Phyre 2 Results for P76464

Email	l.a.kelley@imperial.ac.uk
Description	P76464
Date	Wed Jan 25 15:21:08 GMT 2012
Unique Job ID	169b609148868c42

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3cu7A_

Top template information

PDB header:immune system
Chain: A: PDB Molecule:complement c5;
PDBTitle: human complement component 5

Confidence and coverage

Confidence:

100.0%

Coverage:

79%

1209 residues ( 79% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M D T Q R F Q S Q F H W H L S F K F S G A I A A C L S L S L V G T G L A N A D D S L P S S N Y A P P A G G T F F L L A D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence S S F S S S E E A K V R L E A P G R D Y R R Y Q M E E Y G G V D V R L Y R I P D P M A F L R Q Q K N L H R I V V Q P Q Y

Secondary structure

SS confidence

Disorder ? ? ? ?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ?
? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence L G D G L N N T L T W L W D N W Y G K S R R V M Q R T F S S Q S R Q N V T Q A L P E L Q L G N A I I K P S R Y V Q N N Q

Secondary structure

SS confidence

Disorder
?
?
?
? ? ?
? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence F S P L K K Y P L V K Q F R Y P L W Q A K P F E P Q Q G V K L E G A S S N F I S P Q P G N I Y I P L G Q Q E P G L Y L V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ?
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence E A M V G G Y R A T T V V F V S D T V A L S K V S G K E L L V W T A G K K Q G E A K P G S E I L W T D G L G V M T R G V

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence T D D S G T L Q L Q H I S P E R S Y I L G K D A E G G V F V S E N F F Y E S E I Y N T R L Y I F T D R P L Y R A G D R V

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence D V K V I G R E F H D P L H S S P I V S A P A K L S V L D A N G S L L Q T V N V T L D A R N G G Q G S F R L P E N A V A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence G G Y E L R L A Y R N Q V Y S S S F R V A N Y I K P H F E I G L A L A K K E F K T G E A V S G K L Q L L Y P D G E P V K

Secondary structure

SS confidence

Disorder ?
? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence N A R V Q L S L R A Q Q L S M V G N D L R Y A G R F P V S L E G S E T V S D A S G H V A L N L P A A D K P S R Y L L T V

Secondary structure

SS confidence

Disorder
?
? ? ?
?
?
? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S A S D G A A Y R V T T T K E I L I E R G L A H Y S L S T A A Q Y S N S G E S V V F R Y A A L E S S K Q V P V T Y E W L

Secondary structure

SS confidence

Disorder
?
? ?
?
?
? ?
?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence R L E D R T S H S G E L P S G G K S F T V N F A K P G N Y N L T L R D K D G L I L A G L S H A V S G K G S T A H T G T V

Secondary structure

SS confidence

Disorder
? ?
?
?
? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence D I V A D K T L Y Q P G E T A K M L I T F P E P I D E A L L T L E R D R V E Q Q S L L S H P A N W L T L Q R L N D T Q Y

Secondary structure

SS confidence

Disorder
?
? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence E A R V P V S N S F A P N I T F S V L Y T R N G Q Y S F Q N A G I K V A V P Q L D I R V K T D K T H Y Q P G E L V N V E

Secondary structure

SS confidence

Disorder
?
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L T S S L K G K P V S A Q L T V G V V D E M I Y A L Q P E I A P N I G K F F Y P L G R N N V R T S S S L S F I S Y D Q A

Secondary structure

SS confidence

Disorder
? ? ?
? ?
? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence L S S E P V A P G A T N R S E R R V K M L E R P R R E E V D T A A W M P S L T T D K Q G K A Y F T F L M P D S L T R W R

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence I T A R G M N G D G L V G Q G R A Y L R S E K N L Y M K W S M P T V Y R V G D K P A A G L F I F S Q Q D N E P V A L V T

Secondary structure

SS confidence

Disorder
? ? ?
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence K F A G A E M R Q T L T L H K G A N Y I S L T Q N I Q Q S G L L S A E L Q Q N G Q V Q D S I S T K L S F V D N S W P V E

Secondary structure

SS confidence

Disorder
? ? ? ?
?
?
? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence Q Q K N V M L G G G D N A L M L P E Q A S N I R L Q S S E T P Q E I F R N N L D A L V D E P W G G V I N T G S R L I P L

