Phyre 2 Results for Q21408

Email	l.a.kelley@imperial.ac.uk
Description	Q21408
Date	Sat Apr 13 12:50:02 BST 2013
Unique Job ID	57539a1906360a68

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:220.985 Y:152.859 Z:64.224

Model (left) based on template c1sjjB_

Top template information

PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin

Confidence and coverage

Confidence:

100.0%

Coverage:

24%

582 residues ( 24% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

1113 residues ( 46%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A D S N D T H A P P E P V L E V P P P Q E I R I L E T A D D I H Q R R Q E V L G H Y S I F K D H S Q T K R D R L E E A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence R Q F Q Y F K R D A D E L N V W I L E K L Q T A Q E E N F R D P S N L Q A K I Q K H E A F E A E V Q A H A K T I A N L D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence K T G N A M I Q H N H F A S E H I K K R L E E L H A L W D K L F F K L K D K G I K L Q Q A L K L L H F I R Q C D E I L Y

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence W I R E K E T Y V T A E D M G M D L E H V E I L Q R K F D D F L K E L G N H Q Y R I N E I N Q A A D K L V E E G H S E H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence D Q I Y K K R D D V N D A W H R L N T L A A T R K E G L F G A H Q V Q R F N R D A D E T L A W I G E K D L A L S S D D Y

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence G R D L N N V Q A L Q R K H E G T E R D L A A L E G K M L Q L E K E A H K L A E T H P D R A E A I H Q K N D D T K A A W

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence N A L K E K A Q H R K D G L E R S F Q L H R F L A D Y R D L I S W I G D M K A V I G A D E L A K D V A G A E A L L E S H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence Q E H K G E I D A R A D S F N Q T A S A G Q K L V E M G I P E S P E V Q E K L E K L D H E K S S L L G L W E E R R I L Y

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence E Q C M D L Q L F Y R D T E Q A E T W M N K Q E A F L A N T D L G D S L D S V E H L I K K H E D F E K S L A A Q E E K I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence N A L D E F A T K L I Q G Q H Y A A D D V A E R R Q A L L D R R R R L L D R A R Q R G N A L K E S Y K R Q T F D R D C D

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence E M V S W I T E K L S T A R D D S Y L D P T N I R G K L Q K H I N F E Q E L K A N E N R L D D I R S T G E Q I I D S G H

Secondary structure

SS confidence

Disorder
? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence F A A D H I G D R L R Q V N N L W N E L V D A T N K K G A K L R E A G N E Q Q F N R N I E D V E A W L S E L E G Q V A S

Secondary structure

SS confidence

Disorder ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence E D Y G K D L V S V Q N L Q K K I G L I E S D F N A H N D R V D G I K Q L A Q Q F Q E E E H F N A P V I V R K Q E N L Q

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence Q R Y N A L R D P L E K R K R K L G E S H Q G N Q L F R D I E D E L A W I R E K E Q V A G S T N R G R D L I G V Q N L I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence K K Q Q A L I A E I A N H D S Q I E S V S S A A N D M I Q Q G H F L A P E I R D K L A Q L R D N W R I L K S K A E K R R

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence T D L D D S L Q A H Q Y L S D A N E A D A W M S E K E P I V G S T D Y G K D E D S A E A L L K K H R A L L S D L E A F K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence G T I E D L R K Q A S Q C K Y Q E Q P M G Q L G R D C V L A L Y D Y Q E K S P R E V S M K K G D V L T L L N A S N R D W

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence W K V E V N D R Q G F V P A A Y V K R I E P G T A Q Q H A Q Q Q V N S I G G K Q S E I E D K Y Q R L M M L G E T R K R K

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence L E E A C K G Y Q L L R E A N D L A E W I K S R T N M A E E A V A A Q Q E I G T D L E Q V E V L Q K K F D D F K G D L K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence A N E V R L Q E M N Q I A T A L T S V G Q T E T A V R I R Q Q I E D L N A R W R A L E E Q T E Q R E Q Q L G S A H E V Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence R F H R D V D E T R D W I Q E K D D A L D S E D F G R D L R S V Q A L Q R K H E G V E R D L A A L G D K I K S L D E K A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence N R L R Q S H P E A A E Q I Y D L Q R E L N E Q W N R L T S K A N N R K E K L L D S Y D Y Q R F L S D Y R D L M Q W I A

