Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	E	N	I	H	K	H	R	I	L	I	L	D	F	G	S	Q	Y	T	Q	L	V	A	R	R	V	R	E	L	G	V	Y	C	E	L	W	A	W	D	V	T	E	A	Q	I	R	D	F	N	P	S	G	I	I	L	S	G	G	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	S	T	T	E	E	N	S	P	R	A	P	Q	Y	V	F	E	A	G	V	P	V	F	G	V	C	Y	G	M	Q	T	M	A	M	Q	L	G	G	H	V	E	A	S	N	E	R	E	F	G	Y	A	Q	V	E	V	V	N	D	S	A
Secondary structure
SS confidence
Disorder				?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	V	R	G	I	E	D	A	L	T	A	D	G	K	P	L	L	D	V	W	M	S	H	G	D	K	V	T	A	I	P	S	D	F	I	T	V	A	S	T	E	S	C	P	F	A	I	M	A	N	E	E	K	R	F	Y	G	V	Q	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		H	P	E	V	T	H	T	R	Q	G	M	R	M	L	E	R	F	V	R	D	I	C	Q	C	E	A	L	W	T	P	A	K	I	I	D	D	A	V	A	R	I	R	E	Q	V	G	D	D	K	V	I	L	G	L	S	G	G	V	D	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	V	T	A	M	L	L	H	R	A	I	G	K	N	L	T	C	V	F	V	D	N	G	L	L	R	L	N	E	A	E	Q	V	L	D	M	F	G	D	H	F	G	L	N	I	V	H	V	P	A	E	D	R	F	L	S	A	L	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	N	D	P	E	A	K	R	K	I	I	G	R	V	F	V	E	V	F	D	E	E	A	L	K	L	E	D	V	K	W	L	A	Q	G	T	I	Y	P	D	V	I	E	S	A	A	S	A	T	G	K	A	H	V	I	K	S	H	H	N
Secondary structure
SS confidence
Disorder		?	?																																												?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	G	G	L	P	K	E	M	K	M	G	L	V	E	P	L	K	E	L	F	K	D	E	V	R	K	I	G	L	E	L	G	L	P	Y	D	M	L	Y	R	H	P	F	P	G	P	G	L	G	V	R	V	L	G	E	V	K	K	E	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		C	D	L	L	R	R	A	D	A	I	F	I	E	E	L	R	K	A	D	L	Y	D	K	V	S	Q	A	F	T	V	F	L	P	V	R	S	V	G	V	M	G	D	G	R	K	Y	D	W	V	V	S	L	R	A	V	E	T	I	D	F
Secondary structure
SS confidence
Disorder																				?																																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.
Sequence		M	T	A	H	W	A	H	L	P	Y	D	F	L	G	R	V	S	N	R	I	I	N	E	V	N	G	I	S	R	V	V	Y	D	I	S	G	K	P	P	A	T	I	E	W	E
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1gpm chain D Region: 3 - 525 Aligned: 499 Modelled: 499 Confidence: 100.0% Identity: 100% PDB header:transferase (glutamine amidotransferase) Chain: D: PDB Molecule:gmp synthetase; PDBTitle: escherichia coli gmp synthetase complexed with amp and pyrophosphate Phyre2 PDB 2vxo chain B Region: 9 - 525 Aligned: 504 Modelled: 517 Confidence: 100.0% Identity: 41% PDB header:ligase Chain: B: PDB Molecule:gmp synthase [glutamine-hydrolyzing]; PDBTitle: human gmp synthetase in complex with xmp Phyre2 PDB 3uow chain B Region: 9 - 525 Aligned: 474 Modelled: 487 Confidence: 100.0% Identity: 44% PDB header:ligase Chain: B: PDB Molecule:gmp synthetase; PDBTitle: crystal structure of pf10_0123, a gmp synthetase from plasmodium2 falciparum Phyre2 PDB 2ywc chain C Region: 10 - 525 Aligned: 466 Modelled: 490 Confidence: 100.0% Identity: 51% PDB header:ligase Chain: C: PDB Molecule:gmp synthase [glutamine-hydrolyzing]; PDBTitle: crystal structure of gmp synthetase from thermus thermophilus in2 complex with xmp Phyre2 PDB 3tqi chain B Region: 5 - 524 Aligned: 464 Modelled: 494 Confidence: 100.0% Identity: 64% PDB header:ligase Chain: B: PDB Molecule:gmp synthase [glutamine-hydrolyzing]; PDBTitle: structure of the gmp synthase (guaa) from coxiella burnetii Phyre2 PDB 2dpl chain A Region: 208 - 525 Aligned: 287 Modelled: 290 Confidence: 100.0% Identity: 52% PDB