Secondary structure

SS confidence

Disorder
?
? ? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S L A W R S L A D H Q S A A A N D I R Q M I Q D N R L R L M Q L A G P G A R F T W W G E D G N G D A F L T A W A W Y A D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence W Q A S Q A I G V T Q Q P E Y W Q H M L D S Y A E Q A D N M P L L H R A L V L A W A Q E M N L P C K T L L K G L D E A I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence A R R G T K T E D F S E E D T R D I N D S L I L D T P E S P L A D A V A N V L T M T L L K K A Q L K S T V M P Q V Q Q Y

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?
? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence A W D K A A N S N Q P L A H T V V L L N S G G D A T Q T A A I L S G L T A E Q S T I E R A L A M N W L A K Y M A T M P P

Secondary structure

SS confidence

Disorder
? ?
? ? ?
? ? ? ? ? ?
? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence V V L P A P A G A W A K H K L T G G G E D W R W V G Q G V P D I L S F G D E L S P Q N V Q V R W R E P A K M A Q Q S N I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence P V T V E R Q L Y R L I P G E E E M S F I L Q P V T S N E I D S D A L Y L D E I T L T S E Q D A V L R Y G Q V E V P L P

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ? ? ? ? ? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence P G A D V E R T T W G I S V N K P N A A K Q Q G Q L L E K A R N E M G E L A Y M V P V K E L T G T V T F R H L L R F S Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . .

Sequence K G Q F V L P P A R Y V R S Y A P A Q Q S V A A G S E W T G M Q V K

Secondary structure

SS confidence

Disorder
? ?
?
? ?
?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3cu7 chain A

Region: 264 - 1521
Aligned: 1209
Modelled: 1248
Confidence: 100.0%
Identity: 14%
PDB header:immune system
Chain: A: PDB Molecule:complement c5;
PDBTitle: human complement component 5

Phyre2

PDB 2b39 chain B

Region: 339 - 1521
Aligned: 1125
Modelled: 1162
Confidence: 100.0%
Identity: 14%
PDB header:immune system
Chain: B: PDB Molecule:c3;
PDBTitle: structure of mammalian c3 with an intact thioester at 3a resolution

Phyre2

PDB 2pn5 chain A

Region: 264 - 1521
Aligned: 1169
Modelled: 1220
Confidence: 100.0%
Identity: 13%
PDB header:immune system
Chain: A: PDB Molecule:thioester-containing protein i;
PDBTitle: crystal structure of tep1r

Phyre2

PDB 3pvm chain B

Region: 345 - 1140
Aligned: 737
Modelled: 759
Confidence: 100.0%
Identity: 16%
PDB header:immune system
Chain: B: PDB Molecule:cobra venom factor;
PDBTitle: structure of complement c5 in complex with cvf

Phyre2

PDB 2a73 chain B

Region: 849 - 1521
Aligned: 645
Modelled: 662
Confidence: 100.0%
Identity: 13%
PDB header:immune system
Chain: B: PDB Molecule:complement c3;
PDBTitle: human complement component c3

Phyre2

PDB 3g6j chain B

Region: 864 - 1521
Aligned: 635
Modelled: 645
Confidence: 100.0%
Identity: 13%
PDB header:immune system
Chain: B: PDB Molecule:complement c3 alpha chain;
PDBTitle: c3b in complex with a c3b specific fab

Phyre2

PDB 3hrz chain A

Region: 262 - 829
Aligned: 527
Modelled: 567
Confidence: 100.0%
Identity: 18%
PDB header:immune system
Chain: A: PDB Molecule:cobra venom factor;
PDBTitle: cobra venom factor (cvf) in complex with human factor b

Phyre2

PDB 2qki chain A

Region: 264 - 829
Aligned: 535
Modelled: 566
Confidence: 100.0%
Identity: 15%
PDB header:immune system/hydrolase inhibitor
Chain: A: PDB Molecule:complement c3;
PDBTitle: human c3c in complex with the inhibitor compstatin

Phyre2

PDB 1hzf chain A

Region: 1057 - 1318
Aligned: 251
Modelled: 262
Confidence: 100.0%
Identity: 18%
Fold: alpha/alpha toroid
Superfamily: Terpenoid cyclases/Protein prenyltransferases
Family: Complement components

Phyre2

PDB 1hzf chain A

Region: 1057 - 1318
Aligned: 251
Modelled: 262
Confidence: 100.0%
Identity: 18%
PDB header:immune system
Chain: A: PDB Molecule:complement factor c4a;
PDBTitle: c4adg fragment of human complement factor c4a

