Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	F	F	H	A	S	Q	R	D	A	L	N	Q	S	L	A	E	V	Q	G	Q	I	N	V	S	F	E	F	F	P	P	R	T	S	E	M	E	Q	T	L	W	N	S	I	D	R	L	S	S	L	K	P	K	F	V	S	V	T	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	A	N	S	G	E	R	D	R	T	H	S	I	I	K	G	I	K	D	R	T	G	L	E	A	A	P	H	L	T	C	I	D	A	T	P	D	E	L	R	T	I	A	R	D	Y	W	N	N	G	I	R	H	I	V	A	L	R	G	D
Secondary structure
SS confidence
Disorder							?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	P	P	G	S	G	K	P	E	M	Y	A	S	D	L	V	T	L	L	K	E	V	A	D	F	D	I	S	V	A	A	Y	P	E	V	H	P	E	A	K	S	A	Q	A	D	L	L	N	L	K	R	K	V	D	A	G	A	N	R	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	T	Q	F	F	F	D	V	E	S	Y	L	R	F	R	D	R	C	V	S	A	G	I	D	V	E	I	I	P	G	I	L	P	V	S	N	F	K	Q	A	K	K	F	A	D	M	T	N	V	R	I	P	A	W	M	A	Q	M	F	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Sequence		G	L	D	D	D	A	E	T	R	K	L	V	G	A	N	I	A	M	D	M	V	K	I	L	S	R	E	G	V	K	D	F	H	F	Y	T	L	N	R	A	E	M	S	Y	A	I	C	H	T	L	G	V	R	P	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																														?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1b5t chain A Region: 21 - 295 Aligned: 275 Modelled: 275 Confidence: 100.0% Identity: 100% Fold: TIM beta/alpha-barrel Superfamily: FAD-linked oxidoreductase Family: Methylenetetrahydrofolate reductase Phyre2 PDB 1v93 chain A Region: 12 - 294 Aligned: 281 Modelled: 283 Confidence: 100.0% Identity: 36% Fold: TIM beta/alpha-barrel Superfamily: FAD-linked oxidoreductase Family: Methylenetetrahydrofolate reductase Phyre2 PDB 2fmo chain A Region: 22 - 294 Aligned: 261 Modelled: 273 Confidence: 100.0% Identity: 99% PDB header:oxidoreductase Chain: A: PDB Molecule:5,10-methylenetetrahydrofolate reductase; PDBTitle: ala177val mutant of e. coli methylenetetrahydrofolate2 reductase Phyre2 PDB 3ijd chain B Region: 10 - 290 Aligned: 266 Modelled: 281 Confidence: 100.0% Identity: 19% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: uncharacterized protein cthe_2304 from clostridium2 thermocellum binds two copies of 5-methyl-5,6,7,8-3 tetrahydrofolic acid Phyre2 PDB 1xcf chain A Region: 7 - 266 Aligned: 231 Modelled: 251 Confidence: 97.7% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 2ekc chain A Region: 7 - 266 Aligned: 227 Modelled: 252 Confidence: 96.9% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 Phyre2 PDB 1rd5 chain A Region: 6 - 266 Aligned: 229 Modelled: 249 Confidence: 96.6% Identity: 10% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 1ujp chain A Region: 7 - 252 Aligned: 217 Modelled: 244 Confidence: 96.5% Identity: 11% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 3nav chain B Region: 7 - 260 Aligned: 228 Modelled: 249 Confidence: 96.3% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961 Phyre2 PDB 1qop chain A Region: 7 - 266 Aligned: 235 Modelled: 248 Confidence: 96.1% Identity: 9% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 2p10 chain D Region: 3 - 230 Aligned: 203 Modelled: 218 Confidence: 95.8% Identity: 13% PDB header:hydrolase Chain: D: PDB Molecule:mll9387 protein; PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution Phyre2 PDB 3igs chain B Region: 10 - 226 Aligned: 185 Modelled: 194 Confidence: 92.4% Identity: 10% PDB header:isomerase Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2; PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase Phyre2 PDB 1x7f chain A domain 2 Region: 147 - 230 Aligned: 76 Modelled: 84 Confidence: 91.8% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Outer surface protein, N-terminal domain Phyre2 PDB 1j5t chain A Region: 69 - 231 Aligned: 142 Modelled: 158 Confidence: 91.4% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 1tqj chain A Region: 29 - 210 Aligned: 167 Modelled: 176 Confidence: 91.1% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: D-ribulose-5-phosphate 3-epimerase Phyre2 PDB 3daq chain B Region: 95 - 244 Aligned: 131 Modelled: 150 Confidence: 90.6% Identity: 11% PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus Phyre2 PDB 1x7f chain A Region: 147 - 230 Aligned: 76 Modelled: 84 Confidence: 90.2% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:outer surface