header:ligase Chain: A: PDB Molecule:gmp synthase [glutamine-hydrolyzing] subunit b; PDBTitle: crystal structure of the gmp synthase from pyrococcus horikoshii ot3 Phyre2 PDB 1gpm chain A domain 3 Region: 405 - 525 Aligned: 121 Modelled: 121 Confidence: 100.0% Identity: 100% Fold: Alpha-lytic protease prodomain-like Superfamily: GMP synthetase C-terminal dimerisation domain Family: GMP synthetase C-terminal dimerisation domain Phyre2 PDB 1gpm chain A domain 2 Region: 3 - 206 Aligned: 204 Modelled: 204 Confidence: 100.0% Identity: 100% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 2vpi chain A Region: 7 - 210 Aligned: 186 Modelled: 195 Confidence: 100.0% Identity: 38% PDB header:ligase Chain: A: PDB Molecule:gmp synthase; PDBTitle: human gmp synthetase - glutaminase domain Phyre2 PDB 1wl8 chain A domain 1 Region: 8 - 203 Aligned: 185 Modelled: 196 Confidence: 100.0% Identity: 36% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 1kee chain H Region: 6 - 207 Aligned: 185 Modelled: 188 Confidence: 100.0% Identity: 21% PDB header:ligase Chain: H: PDB Molecule:carbamoyl-phosphate synthetase small chain; PDBTitle: inactivation of the amidotransferase activity of carbamoyl phosphate2 synthetase by the antibiotic acivicin Phyre2 PDB 2a9v chain A domain 1 Region: 7 - 206 Aligned: 189 Modelled: 199 Confidence: 100.0% Identity: 31% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 1i7q chain B Region: 9 - 199 Aligned: 182 Modelled: 191 Confidence: 100.0% Identity: 26% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 3r74 chain B Region: 5 - 203 Aligned: 186 Modelled: 199 Confidence: 100.0% Identity: 17% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 1qdl chain B Region: 8 - 201 Aligned: 189 Modelled: 194 Confidence: 100.0% Identity: 23% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 1a9x chain B domain 2 Region: 6 - 207 Aligned: 185 Modelled: 188 Confidence: 100.0% Identity: 21% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 1gpm chain A domain 1 Region: 208 - 404 Aligned: 175 Modelled: 175 Confidence: 100.0% Identity: 100% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: N-type ATP pyrophosphatases Phyre2 PDB 1i1q chain B Region: 8 - 203 Aligned: 180 Modelled: 193 Confidence: 100.0% Identity: 24% Fold: Flavodoxin-like Superfamily: Class I glutamine amidotransferase-like Family: Class I glutamine amidotransferases (GAT) Phyre2 PDB 1jvn chain B Region: 6 - 287 Aligned: 273 Modelled: 282 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:bifunctional histidine biosynthesis protein hishf; PDBTitle: crystal structure of imidazole glycerol phosphate synthase: a tunnel2 through a (beta/alpha)8 barrel joins two active sites Phyre2 PDB 3q4g chain A Region: 203 - 426 Aligned: 206 Modelled: 224 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:nh(3)-dependent nad(+) synthetase; PDBTitle: structure of nad synthetase from vibrio cholerae Phyre2 1 c1gpmD_ 2 c2vxoB_ 3 c3uowB_ 4 c2ywcC_ 5 c3tqiB_ 6 c2dplA_ 7 d1gpma3 8 d1gpma2 9 c2vpiA_ 10 d1wl8a1 11 c1keeH_ 12 d2a9va1 13 d1i7qb_ 14 c3r74B_ 15 d1qdlb_ 16 d1a9xb2 17 d1gpma1 18 d1i1qb_ 19 c1jvnB_ 20 c3q4gA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476