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence S M N Q L V S S Q E L A N D V T G A E A L L E R H Q E Y R T E I D S R A A T F Q A F D Q F G N Q L L N S H H Y A A G D I

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence E N R L Q G V N E A R K G L E D A W V A R R N I L D Q C L E L Q L F Y R D C E Q A D T W M S A R E A F L A Q E D P S G D

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence N V E S L I K K H E D F D K A I N T Q E E K I K G L K L F A E S L I K N N H Y D S P A V T R K R D Q I L D R W N G L K E

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . . . . . . . 1540 . . . . . . . . . 1550 . . . . . . . . . 1560

Sequence A L I Q K R F K L G E S Q T L Q Q F S R D A D E I E N W M T E K F Q I A Q E E N Y R D P T N I Q Q K H Q K Q Q A F E A E

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 1570 . . . . . . . . . 1580 . . . . . . . . . 1590 . . . . . . . . . 1600 . . . . . . . . . 1610 . . . . . . . . . 1620

Sequence L H A N S D R I A A I I Q A G N N L I E N A K C G G G E A A V S A R L K A L N D Q W D L L V K T T T E K S Y R L K E A N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1630 . . . . . . . . . 1640 . . . . . . . . . 1650 . . . . . . . . . 1660 . . . . . . . . . 1670 . . . . . . . . . 1680

Sequence K Q K S F M A A V K D L E F W L G E V E I L L Q S E D Y G K D L A S V E N L L K K H S L L E A D I V A H Q D R V G E M N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1690 . . . . . . . . . 1700 . . . . . . . . . 1710 . . . . . . . . . 1720 . . . . . . . . . 1730 . . . . . . . . . 1740

Sequence E Q A D S L L E N D Q F Q G Q Q I A E R R K L I A D R Y D G V K K M A T D R R D K L S K A L N V H Q F F R D I D D E E S

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 1750 . . . . . . . . . 1760 . . . . . . . . . 1770 . . . . . . . . . 1780 . . . . . . . . . 1790 . . . . . . . . . 1800

Sequence W I K E K K L L V S S D D Y G R D L P G V Q N L R R K H R R I D T E L A S H E P Q V S L V K L K G E E L L R S A A E A G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1810 . . . . . . . . . 1820 . . . . . . . . . 1830 . . . . . . . . . 1840 . . . . . . . . . 1850 . . . . . . . . . 1860

Sequence V G E D Q I K K R M E D L E Q S W G Q I R D L T G N R H Q R L D E S E A F Q A F L G D V E E E E A W M N E K Q Q I L G S

Secondary structure

SS confidence

Disorder ? ?
?

Disorder confidence

. . . . . . . . . 1870 . . . . . . . . . 1880 . . . . . . . . . 1890 . . . . . . . . . 1900 . . . . . . . . . 1910 . . . . . . . . . 1920

Sequence D N F G E N M A G V Q G L L K K H D T F Q V D L E L H K Q R V A D L I N K G D T L I H N G N H H A P H I K Q R C D Q L R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 1930 . . . . . . . . . 1940 . . . . . . . . . 1950 . . . . . . . . . 1960 . . . . . . . . . 1970 . . . . . . . . . 1980

Sequence A R L I E I E S M A E G R L A K L R D N S A Y L Q F M W K C D V V E S W I A E K E Q Q V R S E D F G R D L S S V Q I L L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1990 . . . . . . . . . 2000 . . . . . . . . . 2010 . . . . . . . . . 2020 . . . . . . . . . 2030 . . . . . . . . . 2040

Sequence T K Q E A F D A G L N A F E H E G I Q R I T E L K D Q L V S S E H Q Q S P A I E K R H T N V I Q R W Q N L L A H S E A R

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 2050 . . . . . . . . . 2060 . . . . . . . . . 2070 . . . . . . . . . 2080 . . . . . . . . . 2090 . . . . . . . . . 2100

Sequence R Q K L L K M Q Q Q F K Q I E E L Y L A F A K K A S T F N S W F E N A E E D L T D P V R C N S L E E I R A L R D A H G E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 2110 . . . . . . . . . 2120 . . . . . . . . . 2130 . . . . . . . . . 2140 . . . . . . . . . 2150 . . . . . . . . . 2160

Sequence F Q R S L S S A E E D F R Q L Q D L D R R I K S F N V G P N P Y T W F T M D A L E D T W R N L Q R I I K E R E Q E L A R