Phyre2

PDB 1c3d chain A

Region: 1056 - 1319
Aligned: 249
Modelled: 264
Confidence: 100.0%
Identity: 14%
Fold: alpha/alpha toroid
Superfamily: Terpenoid cyclases/Protein prenyltransferases
Family: Complement components

Phyre2

PDB 3hs0 chain B

Region: 864 - 1051
Aligned: 188
Modelled: 188
Confidence: 100.0%
Identity: 15%
PDB header:immune system
Chain: B: PDB Molecule:cobra venom factor;
PDBTitle: cobra venom factor (cvf) in complex with human factor b

Phyre2

PDB 2a74 chain B

Region: 853 - 1015
Aligned: 163
Modelled: 163
Confidence: 99.9%
Identity: 15%
PDB header:immune system
Chain: B: PDB Molecule:complement component c3c;
PDBTitle: human complement component c3c

Phyre2

PDB 1qqf chain A

Region: 1070 - 1318
Aligned: 234
Modelled: 249
Confidence: 99.9%
Identity: 12%
Fold: alpha/alpha toroid
Superfamily: Terpenoid cyclases/Protein prenyltransferases
Family: Complement components

Phyre2

PDB 2p9r chain A

Region: 342 - 446
Aligned: 101
Modelled: 105
Confidence: 99.8%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:alpha-2-macroglobulin;
PDBTitle: human alpha2-macroglogulin is composed of multiple domains,2 as predicted by homology with complement component c3

Phyre2

PDB 3es6 chain B domain 1

Region: 921 - 1025
Aligned: 105
Modelled: 105
Confidence: 98.9%
Identity: 11%
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Family: SVA-like

Phyre2

PDB 1o79 chain A

Region: 1080 - 1318
Aligned: 197
Modelled: 201
Confidence: 98.5%
Identity: 12%
PDB header:isomerase
Chain: A: PDB Molecule:squalene--hopene cyclase;
PDBTitle: structures of human oxidosqualene cyclase inhibitors bound2 to a homolgous enzyme

Phyre2

PDB 3hrz chain C

Region: 1324 - 1521
Aligned: 188
Modelled: 198
Confidence: 98.4%
Identity: 6%
PDB header:immune system
Chain: C: PDB Molecule:cobra venom factor;
PDBTitle: cobra venom factor (cvf) in complex with human factor b

Phyre2

PDB 1w6k chain A

Region: 1067 - 1324
Aligned: 224
Modelled: 227
Confidence: 98.1%
Identity: 11%
PDB header:isomerase
Chain: A: PDB Molecule:lanosterol synthase;
PDBTitle: structure of human osc in complex with lanosterol

Phyre2

PDB 1edy chain A

Region: 1398 - 1521
Aligned: 115
Modelled: 122
Confidence: 98.0%
Identity: 12%
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: Alpha-macroglobulin receptor domain
Family: Alpha-macroglobulin receptor domain

Phyre2

PDB 3ott chain B

Region: 210 - 244
Aligned: 35
Modelled: 35
Confidence: 76.8%
Identity: 17%
PDB header:transcription
Chain: B: PDB Molecule:two-component system sensor histidine kinase;
PDBTitle: crystal structure of the extracellular domain of the putative one2 component system bt4673 from b. thetaiotaomicron