protein; PDBTitle: crystal structure of an uncharacterized b. cereus protein Phyre2 PDB 2hmc chain A Region: 95 - 244 Aligned: 131 Modelled: 146 Confidence: 89.9% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: the crystal structure of dihydrodipicolinate synthase dapa from2 agrobacterium tumefaciens Phyre2 PDB 2y85 chain D Region: 42 - 199 Aligned: 143 Modelled: 158 Confidence: 89.9% Identity: 15% PDB header:isomerase Chain: D: PDB Molecule:phosphoribosyl isomerase a; PDBTitle: crystal structure of mycobacterium tuberculosis phosphoribosyl2 isomerase with bound rcdrp Phyre2 PDB 2c3z chain A Region: 7 - 237 Aligned: 197 Modelled: 216 Confidence: 89.3% Identity: 11% PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus Phyre2 1 d1b5ta_ 2 d1v93a_ 3 c2fmoA_ 4 c3ijdB_ 5 d1xcfa_ 6 c2ekcA_ 7 d1rd5a_ 8 d1ujpa_ 9 c3navB_ 10 d1qopa_ 11 c2p10D_ 12 c3igsB_ 13 d1x7fa2 14 d1j5ta_ 15 d1tqja_ 16 c3daqB_ 17 c1x7fA_ 18 c2hmcA_ 19 c2y85D_ 20 c2c3zA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1b5ta_ 100.0 100 Fold:TIM beta/alpha-barrel Superfamily:FAD-linked oxidoreductase Family:Methylenetetrahydrofolate reductase 2 d1v93a_ 100.0 36 Fold:TIM beta/alpha-barrel Superfamily:FAD-linked oxidoreductase Family:Methylenetetrahydrofolate reductase 3 c2fmoA_ 100.0 99 PDB header:oxidoreductase Chain: A: PDB Molecule:5,10-methylenetetrahydrofolate reductase; PDBTitle: ala177val mutant of e. coli methylenetetrahydrofolate2 reductase 4 c3ijdB_ 100.0 19 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: uncharacterized protein cthe_2304 from clostridium2 thermocellum binds two copies of 5-methyl-5,6,7,8-3 tetrahydrofolic acid 5 d1xcfa_ 97.7 11 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 6 c2ekcA_ 96.9 13 PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: structural study of project id aq_1548 from aquifex aeolicus vf5 7 d1rd5a_ 96.6 10 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 8 d1ujpa_ 96.5 11 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 9 c3navB_ 96.3 14 PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of an alpha subunit of tryptophan synthase from2 vibrio cholerae o1 biovar el tor str. n16961 10 d1qopa_ 96.1 9 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 11 c2p10D_ 95.8 13 PDB header:hydrolase Chain: D: PDB Molecule:mll9387 protein; PDBTitle: crystal structure of a putative phosphonopyruvate hydrolase (mll9387)2 from mesorhizobium loti maff303099 at 2.15 a resolution 12 c3igsB_ 92.4 10 PDB header:isomerase Chain: B: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase 2; PDBTitle: structure of the salmonella enterica n-acetylmannosamine-6-phosphate2 2-epimerase 13 d1x7fa2 91.8 18 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Outer surface protein, N-terminal domain 14 d1j5ta_ 91.4 15 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 15 d1tqja_ 91.1 13 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 16 c3daqB_ 90.6 11 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from methicillin-2 resistant staphylococcus aureus 17 c1x7fA_ 90.2 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:outer surface protein; PDBTitle: crystal structure of an uncharacterized b. cereus protein 18 c2hmcA_ 89.9 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: the crystal structure of dihydrodipicolinate synthase dapa from2 agrobacterium tumefaciens 19 c2y85D_ 89.9 15 PDB header:isomerase Chain: D: PDB Molecule:phosphoribosyl isomerase a; PDBTitle: crystal structure of mycobacterium tuberculosis phosphoribosyl2 isomerase with bound rcdrp 20 c2c3zA_ 89.3 11 PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of a truncated variant of indole-3-2 glycerol phosphate synthase from sulfolobus solfataricus 21 c2yw3E_ not modelled 89.2 14 PDB header:lyase Chain: E: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase/2-deydro-3- PDBTitle: crystal structure analysis of the 4-hydroxy-2-oxoglutarate aldolase/2-2 deydro-3-deoxyphosphogluconate aldolase from tthb1 22 d1yxya1 not modelled 88.9 17 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:NanE-like 23 c3thaB_ not modelled 88.8 13 PDB header:lyase Chain: B: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: tryptophan synthase subunit alpha from campylobacter jejuni. 