Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	I	N	K	F	V	L	T	V	S	L	L	I	F	I	M	I	S	A	V	A	C	G	I	Y	T	Q	M	V	K	E	R	V	Y	S	L	K	Q	S	V	I	D	T	A	F	A	V	A	N	I	A	E	Y	R	R	S	V	A
Secondary structure
SS confidence
Disorder		?	?	?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	D	L	I	N	T	L	N	P	T	E	E	Q	L	L	V	G	L	R	T	A	Y	A	D	S	V	S	P	S	Y	L	Y	D	V	G	P	Y	L	I	S	S	D	E	C	I	Q	V	K	E	F	E	K	N	Y	C	A	D	I	M	Q
Secondary structure
SS confidence
Disorder																						?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	K	Y	R	H	V	K	N	T	G	F	I	S	F	D	G	K	T	F	V	Y	Y	L	Y	P	V	T	H	N	R	S	L	I	F	L	L	G	L	E	R	F	S	L	L	S	K	S	L	A	M	D	S	E	N	L	M	F	S	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	K	N	G	K	P	V	T	G	D	E	Y	N	A	K	N	A	I	F	T	V	S	E	A	M	E	H	F	A	Y	L	P	T	G	L	Y	V	F	A	Y	K	K	D	V	Y	L	R	V	C	T	L	I	I	F	F	A	A	L	V	A
Secondary structure
SS confidence
Disorder				?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	I	S	G	A	S	C	L	Y	L	V	R	R	V	I	N	R	G	I	V	E	K	E	A	I	I	N	N	H	F	E	R	V	L	D	G	G	L	F	F	S	A	A	D	V	K	K	L	Y	S	M	Y	N	S	A	F	L	D	D	L
Secondary structure
SS confidence
Disorder																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	K	A	M	G	R	K	S	F	D	E	D	L	K	A	L	P	E	K	G	G	Y	L	C	L	F	D	V	D	K	F	K	N	I	N	D	T	F	G	H	L	L	G	D	E	V	L	M	K	V	V	K	I	L	K	S	Q	I	P	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		D	K	G	K	V	Y	R	F	G	G	D	E	F	A	V	I	Y	T	G	G	T	L	E	E	L	L	S	I	L	K	E	I	V	H	F	Q	V	G	S	I	N	L	S	T	S	I	G	V	A	H	S	N	E	C	P	T	V	E	R	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.
Sequence		K	M	L	A	D	E	R	L	Y	K	S	K	K	N	G	R	A	Q	I	S	W	Q
Secondary structure
SS confidence
Disorder																		?					?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1w25 chain B Region: 264 - 440 Aligned: 176 Modelled: 177 Confidence: 100.0% Identity: 32% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 3ezu chain A Region: 272 - 440 Aligned: 163 Modelled: 169 Confidence: 100.0% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution Phyre2 PDB 3bre chain A Region: 246 - 441 Aligned: 196 Modelled: 196 Confidence: 100.0% Identity: 26% PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 Phyre2 PDB 3i5a chain A Region: 246 - 440 Aligned: 195 Modelled: 195 Confidence: 100.0% Identity: 26% PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae Phyre2 PDB 3qyy chain B Region: 290 - 442 Aligned: 150 Modelled: 153 Confidence: 100.0% Identity: 27% PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp Phyre2 PDB 3i5c chain A Region: 267 - 440 Aligned: 174 Modelled: 174 Confidence: 100.0% Identity: 30% PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa Phyre2 PDB 3i5b chain A Region: 294 - 441 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 30% PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa Phyre2 PDB 3hva chain A Region: 294 - 439 Aligned: 145 Modelled: 146 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa Phyre2 PDB 3icl chain A Region: 297 - 441 Aligned: 144 Modelled: 144 Confidence: 100.0% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c Phyre2 PDB 3ign chain A Region: 293 - 441 Aligned: 148 Modelled: 145 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a Phyre2 PDB 1w25 chain A domain 3 Region: 300 - 442 Aligned: 142 Modelled: 143 Confidence: 100.0% Identity: 38% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: GGDEF domain Phyre2 PDB 3mtk chain A Region: 290 - 441 Aligned: 148 Modelled: 152 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c Phyre2 PDB 3pjw chain A Region: 280 - 442 Aligned: 163 Modelled: 163 Confidence: 100.0% Identity: 24% PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 Phyre2 PDB 3hvw chain A Region: 304 - 442 Aligned: 137 Modelled: 139 Confidence: 100.0% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c Phyre2 PDB 3gfz chain B Region: 294 - 442 Aligned: 127 Modelled: 129 Confidence: 99.8% Identity: 13% PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex Phyre2 PDB 3p7n chain B Region: 281 - 346 Aligned: 66 Modelled: 66 Confidence: 98.9% Identity: 8% PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis Phyre2 PDB 2qv6 chain D Region: 318 - 428 Aligned: 104 Modelled: 111 Confidence: 97.7% Identity: 22% PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions Phyre2 PDB 1fx2 chain A Region: 317 - 407 Aligned: 90 Modelled: 91 Confidence: 94.7% Identity: 16% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: Adenylyl and guanylyl cyclase catalytic domain Phyre2 PDB 1wc6 chain B Region: 