Phyre2

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

c3ottB_

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

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158

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162

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165

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171

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177

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181

182

183

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213

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	D	T	Q	R	F	Q	S	Q	F	H	W	H	L	S	F	K	F	S	G	A	I	A	A	C	L	S	L	S	L	V	G	T	G	L	A	N	A	D	D	S	L	P	S	S	N	Y	A	P	P	A	G	G	T	F	F	L	L	A	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?																								?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?		?								?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	S	S	F	S	S	S	E	E	A	K	V	R	L	E	A	P	G	R	D	Y	R	R	Y	Q	M	E	E	Y	G	G	V	D	V	R	L	Y	R	I	P	D	P	M	A	F	L	R	Q	Q	K	N	L	H	R	I	V	V	Q	P	Q	Y
Secondary structure
SS confidence
Disorder	?	?	?	?			?	?						?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?				?											?	?		?	?	?	?	?	?				?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	L	G	D	G	L	N	N	T	L	T	W	L	W	D	N	W	Y	G	K	S	R	R	V	M	Q	R	T	F	S	S	Q	S	R	Q	N	V	T	Q	A	L	P	E	L	Q	L	G	N	A	I	I	K	P	S	R	Y	V	Q	N	N	Q
Secondary structure
SS confidence
Disorder			?					?				?		?	?	?									?	?						?					?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	F	S	P	L	K	K	Y	P	L	V	K	Q	F	R	Y	P	L	W	Q	A	K	P	F	E	P	Q	Q	G	V	K	L	E	G	A	S	S	N	F	I	S	P	Q	P	G	N	I	Y	I	P	L	G	Q	Q	E	P	G	L	Y	L	V
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?														?	?		?												?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	E	A	M	V	G	G	Y	R	A	T	T	V	V	F	V	S	D	T	V	A	L	S	K	V	S	G	K	E	L	L	V	W	T	A	G	K	K	Q	G	E	A	K	P	G	S	E	I	L	W	T	D	G	L	G	V	M	T	R	G	V
Secondary structure
SS confidence
Disorder																																								?														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	T	D	D	S	G	T	L	Q	L	Q	H	I	S	P	E	R	S	Y	I	L	G	K	D	A	E	G	G	V	F	V	S	E	N	F	F	Y	E	S	E	I	Y	N	T	R	L	Y	I	F	T	D	R	P	L	Y	R	A	G	D	R	V
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	D	V	K	V	I	G	R	E	F	H	D	P	L	H	S	S	P	I	V	S	A	P	A	K	L	S	V	L	D	A	N	G	S	L	L	Q	T	V	N	V	T	L	D	A	R	N	G	G	Q	G	S	F	R	L	P	E	N	A	V	A
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?																																				?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	G	G	Y	E	L	R	L	A	Y	R	N	Q	V	Y	S	S	S	F	R	V	A	N	Y	I	K	P	H	F	E	I	G	L	A	L	A	K	K	E	F	K	T	G	E	A	V	S	G	K	L	Q	L	L	Y	P	D	G	E	P	V	K
Secondary structure
SS confidence
Disorder	?											?	?	?																					?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	N	A	R	V	Q	L	S	L	R	A	Q	Q	L	S	M	V	G	N	D	L	R	Y	A	G	R	F	P	V	S	L	E	G	S	E	T	V	S	D	A	S	G	H	V	A	L	N	L	P	A	A	D	K	P	S	R	Y	L	L	T	V
Secondary structure
SS confidence
Disorder											?		?	?	?							?										?																			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	A	S	D	G	A	A	Y	R	V	T	T	T	K	E	I	L	I	E	R	G	L	A	H	Y	S	L	S	T	A	A	Q	Y	S	N	S	G	E	S	V	V	F	R	Y	A	A	L	E	S	S	K	Q	V	P	V	T	Y	E	W	L
Secondary structure
SS confidence
Disorder					?		?	?												?		?									?	?																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	R	L	E	D	R	T	S	H	S	G	E	L	P	S	G	G	K	S	F	T	V	N	F	A	K	P	G	N	Y	N	L	T	L	R	D	K	D	G	L	I	L	A	G	L	S	H	A	V	S	G	K	G	S	T	A	H	T	G	T	V
Secondary structure
SS confidence
Disorder								?	?				?			?																						?	?												?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	D	I	V	A	D	K	T	L	Y	Q	P	G	E	T	A	K	M	L	I	T	F	P	E	P	I	D	E	A	L	L	T	L	E	R	D	R	V	E	Q	Q	S	L	L	S	H	P	A	N	W	L	T	L	Q	R	L	N	D	T	Q	Y
