Phyre 2 Results for P77748

Email	l.a.kelley@imperial.ac.uk
Description	P77748
Date	Thu Jan 5 12:32:29 GMT 2012
Unique Job ID	b49366d11498ef32

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c1f0xA_

Top template information

PDB header:oxidoreductase
Chain: A: PDB Molecule:d-lactate dehydrogenase;
PDBTitle: crystal structure of d-lactate dehydrogenase, a peripheral2 membrane respiratory enzyme.

Confidence and coverage

Confidence:

100.0%

Coverage:

47%

474 residues ( 47% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

939 residues ( 92%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M I P Q I S Q A P G V V Q L V L N F L Q E L E Q Q G F T G D T A T S Y A D R L T M S T D N S I Y Q L L P D A V V F P R S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence T A D V A L I A R L A A Q E R Y S S L I F T P R G G G T G T N G Q A L N Q G I I V D M S R H M N R I I E I N P E E G W V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence R V E A G V I K D Q L N Q Y L K P F G Y F F A P E L S T S N R A T L G G M I N T D A S G Q G S L V Y G K T S D H V L G V

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence R A V L L G G D I L D T Q P L P V E L A E T L G K S N T T I G R I Y N T V Y Q R C R Q Q R Q L I I D N F P K L N R F L T

Secondary structure

SS confidence

Disorder
?
? ? ? ?
? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence G Y D L R H V F N D E M T E F D L T R I L T G S E G T L A F I T E A R L D I T R L P K V R R L V N V K Y D S F D S A L R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence N A P F M V E A R A L S V E T V D S K V L N L A R E D I V W H S V S E L I T D V P D Q E M L G L N I V E F A G D D E A L

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence I D E R V N A L C A R L D E L I A S H Q A G V I G W Q V C R E L A G V E R I Y A M R K K A V G L L G N A K G A A K P I P

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence F A E D T C V P P E H L A D Y I A E F R A L L D S H G L S Y G M F G H V D A G V L H V R P A L D M C D P Q Q E I L M K Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence I S D D V V A L T A K Y G G L L W G E H G K G F R A E Y S P A F F G E E L F A E L R K V K A A F D P H N R L N P G K I C

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence P P E G L D A P M M K V D A V K R G T F D R Q I P I A V R Q Q W R G A M E C N G N G L C F N F D A R S P M C P S M K I T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence Q N R I H S P K G R A T L V R E W L R L L A D R G V D P L K L E Q E L P E S G V S L R T L I A R T R N S W H A N K G E Y

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ?
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence D F S H E V K E A M S G C L A C K A C S T Q C P I K I D V P E F R S R F L Q L Y H T R Y L R P L R D H L V A T V E S Y A

Secondary structure

SS confidence

Disorder ?
? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence P L M A R A P K T F N F F I N Q P L V R K L S E K H I G M V D L P L L S V P S L Q Q Q M V G H R S A N M T L E Q L E S L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence N A E Q K A R T V L V V Q D P F T S Y Y D A Q V V A D F V R L V E K L G F Q P V L L P F S P N G K A Q H I K G F L N R F

Secondary structure

SS confidence

Disorder ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence A K T A K K T A D F L N R M A K L G M P M V G V D P A L V L C Y R D E Y K L A L G E E R G E F N V L L A N E W L A S A L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence E S Q P V A T V S G E S W Y F F G H C T E V T A L P G A P A Q W A A I F A R F G A K L E N V S V G C C G M A G T Y G H E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . .

Sequence A K N H E N S L G I Y E L S W H Q A M Q R L P R N R C L A T G Y S C R S Q V K R V E G T G V R H P V Q A L L E I I K

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1f0x chain A

Region: 16 - 538
Aligned: 474
Modelled: 501
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase
Chain: A: PDB Molecule:d-lactate dehydrogenase;
PDBTitle: crystal structure of d-lactate dehydrogenase, a peripheral2 membrane respiratory enzyme.

Phyre2

PDB 1ahu chain B

Region: 3 - 543
Aligned: 503
Modelled: 514
Confidence: 100.0%
Identity: 17%
PDB header:flavoenzyme
Chain: B: PDB Molecule:vanillyl-alcohol oxidase;
PDBTitle: structure of the octameric flavoenzyme vanillyl-alcohol2 oxidase in complex with p-cresol

Phyre2

PDB 2uuv chain C

Region: 11 - 536
Aligned: 409
Modelled: 428
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: C: PDB Molecule:alkyldihydroxyacetonephosphate synthase;
PDBTitle: alkyldihydroxyacetonephosphate synthase in p1