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 2170 . . . . . . . . . 2180 . . . . . . . . . 2190 . . . . . . . . . 2200 . . . . . . . . . 2210 . . . . . . . . . 2220

Sequence E H Q R Q E E N D K L R R E F A K L A N A F H A W L T N T R Q E M M E A G G T L E E Q L D A V E R K A K E I K A N K G Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 2230 . . . . . . . . . 2240 . . . . . . . . . 2250 . . . . . . . . . 2260 . . . . . . . . . 2270 . . . . . . . . . 2280

Sequence L R Q I E E K G A M L E R N L I L D N R Y T E H S T V G I A Q A W D Q L D Q L A M R M Q H N L E Q Q I Q A R N Q S G V S

Secondary structure

SS confidence

Disorder
? ?
?

Disorder confidence

. . . . . . . . . 2290 . . . . . . . . . 2300 . . . . . . . . . 2310 . . . . . . . . . 2320 . . . . . . . . . 2330 . . . . . . . . . 2340

Sequence E E A L R E F S M M F K H F D K E K T G R L D H Q Q F K S C L R A L G Y D L P M V D E G Q P E P E F Q R I L D I V D P N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ? ?
?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 2350 . . . . . . . . . 2360 . . . . . . . . . 2370 . . . . . . . . . 2380 . . . . . . . . . 2390 . . . . . . . . . 2400

Sequence R D G Y V T L Q E Y M A F M I S K E T E N I Q S S E E I E M A F R A L S K E F R P Y V T A E E L Y A N L T P E Q A E F C

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?
? ? ? ? ? ?
?
?

Disorder confidence

. . . . . . . . . 2410 . . . . . . . . . 2420 . . . . . . . . . 2430 . .

Sequence I R R M K P Y M D A I S G R S I Q G G L D Y E Q F V H A L F Q S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 12%)

Alpha helix ( 87%)

Beta strand ( 0%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1sjj chain B

Region: 1837 - 2431
Aligned: 582
Modelled: 582
Confidence: 100.0%
Identity: 30%
PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin

Phyre2

PDB 1hci chain B

Region: 1832 - 2275
Aligned: 443
Modelled: 443
Confidence: 99.9%
Identity: 25%
PDB header:triple-helix coiled coil
Chain: B: PDB Molecule:alpha-actinin 2;
PDBTitle: crystal structure of the rod domain of alpha-actinin

Phyre2

PDB 3edv chain B

Region: 58 - 375
Aligned: 317
Modelled: 317
Confidence: 99.9%
Identity: 19%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, brain 1;
PDBTitle: crystal structure of repeats 14-16 of beta2-spectrin

Phyre2

PDB 1u4q chain B

Region: 64 - 376
Aligned: 313
Modelled: 313
Confidence: 99.9%
Identity: 26%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of repeats 15, 16 and 17 of chicken brain2 alpha spectrin

Phyre2

PDB 3kbt chain A

Region: 62 - 363
Aligned: 280
Modelled: 280
Confidence: 99.8%
Identity: 29%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of the ankyrin binding domain of human erythroid2 beta spectrin (repeats 13-15) in complex with the spectrin binding3 domain of human erythroid ankyrin (zu5-ank)

Phyre2

PDB 1h8b chain A

Region: 2361 - 2431
Aligned: 67
Modelled: 67
Confidence: 99.7%
Identity: 40%
Fold: EF Hand-like
Superfamily: EF-hand
Family: EF-hand modules in multidomain proteins

Phyre2

PDB 1cun chain C

Region: 63 - 272
Aligned: 210
Modelled: 210
Confidence: 99.6%
Identity: 28%
PDB header:structural protein
Chain: C: PDB Molecule:protein (alpha spectrin);
PDBTitle: crystal structure of repeats 16 and 17 of chicken brain2 alpha spectrin

Phyre2

PDB 1u5p chain A

Region: 167 - 375
Aligned: 209
Modelled: 209
Confidence: 99.6%
Identity: 33%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of repeats 15 and 16 of chicken brain2 alpha spectrin

Phyre2

PDB 1s35 chain A

Region: 170 - 375
Aligned: 206
Modelled: 206
Confidence: 99.6%
Identity: 20%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of repeats 8 and 9 of human erythroid2 spectrin

Phyre2

PDB 3evr chain A

Region: 2275 - 2429
Aligned: 139
Modelled: 139
Confidence: 99.5%
Identity: 32%
PDB header:signaling protein
Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent
PDBTitle: crystal structure of calcium bound monomeric gcamp2

Phyre2

PDB 3fb2 chain B

Region: 163 - 371
Aligned: 200
Modelled: 195
Confidence: 99.5%
Identity: 21%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain spectrin;
PDBTitle: crystal structure of the human brain alpha spectrin repeats2 15 and 16. northeast structural genomics consortium target3 hr5563a.