318 - 410 Aligned: 93 Modelled: 92 Confidence: 93.6% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate Phyre2 PDB 3mr7 chain B Region: 318 - 410 Aligned: 93 Modelled: 93 Confidence: 92.7% Identity: 9% PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi Phyre2 1 c1w25B_ 2 c3ezuA_ 3 c3breA_ 4 c3i5aA_ 5 c3qyyB_ 6 c3i5cA_ 7 c3i5bA_ 8 c3hvaA_ 9 c3iclA_ 10 c3ignA_ 11 d1w25a3 12 c3mtkA_ 13 c3pjwA_ 14 c3hvwA_ 15 c3gfzB_ 16 c3p7nB_ 17 c2qv6D_ 18 d1fx2a_ 19 c1wc6B_ 20 c3mr7B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1w25B_ 100.0 32 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 2 c3ezuA_ 100.0 24 PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution 3 c3breA_ 100.0 26 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 4 c3i5aA_ 100.0 26 PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae 5 c3qyyB_ 100.0 27 PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp 6 c3i5cA_ 100.0 30 PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa 7 c3i5bA_ 100.0 30 PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa 8 c3hvaA_ 100.0 21 PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa 9 c3iclA_ 100.0 33 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c 10 c3ignA_ 100.0 30 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a 11 d1w25a3 100.0 38 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:GGDEF domain 12 c3mtkA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c 13 c3pjwA_ 100.0 24 PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 14 c3hvwA_ 100.0 13 PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c 15 c3gfzB_ 99.8 13 PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex 16 c3p7nB_ 98.9 8 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 17 c2qv6D_ 97.7 22 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 18 d1fx2a_ 94.7 16 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 19 c1wc6B_ 93.6 14 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate 20 c3mr7B_ 92.7 9 PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi 21 c1cjkA_ not modelled 91.6 8 PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn 22 c2w01C_ not modelled 91.4 14 PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 23 d1wc1a_ not modelled 91.0 15 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 24 c1s97D_ not modelled 90.2 15 PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch 25 c2aq4A_ not modelled 89.9 23 PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. 26 c1ybuA_ not modelled 88.9 13 PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. 27 d1azsa_ not modelled 88.2 8 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 28 d1fx4a_ not modelled 88.0 14 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 29 c3uvjC_ not modelled 87.8 13 PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. 30 c3gqcB_ not modelled 87.7 19 PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex 31 c1k1qA_ not modelled 84.7 15 PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus 32 d1k1sa2 not modelled 83.9 15 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 33 c2r8kB_ not modelled 80.0 24 PDB header:replication, transferase/dna Chain: B: PDB Molecule:dna polymerase eta; PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna 34 c3onqB_ not modelled 79.7 4 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:regulator of polyketide synthase expression; PDBTitle: crystal structure of regulator of polyketide synthase expression2 bad_0249 from bifidobacterium adolescentis 35 d1jx4a2 not modelled 78.6 13 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 36 d1im4a_ not modelled 76.2 14 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 37 c1jihA_ not modelled 74.9 24 PDB header:translation Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: yeast dna polymerase eta 38 c3et6A_ not modelled 72.6 12 PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase 39 c1yk9A_ not modelled 72.3 9 PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c 40 d1jiha2 not modelled 65.7 23 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 41 c1t3nB_ not modelled 65.3 34 PDB header:replication/dna Chain: B: PDB Molecule:polymerase (dna directed) iota; PDBTitle: structure of the catalytic core of dna polymerase iota in2 complex with dna and dttp 42 c2fllA_ not modelled 63.1 31 PDB header:replication/dna Chain: A: PDB Molecule:dna polymerase iota; PDBTitle: ternary complex