Phyre2

PDB 3pm9 chain A

Region: 14 - 540
Aligned: 453
Modelled: 473
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: A: PDB Molecule:putative oxidoreductase;
PDBTitle: crystal structure of a putative dehydrogenase (rpa1076) from2 rhodopseudomonas palustris cga009 at 2.57 a resolution

Phyre2

PDB 1wve chain B

Region: 1 - 539
Aligned: 480
Modelled: 488
Confidence: 100.0%
Identity: 16%
PDB header:oxidoreductase
Chain: B: PDB Molecule:4-cresol dehydrogenase [hydroxylating]
PDBTitle: p-cresol methylhydroxylase: alteration of the structure of2 the flavoprotein subunit upon its binding to the3 cytochrome subunit

Phyre2

PDB 3bw7 chain A

Region: 20 - 541
Aligned: 456
Modelled: 464
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase
Chain: A: PDB Molecule:cytokinin dehydrogenase 1;
PDBTitle: maize cytokinin oxidase/dehydrogenase complexed with the allenic2 cytokinin analog ha-1

Phyre2

PDB 2exr chain A

Region: 25 - 545
Aligned: 453
Modelled: 447
Confidence: 100.0%
Identity: 19%
PDB header:oxidoreductase
Chain: A: PDB Molecule:cytokinin dehydrogenase 7;
PDBTitle: x-ray structure of cytokinin oxidase/dehydrogenase (ckx)2 from arabidopsis thaliana at5g21482

Phyre2

PDB 2bvf chain A

Region: 27 - 543
Aligned: 423
Modelled: 430
Confidence: 100.0%
Identity: 22%
PDB header:oxidase
Chain: A: PDB Molecule:6-hydroxy-d-nicotine oxidase;
PDBTitle: crystal structure of 6-hydoxy-d-nicotine oxidase from2 arthrobacter nicotinovorans. crystal form 3 (p1)

Phyre2

PDB 3fwa chain A

Region: 17 - 542
Aligned: 438
Modelled: 451
Confidence: 100.0%
Identity: 17%
PDB header:flavoprotein
Chain: A: PDB Molecule:reticuline oxidase;
PDBTitle: structure of berberine bridge enzyme, c166a variant in complex with2 (s)-reticuline

Phyre2

PDB 3d2h chain A

Region: 17 - 542
Aligned: 438
Modelled: 451
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase
Chain: A: PDB Molecule:berberine bridge-forming enzyme;
PDBTitle: structure of berberine bridge enzyme from eschscholzia californica,2 monoclinic crystal form

Phyre2

PDB 1zr6 chain A

Region: 19 - 542
Aligned: 435
Modelled: 448
Confidence: 100.0%
Identity: 16%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glucooligosaccharide oxidase;
PDBTitle: the crystal structure of an acremonium strictum glucooligosaccharide2 oxidase reveals a novel flavinylation

Phyre2

PDB 2ipi chain D

Region: 45 - 543
Aligned: 413
Modelled: 428
Confidence: 100.0%
Identity: 14%
PDB header:oxidoreductase
Chain: D: PDB Molecule:aclacinomycin oxidoreductase (aknox);
PDBTitle: crystal structure of aclacinomycin oxidoreductase

Phyre2

PDB 2wdw chain B

Region: 33 - 542
Aligned: 422
Modelled: 436
Confidence: 100.0%
Identity: 17%
PDB header:oxidoreductase
Chain: B: PDB Molecule:putative hexose oxidase;
PDBTitle: the native crystal structure of the primary hexose oxidase (2 dbv29) in antibiotic a40926 biosynthesis

Phyre2

PDB 3pop chain D

Region: 33 - 541
Aligned: 447
Modelled: 455
Confidence: 100.0%
Identity: 15%
PDB header:oxidoreductase
Chain: D: PDB Molecule:gilr oxidase;
PDBTitle: the crystal structure of gilr, an oxidoreductase that catalyzes the2 terminal step of gilvocarcin biosynthesis

Phyre2

PDB 1f0x chain A domain 2

Region: 16 - 281
Aligned: 247
Modelled: 259
Confidence: 100.0%
Identity: 20%
Fold: FAD-binding/transporter-associated domain-like
Superfamily: FAD-binding/transporter-associated domain-like
Family: FAD-linked oxidases, N-terminal domain

Phyre2

PDB 2y3r chain C

Region: 33 - 544
Aligned: 429
Modelled: 433
Confidence: 100.0%
Identity: 17%
PDB header:oxidoreductase
Chain: C: PDB Molecule:taml;
PDBTitle: structure of the tirandamycin-bound fad-dependent2 tirandamycin oxidase taml in p21 space group

