Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	T	N	Y	A	V	I	Y	D	L	H	S	H	T	T	A	S	D	G	C	L	T	P	E	A	L	V	H	R	A	V	E	M	R	V	G	T	L	A	I	T	D	H	D	T	T	A	A	I	A	P	A	R	E	E	I	S	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	G	L	A	L	N	L	I	P	G	V	E	I	S	T	V	W	E	N	H	E	I	H	I	V	G	L	N	I	D	I	T	H	P	L	M	C	E	F	L	A	Q	Q	T	E	R	R	N	Q	R	A	Q	L	I	A	E	R	L	E	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	Q	I	P	G	A	L	E	G	A	Q	R	L	A	Q	G	G	A	V	T	R	G	H	F	A	R	F	L	V	E	C	G	K	A	S	S	M	A	D	V	F	K	K	Y	L	A	R	G	K	T	G	Y	V	P	P	Q	W	C	T	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	Q	A	I	D	V	I	H	H	S	G	G	K	A	V	L	A	H	P	G	R	Y	N	L	S	A	K	W	L	K	R	L	V	A	H	F	A	E	H	H	G	D	A	M	E	V	A	Q	C	Q	Q	S	P	N	E	R	T	Q	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.
Sequence		A	L	A	R	Q	H	H	L	W	A	S	Q	G	S	D	F	H	Q	P	C	P	W	I	E	L	G	R	K	L	W	L	P	A	G	V	E	G	V	W	Q	L	W	E	Q	P	Q	N	T	T	E	R	E	L
Secondary structure
SS confidence
Disorder																																														?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2yb1 chain A Region: 10 - 285 Aligned: 272 Modelled: 276 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: structure of an amidohydrolase from chromobacterium violaceum (efi2 target efi-500202) with bound mn, amp and phosphate. Phyre2 PDB 3e0f chain A Region: 10 - 281 Aligned: 269 Modelled: 272 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent phosphoesterase; PDBTitle: crystal structure of a putative metal-dependent phosphoesterase2 (bad_1165) from bifidobacterium adolescentis atcc 15703 at 2.40 a3 resolution Phyre2 PDB 3dcp chain B Region: 10 - 270 Aligned: 226 Modelled: 230 Confidence: 100.0% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:histidinol-phosphatase; PDBTitle: crystal structure of the putative histidinol phosphatase2 hisk from listeria monocytogenes. northeast structural3 genomics consortium target lmr141. Phyre2 PDB 2yz5 chain B Region: 9 - 290 Aligned: 219 Modelled: 235 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:histidinol phosphatase; PDBTitle: histidinol phosphate phosphatase complexed with phosphate Phyre2 PDB 2w9m chain B Region: 11 - 266 Aligned: 180 Modelled: 193 Confidence: 99.9% Identity: 19% PDB header:dna replication Chain: B: PDB Molecule:polymerase x; PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans Phyre2 PDB 1m65 chain A Region: 9 - 267 Aligned: 182 Modelled: 191 Confidence: 99.9% Identity: 25% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: PHP domain Phyre2 PDB 3qy6 chain A Region: 9 - 269 Aligned: 186 Modelled: 191 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase ywqe; PDBTitle: crystal structures of ywqe from bacillus subtilis and cpsb from2 streptococcus pneumoniae, unique metal-dependent tyrosine3 phosphatases Phyre2 PDB 2wje chain A Region: 9 - 269 Aligned: 186 Modelled: 191 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase cpsb; PDBTitle: crystal structure of the tyrosine phosphatase cps4b from2 steptococcus pneumoniae tigr4. Phyre2 PDB 3e38 chain A Region: 8 - 259 Aligned: 165 Modelled: 171 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:two-domain protein containing predicted php-like metal- PDBTitle: crystal structure of a two-domain protein containing predicted php-2 like metal-dependent phosphoesterase (bvu_3505) from bacteroides3 vulgatus atcc 8482 at 2.20 a resolution Phyre2 PDB 2hnh chain A Region: 1 - 262 Aligned: 197 Modelled: 202 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii alpha subunit; PDBTitle: crystal structure of the catalytic alpha subunit of e. coli2 replicative dna polymerase iii Phyre2 PDB 2anu chain A Region: 8 - 284 Aligned: 181 Modelled: 194 Confidence: 99.9% Identity: 28% PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution Phyre2 PDB 2anu chain A domain 1 Region: 8 - 284 Aligned: 181 Modelled: 194 Confidence: 99.9% Identity: 28% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: PHP domain Phyre2 PDB 3e0d chain A Region: 9 - 262 Aligned: 189 Modelled: 191 Confidence: 99.8% Identity: 23% PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: insights into the replisome from the crystral structure of2 the ternary complex of the eubacterial dna polymerase