Phyre2

PDB 3pe0 chain B

Region: 167 - 344
Aligned: 178
Modelled: 178
Confidence: 99.5%
Identity: 19%
PDB header:structural protein
Chain: B: PDB Molecule:plectin;
PDBTitle: structure of the central region of the plakin domain of plectin

Phyre2

PDB 1quu chain A

Region: 1932 - 2168
Aligned: 236
Modelled: 236
Confidence: 99.5%
Identity: 30%
PDB header:contractile protein
Chain: A: PDB Molecule:human skeletal muscle alpha-actinin 2;
PDBTitle: crystal structure of two central spectrin-like repeats from2 alpha-actinin

Phyre2

PDB 3ek7 chain A

Region: 2278 - 2429
Aligned: 136
Modelled: 136
Confidence: 99.4%
Identity: 32%
PDB header:fluorescent protein
Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent protein,
PDBTitle: calcium-saturated gcamp2 dimer

Phyre2

PDB 3u0k chain A

Region: 2278 - 2429
Aligned: 130
Modelled: 130
Confidence: 99.4%
Identity: 33%
PDB header:fluorescent protein
Chain: A: PDB Molecule:rcamp;
PDBTitle: crystal structure of the genetically encoded calcium indicator rcamp

Phyre2

PDB 1ij5 chain A

Region: 2138 - 2429
Aligned: 267
Modelled: 267
Confidence: 99.4%
Identity: 15%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Cbp40 (plasmodial specific CaII-binding protein LAV1-2)

Phyre2

PDB 3pdy chain B

Region: 66 - 268
Aligned: 197
Modelled: 197
Confidence: 99.4%
Identity: 18%
PDB header:structural protein
Chain: B: PDB Molecule:plectin;
PDBTitle: structure of the third and fourth spectrin repeats of the plakin2 domain of plectin

Phyre2

PDB 3sib chain A

Region: 2276 - 2427
Aligned: 128
Modelled: 128
Confidence: 99.4%
Identity: 16%
PDB header:dna binding protein
Chain: A: PDB Molecule:ure3-bp sequence specific dna binding protein;
PDBTitle: crystal structure of ure3-binding protein, wild-type

Phyre2

PDB 3f57 chain B

Region: 162 - 365
Aligned: 181
Modelled: 181
Confidence: 99.4%
Identity: 33%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of human erythroid beta spectrin repeats 14 and 152 (ankyrin binding domain)

Phyre2

PDB 3lbx chain B

Region: 59 - 226
Aligned: 167
Modelled: 167
Confidence: 99.3%
Identity: 21%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of the erythrocyte spectrin tetramerization domain2 complex

Phyre2

PDB 3f31 chain B

Region: 25 - 164
Aligned: 140
Modelled: 140
Confidence: 99.0%
Identity: 57%
PDB header:actin binding, structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of the n-terminal region of alphaii-spectrin2 tetramerization domain

Phyre2

PDB 3r6n chain A

Region: 171 - 555
Aligned: 370
Modelled: 370
Confidence: 98.5%
Identity: 14%
PDB header:cell adhesion
Chain: A: PDB Molecule:desmoplakin;
PDBTitle: crystal structure of a rigid four spectrin repeat fragment of the2 human desmoplakin plakin domain