24 d1h1ya_ not modelled 88.1 11 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 25 c3cprB_ not modelled 87.2 14 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthetase; PDBTitle: the crystal structure of corynebacterium glutamicum2 dihydrodipicolinate synthase to 2.2 a resolution 26 d2p10a1 not modelled 86.9 10 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Mll9387-like 27 c3fluD_ not modelled 86.0 15 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from the pathogen2 neisseria meningitidis 28 c3ct7E_ not modelled 86.0 14 PDB header:isomerase Chain: E: PDB Molecule:d-allulose-6-phosphate 3-epimerase; PDBTitle: crystal structure of d-allulose 6-phosphate 3-epimerase2 from escherichia coli k-12 29 c2oemA_ not modelled 85.7 14 PDB header:isomerase Chain: A: PDB Molecule:2,3-diketo-5-methylthiopentyl-1-phosphate enolase; PDBTitle: crystal structure of a rubisco-like protein from geobacillus2 kaustophilus liganded with mg2+ and 2,3-diketohexane 1-phosphate 30 d1xxxa1 not modelled 85.6 11 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 31 c3s5oA_ not modelled 84.9 10 PDB header:lyase Chain: A: PDB Molecule:4-hydroxy-2-oxoglutarate aldolase, mitochondrial; PDBTitle: crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to2 pyruvate 32 c2rfgB_ not modelled 83.9 17 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from hahella2 chejuensis at 1.5a resolution 33 c3pueA_ not modelled 82.9 18 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of the complex of dhydrodipicolinate synthase from2 acinetobacter baumannii with lysine at 2.6a resolution 34 c3gr7A_ not modelled 82.6 14 PDB header:oxidoreductase Chain: A: PDB Molecule:nadph dehydrogenase; PDBTitle: structure of oye from geobacillus kaustophilus, hexagonal2 crystal form 35 d1rpxa_ not modelled 82.5 17 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 36 c3bi8A_ not modelled 82.0 11 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: structure of dihydrodipicolinate synthase from clostridium2 botulinum 37 c1rr2A_ not modelled 80.7 19 PDB header:transferase Chain: A: PDB Molecule:transcarboxylase 5s subunit; PDBTitle: propionibacterium shermanii transcarboxylase 5s subunit bound to 2-2 ketobutyric acid 38 c3e96B_ not modelled 80.4 10 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 bacillus clausii 39 c3na8A_ not modelled 80.0 13 PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of a putative dihydrodipicolinate synthetase from2 pseudomonas aeruginosa 40 c2nx9B_ not modelled 79.8 17 PDB header:lyase Chain: B: PDB Molecule:oxaloacetate decarboxylase 2, subunit alpha; PDBTitle: crystal structure of the carboxyltransferase domain of the2 oxaloacetate decarboxylase na+ pump from vibrio cholerae 41 d1geqa_ not modelled 79.6 18 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 42 c3labA_ not modelled 79.6 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative kdpg (2-keto-3-deoxy-6-phosphogluconate) PDBTitle: crystal structure of a putative kdpg (2-keto-3-deoxy-6-2 phosphogluconate) aldolase from oleispira antarctica 43 c3qjaA_ not modelled 78.8 11 PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form 44 d1mkza_ not modelled 78.7 10 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MogA-like 45 d1rvga_ not modelled 76.6 15 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class II FBP aldolase 46 d2a6na1 not modelled 75.8 17 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 47 c3d0cB_ not modelled 75.4 17 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 oceanobacillus iheyensis at 1.9 a resolution 48 d1y5ea1 not modelled 75.0 11 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MogA-like 49 d1vc4a_ not modelled 74.8 15 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 50 c3bolB_ not modelled 74.2 14 PDB header:transferase Chain: B: PDB Molecule:5-methyltetrahydrofolate s-homocysteine PDBTitle: cobalamin-dependent methionine synthase (1-566) from2 thermotoga maritima complexed with zn2+ 51 c2qgqF_ not modelled 73.4 9 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein tm_1862; PDBTitle: crystal structure of tm_1862 from thermotoga maritima.2 northeast structural genomics consortium target vr77 52 d1vzwa1 not modelled 73.4 11 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Histidine biosynthesis enzymes 53 c3g0sA_ not modelled 72.2 18 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: dihydrodipicolinate synthase from salmonella typhimurium lt2 54 c3kwlA_ not modelled 70.8 10 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a hypothetical protein from helicobacter pylori 55 c1kwgA_ not modelled 70.7 20 PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: crystal structure of thermus thermophilus a4 beta-galactosidase 56 d2flia1 not modelled 70.2 12 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:D-ribulose-5-phosphate 3-epimerase 57 c3qfeB_ not modelled 70.0 12 PDB header:lyase Chain: B: PDB Molecule:putative dihydrodipicolinate synthase family protein; PDBTitle: crystal structures of a putative dihydrodipicolinate synthase family2 protein from coccidioides immitis 58 d1a9xa4 not modelled 68.5 20 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:BC N-terminal domain-like 59 d1mxsa_ not modelled 67.9 15 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 60 c3lciA_ not modelled 67.0 13 PDB header:lyase Chain: A: PDB Molecule:n-acetylneuraminate lyase; PDBTitle: the d-sialic acid aldolase mutant v251w 61 c3rfqC_ not modelled 65.5 14 PDB header:biosynthetic protein Chain: C: PDB Molecule:pterin-4-alpha-carbinolamine dehydratase moab2; PDBTitle: crystal structure of pterin-4-alpha-carbinolamine dehydratase moab22 from mycobacterium marinum 62 d1vyra_ not modelled 65.4 10 Fold:TIM beta/alpha-barrel Superfamily:FMN-linked oxidoreductases Family:FMN-linked oxidoreductases 63 c3inpA_ not modelled 64.7 15 PDB header:isomerase Chain: A: PDB Molecule:d-ribulose-phosphate 3-epimerase; PDBTitle: 2.05 angstrom resolution crystal structure of d-ribulose-phosphate 3-2 epimerase from francisella tularensis. 64 d1xkya1 not modelled 64.6 12 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 65 c2vc6A_ not modelled 64.2 14 PDB header:lyase Chain: A: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: structure of mosa from s. meliloti with pyruvate bound 66 c1zlpA_ not modelled 64.0 11 PDB header:lyase Chain: A: PDB Molecule:petal death protein; PDBTitle: petal death protein psr132 with cysteine-linked glutaraldehyde forming2 a thiohemiacetal adduct 67 c3ih1A_ not modelled 63.7 11 PDB header:lyase Chain: A: PDB Molecule:methylisocitrate lyase; PDBTitle: crystal structure of carboxyvinyl-carboxyphosphonate phosphorylmutase2 from bacillus anthracis 68 c2r8wB_ not modelled 63.2 8 PDB header:lyase Chain: B: PDB Molecule:agr_c_1641p; PDBTitle: the crystal structure of dihydrodipicolinate synthase (atu0899) from2 agrobacterium tumefaciens str. c58 69 c3dxiB_ not modelled 62.8 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative aldolase; PDBTitle: crystal structure of the n-terminal domain of a putative2 aldolase (bvu_2661) from bacteroides vulgatus 70 c3eb2A_ not modelled 61.6 10 PDB header:lyase Chain: A: PDB Molecule:putative dihydrodipicolinate synthetase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 rhodopseudomonas palustris at 2.0a resolution 71 d1muma_ not modelled 59.9 16 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 72 d1piia2 not modelled 59.8 11 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Tryptophan biosynthesis enzymes 73 c3o8nA_ not modelled 58.8 14 PDB header:transferase Chain: A: PDB Molecule:6-phosphofructokinase, muscle type; PDBTitle: structure of phosphofructokinase from rabbit skeletal muscle 74 d1rbla1 not modelled 58.5 16 Fold:TIM beta/alpha-barrel Superfamily:RuBisCo, C-terminal domain Family:RuBisCo, large subunit, C-terminal domain 75 c2zviB_ not modelled 57.8 14 PDB header:isomerase Chain: B: PDB Molecule:2,3-diketo-5-methylthiopentyl-1-phosphate PDBTitle: crystal structure