Secondary structure
SS confidence
Disorder							?																																																	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	E	A	R	V	P	V	S	N	S	F	A	P	N	I	T	F	S	V	L	Y	T	R	N	G	Q	Y	S	F	Q	N	A	G	I	K	V	A	V	P	Q	L	D	I	R	V	K	T	D	K	T	H	Y	Q	P	G	E	L	V	N	V	E
Secondary structure
SS confidence
Disorder																																							?							?	?				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	L	T	S	S	L	K	G	K	P	V	S	A	Q	L	T	V	G	V	V	D	E	M	I	Y	A	L	Q	P	E	I	A	P	N	I	G	K	F	F	Y	P	L	G	R	N	N	V	R	T	S	S	S	L	S	F	I	S	Y	D	Q	A
Secondary structure
SS confidence
Disorder				?	?	?																																						?	?													?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	L	S	S	E	P	V	A	P	G	A	T	N	R	S	E	R	R	V	K	M	L	E	R	P	R	R	E	E	V	D	T	A	A	W	M	P	S	L	T	T	D	K	Q	G	K	A	Y	F	T	F	L	M	P	D	S	L	T	R	W	R
Secondary structure
SS confidence
Disorder	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?												?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	I	T	A	R	G	M	N	G	D	G	L	V	G	Q	G	R	A	Y	L	R	S	E	K	N	L	Y	M	K	W	S	M	P	T	V	Y	R	V	G	D	K	P	A	A	G	L	F	I	F	S	Q	Q	D	N	E	P	V	A	L	V	T
Secondary structure
SS confidence
Disorder																						?	?	?								?																							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	K	F	A	G	A	E	M	R	Q	T	L	T	L	H	K	G	A	N	Y	I	S	L	T	Q	N	I	Q	Q	S	G	L	L	S	A	E	L	Q	Q	N	G	Q	V	Q	D	S	I	S	T	K	L	S	F	V	D	N	S	W	P	V	E
Secondary structure
SS confidence
Disorder				?	?	?	?																			?			?												?	?											?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	Q	Q	K	N	V	M	L	G	G	G	D	N	A	L	M	L	P	E	Q	A	S	N	I	R	L	Q	S	S	E	T	P	Q	E	I	F	R	N	N	L	D	A	L	V	D	E	P	W	G	G	V	I	N	T	G	S	R	L	I	P	L
Secondary structure
SS confidence
Disorder								?		?	?	?																			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	L	A	W	R	S	L	A	D	H	Q	S	A	A	A	N	D	I	R	Q	M	I	Q	D	N	R	L	R	L	M	Q	L	A	G	P	G	A	R	F	T	W	W	G	E	D	G	N	G	D	A	F	L	T	A	W	A	W	Y	A	D
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?																		?	?	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	W	Q	A	S	Q	A	I	G	V	T	Q	Q	P	E	Y	W	Q	H	M	L	D	S	Y	A	E	Q	A	D	N	M	P	L	L	H	R	A	L	V	L	A	W	A	Q	E	M	N	L	P	C	K	T	L	L	K	G	L	D	E	A	I
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	A	R	R	G	T	K	T	E	D	F	S	E	E	D	T	R	D	I	N	D	S	L	I	L	D	T	P	E	S	P	L	A	D	A	V	A	N	V	L	T	M	T	L	L	K	K	A	Q	L	K	S	T	V	M	P	Q	V	Q	Q	Y
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?														?	?	?	?															?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	A	W	D	K	A	A	N	S	N	Q	P	L	A	H	T	V	V	L	L	N	S	G	G	D	A	T	Q	T	A	A	I	L	S	G	L	T	A	E	Q	S	T	I	E	R	A	L	A	M	N	W	L	A	K	Y	M	A	T	M	P	P
Secondary structure
SS confidence
Disorder			?	?		?	?	?														?	?	?	?	?	?										?	?	?	?																		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	V	V	L	P	A	P	A	G	A	W	A	K	H	K	L	T	G	G	G	E	D	W	R	W	V	G	Q	G	V	P	D	I	L	S	F	G	D	E	L	S	P	Q	N	V	Q	V	R	W	R	E	P	A	K	M	A	Q	Q	S	N	I
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	P	V	T	V	E	R	Q	L	Y	R	L	I	P	G	E	E	E	M	S	F	I	L	Q	P	V	T	S	N	E	I	D	S	D	A	L	Y	L	D	E	I	T	L	T	S	E	Q	D	A	V	L	R	Y	G	Q	V	E	V	P	L	P
Secondary structure
SS confidence
Disorder														?	?	?	?	?								?	?	?	?	?	?	?	?	?												?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	P	G	A	D	V	E	R	T	T	W	G	I	S	V	N	K	P	N	A	A	K	Q	Q	G	Q	L	L	E	K	A	R	N	E	M	G	E	L	A	Y	M	V	P	V	K	E	L	T	G	T	V	T	F	R	H	L	L	R	F	S	Q
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.
Sequence	K	G	Q	F	V	L	P	P	A	R	Y	V	R	S	Y	A	P	A	Q	Q	S	V	A	A	G	S	E	W	T	G	M	Q	V	K
Secondary structure
SS confidence
Disorder																					?	?		?		?	?							?
Disorder confidence