Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	K	R	K	V	A	I	I	G	S	G	N	I	G	T	D	L	M	I	K	I	L	R	H	G	Q	H	L	E	M	A	V	M	V	G	I	D	P	Q	S	D	G	L	A	R	A	R	R	M	G	V	A	T	T	H	E	G	V	I
Secondary structure
SS confidence
Disorder		?	?	?	?																																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	M	N	M	P	E	F	A	D	I	D	I	V	F	D	A	T	S	A	G	A	H	V	K	N	D	A	A	L	R	E	A	K	P	D	I	R	L	I	D	L	T	P	A	A	I	G	P	Y	C	V	P	V	V	N	L	E	A	N
Secondary structure
SS confidence
Disorder																										?									?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	D	Q	L	N	V	N	M	V	T	C	G	G	Q	A	T	I	P	M	V	A	A	V	S	R	V	A	R	V	H	Y	A	E	I	I	A	S	I	A	S	K	S	A	G	P	G	T	R	A	N	I	D	E	F	T	E	T	T	S	R
Secondary structure
SS confidence
Disorder		?																																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	I	E	V	V	G	G	A	A	K	G	K	A	I	I	V	L	N	P	A	E	P	P	L	M	M	R	D	T	V	Y	V	L	S	D	E	A	S	Q	D	D	I	E	A	S	I	N	E	M	A	E	A	V	Q	A	Y	V	P	G	Y
Secondary structure
SS confidence
Disorder																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	L	K	Q	R	V	Q	F	E	V	I	P	Q	D	K	P	V	N	L	P	G	V	G	Q	F	S	G	L	K	T	A	V	W	L	E	V	E	G	A	A	H	Y	L	P	A	Y	A	G	N	L	D	I	M	T	S	S	A	L	A	T
Secondary structure
SS confidence
Disorder							?		?	?			?	?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Sequence		A	E	K	M	A	Q	S	L	A	R	K	A	G	E	A	A
Secondary structure
SS confidence
Disorder									?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1nvm chain B Region: 2 - 311 Aligned: 310 Modelled: 310 Confidence: 100.0% Identity: 78% PDB header:lyase/oxidoreductase Chain: B: PDB Molecule:acetaldehyde dehydrogenase (acylating); PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate Phyre2 PDB 1nvm chain B domain 1 Region: 2 - 156 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 67% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1nvm chain B domain 2 Region: 131 - 285 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 81% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: GAPDH-like Phyre2 PDB 1b7g chain O Region: 4 - 164 Aligned: 157 Modelled: 161 Confidence: 99.5% Identity: 17% PDB header:oxidoreductase Chain: O: PDB Molecule:protein (glyceraldehyde 3-phosphate dehydrogenase); PDBTitle: glyceraldehyde 3-phosphate dehydrogenase Phyre2 PDB 3kub chain A Region: 4 - 228 Aligned: 217 Modelled: 225 Confidence: 99.5% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:aspartate-semialdehyde dehydrogenase; PDBTitle: crystal structure of aspartate semi-aldehyde dehydrogenase complexed2 with glycerol and phosphate of mycobacterium tuberculosis h37rv Phyre2 PDB 1cf2 chain Q Region: 4 - 168 Aligned: 161 Modelled: 165 Confidence: 99.4% Identity: 18% PDB header:oxidoreductase Chain: Q: PDB Molecule:protein (glyceraldehyde-3-phosphate PDBTitle: three-dimensional structure of d-glyceraldehyde-3-phosphate2 dehydrogenase from the hyperthermophilic archaeon3 methanothermus fervidus Phyre2 PDB 2qz9 chain B Region: 3 - 277 Aligned: 238 Modelled: 262 Confidence: 99.4% Identity: 21% PDB header:oxidoreductase Chain: B: PDB Molecule:aspartate-semialdehyde dehydrogenase; PDBTitle: crystal structure of aspartate semialdehyde dehydrogenase2 ii from vibrio cholerae Phyre2 PDB 2hjs chain A domain 1 Region: 3 - 143 Aligned: 132 Modelled: 141 Confidence: 99.4% Identity: 17% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2czc chain D Region: 3 - 227 Aligned: 222 Modelled: 225 Confidence: 99.4% Identity: 21% PDB header:oxidoreductase Chain: D: PDB Molecule:glyceraldehyde-3-phosphate dehydrogenase; PDBTitle: crystal structure of glyceraldehyde-3-phosphate dehydrogenase from2 pyrococcus horikoshii ot3 Phyre2 PDB 2hjs chain A Region: 3 - 228 Aligned: 214 Modelled: 220 Confidence: 99.3% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:usg-1 protein homolog; PDBTitle: the structure of a probable aspartate-semialdehyde dehydrogenase from2 pseudomonas aeruginosa Phyre2 PDB 2ozp chain A Region: 3 - 166 Aligned: 158 Modelled: 157 Confidence: 99.3% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:n-acetyl-gamma-glutamyl-phosphate reductase; PDBTitle: crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase2 (ttha1904) from thermus thermophilus Phyre2 PDB 1t4b chain A domain 1 Region: 4 - 147 Aligned: 138 Modelled: 144 Confidence: 99.2% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1cf2 chain O domain 1 Region: 4 - 161 Aligned: 144 Modelled: 158 Confidence: 99.2% Identity: 22% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2gz3 chain D Region: 5 - 277 Aligned: 250 Modelled: 264 Confidence: 99.1% Identity: 15% PDB header:oxidoreductase Chain: D: PDB Molecule:aspartate beta-semialdehyde dehydrogenase; PDBTitle: structure of aspartate semialdehyde dehydrogenase (asadh) from2 streptococcus pneumoniae complexed with nadp and aspartate-3 semialdehyde Phyre2 PDB 1ys4 chain A Region: 3 - 228 Aligned: 222 Modelled: 223 Confidence: 99.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:aspartate-semialdehyde dehydrogenase; PDBTitle: structure of aspartate-semialdehyde dehydrogenase from2 methanococcus jannaschii Phyre2 PDB 2yyy chain B Region: 4 - 228 Aligned: 221 Modelled: 225 Confidence: 99.0% Identity: 21% PDB header:oxidoreductase Chain: B: PDB Molecule:glyceraldehyde-3-phosphate dehydrogenase; PDBTitle: crystal structure of glyceraldehyde-3-phosphate2 dehydrogenase Phyre2 PDB 1t4b chain B Region: 5 - 229 Aligned: 221 Modelled: 225 Confidence: 99.0% Identity: 14% PDB header:oxidoreductase Chain: B: PDB Molecule:aspartate-semialdehyde dehydrogenase; PDBTitle: 1.6 angstrom structure of esherichia coli aspartate-2 semialdehyde dehydrogenase. Phyre2 PDB 2gz1 chain A domain 1 Region: 5 - 156 Aligned: 139 Modelled: 152 Confidence: 98.9% Identity: 17% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2yv3 chain B Region: 4 - 182 Aligned: 162 Modelled: 176 Confidence: 98.9% Identity: 22% PDB header:oxidoreductase Chain: B: PDB Molecule:aspartate-semialdehyde dehydrogenase; PDBTitle: crystal structure of aspartate semialdehyde dehydrogenase from thermus2 thermophilus hb8 Phyre2 PDB 2ep5 chain B Region: 3 - 144 Aligned: 138 Modelled: 142 Confidence: 98.9% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:350aa long hypothetical aspartate-semialdehyde PDBTitle: structural study of project id st1242 from sulfolobus tokodaii strain7 Phyre2 1 c1nvmB_ 2 d1nvmb1 3 d1nvmb2 4 c1b7gO_ 5 c3kubA_ 6 c1cf2Q_ 7 c2qz9B_ 8 d2hjsa1 9 c2czcD_ 10 c2hjsA_ 11 c2ozpA_ 12 d1t4ba1 13 d1cf2o1 14 c2gz3D_ 15 c1ys4A_ 16 c2yyyB_ 17 c1t4bB_ 18 d2gz1a1 19 c2yv3B_ 20 c2ep5B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499