iii3 alpha-subunit Phyre2 PDB 3f2c chain A Region: 10 - 262 Aligned: 187 Modelled: 189 Confidence: 99.8% Identity: 18% PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn Phyre2 PDB 1v77 chain A Region: 181 - 282 Aligned: 93 Modelled: 102 Confidence: 89.7% Identity: 10% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: RNase P subunit p30 Phyre2 PDB 1yix chain A domain 1 Region: 8 - 42 Aligned: 35 Modelled: 35 Confidence: 89.2% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 1xwy chain A domain 1 Region: 9 - 68 Aligned: 59 Modelled: 60 Confidence: 87.6% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 3ipw chain A Region: 9 - 71 Aligned: 62 Modelled: 63 Confidence: 87.4% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase tatd family protein; PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica Phyre2 PDB 2y1h chain A Region: 9 - 71 Aligned: 62 Modelled: 63 Confidence: 87.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3; PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3) Phyre2 PDB 2xio chain A Region: 9 - 71 Aligned: 61 Modelled: 63 Confidence: 85.7% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1; PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a Phyre2 PDB 3rys chain A Region: 2 - 38 Aligned: 33 Modelled: 33 Confidence: 66.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase 1; PDBTitle: the crystal structure of adenine deaminase (aaur1117) from2 arthrobacter aurescens Phyre2 1 c2yb1A_ 2 c3e0fA_ 3 c3dcpB_ 4 c2yz5B_ 5 c2w9mB_ 6 d1m65a_ 7 c3qy6A_ 8 c2wjeA_ 9 c3e38A_ 10 c2hnhA_ 11 c2anuA_ 12 d2anua1 13 c3e0dA_ 14 c3f2cA_ 15 d1v77a_ 16 d1yixa1 17 d1xwya1 18 c3ipwA_ 19 c2y1hA_ 20 c2xioA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 c3rysA_ 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2yb1A_ 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: structure of an amidohydrolase from chromobacterium violaceum (efi2 target efi-500202) with bound mn, amp and phosphate. 2 c3e0fA_ 100.0 28 PDB header:hydrolase Chain: A: PDB Molecule:putative metal-dependent phosphoesterase; PDBTitle: crystal structure of a putative metal-dependent phosphoesterase2 (bad_1165) from bifidobacterium adolescentis atcc 15703 at 2.40 a3 resolution 3 c3dcpB_ 100.0 14 PDB header:hydrolase Chain: B: PDB Molecule:histidinol-phosphatase; PDBTitle: crystal structure of the putative histidinol phosphatase2 hisk from listeria monocytogenes. northeast structural3 genomics consortium target lmr141. 4 c2yz5B_ 100.0 22 PDB header:hydrolase Chain: B: PDB Molecule:histidinol phosphatase; PDBTitle: histidinol phosphate phosphatase complexed with phosphate 5 c2w9mB_ 99.9 19 PDB header:dna replication Chain: B: PDB Molecule:polymerase x; PDBTitle: structure of family x dna polymerase from deinococcus2 radiodurans 6 d1m65a_ 99.9 25 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:PHP domain 7 c3qy6A_ 99.9 19 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase ywqe; PDBTitle: crystal structures of ywqe from bacillus subtilis and cpsb from2 streptococcus pneumoniae, unique metal-dependent tyrosine3 phosphatases 8 c2wjeA_ 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase cpsb; PDBTitle: crystal structure of the tyrosine phosphatase cps4b from2 steptococcus pneumoniae tigr4. 9 c3e38A_ 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:two-domain protein containing predicted php-like metal- PDBTitle: crystal structure of a two-domain protein containing predicted php-2 like metal-dependent phosphoesterase (bvu_3505) from bacteroides3 vulgatus atcc 8482 at 2.20 a resolution 10 c2hnhA_ 99.9 20 PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii alpha subunit; PDBTitle: crystal structure of the catalytic alpha subunit of e. coli2 replicative dna polymerase iii 11 c2anuA_ 99.9 28 PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution 12 d2anua1 99.9 28 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:PHP domain 13 c3e0dA_ 99.8 23 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase iii subunit alpha; PDBTitle: insights into the replisome from the crystral structure of2 the ternary complex of the eubacterial dna polymerase