Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP0A6Z3
DateThu Jan 5 11:04:17 GMT 2012
Unique Job IDcc39b1aa0dc0c1e4

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2iopD_
Top template information
PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
Confidence and coverage
Confidence:100.0% Coverage: 97%
604 residues ( 97% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSNPDLYEGD
Secondary structure 
SS confidence 
Disorder  ???????
???
???????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  GELRVRVSFDKDKRTLTISDNGVGMTRDEVIDHLGTIAKSGTKSFLESLGSDQAKDSQLI
Secondary structure 
SS confidence 
Disorder 
????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  GQFGVGFYSAFIVADKVTVRTRAAGEKPENGVFWESAGEGEYTVADITKEDRGTEITLHL
Secondary structure 
SS confidence 
Disorder 
?
???
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  REGEDEFLDDWRVRSIISKYSDHIALPVEIEKREEKDGETVISWEKINKAQALWTRNKSE
Secondary structure 
SS confidence 
Disorder 
????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  ITDEEYKEFYKHIAHDFNDPLTWSHNRVEGKQEYTSLLYIPSQAPWDMWNRDHKHGLKLY
Secondary structure 
SS confidence 
Disorder  ?
??????????
?
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  VQRVFIMDDAEQFMPNYLRFVRGLIDSSDLPLNVSREILQDSTVTRNLRNALTKRVLQML
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  EKLAKDDAEKYQTFWQQFGLVLKEGPAEDFANQEAIAKLLRFASTHTDSSAQTVSLEDYV
Secondary structure 
SS confidence 
Disorder 
??
??
?
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  SRMKEGQEKIYYITADSYAAAKSSPHLELLRKKGIEVLLLSDRIDEWMMNYLTEFDGKPF
Secondary structure 
SS confidence 
Disorder 
??
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  QSVSKVDESLEKLADEVDESAKEAEKALTPFIDRVKALLGERVKDVRLTHRLTDTPAIVS
Secondary structure 
SS confidence 
Disorder 
???????????????????
??????
?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  TDADEMSTQMAKLFAAAGQKVPEVKYIFELNPDHVLVKRAADTEDEAKFSEWVELLLDQA
Secondary structure 
SS confidence 
Disorder  ???????
?????????
???
Disorder confidence 
 
   .........610.........620....
Sequence  LLAERGTLEDPNLFIRRMNQLLVS
Secondary structure 
SS confidence 
Disorder 
??????
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2iop chain D

3D model

Region: 1 - 624
Aligned: 604
Modelled: 607
Confidence: 100.0%
Identity: 99%
PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp

Phyre2

PDB 2cg9 chain A

3D model

Region: 3 - 624
Aligned: 597
Modelled: 622
Confidence: 100.0%
Identity: 41%
PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex

Phyre2

PDB 2o1u chain A

3D model

Region: 16 - 624
Aligned: 558
Modelled: 581
Confidence: 100.0%
Identity: 41%
PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound

Phyre2

PDB 1y4s chain A

3D model

Region: 1 - 483
Aligned: 475
Modelled: 483
Confidence: 100.0%
Identity: 100%
PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding

Phyre2

PDB 2o1w chain B

3D model

Region: 4 - 486
Aligned: 464
Modelled: 483
Confidence: 100.0%
Identity: 46%
PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94

Phyre2

PDB 2cge chain D

3D model

Region: 230 - 622
Aligned: 388
Modelled: 393
Confidence: 100.0%
Identity: 38%
PDB header:chaperone
Chain: D: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex

Phyre2

PDB 2o1t chain B

3D model

Region: 231 - 624
Aligned: 379
Modelled: 394
Confidence: 100.0%
Identity: 38%
PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of middle plus c-terminal domains (m+c) of grp94

Phyre2

PDB 3hjc chain A

3D model

Region: 230 - 622
Aligned: 379
Modelled: 393
Confidence: 100.0%
Identity: 37%
PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein 83-1;
PDBTitle: crystal structure of the carboxy-terminal domain of hsp90 from2 leishmania major, lmjf33.0312

Phyre2

PDB 3q6n chain F

3D model

Region: 234 - 622
Aligned: 353
Modelled: 389
Confidence: 100.0%
Identity: 38%
PDB header:chaperone
Chain: F: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: crystal structure of human mc-hsp90 in p21 space group

Phyre2

PDB 2gq0 chain B

3D model

Region: 231 - 494
Aligned: 264
Modelled: 264
Confidence: 100.0%
Identity: 100%
PDB header:chaperone, hydrolase
Chain: B: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the middle domain of htpg, the e. coli2 hsp90

Phyre2

PDB 3pry chain A

3D model

Region: 229 - 493
Aligned: 255
Modelled: 265
Confidence: 100.0%
Identity: 45%
PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-beta;
PDBTitle: crystal structure of the middle domain of human hsp90-beta refined at2 2.3 a resolution

