Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	P	P	M	W	R	R	L	I	Y	H	P	D	I	N	Y	A	L	R	Q	T	L	V	L	C	L	P	V	A	V	G	L	M	L	G	E	L	R	F	G	L	L	F	S	L	V	P	A	C	C	N	I	A	G	L	D	T	P	H
Secondary structure
SS confidence
Disorder		?	?	?																																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	R	F	F	K	R	L	I	I	G	A	S	L	F	A	T	C	S	L	L	T	Q	L	L	L	A	K	D	V	P	L	P	F	L	L	T	G	L	T	L	V	L	G	V	T	A	E	L	G	P	L	H	A	K	L	L	P	A	S	L
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	A	A	I	F	T	L	S	L	A	G	Y	M	P	V	W	E	P	L	L	I	Y	A	L	G	T	L	W	Y	G	L	F	N	W	F	W	F	W	I	W	R	E	Q	P	L	R	E	S	L	S	L	L	Y	R	E	L	A	D	Y	C
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?																								?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	A	K	Y	S	L	L	T	Q	H	T	D	P	E	K	A	L	P	P	L	L	V	R	Q	Q	K	A	V	D	L	I	T	Q	C	Y	Q	Q	M	H	M	L	S	A	Q	N	N	T	D	Y	K	R	M	L	R	I	F	Q	E	A	L
Secondary structure
SS confidence
Disorder										?		?	?	?	?	?																									?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	L	Q	E	H	I	S	V	S	L	H	Q	P	E	E	V	Q	K	L	V	E	R	S	H	A	E	E	V	I	R	W	N	A	Q	T	V	A	A	R	L	R	V	L	A	D	D	I	L	Y	H	R	L	P	T	R	F	T	M	E	K
Secondary structure
SS confidence
Disorder																																																			?		?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	I	G	A	L	E	K	I	A	R	Q	H	P	D	N	P	V	G	Q	F	C	Y	W	H	F	S	R	I	A	R	V	L	R	T	Q	K	P	L	Y	A	R	D	L	L	A	D	K	Q	R	R	M	P	L	L	P	A	L	K	S	Y
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	S	L	K	S	P	A	L	R	N	A	G	R	L	S	V	M	L	S	V	A	S	L	M	G	T	A	L	H	L	P	K	S	Y	W	I	L	M	T	V	L	L	V	T	Q	N	G	Y	G	A	T	R	L	R	I	V	N	R	S	V
Secondary structure
SS confidence
Disorder																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		G	T	V	V	G	L	I	I	A	G	V	A	L	H	F	K	I	P	E	G	Y	T	L	T	L	M	L	I	T	T	L	A	S	Y	L	I	L	R	K	N	Y	G	W	A	T	V	G	F	T	I	T	A	V	Y	T	L	Q	L	L	W
Secondary structure
SS confidence
Disorder																																																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		L	N	G	E	Q	Y	I	L	P	R	L	I	D	T	I	I	G	C	L	I	A	F	G	G	T	V	W	L	W	P	Q	W	Q	S	G	L	L	R	K	N	A	H	D	A	L	E	A	Y	Q	E	A	I	R	L	I	L	S	E	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		Q	P	T	P	L	A	W	Q	R	M	R	V	N	Q	A	H	N	T	L	Y	N	S	L	N	Q	A	M	Q	E	P	A	F	N	S	H	Y	L	A	D	M	K	L	W	V	T	H	S	Q	F	I	V	E	H	I	N	A	M	T	T	L
Secondary structure
SS confidence
Disorder		?		?	?																								?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		A	R	E	H	R	A	L	P	P	E	L	A	Q	E	Y	L	Q	S	C	E	I	A	I	Q	R	C	Q	Q	R	L	E	Y	D	E	P	G	S	S	G	D	A	N	I	M	D	A	P	E	M	Q	P	H	E	G	A	A	G	T	L	E
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence		Q	H	L	Q	R	V	I	G	H	L	N	T	M	H	T	I	S	S	M	A	W	R	Q	R	P	H	H	G	I	W	L	S	R	K	L	R	D	S	K	A
Secondary structure
SS confidence
Disorder																		?	?	?		?	?	?	?	?	?	?								?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ht2 chain B Region: 419 - 523 Aligned: 93 Modelled: 105 Confidence: 44.4% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 1ots chain A Region: 419 - 527 Aligned: 97 Modelled: 109 Confidence: 41.4% Identity: 16% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 2yvx chain D Region: 60 - 159 Aligned: 100 Modelled: 100 Confidence: 28.6% Identity: 17% PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte Phyre2 PDB 1kpl chain A Region: 419 - 527 Aligned: 97 Modelled: 109 Confidence: 14.7% Identity: 16% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 