iii3 alpha-subunit 14 c3f2cA_ 99.8 18 PDB header:transferase/dna Chain: A: PDB Molecule:geobacillus kaustophilus dna polc; PDBTitle: dna polymerase polc from geobacillus kaustophilus complex with dna,2 dgtp and mn 15 d1v77a_ 89.7 10 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:RNase P subunit p30 16 d1yixa1 89.2 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 17 d1xwya1 87.6 17 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 18 c3ipwA_ 87.4 23 PDB header:hydrolase Chain: A: PDB Molecule:hydrolase tatd family protein; PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica 19 c2y1hA_ 87.0 18 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3; PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3) 20 c2xioA_ 85.7 21 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1; PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a 21 c3e2vA_ not modelled 85.7 27 PDB header:hydrolase Chain: A: PDB Molecule:3'-5'-exonuclease; PDBTitle: crystal structure of an uncharacterized amidohydrolase from2 saccharomyces cerevisiae 22 c2gzxB_ not modelled 84.4 20 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative tatd related dnase; PDBTitle: crystal structure of the tatd deoxyribonuclease mw0446 from2 staphylococcus aureus. northeast structural genomics consortium3 target zr237. 23 d1xrta2 not modelled 83.7 20 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 24 d1zzma1 not modelled 83.3 26 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 25 c3a24A_ not modelled 82.0 17 PDB header:hydrolase Chain: A: PDB Molecule:alpha-galactosidase; PDBTitle: crystal structure of bt1871 retaining glycosidase 26 d1j6oa_ not modelled 81.2 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like 27 c3rcmA_ not modelled 79.4 17 PDB header:hydrolase Chain: A: PDB Molecule:tatd family hydrolase; PDBTitle: crystal structure of efi target 500140:tatd family hydrolase from2 pseudomonas putida 28 d1bf6a_ not modelled 78.9 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 29 d1qwga_ not modelled 78.0 15 Fold:TIM beta/alpha-barrel Superfamily:(2r)-phospho-3-sulfolactate synthase ComA Family:(2r)-phospho-3-sulfolactate synthase ComA 30 d2ffia1 not modelled 78.0 9 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like 31 d1gkra2 not modelled 74.5 18 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 32 d2icsa2 not modelled 73.2 15 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenine deaminase-like 33 d1ynya2 not modelled 72.1 15 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 34 d1k1da2 not modelled 71.5 21 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 35 d1oi7a1 not modelled 69.5 6 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:CoA-binding domain 36 d2fvka2 not modelled 68.8 26 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 37 d1vfla1 not modelled 68.7 23 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 38 c2zq0B_ not modelled 68.5 8 PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase (alpha-glucosidase susb); PDBTitle: crystal structure of susb complexed with acarbose 39 d1a4ma_ not modelled 68.5 27 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 40 d1o12a2 not modelled 67.6 15 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 41 d2amxa1 not modelled 67.1 20 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenosine/AMP deaminase 42 c3rysA_ 66.0 30 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase 1; PDBTitle: the crystal structure of adenine deaminase (aaur1117) from2 arthrobacter aurescens 43 d1nfga2 not modelled 64.6 21 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 44 c3ogrA_ not modelled 64.6 11 PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: complex structure of beta-galactosidase from trichoderma reesei with2 galactose 45 d1yx1a1 not modelled 64.3 16 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:KguE-like 46 d2ftwa2 not modelled 63.3 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 47 d1gkpa2 not modelled 63.0 20 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain 48 d1qtwa_ not modelled 62.5 13 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Endonuclease