Phyre2

PDB 1usu chain A

3D model

Region: 229 - 486
Aligned: 246
Modelled: 258
Confidence: 100.0%
Identity: 44%
Fold: Ribosomal protein S5 domain 2-like
Superfamily: Ribosomal protein S5 domain 2-like
Family: Hsp90 middle domain

Phyre2

PDB 1hk7 chain A

3D model

Region: 230 - 486
Aligned: 247
Modelled: 257
Confidence: 100.0%
Identity: 45%
PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp82;
PDBTitle: middle domain of hsp90

Phyre2

PDB 1y6z chain A

3D model

Region: 232 - 486
Aligned: 240
Modelled: 255
Confidence: 100.0%
Identity: 34%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:heat shock protein, putative;
PDBTitle: middle domain of plasmodium falciparum putative heat shock protein2 pf14_0417

Phyre2

PDB 3peh chain B

3D model

Region: 2 - 268
Aligned: 251
Modelled: 255
Confidence: 100.0%
Identity: 41%
PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative

Phyre2

PDB 2ior chain A

3D model

Region: 1 - 211
Aligned: 211
Modelled: 211
Confidence: 100.0%
Identity: 100%
PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp

Phyre2

PDB 1qy5 chain A

3D model

Region: 5 - 228
Aligned: 218
Modelled: 224
Confidence: 100.0%
Identity: 47%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Heat shock protein 90, HSP90, N-terminal domain

Phyre2

PDB 2iwx chain A domain 1

3D model

Region: 5 - 217
Aligned: 208
Modelled: 213
Confidence: 100.0%
Identity: 45%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Heat shock protein 90, HSP90, N-terminal domain

Phyre2

PDB 1zwh chain A

3D model

Region: 5 - 217
Aligned: 208
Modelled: 213
Confidence: 100.0%
Identity: 45%
PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine

Phyre2

PDB 3ied chain A

3D model

Region: 5 - 212
Aligned: 203
Modelled: 202
Confidence: 100.0%
Identity: 46%
PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn

Phyre2
1
c2iopD_
2
c2cg9A_
3
c2o1uA_
4
c1y4sA_
5
c2o1wB_
6
c2cgeD_
7
c2o1tB_
8
c3hjcA_
9
c3q6nF_
10
c2gq0B_
11
c3pryA_
12
d1usua_
13
c1hk7A_
14
c1y6zA_
15
c3pehB_
16
c2iorA_
17
d1qy5a_
18
d2iwxa1
19
c1zwhA_
20
c3iedA_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2iopD_
100.0 99 PDB header:chaperone
Chain: D: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
2c2cg9A_
100.0 41 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
3c2o1uA_
100.0 41 PDB header:chaperone
Chain: A: PDB Molecule:endoplasmin;
PDBTitle: structure of full length grp94 with amp-pnp bound
4c1y4sA_
100.0 100 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
5c2o1wB_
100.0 46 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
6c2cgeD_
100.0 38 PDB header:chaperone
Chain: D: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
7c2o1tB_
100.0 38 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin;
PDBTitle: structure of middle plus c-terminal domains (m+c) of grp94
8c3hjcA_
100.0 37 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein 83-1;
PDBTitle: crystal structure of the carboxy-terminal domain of hsp90 from2 leishmania major, lmjf33.0312
9c3q6nF_
100.0 38 PDB header:chaperone
Chain: F: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: crystal structure of human mc-hsp90 in p21 space group
10c2gq0B_
100.0 100 PDB header:chaperone, hydrolase
Chain: B: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the middle domain of htpg, the e. coli2 hsp90
11c3pryA_
100.0 45 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-beta;
PDBTitle: crystal structure of the middle domain of human hsp90-beta refined at2 2.3 a resolution
12d1usua_
100.0 44 Fold:Ribosomal protein S5 domain 2-like
Superfamily:Ribosomal protein S5 domain 2-like
Family:Hsp90 middle domain
13c1hk7A_
100.0 45 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp82;
PDBTitle: middle domain of hsp90
14c1y6zA_
100.0 34 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:heat shock protein, putative;
PDBTitle: middle domain of plasmodium falciparum putative heat shock protein2 pf14_0417
15c3pehB_
100.0 41 PDB header:chaperone
Chain: B: PDB Molecule:endoplasmin homolog;
PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
16c2iorA_
100.0 100 PDB header:chaperone
Chain: A: PDB Molecule:chaperone protein htpg;
PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
17d1qy5a_
100.0 47 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
18d2iwxa1
100.0 45 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
19c1zwhA_
100.0 45 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
20c3iedA_
100.0 46 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein;
PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
21d1uyla_
not modelled 100.0 49 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
22c2fwyA_
not modelled 100.0 49 PDB header:chaperone
Chain: A: PDB Molecule:heat shock protein hsp 90-alpha;
PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
23d1uyma_
not modelled 100.0 48 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
24d2gqpa1
not modelled 100.0 47 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Heat shock protein 90, HSP90, N-terminal domain
25c2akpA_
not modelled 100.0 46 PDB header:chaperone
Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82;
PDBTitle: hsp90 delta24-n210 mutant
26d1sf8a_
not modelled 100.0 97 Fold:HSP90 C-terminal domain
Superfamily:HSP90 C-terminal domain
Family:HSP90 C-terminal domain
27c2q2eB_
not modelled 99.9 18 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
28c3h4lB_
not modelled 99.8 16 PDB header:dna binding protein, protein binding
Chain: B: PDB Molecule:dna mismatch repair protein pms1;
PDBTitle: crystal structure of n terminal domain of a dna repair protein
29c3na3A_
not modelled 99.8 19 PDB header:protein binding
Chain: A: PDB Molecule:dna mismatch repair protein mlh1;
PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
30c2zbkB_
not modelled 99.8 23 PDB header:isomerase
Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b;
PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
31d1b63a2
not modelled 99.7 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
32c1bknA_
not modelled 99.7 19 PDB header:dna repair
Chain: A: PDB Molecule:mutl;
PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
33c1mx0D_
not modelled 99.7 20 PDB header:isomerase
Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b;
PDBTitle: structure of topoisomerase subunit
34d1bkna2
not modelled 99.7 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
35d2hkja3
not modelled 99.6 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
36c1ea6A_
not modelled 99.5 18 PDB header:dna repair
Chain: A: PDB Molecule:pms1 protein homolog 2;
PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
37d1kija2
not modelled 99.5 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
38d1h7sa2
not modelled 99.5 23 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
39c1kijB_
not modelled 99.4 17 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
40d1s16a2
not modelled 99.4 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
41d1pvga2
not modelled 99.4 17 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
42c1ei1B_
not modelled 99.4 15 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase b;
PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
43d1ei1a2
not modelled 99.2 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
44c1s16B_
not modelled 99.2 19 PDB header:isomerase
Chain: B: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
45d1s14a_
not modelled 98.7 19 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:DNA gyrase/MutL, N-terminal domain
46c3g7bB_
not modelled 98.5 15 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase subunit b;
PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
47c1y8oA_
not modelled 98.5 25 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex
48c2q8fA_
not modelled 98.5 19 PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
49c1qzrA_
not modelled 98.5 18 PDB header:isomerase
Chain: A: PDB Molecule:dna topoisomerase ii;
PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
50c3d36B_
not modelled 98.2 26 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
51c1zxnB_
not modelled 98.2 22 PDB header:isomerase
Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme;
PDBTitle: human dna topoisomerase iia atpase/adp
52c1gjvA_
not modelled 98.2 25 PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
53c2bu8A_