Phyre2

PDB 2vfv chain A

Region: 40 - 536
Aligned: 394
Modelled: 406
Confidence: 100.0%
Identity: 14%
PDB header:oxidoreductase
Chain: A: PDB Molecule:xylitol oxidase;
PDBTitle: alditol oxidase from streptomyces coelicolor a3(2): complex2 with sulphite

Phyre2

PDB 1i19 chain B

Region: 33 - 541
Aligned: 429
Modelled: 449
Confidence: 100.0%
Identity: 15%
PDB header:oxidoreductase
Chain: B: PDB Molecule:cholesterol oxidase;
PDBTitle: crystal structure of cholesterol oxidase from b.sterolicum

Phyre2

PDB 1e8g chain A domain 2

Region: 3 - 282
Aligned: 248
Modelled: 251
Confidence: 100.0%
Identity: 22%
Fold: FAD-binding/transporter-associated domain-like
Superfamily: FAD-binding/transporter-associated domain-like
Family: FAD-linked oxidases, N-terminal domain

Phyre2

PDB 3js8 chain A

Region: 41 - 536
Aligned: 418
Modelled: 442
Confidence: 100.0%
Identity: 16%
PDB header:oxidoreductase
Chain: A: PDB Molecule:cholesterol oxidase;
PDBTitle: solvent-stable cholesterol oxidase

Phyre2

PDB 3kwl chain A

Region: 779 - 1017
Aligned: 222
Modelled: 218
Confidence: 99.6%
Identity: 14%
PDB header:unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a hypothetical protein from helicobacter pylori

Phyre2

PDB 1nek chain B domain 1

Region: 515 - 704
Aligned: 124
Modelled: 124
Confidence: 99.4%
Identity: 25%
Fold: Globin-like
Superfamily: alpha-helical ferredoxin
Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain

Phyre2

PDB 2h89 chain B

Region: 549 - 704
Aligned: 112
Modelled: 112
Confidence: 99.3%
Identity: 21%
PDB header:oxidoreductase
Chain: B: PDB Molecule:succinate dehydrogenase ip subunit;
PDBTitle: avian respiratory complex ii with malonate bound

Phyre2

PDB 2b76 chain N

Region: 547 - 708
Aligned: 117
Modelled: 117
Confidence: 99.2%
Identity: 17%
PDB header:oxidoreductase
Chain: N: PDB Molecule:fumarate reductase iron-sulfur protein;
PDBTitle: e. coli quinol fumarate reductase frda e49q mutation

Phyre2

PDB 3cf4 chain A

Region: 563 - 869
Aligned: 219
Modelled: 219
Confidence: 99.2%
Identity: 12%
PDB header:oxidoreductase
Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit;
PDBTitle: structure of the codh component of the m. barkeri acds complex

Phyre2

PDB 1nek chain B

Region: 547 - 704
Aligned: 114
Modelled: 114
Confidence: 99.2%
Identity: 24%
PDB header:oxidoreductase/electron transport
Chain: B: PDB Molecule:succinate dehydrogenase iron-sulfur protein;
PDBTitle: complex ii (succinate dehydrogenase) from e. coli with2 ubiquinone bound

Phyre2

PDB 1kf6 chain B domain 1

Region: 515 - 708
Aligned: 128
Modelled: 128
Confidence: 99.2%
Identity: 20%
Fold: Globin-like
Superfamily: alpha-helical ferredoxin
Family: Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain

Phyre2

100

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139

140

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153

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166

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Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	I	P	Q	I	S	Q	A	P	G	V	V	Q	L	V	L	N	F	L	Q	E	L	E	Q	Q	G	F	T	G	D	T	A	T	S	Y	A	D	R	L	T	M	S	T	D	N	S	I	Y	Q	L	L	P	D	A	V	V	F	P	R	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	T	A	D	V	A	L	I	A	R	L	A	A	Q	E	R	Y	S	S	L	I	F	T	P	R	G	G	G	T	G	T	N	G	Q	A	L	N	Q	G	I	I	V	D	M	S	R	H	M	N	R	I	I	E	I	N	P	E	E	G	W	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	R	V	E	A	G	V	I	K	D	Q	L	N	Q	Y	L	K	P	F	G	Y	F	F	A	P	E	L	S	T	S	N	R	A	T	L	G	G	M	I	N	T	D	A	S	G	Q	G	S	L	V	Y	G	K	T	S	D	H	V	L	G	V
Secondary structure
SS confidence
Disorder																															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	R	A	V	L	L	G	G	D	I	L	D	T	Q	P	L	P	V	E	L	A	E	T	L	G	K	S	N	T	T	I	G	R	I	Y	N	T	V	Y	Q	R	C	R	Q	Q	R	Q	L	I	I	D	N	F	P	K	L	N	R	F	L	T
Secondary structure
SS confidence
Disorder															?		?	?	?	?		?	?	?	?	?	?	?	?	?																								?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	G	Y	D	L	R	H	V	F	N	D	E	M	T	E	F	D	L	T	R	I	L	T	G	S	E	G	T	L	A	F	I	T	E	A	R	L	D	I	T	R	L	P	K	V	R	R	L	V	N	V	K	Y	D	S	F	D	S	A	L	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	N	A	P	F	M	V	E	A	R	A	L	S	V	E	T	V	D	S	K	V	L	N	L	A	R	E	D	I	V	W	H	S	V	S	E	L	I	T	D	V	P	D	Q	E	M	L	G	L	N	I	V	E	F	A	G	D	D	E	A	L
Secondary structure
SS confidence
Disorder																														?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	I	D	E	R	V	N	A	L	C	A	R	L	D	E	L	I	A	S	H	Q	A	G	V	I	G	W	Q	V	C	R	E	L	A	G	V	E	R	I	Y	A	M	R	K	K	A	V	G	L	L	G	N	A	K	G	A	A	K	P	I	P
Secondary structure
SS confidence
Disorder																																																				?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	F	A	E	D	T	C	V	P	P	E	H	L	A	D	Y	I	A	E	F	R	A	L	L	D	S	H	G	L	S	Y	G	M	F	G	H	V	D	A	G	V	L	H	V	R	P	A	L	D	M	C	D	P	Q	Q	E	I	L	M	K	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	I	S	D	D	V	V	A	L	T	A	K	Y	G	G	L	L	W	G	E	H	G	K	G	F	R	A	E	Y	S	P	A	F	F	G	E	E	L	F	A	E	L	R	K	V	K	A	A	F	D	P	H	N	R	L	N	P	G	K	I	C
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	P	P	E	G	L	D	A	P	M	M	K	V	D	A	V	K	R	G	T	F	D	R	Q	I	P	I	A	V	R	Q	Q	W	R	G	A	M	E	C	N	G	N	G	L	C	F	N	F	D	A	R	S	P	M	C	P	S	M	K	I	T
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?	?										?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	Q	N	R	I	H	S	P	K	G	R	A	T	L	V	R	E	W	L	R	L	L	A	D	R	G	V	D	P	L	K	L	E	Q	E	L	P	E	S	G	V	S	L	R	T	L	I	A	R	T	R	N	S	W	H	A	N	K	G	E	Y
Secondary structure
SS confidence
Disorder	?	?	?	?	?														?	?	?		?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	D	F	S	H	E	V	K	E	A	M	S	G	C	L	A	C	K	A	C	S	T	Q	C	P	I	K	I	D	V	P	E	F	R	S	R	F	L	Q	L	Y	H	T	R	Y	L	R	P	L	R	D	H	L	V	A	T	V	E	S	Y	A
Secondary structure
SS confidence
Disorder	?																																									?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	P	L	M	A	R	A	P	K	T	F	N	F	F	I	N	Q	P	L	V	R	K	L	S	E	K	H	I	G	M	V	D	L	P	L	L	S	V	P	S	L	Q	Q	Q	M	V	G	H	R	S	A	N	M	T	L	E	Q	L	E	S	L
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?		?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	N	A	E	Q	K	A	R	T	V	L	V	V	Q	D	P	F	T	S	Y	Y	D	A	Q	V	V	A	D	F	V	R	L	V	E	K	L	G	F	Q	P	V	L	L	P	F	S	P	N	G	K	A	Q	H	I	K	G	F	L	N	R	F
Secondary structure
SS confidence
Disorder	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	A	K	T	A	K	K	T	A	D	F	L	N	R	M	A	K	L	G	M	P	M	V	G	V	D	P	A	L	V	L	C	Y	R	D	E	Y	K	L	A	L	G	E	E	R	G	E	F	N	V	L	L	A	N	E	W	L	A	S	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	E	S	Q	P	V	A	T	V	S	G	E	S	W	Y	F	F	G	H	C	T	E	V	T	A	L	P	G	A	P	A	Q	W	A	A	I	F	A	R	F	G	A	K	L	E	N	V	S	V	G	C	C	G	M	A	G	T	Y	G	H	E
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?															?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.
Sequence	A	K	N	H	E	N	S	L	G	I	Y	E	L	S	W	H	Q	A	M	Q	R	L	P	R	N	R	C	L	A	T	G	Y	S	C	R	S	Q	V	K	R	V	E	G	T	G	V	R	H	P	V	Q	A	L	L	E	I	I	K
Secondary structure
SS confidence
Disorder																																																									?	?
Disorder confidence