IV 49 c3ktcB_ not modelled 62.5 7 PDB header:isomerase Chain: B: PDB Molecule:xylose isomerase; PDBTitle: crystal structure of putative sugar isomerase (yp_050048.1) from2 erwinia carotovora atroseptica scri1043 at 1.54 a resolution 50 c2yv2A_ not modelled 61.6 13 PDB header:ligase Chain: A: PDB Molecule:succinyl-coa synthetase alpha chain; PDBTitle: crystal structure of succinyl-coa synthetase alpha chain from2 aeropyrum pernix k1 51 c2x7vA_ not modelled 61.0 10 PDB header:hydrolase Chain: A: PDB Molecule:probable endonuclease 4; PDBTitle: crystal structure of thermotoga maritima endonuclease iv in2 the presence of zinc 52 d1onwa2 not modelled 60.8 27 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Isoaspartyl dipeptidase, catalytic domain 53 c3aamA_ not modelled 60.5 16 PDB header:hydrolase Chain: A: PDB Molecule:endonuclease iv; PDBTitle: crystal structure of endonuclease iv from thermus thermophilus hb8 54 c3gg7A_ not modelled 60.4 29 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized metalloprotein; PDBTitle: crystal structure of an uncharacterized metalloprotein from2 deinococcus radiodurans 55 d1i0da_ not modelled 59.7 14 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 56 c3dmyA_ not modelled 59.0 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:protein fdra; PDBTitle: crystal structure of a predicated acyl-coa synthetase from e.coli 57 d1foba_ not modelled 58.1 17 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 58 d2p9ba2 not modelled 56.4 22 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like 59 c2zvrA_ not modelled 52.5 15 PDB header:isomerase Chain: A: PDB Molecule:uncharacterized protein tm_0416; PDBTitle: crystal structure of a d-tagatose 3-epimerase-related2 protein from thermotoga maritima 60 c3cjpA_ not modelled 51.7 24 PDB header:hydrolase Chain: A: PDB Molecule:predicted amidohydrolase, dihydroorotase family; PDBTitle: crystal structure of an uncharacterized amidohydrolase cac3332 from2 clostridium acetobutylicum 61 d1x92a_ not modelled 50.9 17 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 62 c2x3yA_ not modelled 50.8 13 PDB header:isomerase Chain: A: PDB Molecule:phosphoheptose isomerase; PDBTitle: crystal structure of gmha from burkholderia pseudomallei 63 d1un7a2 not modelled 50.1 23 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 64 c2ou4C_ not modelled 50.1 20 PDB header:isomerase Chain: C: PDB Molecule:d-tagatose 3-epimerase; PDBTitle: crystal structure of d-tagatose 3-epimerase from2 pseudomonas cichorii 65 c3ju2A_ not modelled 49.4 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein smc04130; PDBTitle: crystal structure of protein smc04130 from sinorhizobium meliloti 1021 66 d2d2ja1 not modelled 47.4 13 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like 67 c3msrA_ not modelled 47.1 19 PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolases; PDBTitle: the crystal structure of an amidohydrolase from mycoplasma synoviae 68 c1oi7A_ not modelled 47.1 6 PDB header:synthetase Chain: A: PDB Molecule:succinyl-coa synthetase alpha chain; PDBTitle: the crystal structure of succinyl-coa synthetase alpha2 subunit from thermus thermophilus 69 c3pnuA_ not modelled 46.8 17 PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: 2.4 angstrom crystal structure of dihydroorotase (pyrc) from2 campylobacter jejuni. 70 c2yv1A_ not modelled 46.3 10 PDB header:ligase Chain: A: PDB Molecule:succinyl-coa ligase [adp-forming] subunit alpha; PDBTitle: crystal structure of succinyl-coa synthetase alpha chain from2 methanocaldococcus jannaschii dsm 2661 71 c3jzeC_ not modelled 45.8 17 PDB header:hydrolase Chain: C: PDB Molecule:dihydroorotase; PDBTitle: 1.8 angstrom resolution crystal structure of dihydroorotase (pyrc)2 from salmonella enterica subsp. enterica serovar typhimurium str. lt2 72 c3f4cA_ not modelled 45.5 21 PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus hydrolase; PDBTitle: crystal structure of organophosphorus hydrolase from geobacillus2 stearothermophilus strain 10, with glycerol bound 73 c3shoA_ not modelled 45.1 30 PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, rpir