1fx8 chain A Region: 412 - 518 Aligned: 107 Modelled: 107 Confidence: 12.2% Identity: 13% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 1lda chain A Region: 412 - 518 Aligned: 107 Modelled: 107 Confidence: 12.2% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:glycerol uptake facilitator protein; PDBTitle: crystal structure of the e. coli glycerol facilitator (glpf) without2 substrate glycerol Phyre2 PDB 2ygg chain A Region: 514 - 566 Aligned: 53 Modelled: 53 Confidence: 11.7% Identity: 9% PDB header:metal binding protein/transport protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: complex of cambr and cam Phyre2 PDB 1ymg chain A Region: 412 - 511 Aligned: 100 Modelled: 100 Confidence: 11.7% Identity: 8% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: the channel architecture of aquaporin o at 2.2 angstrom resolution Phyre2 PDB 1ymg chain A domain 1 Region: 412 - 511 Aligned: 100 Modelled: 100 Confidence: 11.7% Identity: 8% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 1ciy chain A domain 3 Region: 496 - 597 Aligned: 92 Modelled: 102 Confidence: 11.4% Identity: 10% Fold: Toxins' membrane translocation domains Superfamily: delta-Endotoxin (insectocide), N-terminal domain Family: delta-Endotoxin (insectocide), N-terminal domain Phyre2 PDB 2nef chain A Region: 157 - 186 Aligned: 30 Modelled: 30 Confidence: 11.4% Identity: 23% Fold: Regulatory factor Nef Superfamily: Regulatory factor Nef Family: Regulatory factor Nef Phyre2 PDB 3nd0 chain A Region: 419 - 521 Aligned: 91 Modelled: 103 Confidence: 11.2% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 2knc chain B Region: 134 - 175 Aligned: 42 Modelled: 42 Confidence: 11.2% Identity: 17% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3rbb chain A Region: 157 - 186 Aligned: 30 Modelled: 30 Confidence: 10.7% Identity: 20% PDB header:viral protein, protein binding Chain: A: PDB Molecule:protein nef; PDBTitle: hiv-1 nef protein in complex with engineered hck sh3 domain Phyre2 PDB 1e12 chain A Region: 40 - 180 Aligned: 141 Modelled: 141 Confidence: 10.5% Identity: 11% Fold: Family A G protein-coupled receptor-like Superfamily: Family A G protein-coupled receptor-like Family: Bacteriorhodopsin-like Phyre2 PDB 1iwg chain A domain 8 Region: 314 - 510 Aligned: 197 Modelled: 197 Confidence: 10.2% Identity: 13% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 1rc2 chain A Region: 412 - 520 Aligned: 109 Modelled: 109 Confidence: 10.1% Identity: 12% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 1j4n chain A Region: 412 - 511 Aligned: 100 Modelled: 100 Confidence: 9.9% Identity: 10% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 2r6g chain F domain 1 Region: 63 - 129 Aligned: 67 Modelled: 67 Confidence: 9.6% Identity: 10% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 2rmz chain A Region: 130 - 159 Aligned: 30 Modelled: 30 Confidence: 9.4% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:integrin beta-3; PDBTitle: bicelle-embedded integrin beta3 transmembrane segment Phyre2 1 c2ht2B_ 2 d1otsa_ 3 c2yvxD_ 4 d1kpla_ 5 d1fx8a_ 6 c1ldaA_ 7 c2yggA_ 8 c1ymgA_ 9 d1ymga1 10 d1ciya3 11 d2nefa_ 12 c3nd0A_ 13 c2kncB_ 14 c3rbbA_ 15 d1e12a_ 16 d1iwga8 17 d1rc2a_ 18 d1j4na_ 19 d2r6gf1 20 c2rmzA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54