Phyre2

100

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108

109

110

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113

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115

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118

119

120

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152

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156

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162

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164

165

166

167

168

169

170

c3r6nA_

171

172

173

174

175

176

177

178

179

180

181

182

183

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186

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188

189

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414

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	D	S	N	D	T	H	A	P	P	E	P	V	L	E	V	P	P	P	Q	E	I	R	I	L	E	T	A	D	D	I	H	Q	R	R	Q	E	V	L	G	H	Y	S	I	F	K	D	H	S	Q	T	K	R	D	R	L	E	E	A
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	R	Q	F	Q	Y	F	K	R	D	A	D	E	L	N	V	W	I	L	E	K	L	Q	T	A	Q	E	E	N	F	R	D	P	S	N	L	Q	A	K	I	Q	K	H	E	A	F	E	A	E	V	Q	A	H	A	K	T	I	A	N	L	D
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	K	T	G	N	A	M	I	Q	H	N	H	F	A	S	E	H	I	K	K	R	L	E	E	L	H	A	L	W	D	K	L	F	F	K	L	K	D	K	G	I	K	L	Q	Q	A	L	K	L	L	H	F	I	R	Q	C	D	E	I	L	Y
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	W	I	R	E	K	E	T	Y	V	T	A	E	D	M	G	M	D	L	E	H	V	E	I	L	Q	R	K	F	D	D	F	L	K	E	L	G	N	H	Q	Y	R	I	N	E	I	N	Q	A	A	D	K	L	V	E	E	G	H	S	E	H
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?																																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	D	Q	I	Y	K	K	R	D	D	V	N	D	A	W	H	R	L	N	T	L	A	A	T	R	K	E	G	L	F	G	A	H	Q	V	Q	R	F	N	R	D	A	D	E	T	L	A	W	I	G	E	K	D	L	A	L	S	S	D	D	Y
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	G	R	D	L	N	N	V	Q	A	L	Q	R	K	H	E	G	T	E	R	D	L	A	A	L	E	G	K	M	L	Q	L	E	K	E	A	H	K	L	A	E	T	H	P	D	R	A	E	A	I	H	Q	K	N	D	D	T	K	A	A	W
Secondary structure
SS confidence
Disorder	?	?	?																																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	N	A	L	K	E	K	A	Q	H	R	K	D	G	L	E	R	S	F	Q	L	H	R	F	L	A	D	Y	R	D	L	I	S	W	I	G	D	M	K	A	V	I	G	A	D	E	L	A	K	D	V	A	G	A	E	A	L	L	E	S	H
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	Q	E	H	K	G	E	I	D	A	R	A	D	S	F	N	Q	T	A	S	A	G	Q	K	L	V	E	M	G	I	P	E	S	P	E	V	Q	E	K	L	E	K	L	D	H	E	K	S	S	L	L	G	L	W	E	E	R	R	I	L	Y
Secondary structure
SS confidence
Disorder																											?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	E	Q	C	M	D	L	Q	L	F	Y	R	D	T	E	Q	A	E	T	W	M	N	K	Q	E	A	F	L	A	N	T	D	L	G	D	S	L	D	S	V	E	H	L	I	K	K	H	E	D	F	E	K	S	L	A	A	Q	E	E	K	I
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	N	A	L	D	E	F	A	T	K	L	I	Q	G	Q	H	Y	A	A	D	D	V	A	E	R	R	Q	A	L	L	D	R	R	R	R	L	L	D	R	A	R	Q	R	G	N	A	L	K	E	S	Y	K	R	Q	T	F	D	R	D	C	D
Secondary structure
SS confidence
Disorder													?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	E	M	V	S	W	I	T	E	K	L	S	T	A	R	D	D	S	Y	L	D	P	T	N	I	R	G	K	L	Q	K	H	I	N	F	E	Q	E	L	K	A	N	E	N	R	L	D	D	I	R	S	T	G	E	Q	I	I	D	S	G	H