family; PDBTitle: crystal structure of rpir transcription factor from sphaerobacter2 thermophilus (sugar isomerase domain) 74 c1o12B_ not modelled 43.8 15 PDB header:hydrolase Chain: B: PDB Molecule:n-acetylglucosamine-6-phosphate deacetylase; PDBTitle: crystal structure of n-acetylglucosamine-6-phosphate2 deacetylase (tm0814) from thermotoga maritima at 2.5 a3 resolution 75 c3pnzD_ not modelled 43.0 11 PDB header:hydrolase Chain: D: PDB Molecule:phosphotriesterase family protein; PDBTitle: crystal structure of the lactonase lmo2620 from listeria monocytogenes 76 c3ou8A_ not modelled 43.0 33 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase; PDBTitle: the crystal structure of adenosine deaminase from pseudomonas2 aeruginosa 77 c3thdD_ not modelled 42.9 12 PDB header:hydrolase Chain: D: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of human beta-galactosidase in complex with 1-2 deoxygalactonojirimycin 78 d1vkya_ not modelled 42.8 15 Fold:QueA-like Superfamily:QueA-like Family:QueA-like 79 d2eg6a1 not modelled 42.2 17 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Dihydroorotase 80 c3lggA_ not modelled 42.1 25 PDB header:hydrolase Chain: A: PDB Molecule:adenosine deaminase cecr1; PDBTitle: crystal structure of human adenosine deaminase growth factor,2 adenosine deaminase type 2 (ada2) complexed with transition state3 analogue, coformycin 81 c3cnyA_ not modelled 41.5 17 PDB header:biosynthetic protein Chain: A: PDB Molecule:inositol catabolism protein iole; PDBTitle: crystal structure of a putative inositol catabolism protein iole2 (iole, lp_3607) from lactobacillus plantarum wcfs1 at 1.85 a3 resolution 82 c3nqbB_ not modelled 41.3 29 PDB header:hydrolase Chain: B: PDB Molecule:adenine deaminase 2; PDBTitle: crystal structure of adenine deaminase from agrobacterium tumefaciens2 (str. c 58) 83 c3ou8B_ not modelled 41.3 33 PDB header:hydrolase Chain: B: PDB Molecule:adenosine deaminase; PDBTitle: the crystal structure of adenosine deaminase from pseudomonas2 aeruginosa 84 c2nu8D_ not modelled 40.9 4 PDB header:ligase Chain: D: PDB Molecule:succinyl-coa ligase [adp-forming] subunit alpha; PDBTitle: c123at mutant of e. coli succinyl-coa synthetase 85 c1pscA_ not modelled 40.1 16 PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: phosphotriesterase from pseudomonas diminuta 86 c2xhzC_ not modelled 39.1 20 PDB header:isomerase Chain: C: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: probing the active site of the sugar isomerase domain from e. coli2 arabinose-5-phosphate isomerase via x-ray crystallography 87 c3trjC_ not modelled 38.9 17 PDB header:isomerase Chain: C: PDB Molecule:phosphoheptose isomerase; PDBTitle: structure of a phosphoheptose isomerase from francisella tularensis 88 c1xrfA_ not modelled 38.2 20 PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: the crystal structure of a novel, latent dihydroorotase from aquifex2 aeolicus at 1.7 a resolution 89 c2je8B_ not modelled 37.8 11 PDB header:hydrolase Chain: B: PDB Molecule:beta-mannosidase; PDBTitle: structure of a beta-mannosidase from bacteroides2 thetaiotaomicron 90 d1rd5a_ not modelled 37.1 12 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 91 c2z00A_ not modelled 37.1 22 PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: crystal structure of dihydroorotase from thermus thermophilus 92 c2hmcA_ not modelled 36.8 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: the crystal structure of dihydrodipicolinate synthase dapa from2 agrobacterium tumefaciens 93 c2vunC_ not modelled 36.7 18 PDB header:hydrolase Chain: C: PDB Molecule:enamidase; PDBTitle: the crystal structure of enamidase at 1.9 a resolution - a2 new member of the amidohydrolase superfamily 94 c3dx5A_ not modelled 36.7 19 PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein asbf; PDBTitle: crystal structure of the probable 3-dhs dehydratase asbf involved in2 the petrobactin synthesis from bacillus anthracis 95 d2je8a5 not modelled 36.0 13 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 96 c3fxaA_ not modelled 35.8 7 PDB header:sugar binding protein Chain: A: PDB Molecule:sis domain