of human dna polymerase iota with dna and dttp 43 c1t94B_ not modelled 62.2 24 PDB header:replication Chain: B: PDB Molecule:polymerase (dna directed) kappa; PDBTitle: crystal structure of the catalytic core of human dna2 polymerase kappa 44 c2oh2B_ not modelled 62.0 21 PDB header:transferase/dna Chain: B: PDB Molecule:dna polymerase kappa; PDBTitle: ternary complex of human dna polymerase 45 c3mr2A_ not modelled 60.4 23 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: human dna polymerase eta in complex with normal dna and incoming2 nucleotide (nrm) 46 c1y10C_ not modelled 56.1 9 PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state 47 c2wz1B_ not modelled 44.7 9 PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble2 guanylate cyclase 1 beta 3. 48 d1t94a2 not modelled 30.8 23 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 49 c1vloA_ not modelled 29.5 23 PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of aminomethyltransferase (t protein;2 tetrahydrofolate-dependent) of glycine cleavage system (np417381)3 from escherichia coli k12 at 1.70 a resolution 50 d1yhta1 not modelled 28.5 20 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 51 c3hf3A_ not modelled 27.3 18 PDB header:oxidoreductase Chain: A: PDB Molecule:chromate reductase; PDBTitle: old yellow enzyme from thermus scotoductus sa-01 52 c3mpbA_ not modelled 23.7 23 PDB header:isomerase Chain: A: PDB Molecule:sugar isomerase; PDBTitle: z5688 from e. coli o157:h7 bound to fructose 53 c2h90A_ not modelled 21.8 21 PDB header:oxidoreductase Chain: A: PDB Molecule:xenobiotic reductase a; PDBTitle: xenobiotic reductase a in complex with coumarin 54 d1ps9a1 not modelled 19.9 21 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 55 c1rgsA_ not modelled 19.7 24 PDB header:kinase Chain: A: PDB Molecule:camp dependent protein kinase; PDBTitle: regulatory subunit of camp dependent protein kinase 56 c2byvE_ not modelled 18.9 15 PDB header:regulation Chain: E: PDB Molecule:rap guanine nucleotide exchange factor 4; PDBTitle: structure of the camp responsive exchange factor epac2 in2 its auto-inhibited state 57 d1mo1a_ not modelled 18.8 32 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 58 d1ptfa_ not modelled 17.3 14 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 59 c1n13J_ not modelled 17.0 17 PDB header:lyase Chain: J: PDB Molecule:pyruvoyl-dependent arginine decarboxylase alpha PDBTitle: the crystal structure of pyruvoyl-dependent arginine2 decarboxylase from methanococcus jannashii 60 c3in6A_ not modelled 16.8 42 PDB header:flavoprotein Chain: A: PDB Molecule:fmn-binding protein; PDBTitle: crystal structure of a fmn-binding protein (swol_0183) from2 syntrophomonas wolfei subsp. wolfei at 2.12 a resolution 61 d1cm3a_ not modelled 16.5 12 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 62 d1zeta2 not modelled 16.4 41 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 63 d3c9fa2 not modelled 15.8 24 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain 64 c3ihsB_ not modelled 15.6 28 PDB header:transport protein Chain: B: PDB Molecule:phosphocarrier protein hpr; PDBTitle: crystal structure of a phosphocarrier protein hpr from2 bacillus anthracis str. ames 65 c1o7fA_ not modelled 15.1 14 PDB header:regulation Chain: A: PDB Molecule:camp-dependent rap1 guanine-nucleotide exchange PDBTitle: crystal structure of the regulatory domain of epac2 66 d1zvvj1 not modelled 13.6 32 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 67 c3le1B_ not modelled 12.5 20 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase system, hpr-related proteins; PDBTitle: crystal structure of apohpr monomer from thermoanaerobacter2 tengcongensis 68 c3k30B_ not modelled 12.0 19 PDB header:oxidoreductase Chain: B: PDB Molecule:histamine dehydrogenase; PDBTitle: histamine dehydrogenase from nocardiodes simplex 69 d1qr5a_ not modelled 11.9 7 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 70 c3shrA_ not modelled 11.8 22 PDB header:transferase Chain: A: PDB Molecule:cgmp-dependent protein kinase 1; PDBTitle: crystal structure of cgmp-dependent protein kinase reveals novel site2 of interchain communication 71 c2i34B_ not modelled 11.8 29 PDB header:hydrolase Chain: B: PDB Molecule:acid phosphatase; PDBTitle: the crystal structure of class c acid phosphatase from bacillus2 anthracis with tungstate bound 72 c3rbuA_ not modelled 11.7 19 