of 2,3-diketo-5-methylthiopentyl-1-2 phosphate enolase from bacillus subtilis 76 d1yx1a1 not modelled 57.4 16 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:KguE-like 77 c3e05B_ not modelled 56.1 15 PDB header:transferase Chain: B: PDB Molecule:precorrin-6y c5,15-methyltransferase (decarboxylating); PDBTitle: crystal structure of precorrin-6y c5,15-methyltransferase from2 geobacter metallireducens gs-15 78 c2ftpA_ not modelled 54.6 15 PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of hydroxymethylglutaryl-coa lyase from pseudomonas2 aeruginosa 79 c2yxgD_ not modelled 54.4 17 PDB header:lyase Chain: D: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihyrodipicolinate synthase (dapa) 80 c3b9bA_ not modelled 54.3 16 PDB header:hydrolase Chain: A: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: structure of the e2 beryllium fluoride complex of the serca2 ca2+-atpase 81 c3ivuB_ not modelled 53.3 10 PDB header:transferase Chain: B: PDB Molecule:homocitrate synthase, mitochondrial; PDBTitle: homocitrate synthase lys4 bound to 2-og 82 c2vcbA_ not modelled 53.3 18 PDB header:hydrolase Chain: A: PDB Molecule:alpha-n-acetylglucosaminidase; PDBTitle: family 89 glycoside hydrolase from clostridium perfringens2 in complex with pugnac 83 d1w3ia_ not modelled 52.0 13 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 84 c2cw6B_ not modelled 51.3 14 PDB header:lyase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial; PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria 85 c3qc3B_ not modelled 50.9 13 PDB header:isomerase Chain: B: PDB Molecule:d-ribulose-5-phosphate-3-epimerase; PDBTitle: crystal structure of a d-ribulose-5-phosphate-3-epimerase (np_954699)2 from homo sapiens at 2.20 a resolution 86 c2wamB_ not modelled 50.8 17 PDB header:unknown function Chain: B: PDB Molecule:conserved hypothetical alanine and leucine rich PDBTitle: crystal structure of mycobacterium tuberculosis unknown2 function protein rv2714 87 c2nuxB_ not modelled 49.8 12 PDB header:lyase Chain: B: PDB Molecule:2-keto-3-deoxygluconate/2-keto-3-deoxy-6-phospho gluconate PDBTitle: 2-keto-3-deoxygluconate aldolase from sulfolobus acidocaldarius,2 native structure in p6522 at 2.5 a resolution 88 c3qfwB_ not modelled 49.7 14 PDB header:lyase Chain: B: PDB Molecule:ribulose-1,5-bisphosphate carboxylase/oxygenase large PDBTitle: crystal structure of rubisco-like protein from rhodopseudomonas2 palustris 89 c3t7vA_ not modelled 49.5 19 PDB header:transferase Chain: A: PDB Molecule:methylornithine synthase pylb; PDBTitle: crystal structure of methylornithine synthase (pylb) 90 d1xi8a3 not modelled 49.5 16 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MoeA central domain-like 91 c1m6vE_ not modelled 47.9 17 PDB header:ligase Chain: E: PDB Molecule:carbamoyl phosphate synthetase large chain; PDBTitle: crystal structure of the g359f (small subunit) point mutant of2 carbamoyl phosphate synthetase 92 c1yadD_ not modelled 47.6 10 PDB header:transcription Chain: D: PDB Molecule:regulatory protein teni; PDBTitle: structure of teni from bacillus subtilis 93 d2b6fa1 not modelled 46.8 15 Fold:ParB/Sulfiredoxin Superfamily:ParB/Sulfiredoxin Family:Sulfiredoxin-like 94 c1ydoC_ not modelled 44.9 12 PDB header:lyase Chain: C: PDB Molecule:hmg-coa lyase; PDBTitle: crystal structure of the bacillis subtilis hmg-coa lyase, northeast2 structural genomics target sr181. 95 c2is8A_ not modelled 43.7 16 PDB header:structural protein Chain: A: PDB Molecule:molybdopterin biosynthesis enzyme, moab; PDBTitle: crystal structure of the molybdopterin biosynthesis enzyme moab2 (ttha0341) from thermus theromophilus hb8 96 c3sdsA_ not modelled 43.5 17 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase, mitochondrial; PDBTitle: crystal structure of a mitochondrial ornithine carbamoyltransferase2 from coccidioides immitis 97 c1rldB_ not modelled 43.4 11 PDB header:lyase(carbon-carbon) Chain: B: PDB Molecule:ribulose 1,5 bisphosphate carboxylase/oxygenase (large PDBTitle: solid-state phase transition in the crystal structure of ribulose 1,5-2 biphosphate carboxylase(slash)oxygenase 98 c2bdqA_ not modelled 43.2 11 PDB header:metal transport Chain: A: PDB Molecule:copper homeostasis protein cutc; PDBTitle: crystal structure of the putative copper homeostasis2 protein cutc from streptococcus agalactiae, northeast3 strucural genomics target sar15. 