoreductase Chain: A: PDB Molecule:aldo-keto reductase; PDBTitle: crystal structure of the plant stress-response enzyme akr4c9 93 d1qm4a1 not modelled 31.3 18 Fold:S-adenosylmethionine synthetase Superfamily:S-adenosylmethionine synthetase Family:S-adenosylmethionine synthetase 94 d1xima_ not modelled 30.4 19 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 95 d2al1a1 not modelled 30.3 22 Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:Enolase 96 d2af4c1 not modelled 30.2 12 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Phosphotransacetylase 97 d1vz6a_ not modelled 30.1 17 Fold:DmpA/ArgJ-like Superfamily:DmpA/ArgJ-like Family:ArgJ-like 98 c4a1aH_ not modelled 30.0 24 PDB header:ribosome Chain: H: PDB Molecule:60s ribosomal protein l10; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 3. 99 c3qc3B_ not modelled 29.8 28 PDB header:isomerase Chain: B: PDB Molecule:d-ribulose-5-phosphate-3-epimerase; PDBTitle: crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699)2 from homo sapiens at 2.20 a resolution 100 d1t9ba3 not modelled 29.7 19 Fold:Thiamin diphosphate-binding fold (THDP-binding) Superfamily:Thiamin diphosphate-binding fold (THDP-binding) Family:Pyruvate oxidase and decarboxylase PP module 101 c1yl7F_ not modelled 29.5 24 PDB header:oxidoreductase Chain: F: PDB Molecule:dihydrodipicolinate reductase; PDBTitle: the crystal structure of mycobacterium tuberculosis2 dihydrodipicolinate reductase (rv2773c) in complex with nadh (crystal3 form c) 102 d1n8fa_ not modelled 29.4 23 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I DAHP synthetase 103 d3clsc1 not modelled 28.3 15 Fold:Adenine nucleotide alpha hydrolase-like Superfamily:Adenine nucleotide alpha hydrolases-like Family:ETFP subunits 104 c1vm6B_ not modelled 28.2 14 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrodipicolinate reductase; PDBTitle: crystal structure of dihydrodipicolinate reductase (tm1520) from2 thermotoga maritima at 2.27 a resolution 105 c3ih1A_ not modelled 28.1 13 PDB header:lyase Chain: A: PDB Molecule:methylisocitrate lyase; PDBTitle: crystal structure of carboxyvinyl-carboxyphosphonate phosphorylmutase2 from bacillus anthracis 106 d1s2wa_ not modelled 28.0 13 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 107 d1ixka_ not modelled 27.4 29 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:NOL1/NOP2/sun 108 c1nofA_ not modelled 27.2 20 PDB header:hydrolase Chain: A: PDB Molecule:xylanase; PDBTitle: the first crystallographic structure of a xylanase from2 glycosyl hydrolase family 5: implications for catalysis 109 c3m4xA_ not modelled 26.9 26 PDB header:transferase Chain: A: PDB Molecule:nol1/nop2/sun family protein; PDBTitle: structure of a ribosomal methyltransferase 110 c3v7nA_ not modelled 26.4 14 PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis 111 c2qb5B_ not modelled 25.8 17 PDB header:transferase Chain: B: PDB Molecule:inositol-tetrakisphosphate 1-kinase; PDBTitle: crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase2 (itpk1) in complex with adp and mn2+ 112 d1e0ta2 not modelled 25.6 22 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase 113 d1oy0a_ not modelled 25.3 20 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Ketopantoate hydroxymethyltransferase PanB 114 d2fyma1 not modelled 25.3 21 Fold:TIM beta/alpha-barrel Superfamily:Enolase C-terminal domain-like Family:Enolase 115 c3so4C_ not modelled 25.2 14 PDB header:transferase Chain: C: PDB Molecule:methionine-adenosyltransferase; PDBTitle: methionine-adenosyltransferase from entamoeba histolytica 116 c1rg9D_ not modelled 24.8 14 PDB header:transferase Chain: D: PDB Molecule:s-adenosylmethionine synthetase; PDBTitle: s-adenosylmethionine synthetase complexed with sam and ppnp 117 d1azta1 not modelled 24.7 15 Fold:Transducin (alpha subunit), insertion domain Superfamily:Transducin (alpha subunit), insertion domain Family:Transducin (alpha subunit), insertion domain 118 d2ebna_ not modelled 24.6 26 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Type II chitinase 119 c2e1mC_ not modelled 24.1 18 PDB header:oxidoreductase Chain: C: PDB Molecule:l-glutamate oxidase; PDBTitle: crystal structure of l-glutamate oxidase from streptomyces sp. x-119-6 120 d1vm6a3 not modelled 24.0 14 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0