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:glutamate carboxypeptidase 2; PDBTitle: n-terminally avitev-tagged human glutamate carboxypeptidase ii in2 complex with 2-pmpa 73 d1k3xa1 not modelled 11.4 30 Fold:S13-like H2TH domain Superfamily:S13-like H2TH domain Family:Middle domain of MutM-like DNA repair proteins 74 c2ootA_ not modelled 10.8 16 PDB header:hydrolase Chain: A: PDB Molecule:glutamate carboxypeptidase 2; PDBTitle: a high resolution structure of ligand-free human glutamate2 carboxypeptidase ii 75 d1ka5a_ not modelled 10.7 8 Fold:HPr-like Superfamily:HPr-like Family:HPr-like 76 c3c9fB_ not modelled 10.7 21 PDB header:hydrolase Chain: B: PDB Molecule:5'-nucleotidase; PDBTitle: crystal structure of 5'-nucleotidase from candida albicans sc5314 77 d1wosa2 not modelled 10.5 21 Fold:Folate-binding domain Superfamily:Folate-binding domain Family:Aminomethyltransferase folate-binding domain 78 d1nowa1 not modelled 10.5 20 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 79 d1qbaa3 not modelled 10.4 29 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-N-acetylhexosaminidase catalytic domain 80 c3of1A_ not modelled 10.3 22 PDB header:transferase Chain: A: PDB Molecule:camp-dependent protein kinase regulatory subunit; PDBTitle: crystal structure of bcy1, the yeast regulatory subunit of pka 81 c1cx8F_ not modelled 10.2 16 PDB header:metal transport Chain: F: PDB Molecule:transferrin receptor protein; PDBTitle: crytal structure of the ectodomain of human transferrin receptor 82 d1vr6a1 not modelled 9.8 17 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I DAHP synthetase 83 c3fgeA_ not modelled 9.7 23 PDB header:oxidoreductase Chain: A: PDB Molecule:putative flavin reductase with split barrel domain; PDBTitle: crystal structure of putative flavin reductase with split barrel2 domain (yp_750721.1) from shewanella frigidimarina ncimb 400 at 1.743 a resolution 84 d2o5aa1 not modelled 9.7 18 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 85 d1cgme_ not modelled 9.6 19 Fold:Four-helical up-and-down bundle Superfamily:TMV-like viral coat proteins Family:TMV-like viral coat proteins 86 d1tdza1 not modelled 9.6 40 Fold:S13-like H2TH domain Superfamily:S13-like H2TH domain Family:Middle domain of MutM-like DNA repair proteins 87 c1worA_ not modelled 9.5 21 PDB header:transferase Chain: A: PDB Molecule:aminomethyltransferase; PDBTitle: crystal structure of t-protein of the glycine cleavage2 system 88 d1ei7a_ not modelled 9.4 36 Fold:Four-helical up-and-down bundle Superfamily:TMV-like viral coat proteins Family:TMV-like viral coat proteins 89 c3kmlB_ not modelled 9.1 36 PDB header:viral protein Chain: B: PDB Molecule:coat protein; PDBTitle: circular permutant of the tobacco mosaic virus 90 c3iyuY_ not modelled 9.1 19 PDB header:virus Chain: Y: PDB Molecule:outer capsid protein vp4; PDBTitle: atomic model of an infectious rotavirus particle 91 c1ps9A_ not modelled 9.1 21 PDB header:oxidoreductase Chain: A: PDB Molecule:2,4-dienoyl-coa reductase; PDBTitle: the crystal structure and reaction mechanism of e. coli 2,4-2 dienoyl coa reductase 92 c1qbaA_ not modelled 9.0 33 PDB header:glycosyl hydrolase Chain: A: PDB Molecule:chitobiase; PDBTitle: bacterial chitobiase, glycosyl hydrolase family 20 93 d1ee8a1 not modelled 8.8 40 Fold:S13-like H2TH domain Superfamily:S13-like H2TH domain Family:Middle domain of MutM-like DNA repair proteins 94 c2jroA_ not modelled 8.6 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of so0334 from shewanella oneidensis. northeast2 structural genomics target sor75 95 d1vh8a_ not modelled 8.5 18 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 96 c2wk1A_ not modelled 8.2 22 PDB header:transferase Chain: A: PDB Molecule:novp; PDBTitle: structure of the o-methyltransferase novp 97 d1k82a1 not modelled 8.1 30 Fold:S13-like H2TH domain Superfamily:S13-like H2TH domain Family:Middle domain of MutM-like DNA repair proteins 98 c3gveB_ not modelled 8.0 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:yfkn protein; PDBTitle: crystal structure of calcineurin-like phosphoesterase yfkn from2 bacillus subtilis 99 c2ylaA_ not modelled 8.0 23 PDB header:hydrolase Chain: A: PDB Molecule:beta-n-acetylhexosaminidase; PDBTitle: inhibition of the pneumococcal virulence factor strh and2 molecular insights into n-glycan recognition and3 hydrolysis

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0