Secondary structure
SS confidence
Disorder																	?	?	?	?																																						?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	F	A	A	D	H	I	G	D	R	L	R	Q	V	N	N	L	W	N	E	L	V	D	A	T	N	K	K	G	A	K	L	R	E	A	G	N	E	Q	Q	F	N	R	N	I	E	D	V	E	A	W	L	S	E	L	E	G	Q	V	A	S
Secondary structure
SS confidence
Disorder	?																																																											?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	E	D	Y	G	K	D	L	V	S	V	Q	N	L	Q	K	K	I	G	L	I	E	S	D	F	N	A	H	N	D	R	V	D	G	I	K	Q	L	A	Q	Q	F	Q	E	E	E	H	F	N	A	P	V	I	V	R	K	Q	E	N	L	Q
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?																																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	Q	R	Y	N	A	L	R	D	P	L	E	K	R	K	R	K	L	G	E	S	H	Q	G	N	Q	L	F	R	D	I	E	D	E	L	A	W	I	R	E	K	E	Q	V	A	G	S	T	N	R	G	R	D	L	I	G	V	Q	N	L	I
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	K	K	Q	Q	A	L	I	A	E	I	A	N	H	D	S	Q	I	E	S	V	S	S	A	A	N	D	M	I	Q	Q	G	H	F	L	A	P	E	I	R	D	K	L	A	Q	L	R	D	N	W	R	I	L	K	S	K	A	E	K	R	R
Secondary structure
SS confidence
Disorder																														?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	T	D	L	D	D	S	L	Q	A	H	Q	Y	L	S	D	A	N	E	A	D	A	W	M	S	E	K	E	P	I	V	G	S	T	D	Y	G	K	D	E	D	S	A	E	A	L	L	K	K	H	R	A	L	L	S	D	L	E	A	F	K
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	G	T	I	E	D	L	R	K	Q	A	S	Q	C	K	Y	Q	E	Q	P	M	G	Q	L	G	R	D	C	V	L	A	L	Y	D	Y	Q	E	K	S	P	R	E	V	S	M	K	K	G	D	V	L	T	L	L	N	A	S	N	R	D	W
Secondary structure
SS confidence
Disorder																?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	W	K	V	E	V	N	D	R	Q	G	F	V	P	A	A	Y	V	K	R	I	E	P	G	T	A	Q	Q	H	A	Q	Q	Q	V	N	S	I	G	G	K	Q	S	E	I	E	D	K	Y	Q	R	L	M	M	L	G	E	T	R	K	R	K
Secondary structure
SS confidence
Disorder																		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	L	E	E	A	C	K	G	Y	Q	L	L	R	E	A	N	D	L	A	E	W	I	K	S	R	T	N	M	A	E	E	A	V	A	A	Q	Q	E	I	G	T	D	L	E	Q	V	E	V	L	Q	K	K	F	D	D	F	K	G	D	L	K
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	A	N	E	V	R	L	Q	E	M	N	Q	I	A	T	A	L	T	S	V	G	Q	T	E	T	A	V	R	I	R	Q	Q	I	E	D	L	N	A	R	W	R	A	L	E	E	Q	T	E	Q	R	E	Q	Q	L	G	S	A	H	E	V	Q
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	R	F	H	R	D	V	D	E	T	R	D	W	I	Q	E	K	D	D	A	L	D	S	E	D	F	G	R	D	L	R	S	V	Q	A	L	Q	R	K	H	E	G	V	E	R	D	L	A	A	L	G	D	K	I	K	S	L	D	E	K	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	N	R	L	R	Q	S	H	P	E	A	A	E	Q	I	Y	D	L	Q	R	E	L	N	E	Q	W	N	R	L	T	S	K	A	N	N	R	K	E	K	L	L	D	S	Y	D	Y	Q	R	F	L	S	D	Y	R	D	L	M	Q	W	I	A
Secondary structure
SS confidence
Disorder						?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	S	M	N	Q	L	V	S	S	Q	E	L	A	N	D	V	T	G	A	E	A	L	L	E	R	H	Q	E	Y	R	T	E	I	D	S	R	A	A	T	F	Q	A	F	D	Q	F	G	N	Q	L	L	N	S	H	H	Y	A	A	G	D	I
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	E	N	R	L	Q	G	V	N	E	A	R	K	G	L	E	D	A	W	V	A	R	R	N	I	L	D	Q	C	L	E	L	Q	L	F	Y	R	D	C	E	Q	A	D	T	W	M	S	A	R	E	A	F	L	A	Q	E	D	P	S	G	D