99 c2h6rG_ not modelled 42.9 16 PDB header:isomerase Chain: G: PDB Molecule:triosephosphate isomerase; PDBTitle: crystal structure of triosephosphate isomerase (tim) from2 methanocaldococcus jannaschii 100 c2v9dB_ not modelled 42.8 9 PDB header:lyase Chain: B: PDB Molecule:yage; PDBTitle: crystal structure of yage, a prophage protein belonging to2 the dihydrodipicolinic acid synthase family from e. coli3 k12 101 c3kc2A_ not modelled 40.9 19 PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein ykr070w; PDBTitle: crystal structure of mitochondrial had-like phosphatase from2 saccharomyces cerevisiae 102 c1ydnA_ not modelled 40.5 16 PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of the hmg-coa lyase from brucella melitensis,2 northeast structural genomics target lr35. 103 c3b8cB_ not modelled 39.9 14 PDB header:hydrolase Chain: B: PDB Molecule:atpase 2, plasma membrane-type; PDBTitle: crystal structure of a plasma membrane proton pump 104 c2p0oA_ not modelled 39.9 10 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein duf871; PDBTitle: crystal structure of a conserved protein from locus ef_2437 in2 enterococcus faecalis with an unknown function 105 c3bleA_ not modelled 39.4 8 PDB header:transferase Chain: A: PDB Molecule:citramalate synthase from leptospira interrogans; PDBTitle: crystal structure of the catalytic domain of licms in2 complexed with malonate 106 c1xc6A_ not modelled 39.3 22 PDB header:hydrolase Chain: A: PDB Molecule:beta-galactosidase; PDBTitle: native structure of beta-galactosidase from penicillium sp. in complex2 with galactose 107 d1s2wa_ not modelled 38.7 13 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Phosphoenolpyruvate mutase/Isocitrate lyase-like 108 c3e0vB_ not modelled 38.7 20 PDB header:transferase Chain: B: PDB Molecule:pyruvate kinase; PDBTitle: crystal structure of pyruvate kinase from leishmania mexicana in2 complex with sulphate ions 109 c3gaaB_ not modelled 38.5 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ta1441; PDBTitle: the crystal structure of the protein with unknown function from2 thermoplasma acidophilum 110 d1q6oa_ not modelled 38.3 14 Fold:TIM beta/alpha-barrel Superfamily:Ribulose-phoshate binding barrel Family:Decarboxylase 111 d1to3a_ not modelled 37.7 16 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:Class I aldolase 112 d2gdwa1 not modelled 37.4 11 Fold:Acyl carrier protein-like Superfamily:ACP-like Family:Peptidyl carrier domain 113 c3fk4A_ not modelled 36.6 12 PDB header:isomerase Chain: A: PDB Molecule:rubisco-like protein; PDBTitle: crystal structure of rubisco-like protein from bacillus2 cereus atcc 14579 114 c1u83A_ not modelled 36.5 18 PDB header:lyase Chain: A: PDB Molecule:phosphosulfolactate synthase; PDBTitle: psl synthase from bacillus subtilis 115 d1u83a_ not modelled 36.5 18 Fold:TIM beta/alpha-barrel Superfamily:(2r)-phospho-3-sulfolactate synthase ComA Family:(2r)-phospho-3-sulfolactate synthase ComA 116 d2tpsa_ not modelled 36.1 12 Fold:TIM beta/alpha-barrel Superfamily:Thiamin phosphate synthase Family:Thiamin phosphate synthase 117 d2o3aa1 not modelled 35.9 27 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:AF0751-like 118 c2ejaB_ not modelled 35.0 8 PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen decarboxylase; PDBTitle: crystal structure of uroporphyrinogen decarboxylase from2 aquifex aeolicus 119 c3ewbX_ not modelled 34.7 9 PDB header:transferase Chain: X: PDB Molecule:2-isopropylmalate synthase; PDBTitle: crystal structure of n-terminal domain of putative 2-2 isopropylmalate synthase from listeria monocytogenes 120 d1pkla2 not modelled 34.5 16 Fold:TIM beta/alpha-barrel Superfamily:Phosphoenolpyruvate/pyruvate domain Family:Pyruvate kinase

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0