not modelled 98.2 22 PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
54d1gkza2
not modelled 98.1 21 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
55c3d2rB_
not modelled 98.1 22 PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
56d1jm6a2
not modelled 98.1 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
57c3lnuA_
not modelled 98.0 18 PDB header:isomerase
Chain: A: PDB Molecule:topoisomerase iv subunit b;
PDBTitle: crystal structure of pare subunit
58c1b3qA_
not modelled 97.8 19 PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
59c2c2aA_
not modelled 97.8 19 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
60d2c2aa2
not modelled 97.5 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
61c2ch4A_
not modelled 97.5 22 PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
62d1y8oa2
not modelled 97.4 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
63d1i58a_
not modelled 97.1 20 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
64c3a0tA_
not modelled 97.1 18 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
65d1ysra1
not modelled 97.1 18 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
66d1id0a_
not modelled 96.9 16 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
67d1th8a_
not modelled 96.7 24 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
68c3a0rA_
not modelled 96.6 15 PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
69d1bxda_
not modelled 96.6 22 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
70c3ehgA_
not modelled 96.4 25 PDB header:transferase
Chain: A: PDB Molecule:sensor kinase (yocf protein);
PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
71c3gieA_
not modelled 96.0 29 PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
72c3cwvB_
not modelled 95.3 15 PDB header:isomerase
Chain: B: PDB Molecule:dna gyrase, b subunit, truncated;
PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
73c3jz3B_
not modelled 95.2 33 PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
74d1ixma_
not modelled 92.3 12 Fold:Sporulation response regulatory protein Spo0B
Superfamily:Sporulation response regulatory protein Spo0B
Family:Sporulation response regulatory protein Spo0B
75c3zxqA_
not modelled 86.0 22 PDB header:transferase
Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost;
PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
76c3zxoB_
not modelled 61.3 23 PDB header:transferase
Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs;
PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
77d1r62a_
not modelled 61.2 25 Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family:Histidine kinase
78d2cwqa1
not modelled 56.6 14 Fold:AhpD-like
Superfamily:AhpD-like
Family:TTHA0727-like
79c3b9qA_
not modelled 40.2 13 PDB header:protein transport
Chain: A: PDB Molecule:chloroplast srp receptor homolog, alpha subunit
PDBTitle: the crystal structure of cpftsy from arabidopsis thaliana
80c2qy9A_
not modelled 33.1 11 PDB header:protein transport
Chain: A: PDB Molecule:cell division protein ftsy;
PDBTitle: structure of the ng+1 construct of the e. coli srp receptor2 ftsy
81c3ndhA_
not modelled 32.0 22 PDB header:hydrolase/dna
Chain: A: PDB Molecule:restriction endonuclease thai;
PDBTitle: restriction endonuclease in complex with substrate dna
82c3lmmA_
not modelled 28.8 24 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
83d1i5ga_
not modelled 26.8 20 Fold:Thioredoxin fold
Superfamily:Thioredoxin-like
Family:Glutathione peroxidase-like
84c2kxxA_
not modelled 26.4 45 PDB header:protein binding
Chain: A: PDB Molecule:small protein a;
PDBTitle: nmr structure of escherichia coli bame, a lipoprotein component of the2 beta-barrel assembly machinery complex
85d2p0sa1
not modelled 25.0 16 Fold:Periplasmic binding protein-like II
Superfamily:Periplasmic binding protein-like II
Family:PG0945 N-terminal domain-like
86d2g2ub1
not modelled 23.7 35 Fold:BLIP-like
Superfamily:beta-lactamase-inhibitor protein, BLIP
Family:beta-lactamase-inhibitor protein, BLIP
87c2ayaA_
not modelled 21.8 16 PDB header:transferase
Chain: A: PDB Molecule:dna polymerase iii subunit tau;
PDBTitle: solution structure of the c-terminal 14 kda domain of the2 tau subunit from escherichia coli dna polymerase iii
88d1j20a2
not modelled 21.0 28 Fold:Argininosuccinate synthetase, C-terminal domain
Superfamily:Argininosuccinate synthetase, C-terminal domain
Family:Argininosuccinate synthetase, C-terminal domain
89d1toaa_
not modelled 19.9 14 Fold:Chelatase-like
Superfamily:"Helical backbone" metal receptor
Family:TroA-like
90c1toaA_
not modelled 19.9 14 PDB header:binding protein
Chain: A: PDB Molecule:protein (periplasmic binding protein troa);
PDBTitle: periplasmic zinc binding protein troa from treponema pallidum
91c2pxgA_
not modelled 18.9 43 PDB header:membrane protein
Chain: A: PDB Molecule:outer membrane protein;
PDBTitle: nmr solution structure of omla
92c3gk0H_
not modelled 17.7 24 PDB header:transferase
Chain: H: PDB Molecule:pyridoxine 5'-phosphate synthase;
PDBTitle: crystal structure of pyridoxal phosphate biosynthetic2 protein from burkholderia pseudomallei
93c1p8cD_
not modelled 17.4 15 PDB header:structural genomics, unknown function
Chain: D: PDB Molecule:conserved hypothetical protein;
PDBTitle: crystal structure of tm1620 (apc4843) from thermotoga2 maritima
94d1k25a2
not modelled 16.6 19 Fold:Penicillin-binding protein 2x (pbp-2x), c-terminal domain
Superfamily:Penicillin-binding protein 2x (pbp-2x), c-terminal domain
Family:Penicillin-binding protein 2x (pbp-2x), c-terminal domain
95c2yhsA_
not modelled 16.4 11 PDB header:cell cycle
Chain: A: PDB Molecule:cell division protein ftsy;
PDBTitle: structure of the e. coli srp receptor ftsy
96c3ke6A_
not modelled 15.8 19 PDB header:unknown function
Chain: A: PDB Molecule:protein rv1364c/mt1410;
PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
97c2x48B_
not modelled 15.6 29 PDB header:viral protein
Chain: B: PDB Molecule:cag38821;
PDBTitle: orf 55 from sulfolobus islandicus rudivirus 1
98c2qeuA_
not modelled 14.8 16 PDB header:lyase
Chain: A: PDB Molecule:putative carboxymuconolactone decarboxylase;
PDBTitle: crystal structure of putative carboxymuconolactone decarboxylase2 (yp_555818.1) from burkholderia xenovorans lb400 at 1.65 a resolution
99c2xhfA_
not modelled 14.7 9 PDB header:oxidoreductase
Chain: A: PDB Molecule:peroxiredoxin 5;
PDBTitle: crystal structure of peroxiredoxin 5 from alvinella pompejana

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0