Secondary structure
SS confidence
Disorder																																																						?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	N	V	E	S	L	I	K	K	H	E	D	F	D	K	A	I	N	T	Q	E	E	K	I	K	G	L	K	L	F	A	E	S	L	I	K	N	N	H	Y	D	S	P	A	V	T	R	K	R	D	Q	I	L	D	R	W	N	G	L	K	E
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.	.	.	.	.	.	1540	.	.	.	.	.	.	.	.	.	1550	.	.	.	.	.	.	.	.	.	1560
Sequence	A	L	I	Q	K	R	F	K	L	G	E	S	Q	T	L	Q	Q	F	S	R	D	A	D	E	I	E	N	W	M	T	E	K	F	Q	I	A	Q	E	E	N	Y	R	D	P	T	N	I	Q	Q	K	H	Q	K	Q	Q	A	F	E	A	E
Secondary structure
SS confidence
Disorder																																										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1570	.	.	.	.	.	.	.	.	.	1580	.	.	.	.	.	.	.	.	.	1590	.	.	.	.	.	.	.	.	.	1600	.	.	.	.	.	.	.	.	.	1610	.	.	.	.	.	.	.	.	.	1620
Sequence	L	H	A	N	S	D	R	I	A	A	I	I	Q	A	G	N	N	L	I	E	N	A	K	C	G	G	G	E	A	A	V	S	A	R	L	K	A	L	N	D	Q	W	D	L	L	V	K	T	T	T	E	K	S	Y	R	L	K	E	A	N
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1630	.	.	.	.	.	.	.	.	.	1640	.	.	.	.	.	.	.	.	.	1650	.	.	.	.	.	.	.	.	.	1660	.	.	.	.	.	.	.	.	.	1670	.	.	.	.	.	.	.	.	.	1680
Sequence	K	Q	K	S	F	M	A	A	V	K	D	L	E	F	W	L	G	E	V	E	I	L	L	Q	S	E	D	Y	G	K	D	L	A	S	V	E	N	L	L	K	K	H	S	L	L	E	A	D	I	V	A	H	Q	D	R	V	G	E	M	N
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1690	.	.	.	.	.	.	.	.	.	1700	.	.	.	.	.	.	.	.	.	1710	.	.	.	.	.	.	.	.	.	1720	.	.	.	.	.	.	.	.	.	1730	.	.	.	.	.	.	.	.	.	1740
Sequence	E	Q	A	D	S	L	L	E	N	D	Q	F	Q	G	Q	Q	I	A	E	R	R	K	L	I	A	D	R	Y	D	G	V	K	K	M	A	T	D	R	R	D	K	L	S	K	A	L	N	V	H	Q	F	F	R	D	I	D	D	E	E	S
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1750	.	.	.	.	.	.	.	.	.	1760	.	.	.	.	.	.	.	.	.	1770	.	.	.	.	.	.	.	.	.	1780	.	.	.	.	.	.	.	.	.	1790	.	.	.	.	.	.	.	.	.	1800
Sequence	W	I	K	E	K	K	L	L	V	S	S	D	D	Y	G	R	D	L	P	G	V	Q	N	L	R	R	K	H	R	R	I	D	T	E	L	A	S	H	E	P	Q	V	S	L	V	K	L	K	G	E	E	L	L	R	S	A	A	E	A	G
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?																																							?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1810	.	.	.	.	.	.	.	.	.	1820	.	.	.	.	.	.	.	.	.	1830	.	.	.	.	.	.	.	.	.	1840	.	.	.	.	.	.	.	.	.	1850	.	.	.	.	.	.	.	.	.	1860
Sequence	V	G	E	D	Q	I	K	K	R	M	E	D	L	E	Q	S	W	G	Q	I	R	D	L	T	G	N	R	H	Q	R	L	D	E	S	E	A	F	Q	A	F	L	G	D	V	E	E	E	E	A	W	M	N	E	K	Q	Q	I	L	G	S
Secondary structure
SS confidence
Disorder	?	?																																																										?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1870	.	.	.	.	.	.	.	.	.	1880	.	.	.	.	.	.	.	.	.	1890	.	.	.	.	.	.	.	.	.	1900	.	.	.	.	.	.	.	.	.	1910	.	.	.	.	.	.	.	.	.	1920
Sequence	D	N	F	G	E	N	M	A	G	V	Q	G	L	L	K	K	H	D	T	F	Q	V	D	L	E	L	H	K	Q	R	V	A	D	L	I	N	K	G	D	T	L	I	H	N	G	N	H	H	A	P	H	I	K	Q	R	C	D	Q	L	R
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?																																							?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1930	.	.	.	.	.	.	.	.	.	1940	.	.	.	.	.	.	.	.	.	1950	.	.	.	.	.	.	.	.	.	1960	.	.	.	.	.	.	.	.	.	1970	.	.	.	.	.	.	.	.	.	1980
