Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	S	I	S	L	I	Q	P	D	R	D	L	F	S	W	P	Q	Y	W	A	A	C	F	G	P	A	P	F	L	P	M	S	R	E	E	M	D	Q	L	G	W	D	S	C	D	I	I	L	V	T	G	D	A	Y	V	D	H	P	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?		?	?	?								?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	G	M	A	I	C	G	R	M	L	E	A	Q	G	F	R	V	G	I	I	A	Q	P	D	W	S	S	K	D	D	F	M	R	L	G	K	P	N	L	F	F	G	V	T	A	G	N	M	D	S	M	I	N	R	Y	T	A	D	R	R
Secondary structure
SS confidence
Disorder																																																										?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	H	D	D	A	Y	T	P	D	N	V	A	G	K	R	P	D	R	A	T	L	V	Y	T	Q	R	C	K	E	A	W	K	D	V	P	V	I	L	G	G	I	E	A	S	L	R	R	T	A	H	Y	D	Y	W	S	D	T	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	S	V	L	V	D	S	K	A	D	M	L	M	F	G	N	G	E	R	P	L	V	E	V	A	H	R	L	A	M	G	E	P	I	S	E	I	R	D	V	R	N	T	A	I	I	V	K	E	A	L	P	G	W	S	G	V	D	S	T
Secondary structure
SS confidence
Disorder																																													?			?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	L	D	T	P	G	K	I	D	P	I	P	H	P	Y	G	E	D	L	P	C	A	D	N	K	P	V	A	P	K	K	Q	E	A	K	A	V	T	V	Q	P	P	R	P	K	P	W	E	K	T	Y	V	L	L	P	S	F	E	K	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	G	D	K	V	L	Y	A	H	A	S	R	I	L	H	H	E	T	N	P	G	C	A	R	A	L	M	Q	K	H	G	D	R	Y	V	W	I	N	P	P	A	I	P	L	S	T	E	E	M	D	S	V	F	A	L	P	Y	K	R	V
Secondary structure
SS confidence
Disorder																			?																								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	H	P	A	Y	G	N	A	R	I	P	A	Y	E	M	I	R	F	S	V	N	I	M	R	G	C	F	G	G	C	S	F	C	S	I	T	E	H	E	G	R	I	I	Q	S	R	S	E	D	S	I	I	N	E	I	E	A	I	R	D
Secondary structure
SS confidence
Disorder					?	?	?				?																												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	V	P	G	F	T	G	V	I	S	D	L	G	G	P	T	A	N	M	Y	M	L	R	C	K	S	P	R	A	E	Q	T	C	R	R	L	S	C	V	Y	P	D	I	C	P	H	M	D	T	N	H	E	P	T	I	N	L	Y	R	R
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	R	D	L	K	G	I	K	K	I	L	I	A	S	G	V	R	Y	D	I	A	V	E	D	P	R	Y	I	K	E	L	A	T	H	H	V	G	G	Y	L	K	I	A	P	E	H	T	E	E	G	P	L	S	K	M	M	K	P	G	M
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		G	S	Y	D	R	F	K	E	L	F	D	T	Y	S	K	Q	A	G	K	E	Q	Y	L	I	P	Y	F	I	S	A	H	P	G	T	R	D	E	D	M	V	N	L	A	L	W	L	K	K	H	R	F	R	L	D	Q	V	Q	N	F	Y
Secondary structure
SS confidence
Disorder																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		P	S	P	L	A	N	S	T	T	M	Y	Y	T	G	K	N	P	L	A	K	I	G	Y	K	S	E	D	V	F	V	P	K	G	D	K	Q	R	R	L	H	K	A	L	L	R	Y	H	D	P	A	N	W	P	L	I	R	Q	A	L	E
Secondary structure
SS confidence
Disorder																		?	?		?	?	?	?	?	?					?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence		A	M	G	K	K	H	L	I	G	S	R	R	D	C	L	V	P	A	P	T	I	E	E	M	R	E	A	R	R	Q	N	R	N	T	R	P	A	L	T	K	H	T	P	M	A	T	Q	R	Q	T	P	A	T	A	K	K	A	S	S	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.