protein; PDBTitle: crystal structure of a putative sugar-phosphate isomerase2 (lmof2365_0531) from listeria monocytogenes str. 4b f2365 at 1.60 a3 resolution 97 c3kwsB_ not modelled 35.6 5 PDB header:isomerase Chain: B: PDB Molecule:putative sugar isomerase; PDBTitle: crystal structure of putative sugar isomerase (yp_001305149.1) from2 parabacteroides distasonis atcc 8503 at 1.68 a resolution 98 d1tg7a5 not modelled 35.4 3 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Glycosyl hydrolases family 35 catalytic domain 99 c2hk1D_ not modelled 35.2 18 PDB header:isomerase Chain: D: PDB Molecule:d-psicose 3-epimerase; PDBTitle: crystal structure of d-psicose 3-epimerase (dpease) in the presence of2 d-fructose 100 c3cqkB_ not modelled 35.1 11 PDB header:isomerase Chain: B: PDB Molecule:l-ribulose-5-phosphate 3-epimerase ulae; PDBTitle: crystal structure of l-xylulose-5-phosphate 3-epimerase ulae (form b)2 complex with zn2+ and sulfate 101 d1vima_ not modelled 34.6 15 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 102 c3e0vB_ not modelled 34.3 12 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions 103 c2zdsB_ not modelled 34.2 17 PDB header:dna binding protein Chain: B: PDB Molecule:putative dna-binding protein; PDBTitle: crystal structure of sco6571 from streptomyces coelicolor2 a3(2) 104 c2vr2A_ not modelled 34.0 15 PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidinase; PDBTitle: human dihydropyrimidinase 105 c1pklB_ not modelled 33.8 12 PDB header:transferase Chain: B: PDB Molecule:protein (pyruvate kinase); PDBTitle: the structure of leishmania pyruvate kinase 106 c2gwnA_ not modelled 33.5 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dihydroorotase; PDBTitle: the structure of putative dihydroorotase from porphyromonas2 gingivalis. 107 d1ezwa_ not modelled 32.9 17 Fold:TIM beta/alpha-barrel Superfamily:Bacterial luciferase-like Family:F420 dependent oxidoreductases 108 c3guwB_ not modelled 32.6 19 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein af_1765; PDBTitle: crystal structure of the tatd-like protein (af1765) from2 archaeoglobus fulgidus, northeast structural genomics3 consortium target gr121 109 d3bula2 not modelled 32.4 16 Fold:Flavodoxin-like Superfamily:Cobalamin (vitamin B12)-binding domain Family:Cobalamin (vitamin B12)-binding domain 110 c3obeB_ not modelled 32.2 9 PDB header:isomerase Chain: B: PDB Molecule:sugar phosphate isomerase/epimerase; PDBTitle: crystal structure of a sugar phosphate isomerase/epimerase (bdi_3400)2 from parabacteroides distasonis atcc 8503 at 1.70 a resolution 111 d2imra2 not modelled 31.5 18 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:DR0824-like 112 c3d6nA_ not modelled 31.4 20 PDB header:hydrolase/transferase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: crystal structure of aquifex dihydroorotase activated by aspartate2 transcarbamoylase 113 d1xrsb1 not modelled 31.3 24 Fold:Flavodoxin-like Superfamily:Cobalamin (vitamin B12)-binding domain Family:Cobalamin (vitamin B12)-binding domain 114 d2ohwa1 not modelled 30.9 13 Fold:Bacillus chorismate mutase-like Superfamily:YueI-like Family:YueI-like 115 c3khdC_ not modelled 30.5 16 PDB header:transferase Chain: C: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pff1300w. 116 c2wm1A_ not modelled 30.3 26 PDB header:lyase Chain: A: PDB Molecule:2-amino-3-carboxymuconate-6-semialdehyde PDBTitle: the crystal structure of human alpha-amino-beta-2 carboxymuconate-epsilon-semialdehyde decarboxylase in3 complex with 1,3- dihydroxyacetonephosphate suggests a4 regulatory link between nad synthesis and glycolysis 117 c1xc6A_ not modelled 30.2 8 PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: native structure of beta-galactosidase from penicillium sp. in complex2 with galactose 118 d1tk9a_ not modelled 30.0 15 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain 119 d4ubpc2 not modelled 29.8 31 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:alpha-subunit of urease, catalytic domain 120 d1jeoa_ not modelled 29.7 14 Fold:SIS domain Superfamily:SIS domain Family:mono-SIS domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0