Sequence	A	R	L	I	E	I	E	S	M	A	E	G	R	L	A	K	L	R	D	N	S	A	Y	L	Q	F	M	W	K	C	D	V	V	E	S	W	I	A	E	K	E	Q	Q	V	R	S	E	D	F	G	R	D	L	S	S	V	Q	I	L	L
Secondary structure
SS confidence
Disorder																																													?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1990	.	.	.	.	.	.	.	.	.	2000	.	.	.	.	.	.	.	.	.	2010	.	.	.	.	.	.	.	.	.	2020	.	.	.	.	.	.	.	.	.	2030	.	.	.	.	.	.	.	.	.	2040
Sequence	T	K	Q	E	A	F	D	A	G	L	N	A	F	E	H	E	G	I	Q	R	I	T	E	L	K	D	Q	L	V	S	S	E	H	Q	Q	S	P	A	I	E	K	R	H	T	N	V	I	Q	R	W	Q	N	L	L	A	H	S	E	A	R
Secondary structure
SS confidence
Disorder																															?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2050	.	.	.	.	.	.	.	.	.	2060	.	.	.	.	.	.	.	.	.	2070	.	.	.	.	.	.	.	.	.	2080	.	.	.	.	.	.	.	.	.	2090	.	.	.	.	.	.	.	.	.	2100
Sequence	R	Q	K	L	L	K	M	Q	Q	Q	F	K	Q	I	E	E	L	Y	L	A	F	A	K	K	A	S	T	F	N	S	W	F	E	N	A	E	E	D	L	T	D	P	V	R	C	N	S	L	E	E	I	R	A	L	R	D	A	H	G	E
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2110	.	.	.	.	.	.	.	.	.	2120	.	.	.	.	.	.	.	.	.	2130	.	.	.	.	.	.	.	.	.	2140	.	.	.	.	.	.	.	.	.	2150	.	.	.	.	.	.	.	.	.	2160
Sequence	F	Q	R	S	L	S	S	A	E	E	D	F	R	Q	L	Q	D	L	D	R	R	I	K	S	F	N	V	G	P	N	P	Y	T	W	F	T	M	D	A	L	E	D	T	W	R	N	L	Q	R	I	I	K	E	R	E	Q	E	L	A	R
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2170	.	.	.	.	.	.	.	.	.	2180	.	.	.	.	.	.	.	.	.	2190	.	.	.	.	.	.	.	.	.	2200	.	.	.	.	.	.	.	.	.	2210	.	.	.	.	.	.	.	.	.	2220
Sequence	E	H	Q	R	Q	E	E	N	D	K	L	R	R	E	F	A	K	L	A	N	A	F	H	A	W	L	T	N	T	R	Q	E	M	M	E	A	G	G	T	L	E	E	Q	L	D	A	V	E	R	K	A	K	E	I	K	A	N	K	G	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	2230	.	.	.	.	.	.	.	.	.	2240	.	.	.	.	.	.	.	.	.	2250	.	.	.	.	.	.	.	.	.	2260	.	.	.	.	.	.	.	.	.	2270	.	.	.	.	.	.	.	.	.	2280
Sequence	L	R	Q	I	E	E	K	G	A	M	L	E	R	N	L	I	L	D	N	R	Y	T	E	H	S	T	V	G	I	A	Q	A	W	D	Q	L	D	Q	L	A	M	R	M	Q	H	N	L	E	Q	Q	I	Q	A	R	N	Q	S	G	V	S
Secondary structure
SS confidence
Disorder																	?	?																																								?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2290	.	.	.	.	.	.	.	.	.	2300	.	.	.	.	.	.	.	.	.	2310	.	.	.	.	.	.	.	.	.	2320	.	.	.	.	.	.	.	.	.	2330	.	.	.	.	.	.	.	.	.	2340
Sequence	E	E	A	L	R	E	F	S	M	M	F	K	H	F	D	K	E	K	T	G	R	L	D	H	Q	Q	F	K	S	C	L	R	A	L	G	Y	D	L	P	M	V	D	E	G	Q	P	E	P	E	F	Q	R	I	L	D	I	V	D	P	N
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?										?	?	?	?		?		?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2350	.	.	.	.	.	.	.	.	.	2360	.	.	.	.	.	.	.	.	.	2370	.	.	.	.	.	.	.	.	.	2380	.	.	.	.	.	.	.	.	.	2390	.	.	.	.	.	.	.	.	.	2400
Sequence	R	D	G	Y	V	T	L	Q	E	Y	M	A	F	M	I	S	K	E	T	E	N	I	Q	S	S	E	E	I	E	M	A	F	R	A	L	S	K	E	F	R	P	Y	V	T	A	E	E	L	Y	A	N	L	T	P	E	Q	A	E	F	C
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?											?		?	?	?	?	?	?		?							?
Disorder confidence

	.	.	.	.	.	.	.	.	.	2410	.	.	.	.	.	.	.	.	.	2420	.	.	.	.	.	.	.	.	.	2430	.	.
Sequence	I	R	R	M	K	P	Y	M	D	A	I	S	G	R	S	I	Q	G	G	L	D	Y	E	Q	F	V	H	A	L	F	Q	S
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?
Disorder confidence