Sequence		Q	S	R	P	V	N	A	G	A	K	K	R	P	K	A	A	V	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2qgq chain F Region: 390 - 682 Aligned: 222 Modelled: 232 Confidence: 100.0% Identity: 18% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein tm_1862; PDBTitle: crystal structure of tm_1862 from thermotoga maritima.2 northeast structural genomics consortium target vr77 Phyre2 PDB 3cix chain A Region: 375 - 610 Aligned: 188 Modelled: 199 Confidence: 99.9% Identity: 16% PDB header:adomet binding protein Chain: A: PDB Molecule:fefe-hydrogenase maturase; PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate Phyre2 PDB 1olt chain A Region: 374 - 663 Aligned: 229 Modelled: 261 Confidence: 99.9% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Oxygen-independent coproporphyrinogen III oxidase HemN Phyre2 PDB 3t7v chain A Region: 375 - 606 Aligned: 187 Modelled: 198 Confidence: 99.9% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:methylornithine synthase pylb; PDBTitle: crystal structure of methylornithine synthase (pylb) Phyre2 PDB 1r30 chain A Region: 375 - 610 Aligned: 189 Modelled: 191 Confidence: 99.8% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Biotin synthase Phyre2 PDB 1r30 chain A Region: 375 - 610 Aligned: 189 Modelled: 191 Confidence: 99.8% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:biotin synthase; PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme Phyre2 PDB 3rfa chain A Region: 370 - 606 Aligned: 200 Modelled: 218 Confidence: 99.7% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:ribosomal rna large subunit methyltransferase n; PDBTitle: x-ray structure of rlmn from escherichia coli in complex with s-2 adenosylmethionine Phyre2 PDB 2yx0 chain A Region: 379 - 602 Aligned: 196 Modelled: 224 Confidence: 99.6% Identity: 11% PDB header:metal binding protein Chain: A: PDB Molecule:radical sam enzyme; PDBTitle: crystal structure of p. horikoshii tyw1 Phyre2 PDB 1tv8 chain A Region: 377 - 605 Aligned: 182 Modelled: 198 Confidence: 99.2% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: MoCo biosynthesis proteins Phyre2 PDB 3c8f chain A Region: 376 - 649 Aligned: 221 Modelled: 243 Confidence: 99.2% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate formate-lyase 1-activating enzyme; PDBTitle: 4fe-4s-pyruvate formate-lyase activating enzyme with2 partially disordered adomet Phyre2 PDB 2a5h chain C Region: 377 - 605 Aligned: 183 Modelled: 198 Confidence: 98.9% Identity: 16% PDB header:isomerase Chain: C: PDB Molecule:l-lysine 2,3-aminomutase; PDBTitle: 2.1 angstrom x-ray crystal structure of lysine-2,3-aminomutase from2 clostridium subterminale sb4, with michaelis analog (l-alpha-lysine3 external aldimine form of pyridoxal-5'-phosphate). Phyre2 PDB 2z2u chain A Region: 386 - 603 Aligned: 162 Modelled: 185 Confidence: 96.3% Identity: 12% PDB header:metal binding protein Chain: A: PDB Molecule:upf0026 protein mj0257; PDBTitle: crystal structure of archaeal tyw1 Phyre2 PDB 1y80 chain A Region: 57 - 208 Aligned: 107 Modelled: 119 Confidence: 92.0% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:predicted cobalamin binding protein; PDBTitle: structure of a corrinoid (factor iiim)-binding protein from2 moorella thermoacetica Phyre2 PDB 1ajz chain A Region: 404 - 590 Aligned: 151 Modelled: 166 Confidence: 90.3% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Dihydropteroate synthetase Phyre2 PDB 3can chain A Region: 471 - 601 Aligned: 116 Modelled: 131 Confidence: 89.7% Identity: 13% PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 Phyre2 PDB 2i2x chain D Region: 49 - 219 Aligned: 124 Modelled: 144 Confidence: 89.7% Identity: 25% PDB header:transferase Chain: D: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri Phyre2 PDB 3nav chain B Region: 534 - 600 Aligned: 55 Modelled: 64 Confidence: 86.8% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961 Phyre2 PDB 1ad1 chain A Region: 404 - 589 Aligned: 150 Modelled: 162 Confidence: 86.0% Identity: 9% Fold: TIM beta/alpha-barrel Superfamily: Dihydropteroate synthetase-like Family: Dihydropteroate synthetase Phyre2 PDB 3ezx chain A Region: 57 - 208 Aligned: 107 Modelled: 111 Confidence: 84.7% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:monomethylamine corrinoid protein 1; PDBTitle: structure of methanosarcina barkeri monomethylamine2 corrinoid protein Phyre2 PDB 1rd5 chain A Region: 545 - 600 Aligned: 52 Modelled: 53 Confidence: 83.9% Identity: 10% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 1w78 chain A Region: 8 - 97 Aligned: 83 Modelled: 83 Confidence: 74.2% Identity: 24% PDB header:synthase Chain: A: PDB Molecule:folc bifunctional protein; PDBTitle: e.coli folc in complex with dhpp and adp Phyre2 1 c2qgqF_ 2 c3cixA_ 3 d1olta_ 4 c3t7vA_ 5 d1r30a_ 6 c1r30A_ 7 c3rfaA_ 8 c2yx0A_ 9 d1tv8a_ 10 c3c8fA_ 11 c2a5hC_ 12 c2z2uA_ 13 c1y80A_ 14 d1ajza_ 15 c3canA_ 16 c2i2xD_ 17 c3navB_ 18 d1ad1a_ 19 c3ezxA_ 20 d1rd5a_ 21 22 23 24 c1w78A_ 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140